Reviewed,
UniProtKB/Swiss-Prot P33066 (NTP1_VARV)
Last modified
June 16, 2009.
Version 58.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Nucleoside triphosphatase I EC=3.6.1.15 Alternative name(s): Nucleoside triphosphate phosphohydrolase I Short name=NPH I | ||||
| Gene names |
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| Organism | Variola virus | ||||
| Taxonomic identifier | 10255 [NCBI] | ||||
| Taxonomic lineage | Viruses › dsDNA viruses, no RNA stage › Poxviridae › Chordopoxvirinae › Orthopoxvirus | ||||
| Virus host | Homo sapiens (Human) [TaxID: 9606] |
Protein attributes
| Sequence length | 631 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Serves two roles in transcription; it acts in concert with viral termination factor/capping enzyme to catalyze release of UUUUUNU-containing nascent RNA from the elongation complex, and it acts by itself as a polymerase elongation factor to facilitate readthrough of intrinsic pause sites By similarity. |
| Catalytic activity | NTP + H2O = NDP + phosphate. |
| Sequence similarities | Belongs to the helicase family. NPH I subfamily. Contains 1 helicase ATP-binding domain. Contains 1 helicase C-terminal domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Transcription |
| Developmental stage | Late protein |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Hydrolase |
| Gene Ontology (GO) | |
| Biological process | transcription Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW DNA bindingInferred from electronic annotation. Source: InterPro helicase activityInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 631 | 631 | Nucleoside triphosphatase I | PRO_0000099093 | |||||
Regions | |||||||||
| Domain | 42 – 204 | 163 | Helicase ATP-binding | ||||||
| Domain | 367 – 532 | 166 | Helicase C-terminal | ||||||
| Nucleotide binding | 55 – 62 | 8 | ATP By similarity | ||||||
| Motif | 141 – 144 | 4 | DEXH box | ||||||
Natural variations | |||||||||
| Natural variant | 331 | 1 | E → K in strain: Garcia-1966. | ||||||
| Natural variant | 577 | 1 | E → K in strain: Garcia-1966. | ||||||
Sequences
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References
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | X67119 Genomic DNA. Translation: CAA47600.1. Different initiation. X69198 Genomic DNA. Translation: CAA49042.1. L22579 Genomic DNA. Translation: AAA60849.1. Y16780 Genomic DNA. Translation: CAB54701.1. |
| PIR | C72163. H36847. T28539. |
| RefSeq | NP_042145.1. |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 1486475. |
Enzyme and pathway databases | |
| BRENDA | 3.6.1.15. 288297. |
Family and domain databases | |
| InterPro | IPR014001. DEAD-like_N. IPR001650. DNA/RNA_helicase_C. IPR014021. Helicase_SF1/SF2_ATP-bd. IPR013676. NPHI_C. IPR000330. SNF2_N. [Graphical view] |
| Pfam | PF00271. Helicase_C. 1 hit. PF08469. NPHI_C. 1 hit. PF00176. SNF2_N. 1 hit. [Graphical view] |
| SMART | SM00487. DEXDc. 1 hit. SM00490. HELICc. 1 hit. [Graphical view] |
| PROSITE | PS51192. HELICASE_ATP_BIND_1. 1 hit. PS51194. HELICASE_CTER. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | NTP1_VARV | ||||||||
| Accession | Primary (citable) accession number: P33066 Secondary accession number(s): Q9QNI4 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | Virus (Virus annotation project) | ||||||||

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