Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P33032

- MC5R_HUMAN

UniProt

P33032 - MC5R_HUMAN

Protein

Melanocortin receptor 5

Gene

MC5R

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 135 (01 Oct 2014)
      Sequence version 3 (01 Feb 1995)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. This receptor is a possible mediator of the immunomodulation properties of melanocortins.

    GO - Molecular functioni

    1. hormone binding Source: Ensembl
    2. melanocortin receptor activity Source: ProtInc
    3. protein binding Source: BHF-UCL

    GO - Biological processi

    1. G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: ProtInc
    2. positive regulation of cAMP biosynthetic process Source: BHF-UCL

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_14819. Peptide ligand-binding receptors.
    REACT_19327. G alpha (s) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Melanocortin receptor 5
    Short name:
    MC5-R
    Alternative name(s):
    MC-2
    Gene namesi
    Name:MC5R
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 18

    Organism-specific databases

    HGNCiHGNC:6933. MC5R.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: ProtInc
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi235 – 2351Q → K: 10% increase of binding to alpha-MSH. 1 Publication
    Mutagenesisi272 – 2721R → C: 690% increase of binding to alpha-MSH. 1 Publication

    Organism-specific databases

    PharmGKBiPA30677.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 325325Melanocortin receptor 5PRO_0000069728Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi2 – 21N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi15 – 151N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi20 – 201N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi28 – 281N-linked (GlcNAc...)Sequence Analysis
    Lipidationi311 – 3111S-palmitoyl cysteineSequence Analysis
    Lipidationi312 – 3121S-palmitoyl cysteineSequence Analysis

    Keywords - PTMi

    Glycoprotein, Lipoprotein, Palmitate

    Proteomic databases

    PaxDbiP33032.
    PRIDEiP33032.

    PTM databases

    PhosphoSiteiP33032.

    Expressioni

    Tissue specificityi

    Expressed in the brain but not in the melanoma cells.

    Gene expression databases

    ArrayExpressiP33032.
    BgeeiP33032.
    CleanExiHS_MC5R.
    GenevestigatoriP33032.

    Organism-specific databases

    HPAiHPA042365.

    Interactioni

    Protein-protein interaction databases

    BioGridi110331. 1 interaction.
    DIPiDIP-48792N.
    IntActiP33032. 2 interactions.
    STRINGi9606.ENSP00000318077.

    Structurei

    3D structure databases

    ProteinModelPortaliP33032.
    SMRiP33032. Positions 38-312.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3737ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini62 – 7312CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini98 – 11417ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini139 – 15517CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini180 – 1867ExtracellularSequence Analysis
    Topological domaini212 – 23928CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini266 – 2738ExtracellularSequence Analysis
    Topological domaini298 – 32528CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei38 – 6124Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei74 – 9724Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei115 – 13824Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei156 – 17924Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei187 – 21125Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei240 – 26526Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei274 – 29724Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG237265.
    HOGENOMiHOG000246927.
    HOVERGENiHBG108148.
    InParanoidiP33032.
    KOiK04203.
    OMAiWETITIY.
    PhylomeDBiP33032.
    TreeFamiTF332646.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR001908. Melancort_rcpt.
    IPR000621. Melancort_rcpt_5.
    IPR001671. Melcrt_ACTH_rcpt.
    [Graphical view]
    PANTHERiPTHR22750:SF5. PTHR22750:SF5. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00534. MCRFAMILY.
    PR00535. MELNOCORTINR.
    PR01063. MELNOCORTN5R.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P33032-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNSSFHLHFL DLNLNATEGN LSGPNVKNKS SPCEDMGIAV EVFLTLGVIS    50
    LLENILVIGA IVKNKNLHSP MYFFVCSLAV ADMLVSMSSA WETITIYLLN 100
    NKHLVIADAF VRHIDNVFDS MICISVVASM CSLLAIAVDR YVTIFYALRY 150
    HHIMTARRSG AIIAGIWAFC TGCGIVFILY SESTYVILCL ISMFFAMLFL 200
    LVSLYIHMFL LARTHVKRIA ALPGASSARQ RTSMQGAVTV TMLLGVFTVC 250
    WAPFFLHLTL MLSCPQNLYC SRFMSHFNMY LILIMCNSVM DPLIYAFRSQ 300
    EMRKTFKEII CCRGFRIACS FPRRD 325
    Length:325
    Mass (Da):36,601
    Last modified:February 1, 1995 - v3
    Checksum:i8BEC17E1BDA059BB
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti149 – 1491R → A in AAA59566. (PubMed:8179577)Curated
    Sequence conflicti221 – 23414ALPGA…QRTSM → LCPGPALRGRGPAW(PubMed:8396929)CuratedAdd
    BLAST
    Sequence conflicti297 – 2971F → Y in AAA59566. (PubMed:8179577)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti209 – 2091F → L.2 Publications
    Corresponds to variant rs2236700 [ dbSNP | Ensembl ].
    VAR_013128

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z25470 Genomic DNA. Translation: CAA80962.1.
    L27080 Genomic DNA. Translation: AAA59566.1.
    U08353 Genomic DNA. Translation: AAB60376.1.
    AY268429 Genomic DNA. Translation: AAP23196.1.
    EF444993 Genomic DNA. Translation: ACA06012.1.
    CH471113 Genomic DNA. Translation: EAX01504.1.
    BC069153 mRNA. Translation: AAH69153.1.
    BC069545 mRNA. Translation: AAH69545.1.
    BC095531 mRNA. Translation: AAH95531.1.
    CCDSiCCDS11868.1.
    PIRiJC5592.
    JN0764.
    RefSeqiNP_005904.1. NM_005913.2.
    UniGeneiHs.248145.

