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Protein

Glucans biosynthesis protein G

Gene

mdoG

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs).

Pathwayi: osmoregulated periplasmic glucan (OPG) biosynthesis

This protein is involved in the pathway osmoregulated periplasmic glucan (OPG) biosynthesis, which is part of Glycan metabolism.
View all proteins of this organism that are known to be involved in the pathway osmoregulated periplasmic glucan (OPG) biosynthesis and in Glycan metabolism.

GO - Molecular functioni

GO - Biological processi

  • beta-glucan biosynthetic process Source: EcoCyc
  • response to osmotic stress Source: EcoCyc
Complete GO annotation...

Enzyme and pathway databases

BioCyciEcoCyc:EG11885-MONOMER.
ECOL316407:JW1035-MONOMER.
UniPathwayiUPA00637.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucans biosynthesis protein G
Gene namesi
Name:mdoG
Synonyms:opgG
Ordered Locus Names:b1048, JW1035
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11885. mdoG.

Subcellular locationi

GO - Cellular componenti

  • outer membrane-bounded periplasmic space Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 221 PublicationAdd BLAST22
ChainiPRO_000002022123 – 511Glucans biosynthesis protein GAdd BLAST489

Proteomic databases

EPDiP33136.
PaxDbiP33136.
PRIDEiP33136.

2D gel databases

SWISS-2DPAGEP33136.

Interactioni

Protein-protein interaction databases

BioGridi4260686. 329 interactors.
DIPiDIP-10177N.
IntActiP33136. 6 interactors.
STRINGi511145.b1048.

Structurei

Secondary structure

1511
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi25 – 36Combined sources12
Helixi56 – 59Combined sources4
Helixi66 – 68Combined sources3
Turni71 – 73Combined sources3
Beta strandi79 – 84Combined sources6
Beta strandi93 – 98Combined sources6
Beta strandi103 – 105Combined sources3
Helixi110 – 112Combined sources3
Turni122 – 124Combined sources3
Beta strandi130 – 137Combined sources8
Beta strandi146 – 153Combined sources8
Beta strandi156 – 159Combined sources4
Beta strandi169 – 172Combined sources4
Beta strandi174 – 176Combined sources3
Beta strandi187 – 194Combined sources8
Beta strandi203 – 211Combined sources9
Beta strandi214 – 223Combined sources10
Beta strandi225 – 240Combined sources16
Beta strandi245 – 252Combined sources8
Beta strandi254 – 257Combined sources4
Beta strandi271 – 273Combined sources3
Beta strandi276 – 280Combined sources5
Beta strandi286 – 290Combined sources5
Beta strandi298 – 306Combined sources9
Beta strandi309 – 313Combined sources5
Helixi319 – 321Combined sources3
Turni325 – 327Combined sources3
Helixi329 – 331Combined sources3
Beta strandi334 – 341Combined sources8
Beta strandi345 – 352Combined sources8
Beta strandi363 – 370Combined sources8
Beta strandi378 – 389Combined sources12
Helixi391 – 394Combined sources4
Beta strandi399 – 410Combined sources12
Beta strandi423 – 432Combined sources10
Helixi436 – 438Combined sources3
Beta strandi446 – 451Combined sources6
Beta strandi455 – 465Combined sources11
Turni466 – 469Combined sources4
Beta strandi470 – 480Combined sources11
Beta strandi486 – 493Combined sources8
Beta strandi495 – 507Combined sources13

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1TXKX-ray2.50A/B23-511[»]
ProteinModelPortaliP33136.
SMRiP33136.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP33136.

Family & Domainsi

Domaini

Contains a large N-terminal domain that would serve as the catalytic core subunit, and a smaller C-terminal domain that would act to modulate this enzymatic activity.

Sequence similaritiesi

Belongs to the OpgD/OpgG family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4105DJ9. Bacteria.
COG3131. LUCA.
HOGENOMiHOG000288261.
InParanoidiP33136.
KOiK03670.
OMAiKQDEIMT.
PhylomeDBiP33136.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
2.70.98.10. 1 hit.
HAMAPiMF_01069. MdoG_OpgG. 1 hit.
InterProiIPR011013. Gal_mutarotase_SF_dom.
IPR014718. GH-type_carb-bd.
IPR007444. Glucan_biosyn_MdoG_C.
IPR014438. Glucan_biosyn_MdoGD.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR023704. MdoG_OpgG.
[Graphical view]
PfamiPF04349. MdoG. 1 hit.
[Graphical view]
PIRSFiPIRSF006281. MdoG. 1 hit.
SUPFAMiSSF74650. SSF74650. 1 hit.
SSF81296. SSF81296. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P33136-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMKMRWLSAA VMLTLYTSSS WAFSIDDVAK QAQSLAGKGY ETPKSNLPSV
60 70 80 90 100
FRDMKYADYQ QIQFNHDKAY WNNLKTPFKL EFYHQGMYFD TPVKINEVTA
110 120 130 140 150
TAVKRIKYSP DYFTFGDVQH DKDTVKDLGF AGFKVLYPIN SKDKNDEIVS
160 170 180 190 200
MLGASYFRVI GAGQVYGLSA RGLAIDTALP SGEEFPRFKE FWIERPKPTD
210 220 230 240 250
KRLTIYALLD SPRATGAYKF VVMPGRDTVV DVQSKIYLRD KVGKLGVAPL
260 270 280 290 300
TSMFLFGPNQ PSPANNYRPE LHDSNGLSIH AGNGEWIWRP LNNPKHLAVS
310 320 330 340 350
SFSMENPQGF GLLQRGRDFS RFEDLDDRYD LRPSAWVTPK GEWGKGSVEL
360 370 380 390 400
VEIPTNDETN DNIVAYWTPD QLPEPGKEMN FKYTITFSRD EDKLHAPDNA
410 420 430 440 450
WVQQTRRSTG DVKQSNLIRQ PDGTIAFVVD FTGAEMKKLP EDTPVTAQTS
460 470 480 490 500
IGDNGEIVES TVRYNPVTKG WRLVMRVKVK DAKKTTEMRA ALVNADQTLS
510
ETWSYQLPAN E
Length:511
Mass (Da):57,912
Last modified:October 1, 1993 - v1
Checksum:i0B53ECE270516C70
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64197 Genomic DNA. Translation: CAA45521.1.
U00096 Genomic DNA. Translation: AAC74132.1.
AP009048 Genomic DNA. Translation: BAA35846.1.
PIRiS35417.
RefSeqiNP_415566.1. NC_000913.3.

Genome annotation databases

EnsemblBacteriaiAAC74132; AAC74132; b1048.
BAA35846; BAA35846; BAA35846.
GeneIDi945005.
KEGGiecj:JW1035.
eco:b1048.
PATRICi32117335. VBIEscCol129921_1090.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64197 Genomic DNA. Translation: CAA45521.1.
U00096 Genomic DNA. Translation: AAC74132.1.
AP009048 Genomic DNA. Translation: BAA35846.1.
PIRiS35417.
RefSeqiNP_415566.1. NC_000913.3.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1TXKX-ray2.50A/B23-511[»]
ProteinModelPortaliP33136.
SMRiP33136.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260686. 329 interactors.
DIPiDIP-10177N.
IntActiP33136. 6 interactors.
STRINGi511145.b1048.

2D gel databases

SWISS-2DPAGEP33136.

Proteomic databases

EPDiP33136.
PaxDbiP33136.
PRIDEiP33136.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74132; AAC74132; b1048.
BAA35846; BAA35846; BAA35846.
GeneIDi945005.
KEGGiecj:JW1035.
eco:b1048.
PATRICi32117335. VBIEscCol129921_1090.

Organism-specific databases

EchoBASEiEB1831.
EcoGeneiEG11885. mdoG.

Phylogenomic databases

eggNOGiENOG4105DJ9. Bacteria.
COG3131. LUCA.
HOGENOMiHOG000288261.
InParanoidiP33136.
KOiK03670.
OMAiKQDEIMT.
PhylomeDBiP33136.

Enzyme and pathway databases

UniPathwayiUPA00637.
BioCyciEcoCyc:EG11885-MONOMER.
ECOL316407:JW1035-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP33136.
PROiP33136.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
2.70.98.10. 1 hit.
HAMAPiMF_01069. MdoG_OpgG. 1 hit.
InterProiIPR011013. Gal_mutarotase_SF_dom.
IPR014718. GH-type_carb-bd.
IPR007444. Glucan_biosyn_MdoG_C.
IPR014438. Glucan_biosyn_MdoGD.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR023704. MdoG_OpgG.
[Graphical view]
PfamiPF04349. MdoG. 1 hit.
[Graphical view]
PIRSFiPIRSF006281. MdoG. 1 hit.
SUPFAMiSSF74650. SSF74650. 1 hit.
SSF81296. SSF81296. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiOPGG_ECOLI
AccessioniPrimary (citable) accession number: P33136
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: November 2, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.