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P32971 (TNFL8_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 109. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tumor necrosis factor ligand superfamily member 8
Alternative name(s):
CD30 ligand
Short name=CD30-L
CD_antigen=CD153
Gene names
Name:TNFSF8
Synonyms:CD30L, CD30LG
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length234 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cytokine that binds to TNFRSF8/CD30. Induces proliferation of T-cells.

Subunit structure

Homotrimer Probable.

Subcellular location

Membrane; Single-pass type II membrane protein.

Sequence similarities

Belongs to the tumor necrosis factor family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 234234Tumor necrosis factor ligand superfamily member 8
PRO_0000185499

Regions

Topological domain1 – 3737Cytoplasmic Potential
Transmembrane38 – 6225Helical; Signal-anchor for type II membrane protein; Potential
Topological domain63 – 234172Extracellular Potential

Amino acid modifications

Glycosylation811N-linked (GlcNAc...) Potential
Glycosylation1091N-linked (GlcNAc...) Potential
Glycosylation1531N-linked (GlcNAc...) Potential
Glycosylation1891N-linked (GlcNAc...) Potential
Glycosylation2011N-linked (GlcNAc...) Potential
Disulfide bond151 ↔ 177 Potential

Sequences

Sequence LengthMass (Da)Tools
P32971 [UniParc].

Last modified October 1, 1993. Version 1.
Checksum: C653615682305B1B

FASTA23426,017
        10         20         30         40         50         60 
MDPGLQQALN GMAPPGDTAM HVPAGSVASH LGTTSRSYFY LTTATLALCL VFTVATIMVL 

        70         80         90        100        110        120 
VVQRTDSIPN SPDNVPLKGG NCSEDLLCIL KRAPFKKSWA YLQVAKHLNK TKLSWNKDGI 

       130        140        150        160        170        180 
LHGVRYQDGN LVIQFPGLYF IICQLQFLVQ CPNNSVDLKL ELLINKHIKK QALVTVCESG 

       190        200        210        220        230 
MQTKHVYQNL SQFLLDYLQV NTTISVNVDT FQYIDTSTFP LENVLSIFLY SNSD 

« Hide

References

[1]"CD30 antigen, a marker for Hodgkin's lymphoma, is a receptor whose ligand defines an emerging family of cytokines with homology to TNF."
Smith C.A., Gruess H.-J., Davis T., Anderson D., Farrah T., Baker E., Sutherland G.R., Brannan C.I., Copeland N.G., Jenkins N.A., Grabstein K.H., Gliniak B., McAlister I.B., Fanslow W., Alderson M., Falk B., Gimpsel S., Gillis S. expand/collapse author list , Din W.S., Goodwin R.G., Armitage R.J.
Cell 73:1349-1360(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Characterisation of the human CD30 ligand gene structure."
Croager E.J., Abraham L.J.
Biochim. Biophys. Acta 1353:231-235(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L09753 mRNA. Translation: AAA74594.1.
AF006384 expand/collapse EMBL AC list , AF006381, AF006382, AF006383 Genomic DNA. Translation: AAB97877.1.
PIRA40710.
RefSeqNP_001235.1. NM_001244.3.
UniGeneHs.494901.
Hs.654445.

3D structure databases

ProteinModelPortalP32971.
SMRP32971. Positions 96-228.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid107382. 1 interaction.
DIPDIP-2929N.
STRING9606.ENSP00000223795.

PTM databases

PhosphoSiteP32971.

Polymorphism databases

DMDM416777.

Proteomic databases

PaxDbP32971.
PRIDEP32971.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000223795; ENSP00000223795; ENSG00000106952.
GeneID944.
KEGGhsa:944.
UCSCuc004bji.2. human.

Organism-specific databases

CTD944.
GeneCardsGC09M117656.
HGNCHGNC:11938. TNFSF8.
MIM603875. gene.
neXtProtNX_P32971.
PharmGKBPA36628.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG40848.
HOGENOMHOG000136320.
HOVERGENHBG055267.
InParanoidP32971.
KOK05471.
OMAWAYLQVS.
OrthoDBEOG7DZ8M6.
PhylomeDBP32971.
TreeFamTF335780.

Gene expression databases

ArrayExpressP32971.
BgeeP32971.
CleanExHS_TNFSF8.
GenevestigatorP32971.

Family and domain databases

Gene3D2.60.120.40. 1 hit.
InterProIPR021185. TNF_CD30_ligand_type.
IPR021184. TNF_CS.
IPR006052. TNF_dom.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamPF00229. TNF. 1 hit.
[Graphical view]
PIRSFPIRSF019548. TNF_CD30_ligand_type. 1 hit.
SMARTSM00207. TNF. 1 hit.
[Graphical view]
SUPFAMSSF49842. SSF49842. 1 hit.
PROSITEPS00251. TNF_1. 1 hit.
PS50049. TNF_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi944.
NextBio3914.
PMAP-CutDBP32971.
PROP32971.
SOURCESearch...

Entry information

Entry nameTNFL8_HUMAN
AccessionPrimary (citable) accession number: P32971
Secondary accession number(s): O43404
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: March 19, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM

Human cell differentiation molecules

CD nomenclature of surface proteins of human leucocytes and list of entries