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Protein

Cadherin-15

Gene

Cdh15

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. M-cadherin is part of the myogenic program and may provide a trigger for terminal muscle differentiation.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-375170. CDO in myogenesis.
R-MMU-418990. Adherens junctions interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin-15
Alternative name(s):
Cadherin-14
Muscle cadherin
Short name:
M-cadherin
Gene namesi
Name:Cdh15
Synonyms:Cdh14
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:106672. Cdh15.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini60 – 605ExtracellularSequence analysisAdd BLAST546
Transmembranei606 – 625HelicalSequence analysisAdd BLAST20
Topological domaini626 – 784CytoplasmicSequence analysisAdd BLAST159

GO - Cellular componenti

  • caveola Source: MGI
  • extracellular exosome Source: MGI
  • integral component of membrane Source: UniProtKB-KW
  • neuromuscular junction Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
PropeptideiPRO_000000380722 – 59Sequence analysisAdd BLAST38
ChainiPRO_000000380860 – 784Cadherin-15Add BLAST725

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi106N-linked (GlcNAc...)1 Publication1
Glycosylationi226N-linked (GlcNAc...)Sequence analysis1
Glycosylationi530N-linked (GlcNAc...)Sequence analysis1
Glycosylationi537N-linked (GlcNAc...)1 Publication1
Glycosylationi575N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein

Proteomic databases

PaxDbiP33146.
PeptideAtlasiP33146.
PRIDEiP33146.

PTM databases

PhosphoSitePlusiP33146.

Expressioni

Tissue specificityi

Skeletal muscle.

Gene expression databases

BgeeiENSMUSG00000031962.
CleanExiMM_CDH15.
GenevisibleiP33146. MM.

Interactioni

Protein-protein interaction databases

BioGridi198634. 2 interactors.
STRINGi10090.ENSMUSP00000034443.

Structurei

3D structure databases

ProteinModelPortaliP33146.
SMRiP33146.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini60 – 151Cadherin 1PROSITE-ProRule annotationAdd BLAST92
Domaini152 – 259Cadherin 2PROSITE-ProRule annotationAdd BLAST108
Domaini260 – 374Cadherin 3PROSITE-ProRule annotationAdd BLAST115
Domaini375 – 480Cadherin 4PROSITE-ProRule annotationAdd BLAST106
Domaini481 – 589Cadherin 5PROSITE-ProRule annotationAdd BLAST109

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi745 – 756Ser-richAdd BLAST12

