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Protein

Sugar efflux transporter B

Gene

setB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the efflux of sugars. The physiological role may be the detoxification of non-metabolizable sugar analogs. Can transport lactose and glucose.

GO - Biological processi

  • chromosome segregation Source: EcoliWiki
  • lactose transport Source: EcoliWiki
  • transmembrane transport Source: InterPro

Keywordsi

Biological processSugar transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:B2170-MONOMER
MetaCyc:B2170-MONOMER

Protein family/group databases

TCDBi2.A.1.20.2 the major facilitator superfamily (mfs)

Names & Taxonomyi

Protein namesi
Recommended name:
Sugar efflux transporter B
Gene namesi
Name:setB
Synonyms:yeiO
Ordered Locus Names:b2170, JW2157
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12034 setB

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei13 – 33HelicalSequence analysisAdd BLAST21
Transmembranei51 – 71HelicalSequence analysisAdd BLAST21
Transmembranei82 – 102HelicalSequence analysisAdd BLAST21
Transmembranei106 – 126HelicalSequence analysisAdd BLAST21
Transmembranei152 – 172HelicalSequence analysisAdd BLAST21
Transmembranei174 – 194HelicalSequence analysisAdd BLAST21
Transmembranei219 – 239HelicalSequence analysisAdd BLAST21
Transmembranei253 – 273HelicalSequence analysisAdd BLAST21
Transmembranei283 – 303HelicalSequence analysisAdd BLAST21
Transmembranei306 – 326HelicalSequence analysisAdd BLAST21
Transmembranei344 – 364HelicalSequence analysisAdd BLAST21
Transmembranei366 – 386HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: EcoliWiki
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002093601 – 393Sugar efflux transporter BAdd BLAST393

Proteomic databases

PaxDbiP33026
PRIDEiP33026

Interactioni

Protein-protein interaction databases

BioGridi4260465, 101 interactors
STRINGi316385.ECDH10B_2327

Structurei

3D structure databases

ProteinModelPortaliP33026
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105S8Q Bacteria
ENOG410XTE9 LUCA
HOGENOMiHOG000281090
InParanoidiP33026
KOiK03291
OMAiFGFTVMY
PhylomeDBiP33026

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
IPR004750 Sugar_efflux
PANTHERiPTHR23535:SF2 PTHR23535:SF2, 1 hit
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
TIGRFAMsiTIGR00899 2A0120, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit

Sequencei

Sequence statusi: Complete.

P33026-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHNSPAVSSA KSFDLTSTAF LIVAFLTGIA GALQTPTLSI FLTDEVHARP
60 70 80 90 100
AMVGFFFTGS AVIGILVSQF LAGRSDKRGD RKSLIVFCCL LGVLACTLFA
110 120 130 140 150
WNRNYFVLLF VGVFLSSFGS TANPQMFALA REHADKTGRE AVMFSSFLRA
160 170 180 190 200
QVSLAWVIGP PLAYALAMGF SFTVMYLSAA VAFIVCGVMV WLFLPSMRKE
210 220 230 240 250
LPLATGTIEA PRRNRRDTLL LFVICTLMWG SNSLYIINMP LFIINELHLP
260 270 280 290 300
EKLAGVMMGT AAGLEIPTML IAGYFAKRLG KRFLMRVAAV GGVCFYAGML
310 320 330 340 350
MAHSPVILLG LQLLNAIFIG ILGGIGMLYF QDLMPGQAGS ATTLYTNTSR
360 370 380 390
VGWIIAGSVA GIVAEIWNYH AVFWFAMVMI IATLFCLLRI KDV
Length:393
Mass (Da):42,746
Last modified:February 1, 1994 - v1
Checksum:i6EC58F00FB632B22
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00007 Genomic DNA Translation: AAA60516.1
U00096 Genomic DNA Translation: AAC75231.1
AP009048 Genomic DNA Translation: BAA15979.1
PIRiA64986
RefSeqiNP_416675.1, NC_000913.3
WP_000551980.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC75231; AAC75231; b2170
BAA15979; BAA15979; BAA15979
GeneIDi946673
KEGGiecj:JW2157
eco:b2170
PATRICifig|1411691.4.peg.68

Similar proteinsi

Entry informationi

Entry nameiSETB_ECOLI
AccessioniPrimary (citable) accession number: P33026
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: April 25, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health