Reviewed, UniProtKB/Swiss-Prot P33006 (CPXL_PSESP)

Names and origin

Protein names

Recommended name:
    Cytochrome P450-terp
      Short name=P450terp
    EC=1.14.-.-
Alternative name(s):
    Cytochrome P450 108

Gene names

Name:	cyp108
Synonyms:	terPC

Organism

Pseudomonas sp.

Taxonomic identifier

306 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria

Protein attributes

Sequence length	428 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Catalyzes the hydroxylation of alpha-terpineol.
Cofactor	Heme group.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the cytochrome P450 family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Heme Iron Metal-binding
Molecular function	Monooxygenase Oxidoreductase
Technical term	3D-structure Direct protein sequencing
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro monooxygenase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 428

428

Cytochrome P450-terp

PRO_0000052222

Sites

Metal binding

377

1

Iron (heme axial ligand)

Secondary structure

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428

Helix Strand Turn

Details...

Helix

9 – 16

8

Helix

19 – 22

4

Helix

24 – 37

14

Beta strand

39 – 43

5

Beta strand

51 – 54

4

Helix

57 – 65

9

Turn

67 – 69

3

Beta strand

70 – 75

6

Helix

82 – 91

10

Turn

92 – 94

3

Helix

102 – 104

3

Helix

109 – 118

10

Helix

123 – 126

4

Helix

127 – 129

3

Helix

130 – 145

16

Beta strand

147 – 152

6

Helix

153 – 156

4

Turn

157 – 160

4

Helix

161 – 170

10

Helix

174 – 176

3

Helix

177 – 185

9

Turn

186 – 188

3

Helix

208 – 230

23

Helix

238 – 244

7

Beta strand

246 – 251

6

Helix

254 – 285

32

Helix

287 – 295

9

Helix

297 – 299

3

Helix

300 – 311

12

Beta strand

318 – 323

6

Beta strand

325 – 327

3

Beta strand

330 – 332

3

Beta strand

337 – 340

4

Helix

342 – 345

4

Turn

349 – 351

3

Helix

380 – 394

15

Helix

395 – 397

3

Beta strand

398 – 405

8

Beta strand

413 – 415

3

Beta strand

417 – 420

4

Beta strand

422 – 427

6

Sequences

	Sequence		Length	Mass (Da)
	P33006-1 [UniParc]. Last modified October 1, 1993. Version 1. Checksum: 29B772460CC4E93F	FASTA	428	47,922
	10 20 30 40 50 60 MDARATIPEH IARTVILPQG YADDEVIYPA FKWLRDEQPL AMAHIEGYDP MWIATKHADV 70 80 90 100 110 120 MQIGKQPGLF SNAEGSEILY DQNNEAFMRS ISGGCPHVID SLTSMDPPTH TAYRGLTLNW 130 140 150 160 170 180 FQPASIRKLE ENIRRIAQAS VQRLLDFDGE CDFMTDCALY YPLHVVMTAL GVPEDDEPLM 190 200 210 220 230 240 LKLTQDFFGV HEPDEQAVAA PRQSADEAAR RFHETIATFY DYFNGFTVDR RSCPKDDVMS 250 260 270 280 290 300 LLANSKLDGN YIDDKYINAY YVAIATAGHD TTSSSSGGAI IGLSRNPEQL ALAKSDPALI 310 320 330 340 350 360 PRLVDEAVRW TAPVKSFMRT ALADTEVRGQ NIKRGDRIML SYPSANRDEE VFSNPDEFDI 370 380 390 400 410 420 TRFPNRHLGF GWGAHMCLGQ HLAKLEMKIF FEELLPKLKS VELSGPPRLV ATNFVGGPKN VPIRFTKA

References

[1]	"Cytochrome P-450terp. Isolation and purification of the protein and cloning and sequencing of its operon." Peterson J.A., Lu J.-Y., Geisselsoder J., Graham-Lorence S., Carmona C., Witney F., Lorence M.C. J. Biol. Chem. 267:14193-14203(1992) [PubMed: 1629218] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PARTIAL PROTEIN SEQUENCE.
[2]	"Crystal structure and refinement of cytochrome P450terp at 2.3-A resolution." Hasemann C.A., Ravichandran K.G., Peterson J.A., Deisenhifer J. J. Mol. Biol. 236:1169-1185(1994) [PubMed: 8120894] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS).

Cross-references

Sequence databases

EMBLGenBankDDBJ

M91440 Genomic DNA. Translation: AAA25996.1.

PIR

A42971.

3D structure databases

PDBPDBe

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1CPT	X-ray	2.30	A	1-428	[»]

ModBase

Search...

Family and domain databases

InterPro

IPR001128. Cyt_P450.
IPR002397. Cyt_P450_B.
IPR017972. Cyt_P450_CS.
[Graphical view]

Gene3D

G3DSA:1.10.630.10. Cyt_P450. 1 hit.

PANTHER

PTHR19383. Cyt_P450. 1 hit.

Pfam

PF00067. p450. 1 hit.
[Graphical view]

PRINTS

PR00359. BP450.

PROSITE

PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

CPXL_PSESP

Accession

Primary (citable) accession number: P33006

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1993
Last sequence update:	October 1, 1993
Last modified:	June 16, 2009
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)