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Sequence similaritiesi

Contains 5 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00760000118906.
HOGENOMiHOG000231254.
HOVERGENiHBG106438.
InParanoidiP33146.
KOiK06809.
OMAiWVARFTI.
OrthoDBiEOG091G02MA.
TreeFamiTF316817.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 4 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 5 hits.
PROSITEiPS00232. CADHERIN_1. 2 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P33146-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSALLLALG LLAQSLGLSW AVPEPKPSTL YPWRRASAPG RVRRAWVIPP
60 70 80 90 100
ISVSENHKRL PYPLVQIKSD KQQLGSVIYS IQGPGVDEEP RNVFSIDKFT
110 120 130 140 150
GRVYLNATLD REKTDRFRLR AFALDLGGST LEDPTDLEIV VVDQNDNRPA
160 170 180 190 200
FLQDVFRGRI LEGAIPGTFV TRAEATDADD PETDNAALRF SILEQGSPEF
210 220 230 240 250
FSIDEHTGEI RTVQVGLDRE VVAVYNLTLQ VADMSGDGLT ATASAIISID
260 270 280 290 300
DINDNAPEFT KDEFFMEAAE AVSGVDVGRL EVEDKDLPGS PNWVARFTIL
310 320 330 340 350
EGDPDGQFKI YTDPKTNEGV LSVVKPLDYE SREQYELRVS VQNEAPLQAA
360 370 380 390 400
APRARRGQTR VSVWVQDTNE APVFPENPLR TSIAEGAPPG TSVATFSARD
410 420 430 440 450
PDTEQLQRIS YSKDYDPEDW LQVDGATGRI QTQRVLSPAS PFLKDGWYRA
460 470 480 490 500
IILALDNAIP PSTATGTLSI EILEVNDHAP ALALPPSGSL CSEPDQGPGL
510 520 530 540 550
LLGATDEDLP PHGAPFHFQL NPRVPDLGRN WSVSQINVSH ARLRLRHQVS
560 570 580 590 600
EGLHRLSLLL QDSGEPPQQR EQTLNVTVCR CGSDGTCLPG AAALRGGGVG
610 620 630 640 650
VSLGALVIVL ASTVVLLVLI LLAALRTRFR GHSRGKSLLH GLQEDLRDNI
660 670 680 690 700
LNYDEQGGGE EDQDAYDINQ LRHPVEPRAT SRSLGRPPLR RDAPFSYVPQ
710 720 730 740 750
PHRVLPTSPS DIANFISDGL EAADSDPSVP PYDTALIYDY EGDGSVAGTL
760 770 780
SSILSSLGDE DQDYDYLRDW GPRFARLADM YGHQ
Length:784
Mass (Da):85,644
Last modified:July 27, 2011 - v3
Checksum:iA21D73960A6F0063
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti26K → E in AAC23585 (PubMed:1840697).Curated1
Sequence conflicti159R → H in AAC23585 (PubMed:1840697).Curated1
Sequence conflicti622L → F in AAC23585 (PubMed:1840697).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC157978 mRNA. Translation: AAI57979.1.
M74541 mRNA. Translation: AAC23585.1.
AJ245402 Genomic DNA. Translation: CAB57281.2.
CCDSiCCDS22746.1.
PIRiA40986. IJMSCM.
RefSeqiNP_031688.2. NM_007662.2.
UniGeneiMm.1976.

Genome annotation databases

EnsembliENSMUST00000034443; ENSMUSP00000034443; ENSMUSG00000031962.
GeneIDi12555.
KEGGimmu:12555.
UCSCiuc009ntv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC157978 mRNA. Translation: AAI57979.1.
M74541 mRNA. Translation: AAC23585.1.
AJ245402 Genomic DNA. Translation: CAB57281.2.
CCDSiCCDS22746.1.
PIRiA40986. IJMSCM.
RefSeqiNP_031688.2. NM_007662.2.
UniGeneiMm.1976.

3D structure databases

ProteinModelPortaliP33146.
SMRiP33146.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198634. 2 interactors.
STRINGi10090.ENSMUSP00000034443.

PTM databases

PhosphoSitePlusiP33146.

Proteomic databases

PaxDbiP33146.
PeptideAtlasiP33146.
PRIDEiP33146.

Protocols and materials databases

DNASUi12555.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034443; ENSMUSP00000034443; ENSMUSG00000031962.
GeneIDi12555.
KEGGimmu:12555.
UCSCiuc009ntv.1. mouse.

Organism-specific databases

CTDi1013.
MGIiMGI:106672. Cdh15.

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00760000118906.
HOGENOMiHOG000231254.
HOVERGENiHBG106438.
InParanoidiP33146.
KOiK06809.
OMAiWVARFTI.
OrthoDBiEOG091G02MA.
TreeFamiTF316817.

Enzyme and pathway databases

ReactomeiR-MMU-375170. CDO in myogenesis.
R-MMU-418990. Adherens junctions interactions.

Miscellaneous databases

PROiP33146.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031962.
CleanExiMM_CDH15.
GenevisibleiP33146. MM.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 4 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 5 hits.
PROSITEiPS00232. CADHERIN_1. 2 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCAD15_MOUSE
AccessioniPrimary (citable) accession number: P33146
Secondary accession number(s): B2RXU1, Q9QYZ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: July 27, 2011
Last modified: November 30, 2016
This is version 134 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.