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P33151

- CADH5_HUMAN

UniProt

P33151 - CADH5_HUMAN

Protein

Cadherin-5

Gene

CDH5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 134 (01 Oct 2014)
      Sequence version 5 (08 Feb 2011)
      Previous versions | rss
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    Functioni

    Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton. Acts in concert with KRIT1 to establish and maintain correct endothelial cell polarity and vascular lumen. These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for activation of PRKCZ and for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction.2 Publications

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi58 – 581Calcium 1By similarity
    Metal bindingi58 – 581Calcium 2By similarity
    Metal bindingi59 – 591Calcium 1By similarity
    Metal bindingi109 – 1091Calcium 1By similarity
    Metal bindingi111 – 1111Calcium 1By similarity
    Metal bindingi111 – 1111Calcium 2By similarity
    Metal bindingi143 – 1431Calcium 2By similarity
    Metal bindingi144 – 1441Calcium 2; via carbonyl oxygenBy similarity
    Metal bindingi145 – 1451Calcium 3By similarity
    Metal bindingi146 – 1461Calcium 1By similarity
    Metal bindingi146 – 1461Calcium 2By similarity
    Metal bindingi147 – 1471Calcium 3; via carbonyl oxygenBy similarity
    Metal bindingi177 – 1771Calcium 3By similarity
    Metal bindingi179 – 1791Calcium 2By similarity
    Metal bindingi179 – 1791Calcium 3By similarity
    Metal bindingi186 – 1861Calcium 3; via carbonyl oxygenBy similarity
    Metal bindingi231 – 2311Calcium 3By similarity

    GO - Molecular functioni

    1. beta-catenin binding Source: BHF-UCL
    2. calcium ion binding Source: InterPro
    3. ion channel binding Source: BHF-UCL
    4. protein binding Source: UniProtKB
    5. receptor binding Source: BHF-UCL

    GO - Biological processi

    1. adherens junction organization Source: Reactome
    2. blood vessel maturation Source: Ensembl
    3. cell-cell junction organization Source: Reactome
    4. cell junction assembly Source: Reactome
    5. homophilic cell adhesion Source: ProtInc
    6. negative regulation of cell proliferation Source: Ensembl
    7. regulation of establishment of cell polarity Source: UniProtKB

    Keywords - Biological processi

    Cell adhesion

    Keywords - Ligandi

    Calcium, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_19195. Adherens junctions interactions.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cadherin-5
    Alternative name(s):
    7B4 antigen
    Vascular endothelial cadherin
    Short name:
    VE-cadherin
    CD_antigen: CD144
    Gene namesi
    Name:CDH5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:1764. CDH5.

    Subcellular locationi

    Cell junction 1 Publication. Cell membrane 1 Publication; Single-pass type I membrane protein 1 Publication
    Note: Found at cell-cell boundaries and probably at cell-matrix boundaries. KRIT1 and CDH5 reciprocally regulate their localization to endothelial cell-cell junctions.

    GO - Cellular componenti

    1. cell-cell junction Source: UniProtKB
    2. cell junction Source: UniProtKB
    3. integral component of membrane Source: UniProtKB-KW
    4. membrane Source: ProtInc
    5. plasma membrane Source: Reactome
    6. tight junction Source: Ensembl

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26301.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Sequence AnalysisAdd
    BLAST
    Propeptidei26 – 4722Sequence AnalysisPRO_0000003755Add
    BLAST
    Chaini48 – 784737Cadherin-5PRO_0000003756Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi61 – 611N-linked (GlcNAc...) (complex)2 Publications
    Glycosylationi112 – 1121N-linked (GlcNAc...) (complex)3 Publications
    Glycosylationi157 – 1571N-linked (GlcNAc...)1 Publication
    Glycosylationi362 – 3621N-linked (GlcNAc...)1 Publication
    Glycosylationi442 – 4421N-linked (GlcNAc...) (complex)3 Publications
    Glycosylationi523 – 5231N-linked (GlcNAc...)1 Publication
    Glycosylationi535 – 5351N-linked (GlcNAc...)1 Publication

    Post-translational modificationi

    Phosphorylated on tyrosine residues by KDR/VEGFR-2. Dephosphorylated by PTPRB By similarity.By similarity
    O-glycosylated.3 Publications

    Keywords - PTMi

    Cleavage on pair of basic residues, Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiP33151.
    PRIDEiP33151.

