Skip Header

Contribute Send feedback
Read comments (0) or add your own

Reviewed, UniProtKB/Swiss-Prot P32972 (TNFL8_MOUSE)

Last modified January 19, 2010. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Tumor necrosis factor ligand superfamily member 8
Alternative name(s):
    CD30 ligand
      Short name=CD30-L
    CD_antigen=CD153
Gene names
Name: Tnfsf8
Synonyms: Cd30l, Cd30lg
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMus

Protein attributes

Sequence length239 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Function

Cytokine that binds to TNFRSF8/CD30. Induces proliferation of T-cells.

Subunit structure

Homotrimer Probable.

Subcellular location

Membrane; Single-pass type II membrane protein.

Sequence similarities

Belongs to the tumor necrosis factor family.

Ontologies

Keywords
   Cellular componentMembrane
   DomainSignal-anchor
Transmembrane
   Molecular functionCytokine
   PTMDisulfide bond
Glycoprotein
Gene Ontology (GO)
   Biological processimmune response

Inferred from electronic annotation. Source: InterPro

   Cellular componentextracellular space

Inferred from electronic annotation. Source: UniProtKB-KW

integral to membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functioncytokine activity

Inferred from electronic annotation. Source: UniProtKB-KW

tumor necrosis factor receptor binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 239239Tumor necrosis factor ligand superfamily member 8
PRO_0000185500

Regions

Topological domain1 – 4343Cytoplasmic Potential
Transmembrane44 – 6724Signal-anchor for type II membrane protein Potential
Topological domain68 – 239172Extracellular Potential

Amino acid modifications

Glycosylation751N-linked (GlcNAc...) Potential
Glycosylation861N-linked (GlcNAc...) Potential
Glycosylation1141N-linked (GlcNAc...) Potential
Glycosylation1581N-linked (GlcNAc...) Potential
Glycosylation1941N-linked (GlcNAc...) Potential
Glycosylation2061N-linked (GlcNAc...) Potential
Disulfide bond156 ↔ 182 Potential

Sequences

Sequence LengthMass (Da)Tools
P32972-1 [UniParc].

Last modified October 1, 1993. Version 1.
Checksum: 29003157DD425159

FASTA23926,519
        10         20         30         40         50         60 
MEPGLQQAGS CGAPSPDPAM QVQPGSVASP WRSTRPWRST SRSYFYLSTT ALVCLVVAVA 

        70         80         90        100        110        120 
IILVLVVQKK DSTPNTTEKA PLKGGNCSED LFCTLKSTPS KKSWAYLQVS KHLNNTKLSW 

       130        140        150        160        170        180 
NEDGTIHGLI YQDGNLIVQF PGLYFIVCQL QFLVQCSNHS VDLTLQLLIN SKIKKQTLVT 

       190        200        210        220        230 
VCESGVQSKN IYQNLSQFLL HYLQVNSTIS VRVDNFQYVD TNTFPLDNVL SVFLYSSSD 

« Hide

References

[1]"CD30 antigen, a marker for Hodgkin's lymphoma, is a receptor whose ligand defines an emerging family of cytokines with homology to TNF."
Smith C.A., Gruess H.-J., Davis T., Anderson D., Farrah T., Baker E., Sutherland G.R., Brannan C.I., Copeland N.G., Jenkins N.A., Grabstein K.H., Gliniak B., McAlister I.B., Fanslow W., Alderson M., Falk B., Gimpsel S., Gillis S. expand/collapse author list , Din W.S., Goodwin R.G., Armitage R.J.
Cell 73:1349-1360(1993) [PubMed: 8391931] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: T-cell.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L09754 mRNA. Translation: AAA74595.1.
IPIIPI00113840.
PIRB40710.
RefSeqNP_033429.1.
UniGeneMm.4664

3D structure databases

SMRP32972. Positions 98-221.
ModBaseSearch...

Protein-protein interaction databases

STRINGP32972.

Proteomic databases

PRIDEP32972.

Genome annotation databases

EnsemblENSMUST00000030047; ENSMUSP00000030047; ENSMUSG00000028362; Mus musculus. [Genome view]
GeneID21949.
KEGGmmu:21949.
UCSCuc008thd.1. mouse.

Organism-specific databases

CTD21949.
MGIMGI:88328. Tnfsf8.

Phylogenomic databases

eggNOGroNOG10304.
HOGENOMHBG278304.
HOVERGENP32972.
InParanoidP32972.
OMAWAYLQVS.
OrthoDBEOG97WR80.
PhylomeDBP32972.

Gene expression databases

ArrayExpressP32972.
BgeeP32972.
GenevestigatorP32972.
GermOnlineENSMUSG00000028362. Mus musculus.

Family and domain databases

InterProIPR006052. TNF_family.
IPR008983. Tumour_necrosis_fac-like.
[Graphical view]
PfamPF00229. TNF. 1 hit.
[Graphical view]
SMARTSM00207. TNF. 1 hit.
[Graphical view]
PROSITEPS00251. TNF_1. 1 hit.
PS50049. TNF_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio301608.
SOURCESearch...

Entry information

Entry nameTNFL8_MOUSE
AccessionPrimary (citable) accession number: P32972
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: January 19, 2010
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents