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Protein

Flagellar biosynthetic protein FliR

Gene

fliR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Role in flagellar biosynthesis.

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciEcoCyc:EG11977-MONOMER.
ECOL316407:JW1934-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Flagellar biosynthetic protein FliR
Gene namesi
Name:fliR
Synonyms:flaP
Ordered Locus Names:b1950, JW1934
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11977. fliR.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei13 – 33HelicalSequence analysisAdd BLAST21
Transmembranei45 – 65HelicalSequence analysisAdd BLAST21
Transmembranei66 – 86HelicalSequence analysisAdd BLAST21
Transmembranei90 – 110HelicalSequence analysisAdd BLAST21
Transmembranei131 – 151HelicalSequence analysisAdd BLAST21
Transmembranei184 – 204HelicalSequence analysisAdd BLAST21
Transmembranei213 – 233HelicalSequence analysisAdd BLAST21
Transmembranei235 – 255HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Bacterial flagellum, Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001920551 – 261Flagellar biosynthetic protein FliRAdd BLAST261

Proteomic databases

PaxDbiP33135.
PRIDEiP33135.

Interactioni

Protein-protein interaction databases

BioGridi4261046. 249 interactors.
IntActiP33135. 4 interactors.
STRINGi511145.b1950.

Structurei

3D structure databases

ProteinModelPortaliP33135.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FliR/MopE/SpaR family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105D19. Bacteria.
COG1684. LUCA.
HOGENOMiHOG000253545.
InParanoidiP33135.
KOiK02421.
OMAiNLAFGVM.
PhylomeDBiP33135.

Family and domain databases

InterProiIPR006303. FliR.
IPR002010. T3SS_IM_R.
[Graphical view]
PfamiPF01311. Bac_export_1. 1 hit.
[Graphical view]
PRINTSiPR00953. TYPE3IMRPROT.
TIGRFAMsiTIGR01400. fliR. 1 hit.

Sequencei

Sequence statusi: Complete.

P33135-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLQVTSEQWL SWLNLYFWPL LRVLALISTA PILSERSVPK RVKLGLAMMI
60 70 80 90 100
TFAIAPSLPA NDVPVFSFFA LWLAVQQILI GIALGFTMQF AFAAVRTAGE
110 120 130 140 150
IIGLQMGLSF ATFVDPASHL NMPVLARIMD MLALLLFLTF NGHLWLISLL
160 170 180 190 200
VDTFHTLPIG GEPLNSNAFL ALTKAGSLIF LNGLMLALPL ITLLLTLNLA
210 220 230 240 250
LGLLNRMAPQ LSIFVIGFPL TLTVGISLMA ALMPLIAPFC EHLFSEIFNL
260
LADIISELPL I
Length:261
Mass (Da):28,543
Last modified:November 1, 1997 - v2
Checksum:i55405C88D4542B7F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti223T → A in AAC36861 (PubMed:8282695).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L22182 Genomic DNA. Translation: AAC36861.1.
U00096 Genomic DNA. Translation: AAC75017.1.
AP009048 Genomic DNA. Translation: BAA15775.1.
PIRiC64959.
RefSeqiNP_416460.1. NC_000913.3.
WP_000942319.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75017; AAC75017; b1950.
BAA15775; BAA15775; BAA15775.
GeneIDi946464.
KEGGiecj:JW1934.
eco:b1950.
PATRICi32119229. VBIEscCol129921_2029.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L22182 Genomic DNA. Translation: AAC36861.1.
U00096 Genomic DNA. Translation: AAC75017.1.
AP009048 Genomic DNA. Translation: BAA15775.1.
PIRiC64959.
RefSeqiNP_416460.1. NC_000913.3.
WP_000942319.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP33135.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261046. 249 interactors.
IntActiP33135. 4 interactors.
STRINGi511145.b1950.

Proteomic databases

PaxDbiP33135.
PRIDEiP33135.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75017; AAC75017; b1950.
BAA15775; BAA15775; BAA15775.
GeneIDi946464.
KEGGiecj:JW1934.
eco:b1950.
PATRICi32119229. VBIEscCol129921_2029.

Organism-specific databases

EchoBASEiEB1920.
EcoGeneiEG11977. fliR.

Phylogenomic databases

eggNOGiENOG4105D19. Bacteria.
COG1684. LUCA.
HOGENOMiHOG000253545.
InParanoidiP33135.
KOiK02421.
OMAiNLAFGVM.
PhylomeDBiP33135.

Enzyme and pathway databases

BioCyciEcoCyc:EG11977-MONOMER.
ECOL316407:JW1934-MONOMER.

Miscellaneous databases

PROiP33135.

Family and domain databases

InterProiIPR006303. FliR.
IPR002010. T3SS_IM_R.
[Graphical view]
PfamiPF01311. Bac_export_1. 1 hit.
[Graphical view]
PRINTSiPR00953. TYPE3IMRPROT.
TIGRFAMsiTIGR01400. fliR. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiFLIR_ECOLI
AccessioniPrimary (citable) accession number: P33135
Secondary accession number(s): P76327
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: November 1, 1997
Last modified: November 2, 2016
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.