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Protein

Melanocortin receptor 5

Gene

MC5R

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. This receptor is a possible mediator of the immunomodulation properties of melanocortins.

GO - Molecular functioni

  • hormone binding Source: Ensembl
  • melanocortin receptor activity Source: ProtInc

GO - Biological processi

  • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: ProtInc
  • positive regulation of cAMP biosynthetic process Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:ENSG00000176136-MONOMER.
ReactomeiR-HSA-375276. Peptide ligand-binding receptors.
R-HSA-418555. G alpha (s) signalling events.
SIGNORiP33032.

Names & Taxonomyi

Protein namesi
Recommended name:
Melanocortin receptor 5
Short name:
MC5-R
Alternative name(s):
MC-2
Gene namesi
Name:MC5R
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

HGNCiHGNC:6933. MC5R.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 37ExtracellularSequence analysisAdd BLAST37
Transmembranei38 – 61Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini62 – 73CytoplasmicSequence analysisAdd BLAST12
Transmembranei74 – 97Helical; Name=2Sequence analysisAdd BLAST24
Topological domaini98 – 114ExtracellularSequence analysisAdd BLAST17
Transmembranei115 – 138Helical; Name=3Sequence analysisAdd BLAST24
Topological domaini139 – 155CytoplasmicSequence analysisAdd BLAST17
Transmembranei156 – 179Helical; Name=4Sequence analysisAdd BLAST24
Topological domaini180 – 186ExtracellularSequence analysis7
Transmembranei187 – 211Helical; Name=5Sequence analysisAdd BLAST25
Topological domaini212 – 239CytoplasmicSequence analysisAdd BLAST28
Transmembranei240 – 265Helical; Name=6Sequence analysisAdd BLAST26
Topological domaini266 – 273ExtracellularSequence analysis8
Transmembranei274 – 297Helical; Name=7Sequence analysisAdd BLAST24
Topological domaini298 – 325CytoplasmicSequence analysisAdd BLAST28

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi235Q → K: 10% increase of binding to alpha-MSH. 1 Publication1
Mutagenesisi272R → C: 690% increase of binding to alpha-MSH. 1 Publication1

Organism-specific databases

DisGeNETi4161.
OpenTargetsiENSG00000176136.
PharmGKBiPA30677.

Chemistry databases

ChEMBLiCHEMBL4608.
GuidetoPHARMACOLOGYi286.

Polymorphism and mutation databases

BioMutaiMC5R.
DMDMi729996.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000697281 – 325Melanocortin receptor 5Add BLAST325

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi2N-linked (GlcNAc...)Sequence analysis1
Glycosylationi15N-linked (GlcNAc...)Sequence analysis1
Glycosylationi20N-linked (GlcNAc...)Sequence analysis1
Glycosylationi28N-linked (GlcNAc...)Sequence analysis1
Lipidationi311S-palmitoyl cysteineSequence analysis1
Lipidationi312S-palmitoyl cysteineSequence analysis1

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP33032.
PRIDEiP33032.

PTM databases

iPTMnetiP33032.
PhosphoSitePlusiP33032.

Expressioni

Tissue specificityi

Expressed in the brain but not in the melanoma cells.

Gene expression databases

BgeeiENSG00000176136.
CleanExiHS_MC5R.
ExpressionAtlasiP33032. baseline and differential.
GenevisibleiP33032. HS.

Organism-specific databases

HPAiHPA042365.

Interactioni

Protein-protein interaction databases

BioGridi110331. 1 interactor.
DIPiDIP-48792N.
IntActiP33032. 2 interactors.
STRINGi9606.ENSP00000318077.

Chemistry databases

BindingDBiP33032.

