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P33032 (MC5R_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 130. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Melanocortin receptor 5

Short name=MC5-R
Alternative name(s):
MC-2
Gene names
Name:MC5R
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length325 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. This receptor is a possible mediator of the immunomodulation properties of melanocortins.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Expressed in the brain but not in the melanoma cells.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 325325Melanocortin receptor 5
PRO_0000069728

Regions

Topological domain1 – 3737Extracellular Potential
Transmembrane38 – 6124Helical; Name=1; Potential
Topological domain62 – 7312Cytoplasmic Potential
Transmembrane74 – 9724Helical; Name=2; Potential
Topological domain98 – 11417Extracellular Potential
Transmembrane115 – 13824Helical; Name=3; Potential
Topological domain139 – 15517Cytoplasmic Potential
Transmembrane156 – 17924Helical; Name=4; Potential
Topological domain180 – 1867Extracellular Potential
Transmembrane187 – 21125Helical; Name=5; Potential
Topological domain212 – 23928Cytoplasmic Potential
Transmembrane240 – 26526Helical; Name=6; Potential
Topological domain266 – 2738Extracellular Potential
Transmembrane274 – 29724Helical; Name=7; Potential
Topological domain298 – 32528Cytoplasmic Potential

Amino acid modifications

Lipidation3111S-palmitoyl cysteine Potential
Lipidation3121S-palmitoyl cysteine Potential
Glycosylation21N-linked (GlcNAc...) Potential
Glycosylation151N-linked (GlcNAc...) Potential
Glycosylation201N-linked (GlcNAc...) Potential
Glycosylation281N-linked (GlcNAc...) Potential

Natural variations

Natural variant2091F → L. Ref.7 Ref.9
Corresponds to variant rs2236700 [ dbSNP | Ensembl ].
VAR_013128

Experimental info

Mutagenesis2351Q → K: 10% increase of binding to alpha-MSH. Ref.8
Mutagenesis2721R → C: 690% increase of binding to alpha-MSH. Ref.8
Sequence conflict1491R → A in AAA59566. Ref.2
Sequence conflict221 – 23414ALPGA…QRTSM → LCPGPALRGRGPAW Ref.1
Sequence conflict2971F → Y in AAA59566. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P33032 [UniParc].

Last modified February 1, 1995. Version 3.
Checksum: 8BEC17E1BDA059BB

FASTA32536,601
        10         20         30         40         50         60 
MNSSFHLHFL DLNLNATEGN LSGPNVKNKS SPCEDMGIAV EVFLTLGVIS LLENILVIGA 

        70         80         90        100        110        120 
IVKNKNLHSP MYFFVCSLAV ADMLVSMSSA WETITIYLLN NKHLVIADAF VRHIDNVFDS 

       130        140        150        160        170        180 
MICISVVASM CSLLAIAVDR YVTIFYALRY HHIMTARRSG AIIAGIWAFC TGCGIVFILY 

       190        200        210        220        230        240 
SESTYVILCL ISMFFAMLFL LVSLYIHMFL LARTHVKRIA ALPGASSARQ RTSMQGAVTV 

       250        260        270        280        290        300 
TMLLGVFTVC WAPFFLHLTL MLSCPQNLYC SRFMSHFNMY LILIMCNSVM DPLIYAFRSQ 

       310        320 
EMRKTFKEII CCRGFRIACS FPRRD 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning of a novel human melanocortin receptor."
Chhajlani V., Muceniece R., Wikberg J.E.S.
Biochem. Biophys. Res. Commun. 195:866-873(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Placenta.
[2]"Molecular cloning and characterization of the rat fifth melanocortin receptor."
Griffon N., Mignon V., Facchinetti P., Diaz J., Schwartz J.-C., Sokoloff P.
Biochem. Biophys. Res. Commun. 200:1007-1014(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Cloning, expression, and tissue distribution of a fifth melanocortin receptor subtype."
Fathi Z., Iben L.G., Parker E.M.
Neurochem. Res. 20:107-113(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Placenta.
[4]"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
Kopatz S.A., Aronstam R.S., Sharma S.V.
Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]NHLBI resequencing and genotyping service (RS&G)
Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[6]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-209.
[8]"Glutamine235 and arginine272 in human melanocortin 5 receptor determines its low affinity to MSH."
Fraendberg P.-A., Xu X., Chhajlani V.
Biochem. Biophys. Res. Commun. 236:489-492(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: MUTAGENESIS OF GLN-235 AND ARG-272.
[9]"Expression, candidate gene, and population studies of the melanocortin 5 receptor."
Hatta N., Dixon C., Ray A.J., Phillips S.R., Cunliffe W.J., Dale M., Todd C., Meggit S., Birch-MacHin M.A., Rees J.L.
J. Invest. Dermatol. 116:564-570(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT LEU-209.
+Additional computationally mapped references.

Web resources

Wikipedia

Melanocortin receptor entry

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z25470 Genomic DNA. Translation: CAA80962.1.
L27080 Genomic DNA. Translation: AAA59566.1.
U08353 Genomic DNA. Translation: AAB60376.1.
AY268429 Genomic DNA. Translation: AAP23196.1.
EF444993 Genomic DNA. Translation: ACA06012.1.
CH471113 Genomic DNA. Translation: EAX01504.1.
BC069153 mRNA. Translation: AAH69153.1.
BC069545 mRNA. Translation: AAH69545.1.
BC095531 mRNA. Translation: AAH95531.1.
PIRJC5592.
JN0764.
RefSeqNP_005904.1. NM_005913.2.
UniGeneHs.248145.

3D structure databases

ProteinModelPortalP33032.
SMRP33032. Positions 38-312.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid110331. 1 interaction.
DIPDIP-48792N.
STRING9606.ENSP00000318077.

Chemistry

BindingDBP33032.
ChEMBLCHEMBL4608.
GuidetoPHARMACOLOGY286.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP33032.

Polymorphism databases

DMDM729996.

Proteomic databases

PaxDbP33032.
PRIDEP33032.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000324750; ENSP00000318077; ENSG00000176136.
GeneID4161.
KEGGhsa:4161.
UCSCuc010xaf.2. human.

Organism-specific databases

CTD4161.
GeneCardsGC18P013815.
HGNCHGNC:6933. MC5R.
HPAHPA042365.
MIM600042. gene.
neXtProtNX_P33032.
PharmGKBPA30677.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG237265.
HOGENOMHOG000246927.
HOVERGENHBG108148.
InParanoidP33032.
KOK04203.
OMAVASMCSL.
PhylomeDBP33032.
TreeFamTF332646.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

ArrayExpressP33032.
BgeeP33032.
CleanExHS_MC5R.
GenevestigatorP33032.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001908. Melancort_rcpt.
IPR000621. Melancort_rcpt_5.
IPR001671. Melcrt_ACTH_rcpt.
[Graphical view]
PANTHERPTHR22750:SF5. PTHR22750:SF5. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00534. MCRFAMILY.
PR00535. MELNOCORTINR.
PR01063. MELNOCORTN5R.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiMelanocortin_5_receptor.
GenomeRNAi4161.
NextBio16394.
PROP33032.
SOURCESearch...

Entry information

Entry nameMC5R_HUMAN
AccessionPrimary (citable) accession number: P33032
Secondary accession number(s): B0YJ34, Q502V1
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: February 1, 1995
Last modified: April 16, 2014
This is version 130 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 18

Human chromosome 18: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries