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P33033

- MC3R_MOUSE

UniProt

P33033 - MC3R_MOUSE

Protein

Melanocortin receptor 3

Gene

Mc3r

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 1 (01 Oct 1993)
      Previous versions | rss
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    Functioni

    Receptor for MSH (alpha, beta and gamma) and ACTH. This receptor is mediated by G proteins which activate adenylate cyclase.

    GO - Molecular functioni

    1. melanocyte-stimulating hormone receptor activity Source: MGI
    2. neuropeptide binding Source: Ensembl
    3. peptide hormone binding Source: Ensembl
    4. protein binding Source: MGI

    GO - Biological processi

    1. adenylate cyclase-modulating G-protein coupled receptor signaling pathway Source: Ensembl
    2. homoiothermy Source: Ensembl
    3. positive regulation of cAMP biosynthetic process Source: Ensembl
    4. regulation of blood pressure Source: Ensembl
    5. regulation of heart rate Source: Ensembl
    6. sodium ion homeostasis Source: Ensembl

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Melanocortin receptor 3
    Short name:
    MC3-R
    Gene namesi
    Name:Mc3r
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:96929. Mc3r.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 323323Melanocortin receptor 3PRO_0000069719Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi2 – 21N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi16 – 161N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi28 – 281N-linked (GlcNAc...)Sequence Analysis
    Lipidationi315 – 3151S-palmitoyl cysteineSequence Analysis

    Keywords - PTMi

    Glycoprotein, Lipoprotein, Palmitate

    Proteomic databases

    PRIDEiP33033.

    Expressioni

    Tissue specificityi

    Brain.

    Gene expression databases

    BgeeiP33033.
    CleanExiMM_MC3R.
    GenevestigatoriP33033.

    Interactioni

    Protein-protein interaction databases

    BioGridi201340. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliP33033.
    SMRiP33033. Positions 44-314.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3737ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini64 – 7512CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini101 – 11818ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini141 – 16020CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini182 – 1865ExtracellularSequence Analysis
    Topological domaini211 – 24535CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini269 – 2779ExtracellularSequence Analysis
    Topological domaini302 – 32322CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei38 – 6326Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei76 – 10025Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei119 – 14022Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei161 – 18121Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei187 – 21024Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei246 – 26823Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei278 – 30124Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG325361.
    HOGENOMiHOG000246927.
    HOVERGENiHBG108148.
    InParanoidiP33033.
    KOiK04201.
    OMAiVHMFLFA.
    OrthoDBiEOG7QK0CF.
    PhylomeDBiP33033.
    TreeFamiTF332646.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR002122. Mcort_3_rcpt.
    IPR001908. Melancort_rcpt.
    IPR001671. Melcrt_ACTH_rcpt.
    [Graphical view]
    PANTHERiPTHR22750:SF4. PTHR22750:SF4. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00534. MCRFAMILY.
    PR00535. MELNOCORTINR.
    PR01061. MELNOCORTN3R.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P33033-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNSSCCLSSV SPMLPNLSEH PAAPPASNRS GSGFCEQVFI KPEVFLALGI    50
    VSLMENILVI LAVVRNGNLH SPMYFFLCSL AAADMLVSLS NSLETIMIAV 100
    INSDSLTLED QFIQHMDNIF DSMICISLVA SICNLLAIAI DRYVTIFYAL 150
    RYHSIMTVRK ALTLIGVIWV CCGICGVMFI IYSESKMVIV CLITMFFAMV 200
    LLMGTLYIHM FLFARLHVQR IAVLPPAGVV APQQHSCMKG AVTITILLGV 250
    FIFCWAPFFL HLVLIITCPT NPYCICYTAH FNTYLVLIMC NSVIDPLIYA 300
    FRSLELRNTF KEILCGCNSM NLG 323
    Length:323
    Mass (Da):35,806
    Last modified:October 1, 1993 - v1
    Checksum:iF4B7B02FA4A87B7B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X74983 Genomic DNA. Translation: CAA52918.1.
    CCDSiCCDS17127.1.
    PIRiS43850.
    RefSeqiNP_032587.1. NM_008561.3.
    UniGeneiMm.57183.

    Genome annotation databases

    EnsembliENSMUST00000038532; ENSMUSP00000047358; ENSMUSG00000038537.
    GeneIDi17201.
    KEGGimmu:17201.
    UCSCiuc008ocl.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X74983 Genomic DNA. Translation: CAA52918.1 .
    CCDSi CCDS17127.1.
    PIRi S43850.
    RefSeqi NP_032587.1. NM_008561.3.
    UniGenei Mm.57183.

    3D structure databases

    ProteinModelPortali P33033.
    SMRi P33033. Positions 44-314.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 201340. 1 interaction.

    Chemistry

    BindingDBi P33033.
    ChEMBLi CHEMBL4774.
    GuidetoPHARMACOLOGYi 284.

    Protein family/group databases

    GPCRDBi Search...

    Proteomic databases

    PRIDEi P33033.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000038532 ; ENSMUSP00000047358 ; ENSMUSG00000038537 .
    GeneIDi 17201.
    KEGGi mmu:17201.
    UCSCi uc008ocl.1. mouse.

    Organism-specific databases

    CTDi 4159.
    MGIi MGI:96929. Mc3r.

    Phylogenomic databases

    eggNOGi NOG325361.
    HOGENOMi HOG000246927.
    HOVERGENi HBG108148.
    InParanoidi P33033.
    KOi K04201.
    OMAi VHMFLFA.
    OrthoDBi EOG7QK0CF.
    PhylomeDBi P33033.
    TreeFami TF332646.

    Miscellaneous databases

    NextBioi 291582.
    PROi P33033.
    SOURCEi Search...

    Gene expression databases

    Bgeei P33033.
    CleanExi MM_MC3R.
    Genevestigatori P33033.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR002122. Mcort_3_rcpt.
    IPR001908. Melancort_rcpt.
    IPR001671. Melcrt_ACTH_rcpt.
    [Graphical view ]
    PANTHERi PTHR22750:SF4. PTHR22750:SF4. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00534. MCRFAMILY.
    PR00535. MELNOCORTINR.
    PR01061. MELNOCORTN3R.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning, functional expression and pharmacological characterization of a mouse melanocortin receptor gene."
      Desarnaud F., Labbe O., Eggerickx D., Vassart G., Parmentier M.
      Biochem. J. 299:367-373(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiMC3R_MOUSE
    AccessioniPrimary (citable) accession number: P33033
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1993
    Last sequence update: October 1, 1993
    Last modified: October 1, 2014
    This is version 110 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3