    Genome annotation databases

    EnsembliENST00000324750; ENSP00000318077; ENSG00000176136.
    GeneIDi4161.
    KEGGihsa:4161.
    UCSCiuc010xaf.2. human.

    Polymorphism databases

    DMDMi729996.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Wikipedia

    Melanocortin receptor entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z25470 Genomic DNA. Translation: CAA80962.1 .
    L27080 Genomic DNA. Translation: AAA59566.1 .
    U08353 Genomic DNA. Translation: AAB60376.1 .
    AY268429 Genomic DNA. Translation: AAP23196.1 .
    EF444993 Genomic DNA. Translation: ACA06012.1 .
    CH471113 Genomic DNA. Translation: EAX01504.1 .
    BC069153 mRNA. Translation: AAH69153.1 .
    BC069545 mRNA. Translation: AAH69545.1 .
    BC095531 mRNA. Translation: AAH95531.1 .
    CCDSi CCDS11868.1.
    PIRi JC5592.
    JN0764.
    RefSeqi NP_005904.1. NM_005913.2.
    UniGenei Hs.248145.

    3D structure databases

    ProteinModelPortali P33032.
    SMRi P33032. Positions 38-312.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110331. 1 interaction.
    DIPi DIP-48792N.
    IntActi P33032. 2 interactions.
    STRINGi 9606.ENSP00000318077.

    Chemistry

    BindingDBi P33032.
    ChEMBLi CHEMBL4608.
    GuidetoPHARMACOLOGYi 286.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P33032.

    Polymorphism databases

    DMDMi 729996.

    Proteomic databases

    PaxDbi P33032.
    PRIDEi P33032.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000324750 ; ENSP00000318077 ; ENSG00000176136 .
    GeneIDi 4161.
    KEGGi hsa:4161.
    UCSCi uc010xaf.2. human.

    Organism-specific databases

    CTDi 4161.
    GeneCardsi GC18P013815.
    HGNCi HGNC:6933. MC5R.
    HPAi HPA042365.
    MIMi 600042. gene.
    neXtProti NX_P33032.
    PharmGKBi PA30677.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG237265.
    HOGENOMi HOG000246927.
    HOVERGENi HBG108148.
    InParanoidi P33032.
    KOi K04203.
    OMAi WETITIY.
    PhylomeDBi P33032.
    TreeFami TF332646.

    Enzyme and pathway databases

    Reactomei REACT_14819. Peptide ligand-binding receptors.
    REACT_19327. G alpha (s) signalling events.

    Miscellaneous databases

    GeneWikii Melanocortin_5_receptor.
    GenomeRNAii 4161.
    NextBioi 16394.
    PROi P33032.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P33032.
    Bgeei P33032.
    CleanExi HS_MC5R.
    Genevestigatori P33032.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR001908. Melancort_rcpt.
    IPR000621. Melancort_rcpt_5.
    IPR001671. Melcrt_ACTH_rcpt.
    [Graphical view ]
    PANTHERi PTHR22750:SF5. PTHR22750:SF5. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00534. MCRFAMILY.
    PR00535. MELNOCORTINR.
    PR01063. MELNOCORTN5R.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Placenta.
    2. "Molecular cloning and characterization of the rat fifth melanocortin receptor."
      Griffon N., Mignon V., Facchinetti P., Diaz J., Schwartz J.-C., Sokoloff P.
      Biochem. Biophys. Res. Commun. 200:1007-1014(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Cloning, expression, and tissue distribution of a fifth melanocortin receptor subtype."
      Fathi Z., Iben L.G., Parker E.M.
      Neurochem. Res. 20:107-113(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Placenta.
    4. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      Kopatz S.A., Aronstam R.S., Sharma S.V.
      Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. NHLBI resequencing and genotyping service (RS&G)
      Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-209.
    8. "Glutamine235 and arginine272 in human melanocortin 5 receptor determines its low affinity to MSH."
      Fraendberg P.-A., Xu X., Chhajlani V.
      Biochem. Biophys. Res. Commun. 236:489-492(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: MUTAGENESIS OF GLN-235 AND ARG-272.
    9. "Expression, candidate gene, and population studies of the melanocortin 5 receptor."
      Hatta N., Dixon C., Ray A.J., Phillips S.R., Cunliffe W.J., Dale M., Todd C., Meggit S., Birch-MacHin M.A., Rees J.L.
      J. Invest. Dermatol. 116:564-570(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT LEU-209.

    Entry informationi

    Entry nameiMC5R_HUMAN
    AccessioniPrimary (citable) accession number: P33032
    Secondary accession number(s): B0YJ34, Q502V1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1993
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 135 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 18
      Human chromosome 18: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3