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P33034 (TOG3A_AGEAP) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Omega-agatoxin-Aa3a

Short name=Omega-AGTX-Aa3a
Alternative name(s):
Omega-agatoxin IIIA
Short name=Omega-Aga-IIIA
Omega-agatoxin-3A
OrganismAgelenopsis aperta (North American funnel-web spider) (Agelenopsis gertschi)
Taxonomic identifier6908 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAraneaeAraneomorphaeEntelegynaeAgelenidaeAgelenopsis

Protein attributes

Sequence length76 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Omega-agatoxin are antagonist of voltage-gated calcium channels. They block insect neuromuscular transmission presynaptically. Potent blocker of N- (Cav2.2/CACNA1B) and L-type (Cav1/CACNA1) calcium channels.

Subcellular location

Secreted.

Tissue specificity

Expressed by the venom gland.

Domain

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin Probable.

Sequence similarities

Belongs to the omega-agatoxin superfamily. Type II/III omega-agatoxin family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 7676Omega-agatoxin-Aa3a
PRO_0000087606

Amino acid modifications

Disulfide bond2 ↔ 19 Probable
Disulfide bond9 ↔ 25 Probable
Disulfide bond16 ↔ 52 Probable
Disulfide bond18 ↔ 40 Probable
Disulfide bond27 ↔ 38 Probable
Disulfide bond59 ↔ 67 Probable

Natural variations

Natural variant581Q → T.

Sequences

Sequence LengthMass (Da)Tools
P33034 [UniParc].

Last modified October 1, 1993. Version 1.
Checksum: 6A715CAC9591888B

FASTA768,518
        10         20         30         40         50         60 
SCIDIGGDCD GEKDDCQCCR RNGYCSCYSL FGYLKSGCKC VVGTSAEFQG ICRRKARQCY 

        70 
NSDPDKCESH NKPKRR 

« Hide

References

[1]"Antagonism of synaptosomal calcium channels by subtypes of omega-agatoxins."
Venema V.J., Swiderek K.M., Lee T.D., Hathaway G.M., Adams M.E.
J. Biol. Chem. 267:2610-2615(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE.
Tissue: Venom.

Cross-references

Sequence databases

PIRA42335.
A54252.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

ArachnoServerAS000178. omega-agatoxin-Aa3a.

Family and domain databases

InterProIPR005853. Omega-agatoxin_II/III_CS.
IPR013605. Toxin_34.
[Graphical view]
PfamPF08396. Toxin_34. 1 hit.
[Graphical view]
PROSITEPS60023. OMEGA_AGA_II_III. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTOG3A_AGEAP
AccessionPrimary (citable) accession number: P33034
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: October 16, 2013
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families