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Protein

Probable fimbrial chaperone YadV

Gene

yadV

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Part of the yadCKLM-htrE-yadVN fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches.1 Publication

Miscellaneous

The operon is cryptic under classical laboratory conditions, but is functional when constitutively expressed.1 Publication

Caution

Was originally called ecpD, but ecp is now used for the ecpABCDE operon involved in E.coli common pilus (ECP) synthesis.1 Publication

GO - Biological processi

  • cell adhesion Source: EcoCyc
  • cell wall organization Source: InterPro
  • chaperone-mediated protein folding Source: InterPro
  • pilus organization Source: EcoCyc

Keywordsi

Molecular functionChaperone
Biological processFimbrium biogenesis, Stress response

Enzyme and pathway databases

BioCyciEcoCyc:EG11973-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Probable fimbrial chaperone YadV
Gene namesi
Name:yadV
Synonyms:ecpD
Ordered Locus Names:b0140, JW0136
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11973 yadV

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Periplasm

Pathology & Biotechi

Disruption phenotypei

Deletion of the operon under classical laboratory conditions does not result in any major effect on E.coli capacity to form biofilms compared with the wild-type strain.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000000926926 – 246Probable fimbrial chaperone YadVAdd BLAST221

Proteomic databases

PaxDbiP33128
PRIDEiP33128

Expressioni

Inductioni

Repressed by H-NS. Induced by heat shock.2 Publications

Interactioni

Protein-protein interaction databases

BioGridi4263031, 16 interactors
DIPiDIP-9492N
IntActiP33128, 1 interactor
STRINGi316385.ECDH10B_0120

Structurei

Secondary structure

1246
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi27 – 37Combined sources11
Beta strandi43 – 49Combined sources7
Beta strandi51 – 53Combined sources3
Beta strandi55 – 63Combined sources9
Beta strandi76 – 86Combined sources11
Beta strandi91 – 98Combined sources8
Beta strandi106 – 108Combined sources3
Beta strandi110 – 119Combined sources10
Beta strandi138 – 147Combined sources10
Helixi155 – 157Combined sources3
Helixi158 – 161Combined sources4
Beta strandi163 – 167Combined sources5
Beta strandi174 – 179Combined sources6
Beta strandi181 – 183Combined sources3
Beta strandi187 – 194Combined sources8
Beta strandi197 – 201Combined sources5
Beta strandi210 – 216Combined sources7
Beta strandi227 – 233Combined sources7
Beta strandi239 – 245Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5GHUX-ray1.63A26-246[»]
ProteinModelPortaliP33128
SMRiP33128
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the periplasmic pilus chaperone family.Curated

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

eggNOGiENOG4108VEV Bacteria
ENOG4111JH1 LUCA
HOGENOMiHOG000260152
InParanoidiP33128
KOiK15540
OMAiNVKMVAP
PhylomeDBiP33128

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR013783 Ig-like_fold
IPR008962 PapD-like_sf
IPR036316 Pili_assmbl_chap_C_dom_sf
IPR001829 Pili_assmbl_chaperone_bac
IPR016148 Pili_assmbl_chaperone_C
IPR018046 Pili_assmbl_chaperone_CS
IPR016147 Pili_assmbl_chaperone_N
PfamiView protein in Pfam
PF02753 PapD_C, 1 hit
PF00345 PapD_N, 1 hit
PRINTSiPR00969 CHAPERONPILI
SUPFAMiSSF49354 SSF49354, 1 hit
SSF49584 SSF49584, 1 hit
PROSITEiView protein in PROSITE
PS00635 PILI_CHAPERONE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P33128-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFFNTKHTTA LCFVTCMAFS SSSIADIVIS GTRVIYKSDQ KSVNVRLENK
60 70 80 90 100
GNNPLLVQSW LDTGDDNAEP GSITVPFTAT PPVSRIDAKR GQTIKLMYTA
110 120 130 140 150
STSLPKDRES VFWFNVLEVP PKPDAEKVAN QSLLQLAFRT RIKLFYRPDG
160 170 180 190 200
LKGNPSEAPL ALKWFWSGSE GKASLRVTNP TPYYVSFSSG DLEASGKRYP
210 220 230 240
IDVKMIAPFS DEVMKVNGLN GKANSAKVHF YAINDFGGAI EGNARL
Length:246
Mass (Da):27,054
Last modified:November 1, 1997 - v2
Checksum:i33C77D484DD77E08
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti79A → R in AAA23720 (PubMed:8102362).Curated1
Sequence conflicti110 – 111SV → RA in AAA23720 (PubMed:8102362).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L00680 Genomic DNA Translation: AAA23720.1
U00096 Genomic DNA Translation: AAC73251.1
AP009048 Genomic DNA Translation: BAB96716.1
PIRiS45209
RefSeqiNP_414682.1, NC_000913.3
WP_000465928.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC73251; AAC73251; b0140
BAB96716; BAB96716; BAB96716
GeneIDi944859
KEGGiecj:JW0136
eco:b0140
PATRICifig|1411691.4.peg.2141

Entry informationi

Entry nameiYADV_ECOLI
AccessioniPrimary (citable) accession number: P33128
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: November 1, 1997
Last modified: March 28, 2018
This is version 143 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

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