Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P33033 (MC3R_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 109. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Melanocortin receptor 3

Short name=MC3-R
Gene names
Name:Mc3r
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length323 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for MSH (alpha, beta and gamma) and ACTH. This receptor is mediated by G proteins which activate adenylate cyclase.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Brain.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 323323Melanocortin receptor 3
PRO_0000069719

Regions

Topological domain1 – 3737Extracellular Potential
Transmembrane38 – 6326Helical; Name=1; Potential
Topological domain64 – 7512Cytoplasmic Potential
Transmembrane76 – 10025Helical; Name=2; Potential
Topological domain101 – 11818Extracellular Potential
Transmembrane119 – 14022Helical; Name=3; Potential
Topological domain141 – 16020Cytoplasmic Potential
Transmembrane161 – 18121Helical; Name=4; Potential
Topological domain182 – 1865Extracellular Potential
Transmembrane187 – 21024Helical; Name=5; Potential
Topological domain211 – 24535Cytoplasmic Potential
Transmembrane246 – 26823Helical; Name=6; Potential
Topological domain269 – 2779Extracellular Potential
Transmembrane278 – 30124Helical; Name=7; Potential
Topological domain302 – 32322Cytoplasmic Potential

Amino acid modifications

Lipidation3151S-palmitoyl cysteine Potential
Glycosylation21N-linked (GlcNAc...) Potential
Glycosylation161N-linked (GlcNAc...) Potential
Glycosylation281N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
P33033 [UniParc].

Last modified October 1, 1993. Version 1.
Checksum: F4B7B02FA4A87B7B

FASTA32335,806
        10         20         30         40         50         60 
MNSSCCLSSV SPMLPNLSEH PAAPPASNRS GSGFCEQVFI KPEVFLALGI VSLMENILVI 

        70         80         90        100        110        120 
LAVVRNGNLH SPMYFFLCSL AAADMLVSLS NSLETIMIAV INSDSLTLED QFIQHMDNIF 

       130        140        150        160        170        180 
DSMICISLVA SICNLLAIAI DRYVTIFYAL RYHSIMTVRK ALTLIGVIWV CCGICGVMFI 

       190        200        210        220        230        240 
IYSESKMVIV CLITMFFAMV LLMGTLYIHM FLFARLHVQR IAVLPPAGVV APQQHSCMKG 

       250        260        270        280        290        300 
AVTITILLGV FIFCWAPFFL HLVLIITCPT NPYCICYTAH FNTYLVLIMC NSVIDPLIYA 

       310        320 
FRSLELRNTF KEILCGCNSM NLG 

« Hide

References

[1]"Molecular cloning, functional expression and pharmacological characterization of a mouse melanocortin receptor gene."
Desarnaud F., Labbe O., Eggerickx D., Vassart G., Parmentier M.
Biochem. J. 299:367-373(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X74983 Genomic DNA. Translation: CAA52918.1.
CCDSCCDS17127.1.
PIRS43850.
RefSeqNP_032587.1. NM_008561.3.
UniGeneMm.57183.

3D structure databases

ProteinModelPortalP33033.
SMRP33033. Positions 44-314.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid201340. 1 interaction.

Chemistry

BindingDBP33033.
ChEMBLCHEMBL4774.
GuidetoPHARMACOLOGY284.

Protein family/group databases

GPCRDBSearch...

Proteomic databases

PRIDEP33033.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000038532; ENSMUSP00000047358; ENSMUSG00000038537.
GeneID17201.
KEGGmmu:17201.
UCSCuc008ocl.1. mouse.

Organism-specific databases

CTD4159.
MGIMGI:96929. Mc3r.

Phylogenomic databases

eggNOGNOG325361.
HOGENOMHOG000246927.
HOVERGENHBG108148.
InParanoidP33033.
KOK04201.
OMAVHMFLFA.
OrthoDBEOG7QK0CF.
PhylomeDBP33033.
TreeFamTF332646.

Gene expression databases

BgeeP33033.
CleanExMM_MC3R.
GenevestigatorP33033.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002122. Mcort_3_rcpt.
IPR001908. Melancort_rcpt.
IPR001671. Melcrt_ACTH_rcpt.
[Graphical view]
PANTHERPTHR22750:SF4. PTHR22750:SF4. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00534. MCRFAMILY.
PR00535. MELNOCORTINR.
PR01061. MELNOCORTN3R.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio291582.
PROP33033.
SOURCESearch...

Entry information

Entry nameMC3R_MOUSE
AccessionPrimary (citable) accession number: P33033
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: July 9, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries