Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Sugar efflux transporter B

Gene

setB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the efflux of sugars. The physiological role may be the detoxification of non-metabolizable sugar analogs. Can transport lactose and glucose.

GO - Molecular functioni

  • sugar efflux transmembrane transporter activity Source: EcoliWiki

GO - Biological processi

  • chromosome segregation Source: EcoliWiki
  • glucose transport Source: EcoliWiki
  • lactose transport Source: EcoliWiki
  • proton transport Source: GOC
Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:B2170-MONOMER.
ECOL316407:JW2157-MONOMER.
MetaCyc:B2170-MONOMER.

Protein family/group databases

TCDBi2.A.1.20.2. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Sugar efflux transporter B
Gene namesi
Name:setB
Synonyms:yeiO
Ordered Locus Names:b2170, JW2157
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12034. setB.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei13 – 3321HelicalSequence analysisAdd
BLAST
Transmembranei51 – 7121HelicalSequence analysisAdd
BLAST
Transmembranei82 – 10221HelicalSequence analysisAdd
BLAST
Transmembranei106 – 12621HelicalSequence analysisAdd
BLAST
Transmembranei152 – 17221HelicalSequence analysisAdd
BLAST
Transmembranei174 – 19421HelicalSequence analysisAdd
BLAST
Transmembranei219 – 23921HelicalSequence analysisAdd
BLAST
Transmembranei253 – 27321HelicalSequence analysisAdd
BLAST
Transmembranei283 – 30321HelicalSequence analysisAdd
BLAST
Transmembranei306 – 32621HelicalSequence analysisAdd
BLAST
Transmembranei344 – 36421HelicalSequence analysisAdd
BLAST
Transmembranei366 – 38621HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: EcoliWiki
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 393393Sugar efflux transporter BPRO_0000209360Add
BLAST

Proteomic databases

PaxDbiP33026.

Interactioni

Protein-protein interaction databases

BioGridi4260465. 100 interactions.
STRINGi511145.b2170.

Structurei

3D structure databases

ProteinModelPortaliP33026.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105S8Q. Bacteria.
ENOG410XTE9. LUCA.
HOGENOMiHOG000281090.
InParanoidiP33026.
KOiK03291.
OMAiYYAKRFG.
OrthoDBiEOG64JFK7.
PhylomeDBiP33026.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR004750. Sugar_efflux.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00899. 2A0120. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P33026-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHNSPAVSSA KSFDLTSTAF LIVAFLTGIA GALQTPTLSI FLTDEVHARP
60 70 80 90 100
AMVGFFFTGS AVIGILVSQF LAGRSDKRGD RKSLIVFCCL LGVLACTLFA
110 120 130 140 150
WNRNYFVLLF VGVFLSSFGS TANPQMFALA REHADKTGRE AVMFSSFLRA
160 170 180 190 200
QVSLAWVIGP PLAYALAMGF SFTVMYLSAA VAFIVCGVMV WLFLPSMRKE
210 220 230 240 250
LPLATGTIEA PRRNRRDTLL LFVICTLMWG SNSLYIINMP LFIINELHLP
260 270 280 290 300
EKLAGVMMGT AAGLEIPTML IAGYFAKRLG KRFLMRVAAV GGVCFYAGML
310 320 330 340 350
MAHSPVILLG LQLLNAIFIG ILGGIGMLYF QDLMPGQAGS ATTLYTNTSR
360 370 380 390
VGWIIAGSVA GIVAEIWNYH AVFWFAMVMI IATLFCLLRI KDV
Length:393
Mass (Da):42,746
Last modified:February 1, 1994 - v1
Checksum:i6EC58F00FB632B22
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00007 Genomic DNA. Translation: AAA60516.1.
U00096 Genomic DNA. Translation: AAC75231.1.
AP009048 Genomic DNA. Translation: BAA15979.1.
PIRiA64986.
RefSeqiNP_416675.1. NC_000913.3.
WP_000551980.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75231; AAC75231; b2170.
BAA15979; BAA15979; BAA15979.
GeneIDi946673.
KEGGiecj:JW2157.
eco:b2170.
PATRICi32119691. VBIEscCol129921_2256.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00007 Genomic DNA. Translation: AAA60516.1.
U00096 Genomic DNA. Translation: AAC75231.1.
AP009048 Genomic DNA. Translation: BAA15979.1.
PIRiA64986.
RefSeqiNP_416675.1. NC_000913.3.
WP_000551980.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP33026.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260465. 100 interactions.
STRINGi511145.b2170.

Protein family/group databases

TCDBi2.A.1.20.2. the major facilitator superfamily (mfs).

Proteomic databases

PaxDbiP33026.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75231; AAC75231; b2170.
BAA15979; BAA15979; BAA15979.
GeneIDi946673.
KEGGiecj:JW2157.
eco:b2170.
PATRICi32119691. VBIEscCol129921_2256.

Organism-specific databases

EchoBASEiEB1969.
EcoGeneiEG12034. setB.

Phylogenomic databases

eggNOGiENOG4105S8Q. Bacteria.
ENOG410XTE9. LUCA.
HOGENOMiHOG000281090.
InParanoidiP33026.
KOiK03291.
OMAiYYAKRFG.
OrthoDBiEOG64JFK7.
PhylomeDBiP33026.

Enzyme and pathway databases

BioCyciEcoCyc:B2170-MONOMER.
ECOL316407:JW2157-MONOMER.
MetaCyc:B2170-MONOMER.

Miscellaneous databases

PROiP33026.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR004750. Sugar_efflux.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00899. 2A0120. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Automated multiplex sequencing of the E.coli genome."
    Richterich P., Lakey N., Gryan G., Jaehn L., Mintz L., Robison K., Church G.M.
    Submitted (OCT-1993) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / BHB2600.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  4. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  5. "The identification of a new family of sugar efflux pumps in Escherichia coli."
    Liu J.Y., Miller P.F., Gosink M., Olson E.R.
    Mol. Microbiol. 31:1845-1851(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  6. "Functional and biochemical characterization of Escherichia coli sugar efflux transporters."
    Liu J.Y., Miller P.F., Willard J., Olson E.R.
    J. Biol. Chem. 274:22977-22984(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.

Entry informationi

Entry nameiSETB_ECOLI
AccessioniPrimary (citable) accession number: P33026
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: April 13, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.