Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Alpha-S2-casein

Gene

CSN1S2

Organism
Capra hircus (Goat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Important role in the capacity of milk to transport calcium phosphate.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Milk protein

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-S2-casein
Short name:
Alpha-S2-CN
Gene namesi
Name:CSN1S2
OrganismiCapra hircus (Goat)
Taxonomic identifieri9925 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeCapra

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Protein family/group databases

Allergomei1242. Cap h 8.
2967. Cap h 10.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 15By similarityAdd BLAST15
ChainiPRO_000000446316 – 223Alpha-S2-caseinAdd BLAST208

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei23PhosphoserineBy similarity1
Modified residuei24PhosphoserineBy similarity1
Modified residuei25PhosphoserineBy similarity1
Modified residuei72PhosphoserineBy similarity1
Modified residuei73PhosphoserineBy similarity1
Modified residuei74PhosphoserineBy similarity1
Modified residuei77PhosphoserineBy similarity1
Modified residuei159PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Expressioni

Tissue specificityi

Mammary gland specific. Secreted in milk.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati77 – 141Add BLAST65
Repeati159 – 223Add BLAST65

Sequence similaritiesi

Belongs to the alpha-casein family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

HOVERGENiHBG005244.
OrthoDBiEOG091G0QMQ.

Family and domain databases

InterProiIPR011175. Alpha-s2_casein.
IPR001588. Casein.
IPR031305. Casein_CS.
[Graphical view]
PfamiPF00363. Casein. 2 hits.
[Graphical view]
PIRSFiPIRSF002371. Alpha-s2-casein. 1 hit.
PROSITEiPS00306. CASEIN_ALPHA_BETA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P33049-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFFIFTCLL AVALAKHKME HVSSSEEPIN IFQEIYKQEK NMAIHPRKEK
60 70 80 90 100
LCTTSCEEVV RNANEEEYSI RSSSEESAEV APEEIKITVD DKHYQKALNE
110 120 130 140 150
INQFYQKFPQ YLQYPYQGPI VLNPWDQVKR NAGPFTPTVN REQLSTSEEN
160 170 180 190 200
SKKTIDMEST EVFTKKTKLT EEEKNRLNFL KKISQYYQKF AWPQYLKTVD
210 220
QHQKAMKPWT QPKTNAIPYV RYL
Length:223
Mass (Da):26,389
Last modified:October 1, 1993 - v1
Checksum:i187DEF42FD688291
GO

Polymorphismi

The frequencies of the A, B and C alleles is estimated to be 0.85, 0.04 and 0.11 in the French dairy breeds 'Alpine' and 'Saanen'.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti22V → I in allele F. 1 Publication1
Natural varianti79E → K in allele B. 1 Publication1
Natural varianti161E → K in allele 0. 1
Natural varianti182K → I in allele C and allele E. 2 Publications1
Natural varianti208P → R in allele E. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X65160 mRNA. Translation: CAA46278.1.
S74171 Genomic DNA. Translation: AAB32166.1.
AJ249995 mRNA. Translation: CAB59920.1.
AJ289715 mRNA. Translation: CAB94235.1.
AJ289716 mRNA. Translation: CAB94236.1.
AJ297310
, AJ242526, AJ242528, AJ242527, AJ242533, AJ297311, AJ297313, AJ297315, AJ297316, AJ297314, AJ297312, AJ242728 Genomic DNA. Translation: CAC21704.2.
PIRiI46995.
S33881. JN0547.
RefSeqiNP_001272514.1. NM_001285585.1.
UniGeneiChi.518.

Genome annotation databases

GeneIDi100861229.
KEGGichx:100861229.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X65160 mRNA. Translation: CAA46278.1.
S74171 Genomic DNA. Translation: AAB32166.1.
AJ249995 mRNA. Translation: CAB59920.1.
AJ289715 mRNA. Translation: CAB94235.1.
AJ289716 mRNA. Translation: CAB94236.1.
AJ297310
, AJ242526, AJ242528, AJ242527, AJ242533, AJ297311, AJ297313, AJ297315, AJ297316, AJ297314, AJ297312, AJ242728 Genomic DNA. Translation: CAC21704.2.
PIRiI46995.
S33881. JN0547.
RefSeqiNP_001272514.1. NM_001285585.1.
UniGeneiChi.518.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei1242. Cap h 8.
2967. Cap h 10.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100861229.
KEGGichx:100861229.

Phylogenomic databases

HOVERGENiHBG005244.
OrthoDBiEOG091G0QMQ.

Family and domain databases

InterProiIPR011175. Alpha-s2_casein.
IPR001588. Casein.
IPR031305. Casein_CS.
[Graphical view]
PfamiPF00363. Casein. 2 hits.
[Graphical view]
PIRSFiPIRSF002371. Alpha-s2-casein. 1 hit.
PROSITEiPS00306. CASEIN_ALPHA_BETA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCASA2_CAPHI
AccessioniPrimary (citable) accession number: P33049
Secondary accession number(s): Q9GK07
, Q9MYU6, Q9MYU7, Q9TTQ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: September 7, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.