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Protein

Omega-agatoxin-Aa3a

Gene
N/A
Organism
Agelenopsis aperta (North American funnel-web spider) (Agelenopsis gertschi)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Omega-agatoxin are antagonist of voltage-gated calcium channels. They block insect neuromuscular transmission presynaptically. Potent blocker of N- (Cav2.2/CACNA1B) and L-type (Cav1/CACNA1) calcium channels.

Keywords - Molecular functioni

Calcium channel impairing toxin, Ion channel impairing toxin, Neurotoxin, Presynaptic neurotoxin, Toxin, Voltage-gated calcium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Omega-agatoxin-Aa3a
Short name:
Omega-AGTX-Aa3a
Alternative name(s):
Omega-agatoxin IIIA
Short name:
Omega-Aga-IIIA
Omega-agatoxin-3A
OrganismiAgelenopsis aperta (North American funnel-web spider) (Agelenopsis gertschi)
Taxonomic identifieri6908 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAraneaeAraneomorphaeEntelegynaeAgelenidaeAgelenopsis

Organism-specific databases

ArachnoServeriAS000178. omega-agatoxin-Aa3a.

Subcellular locationi

GO - Cellular componenti

  1. other organism presynaptic membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 7676Omega-agatoxin-Aa3aPRO_0000087606Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi2 ↔ 19Curated
Disulfide bondi9 ↔ 25Curated
Disulfide bondi16 ↔ 52Curated
Disulfide bondi18 ↔ 40Curated
Disulfide bondi27 ↔ 38Curated
Disulfide bondi59 ↔ 67Curated

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Family & Domainsi

Domaini

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.Curated

Sequence similaritiesi

Keywords - Domaini

Knottin

Family and domain databases

InterProiIPR005853. Omega-agatoxin_II/III_CS.
IPR013605. Toxin_34.
[Graphical view]
PfamiPF08396. Toxin_34. 1 hit.
[Graphical view]
PROSITEiPS60023. OMEGA_AGA_II_III. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P33034-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
SCIDIGGDCD GEKDDCQCCR RNGYCSCYSL FGYLKSGCKC VVGTSAEFQG
60 70
ICRRKARQCY NSDPDKCESH NKPKRR
Length:76
Mass (Da):8,518
Last modified:October 1, 1993 - v1
Checksum:i6A715CAC9591888B
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti58 – 581Q → T.

Sequence databases

PIRiA42335.
A54252.

Cross-referencesi

Sequence databases

PIRiA42335.
A54252.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

ArachnoServeriAS000178. omega-agatoxin-Aa3a.

Family and domain databases

InterProiIPR005853. Omega-agatoxin_II/III_CS.
IPR013605. Toxin_34.
[Graphical view]
PfamiPF08396. Toxin_34. 1 hit.
[Graphical view]
PROSITEiPS60023. OMEGA_AGA_II_III. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Antagonism of synaptosomal calcium channels by subtypes of omega-agatoxins."
    Venema V.J., Swiderek K.M., Lee T.D., Hathaway G.M., Adams M.E.
    J. Biol. Chem. 267:2610-2615(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE.
    Tissue: Venom.

Entry informationi

Entry nameiTOG3A_AGEAP
AccessioniPrimary (citable) accession number: P33034
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: October 1, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.