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Protein

Melanocortin receptor 3

Gene

Mc3r

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for MSH (alpha, beta and gamma) and ACTH. This receptor is mediated by G proteins which activate adenylate cyclase. Required for expression of anticipatory patterns of activity and wakefulness during periods of limited nutrient availability and for the normal regulation of circadian clock activity in the brain (PubMed:19036988).1 Publication

GO - Molecular functioni

  1. melanocyte-stimulating hormone receptor activity Source: MGI
  2. neuropeptide binding Source: MGI
  3. peptide hormone binding Source: Ensembl

GO - Biological processi

  1. adenylate cyclase-modulating G-protein coupled receptor signaling pathway Source: Ensembl
  2. circadian regulation of gene expression Source: UniProtKB
  3. homoiothermy Source: Ensembl
  4. locomotor rhythm Source: UniProtKB
  5. positive regulation of cAMP biosynthetic process Source: MGI
  6. regulation of blood pressure Source: Ensembl
  7. regulation of feeding behavior Source: UniProtKB
  8. regulation of heart rate Source: Ensembl
  9. sodium ion homeostasis Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Biological rhythms

Enzyme and pathway databases

ReactomeiREACT_313192. G alpha (s) signalling events.
REACT_319210. Peptide ligand-binding receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Melanocortin receptor 3
Short name:
MC3-R
Gene namesi
Name:Mc3r
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:96929. Mc3r.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3737ExtracellularSequence AnalysisAdd
BLAST
Transmembranei38 – 6326Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini64 – 7512CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei76 – 10025Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini101 – 11818ExtracellularSequence AnalysisAdd
BLAST
Transmembranei119 – 14022Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini141 – 16020CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei161 – 18121Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini182 – 1865ExtracellularSequence Analysis
Transmembranei187 – 21024Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini211 – 24535CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei246 – 26823Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini269 – 2779ExtracellularSequence Analysis
Transmembranei278 – 30124Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini302 – 32322CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 323323Melanocortin receptor 3PRO_0000069719Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi2 – 21N-linked (GlcNAc...)Sequence Analysis
Glycosylationi16 – 161N-linked (GlcNAc...)Sequence Analysis
Glycosylationi28 – 281N-linked (GlcNAc...)Sequence Analysis
Lipidationi315 – 3151S-palmitoyl cysteineSequence Analysis

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PRIDEiP33033.

Expressioni

Tissue specificityi

Brain.

Gene expression databases

BgeeiP33033.
CleanExiMM_MC3R.
ExpressionAtlasiP33033. baseline.
GenevestigatoriP33033.

Interactioni

Protein-protein interaction databases

BioGridi201340. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP33033.
SMRiP33033. Positions 44-314.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG325361.
HOGENOMiHOG000246927.
HOVERGENiHBG108148.
InParanoidiP33033.
KOiK04201.
OMAiVHMFLFA.
OrthoDBiEOG7QK0CF.
PhylomeDBiP33033.
TreeFamiTF332646.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002122. Mcort_3_rcpt.
IPR001908. Melancort_rcpt.
IPR001671. Melcrt_ACTH_rcpt.
[Graphical view]
PANTHERiPTHR22750:SF4. PTHR22750:SF4. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00534. MCRFAMILY.
PR00535. MELNOCORTINR.
PR01061. MELNOCORTN3R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P33033-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSSCCLSSV SPMLPNLSEH PAAPPASNRS GSGFCEQVFI KPEVFLALGI
60 70 80 90 100
VSLMENILVI LAVVRNGNLH SPMYFFLCSL AAADMLVSLS NSLETIMIAV
110 120 130 140 150
INSDSLTLED QFIQHMDNIF DSMICISLVA SICNLLAIAI DRYVTIFYAL
160 170 180 190 200
RYHSIMTVRK ALTLIGVIWV CCGICGVMFI IYSESKMVIV CLITMFFAMV
210 220 230 240 250
LLMGTLYIHM FLFARLHVQR IAVLPPAGVV APQQHSCMKG AVTITILLGV
260 270 280 290 300
FIFCWAPFFL HLVLIITCPT NPYCICYTAH FNTYLVLIMC NSVIDPLIYA
310 320
FRSLELRNTF KEILCGCNSM NLG
Length:323
Mass (Da):35,806
Last modified:September 30, 1993 - v1
Checksum:iF4B7B02FA4A87B7B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74983 Genomic DNA. Translation: CAA52918.1.
CCDSiCCDS17127.1.
PIRiS43850.
RefSeqiNP_032587.1. NM_008561.3.
UniGeneiMm.57183.

Genome annotation databases

EnsembliENSMUST00000038532; ENSMUSP00000047358; ENSMUSG00000038537.
GeneIDi17201.
KEGGimmu:17201.
UCSCiuc008ocl.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74983 Genomic DNA. Translation: CAA52918.1.
CCDSiCCDS17127.1.
PIRiS43850.
RefSeqiNP_032587.1. NM_008561.3.
UniGeneiMm.57183.

3D structure databases

ProteinModelPortaliP33033.
SMRiP33033. Positions 44-314.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201340. 1 interaction.

Chemistry

BindingDBiP33033.
ChEMBLiCHEMBL4774.
GuidetoPHARMACOLOGYi284.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PRIDEiP33033.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000038532; ENSMUSP00000047358; ENSMUSG00000038537.
GeneIDi17201.
KEGGimmu:17201.
UCSCiuc008ocl.1. mouse.

Organism-specific databases

CTDi4159.
MGIiMGI:96929. Mc3r.

Phylogenomic databases

eggNOGiNOG325361.
HOGENOMiHOG000246927.
HOVERGENiHBG108148.
InParanoidiP33033.
KOiK04201.
OMAiVHMFLFA.
OrthoDBiEOG7QK0CF.
PhylomeDBiP33033.
TreeFamiTF332646.

Enzyme and pathway databases

ReactomeiREACT_313192. G alpha (s) signalling events.
REACT_319210. Peptide ligand-binding receptors.

Miscellaneous databases

NextBioi291582.
PROiP33033.
SOURCEiSearch...

Gene expression databases

BgeeiP33033.
CleanExiMM_MC3R.
ExpressionAtlasiP33033. baseline.
GenevestigatoriP33033.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002122. Mcort_3_rcpt.
IPR001908. Melancort_rcpt.
IPR001671. Melcrt_ACTH_rcpt.
[Graphical view]
PANTHERiPTHR22750:SF4. PTHR22750:SF4. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00534. MCRFAMILY.
PR00535. MELNOCORTINR.
PR01061. MELNOCORTN3R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning, functional expression and pharmacological characterization of a mouse melanocortin receptor gene."
    Desarnaud F., Labbe O., Eggerickx D., Vassart G., Parmentier M.
    Biochem. J. 299:367-373(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: FUNCTION.

Entry informationi

Entry nameiMC3R_MOUSE
AccessioniPrimary (citable) accession number: P33033
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 30, 1993
Last sequence update: September 30, 1993
Last modified: March 31, 2015
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.