Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cadherin-5

Gene

CDH5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton. Acts in concert with KRIT1 to establish and maintain correct endothelial cell polarity and vascular lumen. These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for activation of PRKCZ and for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi58Calcium 1By similarity1
Metal bindingi58Calcium 2By similarity1
Metal bindingi59Calcium 1By similarity1
Metal bindingi109Calcium 1By similarity1
Metal bindingi111Calcium 1By similarity1
Metal bindingi111Calcium 2By similarity1
Metal bindingi143Calcium 2By similarity1
Metal bindingi144Calcium 2; via carbonyl oxygenBy similarity1
Metal bindingi145Calcium 3By similarity1
Metal bindingi146Calcium 1By similarity1
Metal bindingi146Calcium 2By similarity1
Metal bindingi147Calcium 3; via carbonyl oxygenBy similarity1
Metal bindingi177Calcium 3By similarity1
Metal bindingi179Calcium 2By similarity1
Metal bindingi179Calcium 3By similarity1
Metal bindingi186Calcium 3; via carbonyl oxygenBy similarity1
Metal bindingi231Calcium 3By similarity1

GO - Molecular functioni

  • beta-catenin binding Source: BHF-UCL
  • calcium ion binding Source: InterPro
  • ion channel binding Source: BHF-UCL
  • protein phosphatase binding Source: Ensembl
  • signaling receptor binding Source: BHF-UCL

GO - Biological processi

  • adherens junction organization Source: Reactome
  • blood vessel maturation Source: Ensembl
  • cell-cell junction assembly Source: UniProtKB
  • homophilic cell adhesion via plasma membrane adhesion molecules Source: ProtInc
  • negative regulation of cell proliferation Source: Ensembl
  • negative regulation of inflammatory response Source: BHF-UCL
  • positive regulation of angiogenesis Source: BHF-UCL
  • positive regulation of establishment of endothelial barrier Source: UniProtKB
  • regulation of establishment of cell polarity Source: UniProtKB
  • transforming growth factor beta receptor signaling pathway Source: UniProtKB

Keywordsi

Biological processCell adhesion
LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-418990 Adherens junctions interactions
R-HSA-5218920 VEGFR2 mediated vascular permeability
SIGNORiP33151

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin-5
Alternative name(s):
7B4 antigen
Vascular endothelial cadherin
Short name:
VE-cadherin
CD_antigen: CD144
Gene namesi
Name:CDH5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000179776.17
HGNCiHGNC:1764 CDH5
MIMi601120 gene
neXtProtiNX_P33151

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini48 – 599ExtracellularSequence analysisAdd BLAST552
Transmembranei600 – 620HelicalSequence analysisAdd BLAST21
Topological domaini621 – 784CytoplasmicSequence analysisAdd BLAST164

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi1003
OpenTargetsiENSG00000179776
PharmGKBiPA26301

Chemistry databases

DrugBankiDB05685 FX06
DB00480 Lenalidomide

Polymorphism and mutation databases

BioMutaiCDH5
DMDMi322510142

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
PropeptideiPRO_000000375526 – 47Sequence analysisAdd BLAST22
ChainiPRO_000000375648 – 784Cadherin-5Add BLAST737

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi61N-linked (GlcNAc...) (complex) asparagine2 Publications1
Glycosylationi112N-linked (GlcNAc...) (complex) asparagine3 Publications1
Glycosylationi157N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi362N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi442N-linked (GlcNAc...) (complex) asparagine3 Publications1
Glycosylationi523N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi535N-linked (GlcNAc...) asparagine1 Publication1

Post-translational modificationi

Phosphorylated on tyrosine residues by KDR/VEGFR-2. Dephosphorylated by PTPRB (By similarity).By similarity
O-glycosylated.3 Publications

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP33151
PaxDbiP33151
PeptideAtlasiP33151
PRIDEiP33151
TopDownProteomicsiP33151-1 [P33151-1]

PTM databases

GlyConnecti617
iPTMnetiP33151
PhosphoSitePlusiP33151
UniCarbKBiP33151

Miscellaneous databases

PMAP-CutDBiP33151

Expressioni

Tissue specificityi

Endothelial tissues and brain.

Gene expression databases

BgeeiENSG00000179776
CleanExiHS_CDH5
ExpressionAtlasiP33151 baseline and differential
GenevisibleiP33151 HS

Organism-specific databases

HPAiCAB028366

Interactioni

Subunit structurei

Interacts (via cadherin 5 domain) with PTPRB (By similarity). Interacts with TRPC4. Interacts with KRIT1. Interacts with PARD3 (By similarity).By similarity

Binary interactionsi

Show more details

GO - Molecular functioni

  • beta-catenin binding Source: BHF-UCL
  • ion channel binding Source: BHF-UCL
  • protein phosphatase binding Source: Ensembl
  • signaling receptor binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi107438, 94 interactors
CORUMiP33151
DIPiDIP-41172N
IntActiP33151, 11 interactors
MINTiP33151
STRINGi9606.ENSP00000344115

Structurei

3D structure databases

ProteinModelPortaliP33151
SMRiP33151
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini48 – 151Cadherin 1PROSITE-ProRule annotationAdd BLAST104
Domaini152 – 258Cadherin 2PROSITE-ProRule annotationAdd BLAST107
Domaini259 – 372Cadherin 3PROSITE-ProRule annotationAdd BLAST114
Domaini373 – 477Cadherin 4PROSITE-ProRule annotationAdd BLAST105
Domaini478 – 593Cadherin 5PROSITE-ProRule annotationAdd BLAST116

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi736 – 753Ser-richAdd BLAST18

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
GeneTreeiENSGT00900000140970
HOGENOMiHOG000231252
HOVERGENiHBG005217
InParanoidiP33151
KOiK06533
OMAiHGKSVPE
OrthoDBiEOG091G03WQ
PhylomeDBiP33151
TreeFamiTF329887

Family and domain databases

Gene3Di4.10.900.10, 1 hit
InterProiView protein in InterPro
IPR002126 Cadherin
IPR015919 Cadherin-like
IPR020894 Cadherin_CS
IPR000233 Cadherin_cytoplasmic-dom
IPR027397 Catenin_binding_dom_sf
IPR030052 CDH5
PANTHERiPTHR24027:SF89 PTHR24027:SF89, 1 hit
PfamiView protein in Pfam
PF00028 Cadherin, 5 hits
PF01049 Cadherin_C, 1 hit
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 5 hits
SUPFAMiSSF49313 SSF49313, 5 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 3 hits
PS50268 CADHERIN_2, 5 hits

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P33151-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQRLMMLLAT SGACLGLLAV AAVAAAGANP AQRDTHSLLP THRRQKRDWI
60 70 80 90 100
WNQMHIDEEK NTSLPHHVGK IKSSVSRKNA KYLLKGEYVG KVFRVDAETG
110 120 130 140 150
DVFAIERLDR ENISEYHLTA VIVDKDTGEN LETPSSFTIK VHDVNDNWPV
160 170 180 190 200
FTHRLFNASV PESSAVGTSV ISVTAVDADD PTVGDHASVM YQILKGKEYF
210 220 230 240 250
AIDNSGRIIT ITKSLDREKQ ARYEIVVEAR DAQGLRGDSG TATVLVTLQD
260 270 280 290 300
INDNFPFFTQ TKYTFVVPED TRVGTSVGSL FVEDPDEPQN RMTKYSILRG
310 320 330 340 350
DYQDAFTIET NPAHNEGIIK PMKPLDYEYI QQYSFIVEAT DPTIDLRYMS
360 370 380 390 400
PPAGNRAQVI INITDVDEPP IFQQPFYHFQ LKENQKKPLI GTVLAMDPDA
410 420 430 440 450
ARHSIGYSIR RTSDKGQFFR VTKKGDIYNE KELDREVYPW YNLTVEAKEL
460 470 480 490 500
DSTGTPTGKE SIVQVHIEVL DENDNAPEFA KPYQPKVCEN AVHGQLVLQI
510 520 530 540 550
SAIDKDITPR NVKFKFILNT ENNFTLTDNH DNTANITVKY GQFDREHTKV
560 570 580 590 600
HFLPVVISDN GMPSRTGTST LTVAVCKCNE QGEFTFCEDM AAQVGVSIQA
610 620 630 640 650
VVAILLCILT ITVITLLIFL RRRLRKQARA HGKSVPEIHE QLVTYDEEGG
660 670 680 690 700
GEMDTTSYDV SVLNSVRRGG AKPPRPALDA RPSLYAQVQK PPRHAPGAHG
710 720 730 740 750
GPGEMAAMIE VKKDEADHDG DGPPYDTLHI YGYEGSESIA ESLSSLGTDS
760 770 780
SDSDVDYDFL NDWGPRFKML AELYGSDPRE ELLY
Length:784
Mass (Da):87,528
Last modified:February 8, 2011 - v5
Checksum:i6DBEBFC4DA6899D1
GO
Isoform 2 (identifier: P33151-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     380-494: Missing.

Note: No experimental confirmation available.
Show »
Length:669
Mass (Da):74,499
Checksum:i379A177E6E279C9A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti602V → A in AAH96363 (PubMed:15489334).Curated1
Sequence conflicti602V → A in AAI17521 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_028003503I → T. Corresponds to variant dbSNP:rs16956504Ensembl.1
Natural variantiVAR_028004517I → T3 PublicationsCorresponds to variant dbSNP:rs1049970Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_053861380 – 494Missing in isoform 2. 1 PublicationAdd BLAST115

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X79981 mRNA Translation: CAA56306.1
U84722 mRNA Translation: AAB41796.1
AB035304 mRNA Translation: BAA87418.1
BC096363 mRNA Translation: AAH96363.1
BC096364 mRNA Translation: AAH96364.3
BC117520 mRNA Translation: AAI17521.1
X59796 mRNA Translation: CAA42468.1
CCDSiCCDS10804.1 [P33151-1]
PIRiS49893 IJHUC5
RefSeqiNP_001786.2, NM_001795.4 [P33151-1]
UniGeneiHs.76206

Genome annotation databases

EnsembliENST00000341529; ENSP00000344115; ENSG00000179776 [P33151-1]
ENST00000614547; ENSP00000479381; ENSG00000179776 [P33151-2]
GeneIDi1003
KEGGihsa:1003
UCSCiuc002eom.5 human [P33151-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCADH5_HUMAN
AccessioniPrimary (citable) accession number: P33151
Secondary accession number(s): Q4VAI5, Q4VAI6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: February 8, 2011
Last modified: May 23, 2018
This is version 169 of the entry and version 5 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health