    PTM databases

    PhosphoSiteiP33151.
    UniCarbKBiP33151.

    Miscellaneous databases

    PMAP-CutDBP33151.

    Expressioni

    Tissue specificityi

    Endothelial tissues and brain.

    Gene expression databases

    ArrayExpressiP33151.
    BgeeiP33151.
    CleanExiHS_CDH5.
    GenevestigatoriP33151.

    Organism-specific databases

    HPAiCAB028366.
    HPA030562.

    Interactioni

    Subunit structurei

    Interacts (via cadherin 5 domain) with PTPRB By similarity. Interacts with TRPC4. Interacts with KRIT1. Interacts with PARD3 By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CTNNB1P352226EBI-2903122,EBI-491549
    PARD3Q8TEW05EBI-2903122,EBI-81968
    PARD6AQ9NPB64EBI-2903122,EBI-81876

    Protein-protein interaction databases

    BioGridi107438. 13 interactions.
    DIPiDIP-41172N.
    IntActiP33151. 10 interactions.
    MINTiMINT-235470.
    STRINGi9606.ENSP00000344115.

    Structurei

    3D structure databases

    ProteinModelPortaliP33151.
    SMRiP33151. Positions 48-576, 679-775.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini48 – 599552ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini621 – 784164CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei600 – 62021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini48 – 151104Cadherin 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini152 – 258107Cadherin 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini259 – 372114Cadherin 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini373 – 477105Cadherin 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini478 – 593116Cadherin 5PROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi736 – 75318Ser-richAdd
    BLAST

    Domaini

    Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

    Sequence similaritiesi

    Contains 5 cadherin domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG270902.
    HOVERGENiHBG005217.
    InParanoidiP33151.
    KOiK06533.
    OMAiYGYEGSE.
    OrthoDBiEOG773XFF.
    PhylomeDBiP33151.
    TreeFamiTF329887.

    Family and domain databases

    Gene3Di2.60.40.60. 5 hits.
    4.10.900.10. 1 hit.
    InterProiIPR002126. Cadherin.
    IPR015919. Cadherin-like.
    IPR020894. Cadherin_CS.
    IPR000233. Cadherin_cytoplasmic-dom.
    IPR027397. Catenin_binding_dom.
    [Graphical view]
    PfamiPF00028. Cadherin. 5 hits.
    PF01049. Cadherin_C. 1 hit.
    [Graphical view]
    PRINTSiPR00205. CADHERIN.
    SMARTiSM00112. CA. 5 hits.
    [Graphical view]
    SUPFAMiSSF49313. SSF49313. 5 hits.
    PROSITEiPS00232. CADHERIN_1. 3 hits.
    PS50268. CADHERIN_2. 5 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P33151-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MQRLMMLLAT SGACLGLLAV AAVAAAGANP AQRDTHSLLP THRRQKRDWI    50
    WNQMHIDEEK NTSLPHHVGK IKSSVSRKNA KYLLKGEYVG KVFRVDAETG 100
    DVFAIERLDR ENISEYHLTA VIVDKDTGEN LETPSSFTIK VHDVNDNWPV 150
    FTHRLFNASV PESSAVGTSV ISVTAVDADD PTVGDHASVM YQILKGKEYF 200
    AIDNSGRIIT ITKSLDREKQ ARYEIVVEAR DAQGLRGDSG TATVLVTLQD 250
    INDNFPFFTQ TKYTFVVPED TRVGTSVGSL FVEDPDEPQN RMTKYSILRG 300
    DYQDAFTIET NPAHNEGIIK PMKPLDYEYI QQYSFIVEAT DPTIDLRYMS 350
    PPAGNRAQVI INITDVDEPP IFQQPFYHFQ LKENQKKPLI GTVLAMDPDA 400
    ARHSIGYSIR RTSDKGQFFR VTKKGDIYNE KELDREVYPW YNLTVEAKEL 450
    DSTGTPTGKE SIVQVHIEVL DENDNAPEFA KPYQPKVCEN AVHGQLVLQI 500
    SAIDKDITPR NVKFKFILNT ENNFTLTDNH DNTANITVKY GQFDREHTKV 550
    HFLPVVISDN GMPSRTGTST LTVAVCKCNE QGEFTFCEDM AAQVGVSIQA 600
    VVAILLCILT ITVITLLIFL RRRLRKQARA HGKSVPEIHE QLVTYDEEGG 650
    GEMDTTSYDV SVLNSVRRGG AKPPRPALDA RPSLYAQVQK PPRHAPGAHG 700
    GPGEMAAMIE VKKDEADHDG DGPPYDTLHI YGYEGSESIA ESLSSLGTDS 750
    SDSDVDYDFL NDWGPRFKML AELYGSDPRE ELLY 784
    Length:784
    Mass (Da):87,528
    Last modified:February 8, 2011 - v5
    Checksum:i6DBEBFC4DA6899D1
    GO
    Isoform 2 (identifier: P33151-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         380-494: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:669
    Mass (Da):74,499
    Checksum:i379A177E6E279C9A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti602 – 6021V → A in AAH96363. (PubMed:15489334)Curated
    Sequence conflicti602 – 6021V → A in AAI17521. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti503 – 5031I → T.
    Corresponds to variant rs16956504 [ dbSNP | Ensembl ].
    VAR_028003
    Natural varianti517 – 5171I → T.3 Publications
    Corresponds to variant rs1049970 [ dbSNP | Ensembl ].
    VAR_028004