Structurei

3D structure databases

ProteinModelPortaliP33032.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00770000120529.
HOGENOMiHOG000246927.
HOVERGENiHBG108148.
InParanoidiP33032.
KOiK04203.
OMAiVSLYIHM.
OrthoDBiEOG091G0BVW.
PhylomeDBiP33032.
TreeFamiTF332646.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001908. Melancort_rcpt.
IPR000621. Melancort_rcpt_5.
IPR001671. Melcrt_ACTH_rcpt.
[Graphical view]
PANTHERiPTHR22750:SF5. PTHR22750:SF5. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00534. MCRFAMILY.
PR00535. MELNOCORTINR.
PR01063. MELNOCORTN5R.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P33032-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSSFHLHFL DLNLNATEGN LSGPNVKNKS SPCEDMGIAV EVFLTLGVIS
60 70 80 90 100
LLENILVIGA IVKNKNLHSP MYFFVCSLAV ADMLVSMSSA WETITIYLLN
110 120 130 140 150
NKHLVIADAF VRHIDNVFDS MICISVVASM CSLLAIAVDR YVTIFYALRY
160 170 180 190 200
HHIMTARRSG AIIAGIWAFC TGCGIVFILY SESTYVILCL ISMFFAMLFL
210 220 230 240 250
LVSLYIHMFL LARTHVKRIA ALPGASSARQ RTSMQGAVTV TMLLGVFTVC
260 270 280 290 300
WAPFFLHLTL MLSCPQNLYC SRFMSHFNMY LILIMCNSVM DPLIYAFRSQ
310 320
EMRKTFKEII CCRGFRIACS FPRRD
Length:325
Mass (Da):36,601
Last modified:February 1, 1995 - v3
Checksum:i8BEC17E1BDA059BB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti149R → A in AAA59566 (PubMed:8179577).Curated1
Sequence conflicti221 – 234ALPGA…QRTSM → LCPGPALRGRGPAW (PubMed:8396929).CuratedAdd BLAST14
Sequence conflicti297F → Y in AAA59566 (PubMed:8179577).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_013128209F → L.2 PublicationsCorresponds to variant rs2236700dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z25470 Genomic DNA. Translation: CAA80962.1.
L27080 Genomic DNA. Translation: AAA59566.1.
U08353 Genomic DNA. Translation: AAB60376.1.
AY268429 Genomic DNA. Translation: AAP23196.1.
EF444993 Genomic DNA. Translation: ACA06012.1.
CH471113 Genomic DNA. Translation: EAX01504.1.
BC069153 mRNA. Translation: AAH69153.1.
BC069545 mRNA. Translation: AAH69545.1.
BC095531 mRNA. Translation: AAH95531.1.
CCDSiCCDS11868.1.
PIRiJC5592.
JN0764.
RefSeqiNP_005904.1. NM_005913.2.
UniGeneiHs.248145.

Genome annotation databases

EnsembliENST00000324750; ENSP00000318077; ENSG00000176136.
GeneIDi4161.
KEGGihsa:4161.
UCSCiuc010xaf.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

Melanocortin receptor entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z25470 Genomic DNA. Translation: CAA80962.1.
L27080 Genomic DNA. Translation: AAA59566.1.
U08353 Genomic DNA. Translation: AAB60376.1.
AY268429 Genomic DNA. Translation: AAP23196.1.
EF444993 Genomic DNA. Translation: ACA06012.1.
CH471113 Genomic DNA. Translation: EAX01504.1.
BC069153 mRNA. Translation: AAH69153.1.
BC069545 mRNA. Translation: AAH69545.1.
BC095531 mRNA. Translation: AAH95531.1.
CCDSiCCDS11868.1.
PIRiJC5592.
JN0764.
RefSeqiNP_005904.1. NM_005913.2.
UniGeneiHs.248145.

3D structure databases

ProteinModelPortaliP33032.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110331. 1 interactor.
DIPiDIP-48792N.
IntActiP33032. 2 interactors.
STRINGi9606.ENSP00000318077.

Chemistry databases

BindingDBiP33032.
ChEMBLiCHEMBL4608.
GuidetoPHARMACOLOGYi286.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP33032.
PhosphoSitePlusiP33032.

Polymorphism and mutation databases

BioMutaiMC5R.
DMDMi729996.

Proteomic databases

PaxDbiP33032.
PRIDEiP33032.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000324750; ENSP00000318077; ENSG00000176136.
GeneIDi4161.
KEGGihsa:4161.
UCSCiuc010xaf.3. human.

Organism-specific databases

CTDi4161.
DisGeNETi4161.
GeneCardsiMC5R.
HGNCiHGNC:6933. MC5R.
HPAiHPA042365.
MIMi600042. gene.
neXtProtiNX_P33032.
OpenTargetsiENSG00000176136.
PharmGKBiPA30677.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00770000120529.
HOGENOMiHOG000246927.
HOVERGENiHBG108148.
InParanoidiP33032.
KOiK04203.
OMAiVSLYIHM.
OrthoDBiEOG091G0BVW.
PhylomeDBiP33032.
TreeFamiTF332646.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000176136-MONOMER.
ReactomeiR-HSA-375276. Peptide ligand-binding receptors.
R-HSA-418555. G alpha (s) signalling events.
SIGNORiP33032.

Miscellaneous databases

GeneWikiiMelanocortin_5_receptor.
GenomeRNAii4161.
PROiP33032.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000176136.
CleanExiHS_MC5R.
ExpressionAtlasiP33032. baseline and differential.
GenevisibleiP33032. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001908. Melancort_rcpt.
IPR000621. Melancort_rcpt_5.
IPR001671. Melcrt_ACTH_rcpt.
[Graphical view]
PANTHERiPTHR22750:SF5. PTHR22750:SF5. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00534. MCRFAMILY.
PR00535. MELNOCORTINR.
PR01063. MELNOCORTN5R.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMC5R_HUMAN
AccessioniPrimary (citable) accession number: P33032
Secondary accession number(s): B0YJ34, Q502V1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: February 1, 1995
Last modified: November 2, 2016
This is version 150 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.