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P33146

- CAD15_MOUSE

UniProt

P33146 - CAD15_MOUSE

Protein

Cadherin-15

Gene

Cdh15

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 3 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. M-cadherin is part of the myogenic program and may provide a trigger for terminal muscle differentiation.

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. protein binding Source: MGI

    GO - Biological processi

    1. homophilic cell adhesion Source: InterPro

    Keywords - Biological processi

    Cell adhesion

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cadherin-15
    Alternative name(s):
    Cadherin-14
    Muscle cadherin
    Short name:
    M-cadherin
    Gene namesi
    Name:Cdh15
    Synonyms:Cdh14
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 8

    Organism-specific databases

    MGIiMGI:106672. Cdh15.

    Subcellular locationi

    GO - Cellular componenti

    1. caveola Source: MGI
    2. integral component of membrane Source: UniProtKB-KW
    3. neuromuscular junction Source: MGI

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Propeptidei22 – 5938Sequence AnalysisPRO_0000003807Add
    BLAST
    Chaini60 – 784725Cadherin-15PRO_0000003808Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi106 – 1061N-linked (GlcNAc...)1 Publication
    Glycosylationi226 – 2261N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi530 – 5301N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi537 – 5371N-linked (GlcNAc...)1 Publication
    Glycosylationi575 – 5751N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Cleavage on pair of basic residues, Glycoprotein

    Proteomic databases

    PaxDbiP33146.
    PRIDEiP33146.

    PTM databases

    PhosphoSiteiP33146.

    Expressioni

    Tissue specificityi

    Skeletal muscle.

    Gene expression databases

    BgeeiP33146.
    CleanExiMM_CDH15.
    GenevestigatoriP33146.

    Interactioni

    Protein-protein interaction databases

    BioGridi198634. 2 interactions.
    STRINGi10090.ENSMUSP00000034443.

    Structurei

    3D structure databases

    ProteinModelPortaliP33146.
    SMRiP33146. Positions 46-467, 698-780.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini60 – 605546ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini626 – 784159CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei606 – 62520HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini60 – 15192Cadherin 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini152 – 259108Cadherin 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini260 – 374115Cadherin 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini375 – 480106Cadherin 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini481 – 589109Cadherin 5PROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi745 – 75612Ser-richAdd
    BLAST

    Domaini

    Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

    Sequence similaritiesi

    Contains 5 cadherin domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG306443.
    GeneTreeiENSGT00740000115457.
    HOGENOMiHOG000231254.
    HOVERGENiHBG106438.
    InParanoidiB2RXU1.
    KOiK06809.
    OMAiWVARFTI.
    OrthoDBiEOG7RJPQM.
    TreeFamiTF316817.

    Family and domain databases

    Gene3Di2.60.40.60. 4 hits.
    4.10.900.10. 1 hit.
    InterProiIPR002126. Cadherin.
    IPR015919. Cadherin-like.
    IPR020894. Cadherin_CS.
    IPR000233. Cadherin_cytoplasmic-dom.
    IPR027397. Catenin_binding_dom.
    [Graphical view]
    PfamiPF00028. Cadherin. 5 hits.
    PF01049. Cadherin_C. 1 hit.
    [Graphical view]
    PRINTSiPR00205. CADHERIN.
    SMARTiSM00112. CA. 4 hits.
    [Graphical view]
    SUPFAMiSSF49313. SSF49313. 5 hits.
    PROSITEiPS00232. CADHERIN_1. 2 hits.
    PS50268. CADHERIN_2. 5 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P33146-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGSALLLALG LLAQSLGLSW AVPEPKPSTL YPWRRASAPG RVRRAWVIPP    50
    ISVSENHKRL PYPLVQIKSD KQQLGSVIYS IQGPGVDEEP RNVFSIDKFT 100
    GRVYLNATLD REKTDRFRLR AFALDLGGST LEDPTDLEIV VVDQNDNRPA 150
    FLQDVFRGRI LEGAIPGTFV TRAEATDADD PETDNAALRF SILEQGSPEF 200
    FSIDEHTGEI RTVQVGLDRE VVAVYNLTLQ VADMSGDGLT ATASAIISID 250
    DINDNAPEFT KDEFFMEAAE AVSGVDVGRL EVEDKDLPGS PNWVARFTIL 300
    EGDPDGQFKI YTDPKTNEGV LSVVKPLDYE SREQYELRVS VQNEAPLQAA 350
    APRARRGQTR VSVWVQDTNE APVFPENPLR TSIAEGAPPG TSVATFSARD 400
    PDTEQLQRIS YSKDYDPEDW LQVDGATGRI QTQRVLSPAS PFLKDGWYRA 450
    IILALDNAIP PSTATGTLSI EILEVNDHAP ALALPPSGSL CSEPDQGPGL 500
    LLGATDEDLP PHGAPFHFQL NPRVPDLGRN WSVSQINVSH ARLRLRHQVS 550
    EGLHRLSLLL QDSGEPPQQR EQTLNVTVCR CGSDGTCLPG AAALRGGGVG 600
    VSLGALVIVL ASTVVLLVLI LLAALRTRFR GHSRGKSLLH GLQEDLRDNI 650
    LNYDEQGGGE EDQDAYDINQ LRHPVEPRAT SRSLGRPPLR RDAPFSYVPQ 700
    PHRVLPTSPS DIANFISDGL EAADSDPSVP PYDTALIYDY EGDGSVAGTL 750
    SSILSSLGDE DQDYDYLRDW GPRFARLADM YGHQ 784
    Length:784
    Mass (Da):85,644
    Last modified:July 27, 2011 - v3
    Checksum:iA21D73960A6F0063
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti26 – 261K → E in AAC23585. (PubMed:1840697)Curated
    Sequence conflicti159 – 1591R → H in AAC23585. (PubMed:1840697)Curated
    Sequence conflicti622 – 6221L → F in AAC23585. (PubMed:1840697)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC157978 mRNA. Translation: AAI57979.1.
    M74541 mRNA. Translation: AAC23585.1.
    AJ245402 Genomic DNA. Translation: CAB57281.2.
    CCDSiCCDS22746.1.
    PIRiA40986. IJMSCM.
    RefSeqiNP_031688.2. NM_007662.2.
    UniGeneiMm.1976.