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei380 – 494115Missing in isoform 2. 1 PublicationVSP_053861Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X79981 mRNA. Translation: CAA56306.1.
    U84722 mRNA. Translation: AAB41796.1.
    AB035304 mRNA. Translation: BAA87418.1.
    BC096363 mRNA. Translation: AAH96363.1.
    BC096364 mRNA. Translation: AAH96364.3.
    BC117520 mRNA. Translation: AAI17521.1.
    X59796 mRNA. Translation: CAA42468.1.
    CCDSiCCDS10804.1. [P33151-1]
    PIRiS49893. IJHUC5.
    RefSeqiNP_001786.2. NM_001795.3. [P33151-1]
    UniGeneiHs.76206.

    Genome annotation databases

    EnsembliENST00000341529; ENSP00000344115; ENSG00000179776. [P33151-1]
    GeneIDi1003.
    KEGGihsa:1003.
    UCSCiuc002eom.4. human. [P33151-1]

    Polymorphism databases

    DMDMi322510142.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X79981 mRNA. Translation: CAA56306.1 .
    U84722 mRNA. Translation: AAB41796.1 .
    AB035304 mRNA. Translation: BAA87418.1 .
    BC096363 mRNA. Translation: AAH96363.1 .
    BC096364 mRNA. Translation: AAH96364.3 .
    BC117520 mRNA. Translation: AAI17521.1 .
    X59796 mRNA. Translation: CAA42468.1 .
    CCDSi CCDS10804.1. [P33151-1 ]
    PIRi S49893. IJHUC5.
    RefSeqi NP_001786.2. NM_001795.3. [P33151-1 ]
    UniGenei Hs.76206.

    3D structure databases

    ProteinModelPortali P33151.
    SMRi P33151. Positions 48-576, 679-775.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107438. 13 interactions.
    DIPi DIP-41172N.
    IntActi P33151. 10 interactions.
    MINTi MINT-235470.
    STRINGi 9606.ENSP00000344115.

    PTM databases

    PhosphoSitei P33151.
    UniCarbKBi P33151.

    Polymorphism databases

    DMDMi 322510142.

    Proteomic databases

    PaxDbi P33151.
    PRIDEi P33151.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000341529 ; ENSP00000344115 ; ENSG00000179776 . [P33151-1 ]
    GeneIDi 1003.
    KEGGi hsa:1003.
    UCSCi uc002eom.4. human. [P33151-1 ]

    Organism-specific databases

    CTDi 1003.
    GeneCardsi GC16P066400.
    H-InvDB HIX0038527.
    HGNCi HGNC:1764. CDH5.
    HPAi CAB028366.
    HPA030562.
    MIMi 601120. gene.
    neXtProti NX_P33151.
    PharmGKBi PA26301.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG270902.
    HOVERGENi HBG005217.
    InParanoidi P33151.
    KOi K06533.
    OMAi YGYEGSE.
    OrthoDBi EOG773XFF.
    PhylomeDBi P33151.
    TreeFami TF329887.

    Enzyme and pathway databases

    Reactomei REACT_19195. Adherens junctions interactions.

