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P33034

- TOG3A_AGEAP

UniProt

P33034 - TOG3A_AGEAP

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Protein

Omega-agatoxin-Aa3a

Gene
N/A
Organism
Agelenopsis aperta (North American funnel-web spider) (Agelenopsis gertschi)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Omega-agatoxin are antagonist of voltage-gated calcium channels. They block insect neuromuscular transmission presynaptically. Potent blocker of N- (Cav2.2/CACNA1B) and L-type (Cav1/CACNA1) calcium channels.

Keywords - Molecular functioni

Calcium channel impairing toxin, Ion channel impairing toxin, Neurotoxin, Presynaptic neurotoxin, Toxin, Voltage-gated calcium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Omega-agatoxin-Aa3a
Short name:
Omega-AGTX-Aa3a
Alternative name(s):
Omega-agatoxin IIIA
Short name:
Omega-Aga-IIIA
Omega-agatoxin-3A
OrganismiAgelenopsis aperta (North American funnel-web spider) (Agelenopsis gertschi)
Taxonomic identifieri6908 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAraneaeAraneomorphaeEntelegynaeAgelenidaeAgelenopsis

Organism-specific databases

ArachnoServeriAS000178. omega-agatoxin-Aa3a.

Subcellular locationi

GO - Cellular componenti

  1. other organism presynaptic membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 7676Omega-agatoxin-Aa3aPRO_0000087606Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi2 ↔ 19 Inferred
Disulfide bondi9 ↔ 25 Inferred
Disulfide bondi16 ↔ 52 Inferred
Disulfide bondi18 ↔ 40 Inferred
Disulfide bondi27 ↔ 38 Inferred
Disulfide bondi59 ↔ 67 Inferred

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Family & Domainsi

Domaini

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin Inferred.

Sequence similaritiesi

Keywords - Domaini

Knottin

Family and domain databases

InterProiIPR005853. Omega-agatoxin_II/III_CS.
IPR013605. Toxin_34.
[Graphical view]
PfamiPF08396. Toxin_34. 1 hit.
[Graphical view]
PROSITEiPS60023. OMEGA_AGA_II_III. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P33034-1 [UniParc]FASTAAdd to Basket

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SCIDIGGDCD GEKDDCQCCR RNGYCSCYSL FGYLKSGCKC VVGTSAEFQG   50
ICRRKARQCY NSDPDKCESH NKPKRR 76
Length:76
Mass (Da):8,518
Last modified:October 1, 1993 - v1
Checksum:i6A715CAC9591888B
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti58 – 581Q → T.

Sequence databases

PIRiA42335.
A54252.

Cross-referencesi

Sequence databases

PIRi A42335.
A54252.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

ArachnoServeri AS000178. omega-agatoxin-Aa3a.

Family and domain databases

InterProi IPR005853. Omega-agatoxin_II/III_CS.
IPR013605. Toxin_34.
[Graphical view ]
Pfami PF08396. Toxin_34. 1 hit.
[Graphical view ]
PROSITEi PS60023. OMEGA_AGA_II_III. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Antagonism of synaptosomal calcium channels by subtypes of omega-agatoxins."
    Venema V.J., Swiderek K.M., Lee T.D., Hathaway G.M., Adams M.E.
    J. Biol. Chem. 267:2610-2615(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE.
    Tissue: Venom.

Entry informationi

Entry nameiTOG3A_AGEAP
AccessioniPrimary (citable) accession number: P33034
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: October 16, 2013
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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