Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cathelicidin-4

Gene

CATHL4

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Potent microbicidal activity; active against S.aureus and E.coli.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Fungicide

Protein family/group databases

TCDBi1.C.33.1.2. the cathelicidin (cathelicidin) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Cathelicidin-4
Alternative name(s):
Indolicidin
Gene namesi
Name:CATHL4
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
PropeptideiPRO_000000472030 – 1301 PublicationAdd BLAST101
PeptideiPRO_0000004721131 – 143Cathelicidin-4Add BLAST13

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi85 ↔ 96By similarity
Disulfide bondi107 ↔ 124By similarity
Modified residuei143Arginine amide1 Publication1

Post-translational modificationi

Elastase might be responsible for its maturation.

Keywords - PTMi

Amidation, Disulfide bond

Proteomic databases

PaxDbiP33046.
PeptideAtlasiP33046.
PRIDEiP33046.

Expressioni

Tissue specificityi

Large granules of neutrophils.

Gene expression databases

BgeeiENSBTAG00000020072.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000026747.

Structurei

Secondary structure

1144
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi135 – 142Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1G89NMR-A131-143[»]
1G8CNMR-A131-143[»]
1HR1NMR-A131-143[»]
1QX9NMR-A132-144[»]
1QXQNMR-A134-144[»]
ProteinModelPortaliP33046.
SMRiP33046.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP33046.

Family & Domainsi

Sequence similaritiesi

Belongs to the cathelicidin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J18R. Eukaryota.
ENOG41119S0. LUCA.
GeneTreeiENSGT00390000000410.
HOGENOMiHOG000093184.
HOVERGENiHBG006116.
InParanoidiP33046.
OMAiMIAKRIR.
OrthoDBiEOG091G0XQS.
TreeFamiTF338457.

Family and domain databases

InterProiIPR001894. Cathelicidin.
IPR018216. Cathelicidin_CS.
[Graphical view]
PANTHERiPTHR10206. PTHR10206. 1 hit.
PROSITEiPS00946. CATHELICIDINS_1. 1 hit.
PS00947. CATHELICIDINS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P33046-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQTQRASLSL GRWSLWLLLL GLVVPSASAQ ALSYREAVLR AVDQLNELSS
60 70 80 90 100
EANLYRLLEL DPPPKDNEDL GTRKPVSFTV KETVCPRTIQ QPAEQCDFKE
110 120 130 140
KGRVKQCVGT VTLDPSNDQF DLNCNELQSV ILPWKWPWWP WRRG
Length:144
Mass (Da):16,479
Last modified:October 1, 1993 - v1
Checksum:iE3B1CBBE55C09911
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X67340 mRNA. Translation: CAA47755.1.
BC133480 mRNA. Translation: AAI33481.1.
PIRiJC1222.
RefSeqiNP_777252.1. NM_174827.2.
UniGeneiBt.3.
Bt.88494.

Genome annotation databases

EnsembliENSBTAT00000026747; ENSBTAP00000026747; ENSBTAG00000020072.
GeneIDi282166.
KEGGibta:282166.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X67340 mRNA. Translation: CAA47755.1.
BC133480 mRNA. Translation: AAI33481.1.
PIRiJC1222.
RefSeqiNP_777252.1. NM_174827.2.
UniGeneiBt.3.
Bt.88494.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1G89NMR-A131-143[»]
1G8CNMR-A131-143[»]
1HR1NMR-A131-143[»]
1QX9NMR-A132-144[»]
1QXQNMR-A134-144[»]
ProteinModelPortaliP33046.
SMRiP33046.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000026747.

Protein family/group databases

TCDBi1.C.33.1.2. the cathelicidin (cathelicidin) family.

Proteomic databases

PaxDbiP33046.
PeptideAtlasiP33046.
PRIDEiP33046.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000026747; ENSBTAP00000026747; ENSBTAG00000020072.
GeneIDi282166.
KEGGibta:282166.

Organism-specific databases

CTDi282166.

Phylogenomic databases

eggNOGiENOG410J18R. Eukaryota.
ENOG41119S0. LUCA.
GeneTreeiENSGT00390000000410.
HOGENOMiHOG000093184.
HOVERGENiHBG006116.
InParanoidiP33046.
OMAiMIAKRIR.
OrthoDBiEOG091G0XQS.
TreeFamiTF338457.

Miscellaneous databases

EvolutionaryTraceiP33046.

Gene expression databases

BgeeiENSBTAG00000020072.

Family and domain databases

InterProiIPR001894. Cathelicidin.
IPR018216. Cathelicidin_CS.
[Graphical view]
PANTHERiPTHR10206. PTHR10206. 1 hit.
PROSITEiPS00946. CATHELICIDINS_1. 1 hit.
PS00947. CATHELICIDINS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCTHL4_BOVIN
AccessioniPrimary (citable) accession number: P33046
Secondary accession number(s): A3KN14
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: November 2, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.