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Protein

Somatostatin

Gene

SST

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Somatostatin inhibits the release of somatotropin.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

ReactomeiR-GGA-375276. Peptide ligand-binding receptors.
R-GGA-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Somatostatin
Cleaved into the following 2 chains:
Gene namesi
Name:SST
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 9

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24By similarityAdd BLAST24
PropeptideiPRO_000003310625 – 88By similarityAdd BLAST64
PeptideiPRO_000003310789 – 116Somatostatin-28Add BLAST28
PeptideiPRO_0000033108103 – 116Somatostatin-14Add BLAST14

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi105 ↔ 116By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Expressioni

Gene expression databases

BgeeiENSGALG00000007361.
ExpressionAtlasiP33094. differential.

Interactioni

GO - Molecular functioni

Family & Domainsi

Sequence similaritiesi

Belongs to the somatostatin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00510000047914.
HOVERGENiHBG017816.
InParanoidiP33094.
KOiK05237.
OMAiAEQDDMR.
OrthoDBiEOG091G157X.
PhylomeDBiP33094.

Family and domain databases

InterProiIPR004250. Somatostatin.
IPR018142. Somatostatin/Cortistatin_C.
[Graphical view]
PANTHERiPTHR10558. PTHR10558. 1 hit.
PfamiPF03002. Somatostatin. 1 hit.
[Graphical view]
PIRSFiPIRSF001814. Somatostatin. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P33094-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSCRLQCAL ALLSIALAVG TVSAAPSDPR LRQFLQKSLA AAAGKQELAK
60 70 80 90 100
YFLAELLSEP SQTENEALES EDLSRGAEQD EVRLELERSA NSNPALAPRE
110
RKAGCKNFFW KTFTSC
Length:116
Mass (Da):12,675
Last modified:October 1, 1993 - v1
Checksum:i8A5BB9BDA8A291BA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X60191 mRNA. Translation: CAA42747.1.
PIRiS20630.
RefSeqiNP_990667.1. NM_205336.1.
UniGeneiGga.742.

Genome annotation databases

EnsembliENSGALT00000011903; ENSGALP00000011889; ENSGALG00000007361.
GeneIDi396279.
KEGGigga:396279.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X60191 mRNA. Translation: CAA42747.1.
PIRiS20630.
RefSeqiNP_990667.1. NM_205336.1.
UniGeneiGga.742.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000011903; ENSGALP00000011889; ENSGALG00000007361.
GeneIDi396279.
KEGGigga:396279.

Organism-specific databases

CTDi6750.

Phylogenomic databases

GeneTreeiENSGT00510000047914.
HOVERGENiHBG017816.
InParanoidiP33094.
KOiK05237.
OMAiAEQDDMR.
OrthoDBiEOG091G157X.
PhylomeDBiP33094.

Enzyme and pathway databases

ReactomeiR-GGA-375276. Peptide ligand-binding receptors.
R-GGA-418594. G alpha (i) signalling events.

Miscellaneous databases

PROiP33094.

Gene expression databases

BgeeiENSGALG00000007361.
ExpressionAtlasiP33094. differential.

Family and domain databases

InterProiIPR004250. Somatostatin.
IPR018142. Somatostatin/Cortistatin_C.
[Graphical view]
PANTHERiPTHR10558. PTHR10558. 1 hit.
PfamiPF03002. Somatostatin. 1 hit.
[Graphical view]
PIRSFiPIRSF001814. Somatostatin. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSMS_CHICK
AccessioniPrimary (citable) accession number: P33094
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: November 30, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.