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P33033

- MC3R_MOUSE

UniProt

P33033 - MC3R_MOUSE

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Protein

Melanocortin receptor 3

Gene

Mc3r

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Receptor for MSH (alpha, beta and gamma) and ACTH. This receptor is mediated by G proteins which activate adenylate cyclase.

GO - Molecular functioni

  1. melanocyte-stimulating hormone receptor activity Source: MGI
  2. neuropeptide binding Source: Ensembl
  3. peptide hormone binding Source: Ensembl

GO - Biological processi

  1. adenylate cyclase-modulating G-protein coupled receptor signaling pathway Source: Ensembl
  2. homoiothermy Source: Ensembl
  3. positive regulation of cAMP biosynthetic process Source: Ensembl
  4. regulation of blood pressure Source: Ensembl
  5. regulation of heart rate Source: Ensembl
  6. sodium ion homeostasis Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_235286. Peptide ligand-binding receptors.
REACT_242871. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Melanocortin receptor 3
Short name:
MC3-R
Gene namesi
Name:Mc3r
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:96929. Mc3r.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3737ExtracellularSequence AnalysisAdd
BLAST
Transmembranei38 – 6326Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini64 – 7512CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei76 – 10025Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini101 – 11818ExtracellularSequence AnalysisAdd
BLAST
Transmembranei119 – 14022Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini141 – 16020CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei161 – 18121Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini182 – 1865ExtracellularSequence Analysis
Transmembranei187 – 21024Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini211 – 24535CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei246 – 26823Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini269 – 2779ExtracellularSequence Analysis
Transmembranei278 – 30124Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini302 – 32322CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 323323Melanocortin receptor 3PRO_0000069719Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi2 – 21N-linked (GlcNAc...)Sequence Analysis
Glycosylationi16 – 161N-linked (GlcNAc...)Sequence Analysis
Glycosylationi28 – 281N-linked (GlcNAc...)Sequence Analysis
Lipidationi315 – 3151S-palmitoyl cysteineSequence Analysis

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PRIDEiP33033.

Expressioni

Tissue specificityi

Brain.

Gene expression databases

BgeeiP33033.
CleanExiMM_MC3R.
GenevestigatoriP33033.

Interactioni

Protein-protein interaction databases

BioGridi201340. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP33033.
SMRiP33033. Positions 44-314.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG325361.
HOGENOMiHOG000246927.
HOVERGENiHBG108148.
InParanoidiP33033.
KOiK04201.
OMAiVHMFLFA.
OrthoDBiEOG7QK0CF.
PhylomeDBiP33033.
TreeFamiTF332646.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002122. Mcort_3_rcpt.
IPR001908. Melancort_rcpt.
IPR001671. Melcrt_ACTH_rcpt.
[Graphical view]
PANTHERiPTHR22750:SF4. PTHR22750:SF4. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00534. MCRFAMILY.
PR00535. MELNOCORTINR.
PR01061. MELNOCORTN3R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P33033-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNSSCCLSSV SPMLPNLSEH PAAPPASNRS GSGFCEQVFI KPEVFLALGI
60 70 80 90 100
VSLMENILVI LAVVRNGNLH SPMYFFLCSL AAADMLVSLS NSLETIMIAV
110 120 130 140 150
INSDSLTLED QFIQHMDNIF DSMICISLVA SICNLLAIAI DRYVTIFYAL
160 170 180 190 200
RYHSIMTVRK ALTLIGVIWV CCGICGVMFI IYSESKMVIV CLITMFFAMV
210 220 230 240 250
LLMGTLYIHM FLFARLHVQR IAVLPPAGVV APQQHSCMKG AVTITILLGV
260 270 280 290 300
FIFCWAPFFL HLVLIITCPT NPYCICYTAH FNTYLVLIMC NSVIDPLIYA
310 320
FRSLELRNTF KEILCGCNSM NLG
Length:323
Mass (Da):35,806
Last modified:October 1, 1993 - v1
Checksum:iF4B7B02FA4A87B7B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74983 Genomic DNA. Translation: CAA52918.1.
CCDSiCCDS17127.1.
PIRiS43850.
RefSeqiNP_032587.1. NM_008561.3.
UniGeneiMm.57183.

Genome annotation databases

EnsembliENSMUST00000038532; ENSMUSP00000047358; ENSMUSG00000038537.
GeneIDi17201.
KEGGimmu:17201.
UCSCiuc008ocl.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74983 Genomic DNA. Translation: CAA52918.1 .
CCDSi CCDS17127.1.
PIRi S43850.
RefSeqi NP_032587.1. NM_008561.3.
UniGenei Mm.57183.

3D structure databases

ProteinModelPortali P33033.
SMRi P33033. Positions 44-314.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 201340. 1 interaction.

Chemistry

BindingDBi P33033.
ChEMBLi CHEMBL4774.
GuidetoPHARMACOLOGYi 284.

Protein family/group databases

GPCRDBi Search...

Proteomic databases

PRIDEi P33033.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000038532 ; ENSMUSP00000047358 ; ENSMUSG00000038537 .
GeneIDi 17201.
KEGGi mmu:17201.
UCSCi uc008ocl.1. mouse.

Organism-specific databases

CTDi 4159.
MGIi MGI:96929. Mc3r.

Phylogenomic databases

eggNOGi NOG325361.
HOGENOMi HOG000246927.
HOVERGENi HBG108148.
InParanoidi P33033.
KOi K04201.
OMAi VHMFLFA.
OrthoDBi EOG7QK0CF.
PhylomeDBi P33033.
TreeFami TF332646.

Enzyme and pathway databases

Reactomei REACT_235286. Peptide ligand-binding receptors.
REACT_242871. G alpha (s) signalling events.

Miscellaneous databases

NextBioi 291582.
PROi P33033.
SOURCEi Search...

Gene expression databases

Bgeei P33033.
CleanExi MM_MC3R.
Genevestigatori P33033.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002122. Mcort_3_rcpt.
IPR001908. Melancort_rcpt.
IPR001671. Melcrt_ACTH_rcpt.
[Graphical view ]
PANTHERi PTHR22750:SF4. PTHR22750:SF4. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00534. MCRFAMILY.
PR00535. MELNOCORTINR.
PR01061. MELNOCORTN3R.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning, functional expression and pharmacological characterization of a mouse melanocortin receptor gene."
    Desarnaud F., Labbe O., Eggerickx D., Vassart G., Parmentier M.
    Biochem. J. 299:367-373(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiMC3R_MOUSE
AccessioniPrimary (citable) accession number: P33033
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: November 26, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3