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Protein

Putative nucleoside permease NupX

Gene

nupX

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciEcoCyc:YEIJ-MONOMER.
ECOL316407:JW2148-MONOMER.

Protein family/group databases

TCDBi2.A.41.2.10. the concentrative nucleoside transporter (cnt) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative nucleoside permease NupXCurated
Gene namesi
Name:nupXImported
Synonyms:yeiJ
Ordered Locus Names:b2161, JW2148
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12029. nupX.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 2PeriplasmicCurated2
Transmembranei3 – 23HelicalSequence analysisAdd BLAST21
Topological domaini24 – 31CytoplasmicCurated8
Transmembranei32 – 52HelicalSequence analysisAdd BLAST21
Topological domaini53 – 95PeriplasmicCuratedAdd BLAST43
Transmembranei96 – 118HelicalSequence analysisAdd BLAST23
Topological domaini119 – 172CytoplasmicCuratedAdd BLAST54
Transmembranei173 – 193HelicalSequence analysisAdd BLAST21
Topological domaini194 – 196PeriplasmicCurated3
Transmembranei197 – 217HelicalSequence analysisAdd BLAST21
Topological domaini218 – 246CytoplasmicCuratedAdd BLAST29
Transmembranei247 – 267HelicalSequence analysisAdd BLAST21
Topological domaini268 – 352PeriplasmicCuratedAdd BLAST85
Transmembranei353 – 373HelicalSequence analysisAdd BLAST21
Topological domaini374 – 394CytoplasmicCuratedAdd BLAST21
Transmembranei395 – 415HelicalSequence analysisAdd BLAST21
Topological domaini416Periplasmic1 Publication1

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000704571 – 416Putative nucleoside permease NupXAdd BLAST416

Proteomic databases

PaxDbiP33021.
PRIDEiP33021.

Interactioni

Protein-protein interaction databases

BioGridi4260459. 7 interactors.
DIPiDIP-11922N.
IntActiP33021. 1 interactor.
MINTiMINT-1264070.
STRINGi511145.b2161.

Structurei

3D structure databases

ProteinModelPortaliP33021.
SMRiP33021.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105D9N. Bacteria.
COG1972. LUCA.
HOGENOMiHOG000267656.
InParanoidiP33021.
KOiK16325.
OMAiSEICAIM.
PhylomeDBiP33021.

Family and domain databases

InterProiIPR008276. C_nuclsd_transpt.
IPR018270. C_nuclsd_transpt_met_bac.
IPR011657. CNT_C_dom.
IPR002668. CNT_N_dom.
[Graphical view]
PANTHERiPTHR10590. PTHR10590. 1 hit.
PfamiPF07662. Nucleos_tra2_C. 1 hit.
PF01773. Nucleos_tra2_N. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00804. nupC. 1 hit.

Sequencei

Sequence statusi: Complete.

P33021-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVMRSVLGM VVLLTIAFLL SVNKKKISLR TVGAALVLQV VIGGIMLWLP
60 70 80 90 100
PGRWVAEKVA FGVHKVMAYS DAGSAFIFGS LVGPKMDTLF DGAGFIFGFR
110 120 130 140 150
VLPAIIFVTA LVSILYYIGV MGILIRILGG IFQKALNISK IESFVAVTTI
160 170 180 190 200
FLGQNEIPAI VKPFIDRLNR NELFTAICSG MASIAGSTMI GYAALGVPVE
210 220 230 240 250
YLLAASLMAI PGGILFARLL SPATESSQVS FNNLSFTETP PKSIIEAAAT
260 270 280 290 300
GAMTGLKIAA GVATVVMAFV AIIALINGII GGVGGWFGFE HASLESILGY
310 320 330 340 350
LLAPLAWVMG VDWSDANLAG SLIGQKLAIN EFVAYLNFSP YLQTAGTLDA
360 370 380 390 400
KTVAIISFAL CGFANFGSIG VVVGAFSAVA PHRAPEIAQL GLRALAAATL
410
SNLMSATIAG FFIGLA
Length:416
Mass (Da):43,410
Last modified:February 1, 1994 - v1
Checksum:iFB8E9C284A028B4D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00007 Genomic DNA. Translation: AAA60513.1.
U00096 Genomic DNA. Translation: AAC75222.1.
AP009048 Genomic DNA. Translation: BAE76638.1.
PIRiH64984.
RefSeqiNP_416666.1. NC_000913.3.
WP_000382966.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75222; AAC75222; b2161.
BAE76638; BAE76638; BAE76638.
GeneIDi946655.
KEGGiecj:JW2148.
eco:b2161.
PATRICi32119671. VBIEscCol129921_2246.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00007 Genomic DNA. Translation: AAA60513.1.
U00096 Genomic DNA. Translation: AAC75222.1.
AP009048 Genomic DNA. Translation: BAE76638.1.
PIRiH64984.
RefSeqiNP_416666.1. NC_000913.3.
WP_000382966.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP33021.
SMRiP33021.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260459. 7 interactors.
DIPiDIP-11922N.
IntActiP33021. 1 interactor.
MINTiMINT-1264070.
STRINGi511145.b2161.

Protein family/group databases

TCDBi2.A.41.2.10. the concentrative nucleoside transporter (cnt) family.

Proteomic databases

PaxDbiP33021.
PRIDEiP33021.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75222; AAC75222; b2161.
BAE76638; BAE76638; BAE76638.
GeneIDi946655.
KEGGiecj:JW2148.
eco:b2161.
PATRICi32119671. VBIEscCol129921_2246.

Organism-specific databases

EchoBASEiEB1964.
EcoGeneiEG12029. nupX.

Phylogenomic databases

eggNOGiENOG4105D9N. Bacteria.
COG1972. LUCA.
HOGENOMiHOG000267656.
InParanoidiP33021.
KOiK16325.
OMAiSEICAIM.
PhylomeDBiP33021.

Enzyme and pathway databases

BioCyciEcoCyc:YEIJ-MONOMER.
ECOL316407:JW2148-MONOMER.

Miscellaneous databases

PROiP33021.

Family and domain databases

InterProiIPR008276. C_nuclsd_transpt.
IPR018270. C_nuclsd_transpt_met_bac.
IPR011657. CNT_C_dom.
IPR002668. CNT_N_dom.
[Graphical view]
PANTHERiPTHR10590. PTHR10590. 1 hit.
PfamiPF07662. Nucleos_tra2_C. 1 hit.
PF01773. Nucleos_tra2_N. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00804. nupC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNUPX_ECOLI
AccessioniPrimary (citable) accession number: P33021
Secondary accession number(s): Q2MAR8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: November 2, 2016
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.