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Protein

Tumor necrosis factor ligand superfamily member 8

Gene

Tnfsf8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Cytokine that binds to TNFRSF8/CD30. Induces proliferation of T-cells.

GO - Biological processi

  • CD8-positive, alpha-beta T cell differentiation Source: MGI
  • defense response to Gram-positive bacterium Source: MGI
  • immune response Source: InterPro
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor ligand superfamily member 8
Alternative name(s):
CD30 ligand
Short name:
CD30-L
CD_antigen: CD153
Gene namesi
Name:Tnfsf8
Synonyms:Cd30l, Cd30lg
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:88328. Tnfsf8.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4343CytoplasmicSequence analysisAdd
BLAST
Transmembranei44 – 6724Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST
Topological domaini68 – 239172ExtracellularSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 239239Tumor necrosis factor ligand superfamily member 8PRO_0000185500Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi75 – 751N-linked (GlcNAc...)Sequence analysis
Glycosylationi86 – 861N-linked (GlcNAc...)Sequence analysis
Glycosylationi114 – 1141N-linked (GlcNAc...)Sequence analysis
Disulfide bondi156 ↔ 182Sequence analysis
Glycosylationi158 – 1581N-linked (GlcNAc...)Sequence analysis
Glycosylationi194 – 1941N-linked (GlcNAc...)Sequence analysis
Glycosylationi206 – 2061N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP32972.
PRIDEiP32972.

PTM databases

PhosphoSiteiP32972.

Expressioni

Gene expression databases

BgeeiP32972.
ExpressionAtlasiP32972. baseline and differential.
GenevisibleiP32972. MM.

Interactioni

Subunit structurei

Homotrimer.Curated

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030047.

Structurei

3D structure databases

ProteinModelPortaliP32972.
SMRiP32972. Positions 112-234.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tumor necrosis factor family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHE9. Eukaryota.
ENOG4111CQK. LUCA.
HOGENOMiHOG000136320.
HOVERGENiHBG055267.
InParanoidiP32972.
KOiK05471.
OMAiWAYLQVS.
OrthoDBiEOG7DZ8M6.
PhylomeDBiP32972.
TreeFamiTF335780.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR021185. TNF_CD30_ligand_type.
IPR021184. TNF_CS.
IPR006052. TNF_dom.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00229. TNF. 1 hit.
[Graphical view]
PIRSFiPIRSF019548. TNF_CD30_ligand_type. 1 hit.
SMARTiSM00207. TNF. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS00251. TNF_1. 1 hit.
PS50049. TNF_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P32972-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPGLQQAGS CGAPSPDPAM QVQPGSVASP WRSTRPWRST SRSYFYLSTT
60 70 80 90 100
ALVCLVVAVA IILVLVVQKK DSTPNTTEKA PLKGGNCSED LFCTLKSTPS
110 120 130 140 150
KKSWAYLQVS KHLNNTKLSW NEDGTIHGLI YQDGNLIVQF PGLYFIVCQL
160 170 180 190 200
QFLVQCSNHS VDLTLQLLIN SKIKKQTLVT VCESGVQSKN IYQNLSQFLL
210 220 230
HYLQVNSTIS VRVDNFQYVD TNTFPLDNVL SVFLYSSSD
Length:239
Mass (Da):26,519
Last modified:October 1, 1993 - v1
Checksum:i29003157DD425159
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L09754 mRNA. Translation: AAA74595.1.
CCDSiCCDS18264.1.
PIRiB40710.
RefSeqiNP_033429.1. NM_009403.3.
XP_006537841.1. XM_006537778.1.
UniGeneiMm.4664.

Genome annotation databases

EnsembliENSMUST00000030047; ENSMUSP00000030047; ENSMUSG00000028362.
GeneIDi21949.
KEGGimmu:21949.
UCSCiuc008thd.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L09754 mRNA. Translation: AAA74595.1.
CCDSiCCDS18264.1.
PIRiB40710.
RefSeqiNP_033429.1. NM_009403.3.
XP_006537841.1. XM_006537778.1.
UniGeneiMm.4664.

3D structure databases

ProteinModelPortaliP32972.
SMRiP32972. Positions 112-234.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030047.

PTM databases

PhosphoSiteiP32972.

Proteomic databases

PaxDbiP32972.
PRIDEiP32972.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030047; ENSMUSP00000030047; ENSMUSG00000028362.
GeneIDi21949.
KEGGimmu:21949.
UCSCiuc008thd.1. mouse.

Organism-specific databases

CTDi944.
MGIiMGI:88328. Tnfsf8.

Phylogenomic databases

eggNOGiENOG410IHE9. Eukaryota.
ENOG4111CQK. LUCA.
HOGENOMiHOG000136320.
HOVERGENiHBG055267.
InParanoidiP32972.
KOiK05471.
OMAiWAYLQVS.
OrthoDBiEOG7DZ8M6.
PhylomeDBiP32972.
TreeFamiTF335780.

Miscellaneous databases

NextBioi301608.
PROiP32972.
SOURCEiSearch...

Gene expression databases

BgeeiP32972.
ExpressionAtlasiP32972. baseline and differential.
GenevisibleiP32972. MM.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR021185. TNF_CD30_ligand_type.
IPR021184. TNF_CS.
IPR006052. TNF_dom.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00229. TNF. 1 hit.
[Graphical view]
PIRSFiPIRSF019548. TNF_CD30_ligand_type. 1 hit.
SMARTiSM00207. TNF. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS00251. TNF_1. 1 hit.
PS50049. TNF_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "CD30 antigen, a marker for Hodgkin's lymphoma, is a receptor whose ligand defines an emerging family of cytokines with homology to TNF."
    Smith C.A., Gruess H.-J., Davis T., Anderson D., Farrah T., Baker E., Sutherland G.R., Brannan C.I., Copeland N.G., Jenkins N.A., Grabstein K.H., Gliniak B., McAlister I.B., Fanslow W., Alderson M., Falk B., Gimpsel S., Gillis S.
    , Din W.S., Goodwin R.G., Armitage R.J.
    Cell 73:1349-1360(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: T-cell.

Entry informationi

Entry nameiTNFL8_MOUSE
AccessioniPrimary (citable) accession number: P32972
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: December 9, 2015
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.