    Genome annotation databases

    EnsembliENSMUST00000034443; ENSMUSP00000034443; ENSMUSG00000031962.
    GeneIDi12555.
    KEGGimmu:12555.
    UCSCiuc009ntv.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC157978 mRNA. Translation: AAI57979.1 .
    M74541 mRNA. Translation: AAC23585.1 .
    AJ245402 Genomic DNA. Translation: CAB57281.2 .
    CCDSi CCDS22746.1.
    PIRi A40986. IJMSCM.
    RefSeqi NP_031688.2. NM_007662.2.
    UniGenei Mm.1976.

    3D structure databases

    ProteinModelPortali P33146.
    SMRi P33146. Positions 46-467, 698-780.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 198634. 2 interactions.
    STRINGi 10090.ENSMUSP00000034443.

    PTM databases

    PhosphoSitei P33146.

    Proteomic databases

    PaxDbi P33146.
    PRIDEi P33146.

    Protocols and materials databases

    DNASUi 12555.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000034443 ; ENSMUSP00000034443 ; ENSMUSG00000031962 .
    GeneIDi 12555.
    KEGGi mmu:12555.
    UCSCi uc009ntv.1. mouse.

    Organism-specific databases

    CTDi 1013.
    MGIi MGI:106672. Cdh15.

    Phylogenomic databases

    eggNOGi NOG306443.
    GeneTreei ENSGT00740000115457.
    HOGENOMi HOG000231254.
    HOVERGENi HBG106438.
    InParanoidi B2RXU1.
    KOi K06809.
    OMAi WVARFTI.
    OrthoDBi EOG7RJPQM.
    TreeFami TF316817.

    Miscellaneous databases

    NextBioi 281610.
    PROi P33146.
    SOURCEi Search...

    Gene expression databases

    Bgeei P33146.
    CleanExi MM_CDH15.
    Genevestigatori P33146.

    Family and domain databases

    Gene3Di 2.60.40.60. 4 hits.
    4.10.900.10. 1 hit.
    InterProi IPR002126. Cadherin.
    IPR015919. Cadherin-like.
    IPR020894. Cadherin_CS.
    IPR000233. Cadherin_cytoplasmic-dom.
    IPR027397. Catenin_binding_dom.
    [Graphical view ]
    Pfami PF00028. Cadherin. 5 hits.
    PF01049. Cadherin_C. 1 hit.
    [Graphical view ]
    PRINTSi PR00205. CADHERIN.
    SMARTi SM00112. CA. 4 hits.
    [Graphical view ]
    SUPFAMi SSF49313. SSF49313. 5 hits.
    PROSITEi PS00232. CADHERIN_1. 2 hits.
    PS50268. CADHERIN_2. 5 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Link D.
      Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C3H.
      Tissue: Muscle.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    3. "Expression of M-cadherin, a member of the cadherin multigene family, correlates with differentiation of skeletal muscle cells."
      Donalies M., Cramer M., Ringwald M., Starzinski-Powitz A.
      Proc. Natl. Acad. Sci. U.S.A. 88:8024-8028(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Muscle.
    4. "Identification of imprinted loci by methylation-sensitive representational difference analysis: application to mouse distal chromosome 2."
      Kelsey G., Bodle D., Miller H.J., Beechey C.V., Coombes C., Peters J., Williamson C.M.
      Genomics 62:129-138(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 539-617.
    5. "The mouse C2C12 myoblast cell surface N-linked glycoproteome: identification, glycosite occupancy, and membrane orientation."
      Gundry R.L., Raginski K., Tarasova Y., Tchernyshyov I., Bausch-Fluck D., Elliott S.T., Boheler K.R., Van Eyk J.E., Wollscheid B.
      Mol. Cell. Proteomics 8:2555-2569(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-106 AND ASN-537.
      Tissue: Myoblast.

    Entry informationi

    Entry nameiCAD15_MOUSE
    AccessioniPrimary (citable) accession number: P33146
    Secondary accession number(s): B2RXU1, Q9QYZ7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1993
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 118 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3