ID   TNFL8_MOUSE             Reviewed;         239 AA.
AC   P32972;
DT   01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1993, sequence version 1.
DT   25-JAN-2012, entry version 85.
DE   RecName: Full=Tumor necrosis factor ligand superfamily member 8;
DE   AltName: Full=CD30 ligand;
DE            Short=CD30-L;
DE   AltName: CD_antigen=CD153;
GN   Name=Tnfsf8; Synonyms=Cd30l, Cd30lg;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=T-cell;
RX   MEDLINE=93313964; PubMed=8391931; DOI=10.1016/0092-8674(93)90361-S;
RA   Smith C.A., Gruess H.-J., Davis T., Anderson D., Farrah T., Baker E.,
RA   Sutherland G.R., Brannan C.I., Copeland N.G., Jenkins N.A.,
RA   Grabstein K.H., Gliniak B., McAlister I.B., Fanslow W., Alderson M.,
RA   Falk B., Gimpsel S., Gillis S., Din W.S., Goodwin R.G., Armitage R.J.;
RT   "CD30 antigen, a marker for Hodgkin's lymphoma, is a receptor whose
RT   ligand defines an emerging family of cytokines with homology to TNF.";
RL   Cell 73:1349-1360(1993).
CC   -!- FUNCTION: Cytokine that binds to TNFRSF8/CD30. Induces
CC       proliferation of T-cells.
CC   -!- SUBUNIT: Homotrimer (Probable).
CC   -!- SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane
CC       protein.
CC   -!- SIMILARITY: Belongs to the tumor necrosis factor family.
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DR   EMBL; L09754; AAA74595.1; -; mRNA.
DR   IPI; IPI00113840; -.
DR   PIR; B40710; B40710.
DR   RefSeq; NP_033429.1; NM_009403.3.
DR   UniGene; Mm.4664; -.
DR   ProteinModelPortal; P32972; -.
DR   STRING; P32972; -.
DR   PRIDE; P32972; -.
DR   Ensembl; ENSMUST00000030047; ENSMUSP00000030047; ENSMUSG00000028362.
DR   GeneID; 21949; -.
DR   KEGG; mmu:21949; -.
DR   CTD; 944; -.
DR   MGI; MGI:88328; Tnfsf8.
DR   eggNOG; roNOG10304; -.
DR   HOGENOM; HBG278304; -.
DR   HOVERGEN; HBG055267; -.
DR   InParanoid; P32972; -.
DR   OMA; WAYLQVS; -.
DR   OrthoDB; EOG42RD8M; -.
DR   PhylomeDB; P32972; -.
DR   NextBio; 301608; -.
DR   ArrayExpress; P32972; -.
DR   Bgee; P32972; -.
DR   Genevestigator; P32972; -.
DR   GermOnline; ENSMUSG00000028362; Mus musculus.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR   GO; GO:0005164; F:tumor necrosis factor receptor binding; IEA:InterPro.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   InterPro; IPR006052; TNF.
DR   InterPro; IPR021185; TNF_CD30_ligand_type.
DR   InterPro; IPR021184; TNF_CS.
DR   InterPro; IPR008983; Tumour_necrosis_fac-like.
DR   Gene3D; G3DSA:2.60.120.40; Tumour_necrosis_fac-like; 1.
DR   KO; K05471; -.
DR   Pfam; PF00229; TNF; 1.
DR   PIRSF; PIRSF019548; TNF_CD30_ligand_type; 1.
DR   SMART; SM00207; TNF; 1.
DR   SUPFAM; SSF49842; TNF_like; 1.
DR   PROSITE; PS00251; TNF_1; 1.
DR   PROSITE; PS50049; TNF_2; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Cytokine; Disulfide bond; Glycoprotein; Membrane;
KW   Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix.
FT   CHAIN         1    239       Tumor necrosis factor ligand superfamily
FT                                member 8.
FT                                /FTId=PRO_0000185500.
FT   TOPO_DOM      1     43       Cytoplasmic (Potential).
FT   TRANSMEM     44     67       Helical; Signal-anchor for type II
FT                                membrane protein; (Potential).
FT   TOPO_DOM     68    239       Extracellular (Potential).
FT   CARBOHYD     75     75       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD     86     86       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    114    114       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    158    158       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    194    194       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    206    206       N-linked (GlcNAc...) (Potential).
FT   DISULFID    156    182       Potential.
SQ   SEQUENCE   239 AA;  26519 MW;  29003157DD425159 CRC64;
     MEPGLQQAGS CGAPSPDPAM QVQPGSVASP WRSTRPWRST SRSYFYLSTT ALVCLVVAVA
     IILVLVVQKK DSTPNTTEKA PLKGGNCSED LFCTLKSTPS KKSWAYLQVS KHLNNTKLSW
     NEDGTIHGLI YQDGNLIVQF PGLYFIVCQL QFLVQCSNHS VDLTLQLLIN SKIKKQTLVT
     VCESGVQSKN IYQNLSQFLL HYLQVNSTIS VRVDNFQYVD TNTFPLDNVL SVFLYSSSD
//