P33006 (CPXL_PSESP) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome P450-terp
Short name=Cytochrome P450terp
EC=1.14.-.-

Alternative name(s):
Cytochrome P450 108

Gene names

Name:	cyp108
Synonyms:	terPC

Organism

Pseudomonas sp.

Taxonomic identifier

306 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › unclassified Proteobacteria › unclassified pseudomonads

Protein attributes

Sequence length	428 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Catalyzes the hydroxylation of alpha-terpineol.
Cofactor	Heme group.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the cytochrome P450 family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Heme Iron Metal-binding
Molecular function	Monooxygenase Oxidoreductase
Technical term	3D-structure Direct protein sequencing
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro iron ion binding Inferred from electronic annotation. Source: InterPro monooxygenase activity Inferred from electronic annotation. Source: UniProtKB-KW oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 428

428

Cytochrome P450-terp

PRO_0000052222

Sites

Metal binding

377

1

Iron (heme axial ligand)

Secondary structure

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428

Helix Strand Turn

Details...

Helix

9 – 16

8

Helix

19 – 22

4

Helix

24 – 37

14

Beta strand

39 – 43

5

Beta strand

51 – 54

4

Helix

57 – 65

9

Turn

67 – 69

3

Beta strand

70 – 75

6

Helix

82 – 91

10

Turn

92 – 94

3

Helix

102 – 104

3

Helix

109 – 118

10

Helix

123 – 126

4

Helix

127 – 129

3

Helix

130 – 145

16

Beta strand

147 – 152

6

Helix

153 – 156

4

Turn

157 – 160

4

Helix

161 – 170

10

Helix

174 – 176

3

Helix

177 – 185

9

Turn

186 – 188

3

Helix

208 – 230

23

Helix

238 – 244

7

Beta strand

246 – 251

6

Helix

254 – 285

32

Helix

287 – 295

9

Helix

297 – 299

3

Helix

300 – 311

12

Beta strand

318 – 323

6

Beta strand

325 – 327

3

Beta strand

330 – 332

3

Beta strand

337 – 340

4

Helix

342 – 345

4

Turn

349 – 351

3

Helix

380 – 394

15

Helix

395 – 397

3

Beta strand

398 – 405

8

Beta strand

413 – 415

3

Beta strand

417 – 420

4

Beta strand

422 – 427

6

Sequences

	Sequence		Length	Mass (Da)
	P33006 [UniParc]. Last modified October 1, 1993. Version 1. Checksum: 29B772460CC4E93F	FASTA	428	47,922
	10 20 30 40 50 60 MDARATIPEH IARTVILPQG YADDEVIYPA FKWLRDEQPL AMAHIEGYDP MWIATKHADV 70 80 90 100 110 120 MQIGKQPGLF SNAEGSEILY DQNNEAFMRS ISGGCPHVID SLTSMDPPTH TAYRGLTLNW 130 140 150 160 170 180 FQPASIRKLE ENIRRIAQAS VQRLLDFDGE CDFMTDCALY YPLHVVMTAL GVPEDDEPLM 190 200 210 220 230 240 LKLTQDFFGV HEPDEQAVAA PRQSADEAAR RFHETIATFY DYFNGFTVDR RSCPKDDVMS 250 260 270 280 290 300 LLANSKLDGN YIDDKYINAY YVAIATAGHD TTSSSSGGAI IGLSRNPEQL ALAKSDPALI 310 320 330 340 350 360 PRLVDEAVRW TAPVKSFMRT ALADTEVRGQ NIKRGDRIML SYPSANRDEE VFSNPDEFDI 370 380 390 400 410 420 TRFPNRHLGF GWGAHMCLGQ HLAKLEMKIF FEELLPKLKS VELSGPPRLV ATNFVGGPKN VPIRFTKA

References

[1]	"Cytochrome P-450terp. Isolation and purification of the protein and cloning and sequencing of its operon." Peterson J.A., Lu J.-Y., Geisselsoder J., Graham-Lorence S., Carmona C., Witney F., Lorence M.C. J. Biol. Chem. 267:14193-14203(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PARTIAL PROTEIN SEQUENCE.
[2]	"Crystal structure and refinement of cytochrome P450terp at 2.3-A resolution." Hasemann C.A., Ravichandran K.G., Peterson J.A., Deisenhifer J. J. Mol. Biol. 236:1169-1185(1994) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS).

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

M91440 Genomic DNA. Translation: AAA25996.1.

PIR

A42971.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1CPT	X-ray	2.30	A	1-428	[»]

ProteinModelPortal

P33006.

SMR

P33006. Positions 1-428.

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Family and domain databases

Gene3D

1.10.630.10. 1 hit.

InterPro

IPR001128. Cyt_P450.
IPR002397. Cyt_P450_B.
IPR017972. Cyt_P450_CS.
[Graphical view]

Pfam

PF00067. p450. 1 hit.
[Graphical view]

PRINTS

PR00359. BP450.

SUPFAM

SSF48264. Cytochrome_P450. 1 hit.

PROSITE

PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

P33006.

Entry information

Entry name

CPXL_PSESP

Accession

Primary (citable) accession number: P33006

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1993
Last sequence update:	October 1, 1993
Last modified:	April 3, 2013
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program