    Miscellaneous databases

    ChiTaRSi CDH5. human.
    GeneWikii VE-cadherin.
    GenomeRNAii 1003.
    NextBioi 4216.
    PMAP-CutDB P33151.
    PROi P33151.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P33151.
    Bgeei P33151.
    CleanExi HS_CDH5.
    Genevestigatori P33151.

    Family and domain databases

    Gene3Di 2.60.40.60. 5 hits.
    4.10.900.10. 1 hit.
    InterProi IPR002126. Cadherin.
    IPR015919. Cadherin-like.
    IPR020894. Cadherin_CS.
    IPR000233. Cadherin_cytoplasmic-dom.
    IPR027397. Catenin_binding_dom.
    [Graphical view ]
    Pfami PF00028. Cadherin. 5 hits.
    PF01049. Cadherin_C. 1 hit.
    [Graphical view ]
    PRINTSi PR00205. CADHERIN.
    SMARTi SM00112. CA. 5 hits.
    [Graphical view ]
    SUPFAMi SSF49313. SSF49313. 5 hits.
    PROSITEi PS00232. CADHERIN_1. 3 hits.
    PS50268. CADHERIN_2. 5 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Functional properties of human vascular endothelial cadherin (7B4/cadherin-5), an endothelium-specific cadherin."
      Breviario F., Caveda L., Corada M., Martin-Padura I., Navarro P., Golay J., Introna M., Gulino D., Lampugnani M.G., Dejana E.
      Arterioscler. Thromb. Vasc. Biol. 15:1229-1239(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT THR-517.
      Tissue: Endothelial cell.
    2. "Vascular endothelial cadherin (VE-cadherin): cloning and role in endothelial cell-cell adhesion."
      Ali J., Liao F., Martens E., Muller W.A.
      Microcirculation 4:267-277(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Placenta.
    3. "Identification of three human type-II classic cadherins and frequent heterophilic interactions between different subclasses of type-II classic cadherins."
      Shimoyama Y., Tsujimoto G., Kitajima M., Natori M.
      Biochem. J. 349:159-167(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT THR-517.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT THR-517.
    5. "Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue."
      Suzuki S., Sano K., Tanihara H.
      Cell Regul. 2:261-270(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 5-784 (ISOFORM 1).
      Tissue: Brain.
    6. "A novel endothelial-specific membrane protein is a marker of cell-cell contacts."
      Lampugnani M.G., Resnati M., Raiteri M., Pigott R., Pisacane A., Houen G., Ruco L.P., Dejana E.
      J. Cell Biol. 118:1511-1522(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: PARTIAL PROTEIN SEQUENCE.
      Tissue: Endothelial cell.
    7. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
      Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
      J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-112; ASN-442; ASN-523 AND ASN-535.
      Tissue: Plasma.
    8. Cited for: GLYCOSYLATION AT ASN-61; ASN-112 AND ASN-442.
    9. "Cell-cell contact formation governs Ca2+ signaling by TRPC4 in the vascular endothelium: evidence for a regulatory TRPC4-beta-catenin interaction."
      Graziani A., Poteser M., Heupel W.M., Schleifer H., Krenn M., Drenckhahn D., Romanin C., Baumgartner W., Groschner K.
      J. Biol. Chem. 285:4213-4223(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH TRPC4.
    10. "CCM1 regulates vascular-lumen organization by inducing endothelial polarity."
      Lampugnani M.G., Orsenigo F., Rudini N., Maddaluno L., Boulday G., Chapon F., Dejana E.
      J. Cell Sci. 123:1073-1080(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH KRIT1.
    11. "Structure and binding mechanism of vascular endothelial cadherin: a divergent classical cadherin."
      Brasch J., Harrison O.J., Ahlsen G., Carnally S.M., Henderson R.M., Honig B., Shapiro L.
      J. Mol. Biol. 408:57-73(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, GLYCOSYLATION AT ASN-61; ASN-112; ASN-157; ASN-362 AND ASN-442.

    Entry informationi

    Entry nameiCADH5_HUMAN
    AccessioniPrimary (citable) accession number: P33151
    Secondary accession number(s): Q4VAI5, Q4VAI6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1993
    Last sequence update: February 8, 2011
    Last modified: October 1, 2014
    This is version 134 of the entry and version 5 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3