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Protein

Tumor necrosis factor ligand superfamily member 8

Gene

TNFSF8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Cytokine that binds to TNFRSF8/CD30. Induces proliferation of T-cells.

GO - Molecular functioni

  • receptor binding Source: ProtInc

GO - Biological processi

  • apoptotic process Source: ProtInc
  • CD8-positive, alpha-beta T cell differentiation Source: Ensembl
  • cell-cell signaling Source: ProtInc
  • cell proliferation Source: ProtInc
  • defense response to Gram-positive bacterium Source: Ensembl
  • immune response Source: InterPro
  • positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  • signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Enzyme and pathway databases

BioCyciZFISH:ENSG00000106952-MONOMER.
ReactomeiR-HSA-5669034. TNFs bind their physiological receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor ligand superfamily member 8
Alternative name(s):
CD30 ligand
Short name:
CD30-L
CD_antigen: CD153
Gene namesi
Name:TNFSF8
Synonyms:CD30L, CD30LG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:11938. TNFSF8.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 37CytoplasmicSequence analysisAdd BLAST37
Transmembranei38 – 62Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST25
Topological domaini63 – 234ExtracellularSequence analysisAdd BLAST172

GO - Cellular componenti

  • extracellular space Source: UniProtKB-KW
  • integral component of plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi944.
OpenTargetsiENSG00000106952.
PharmGKBiPA36628.

Polymorphism and mutation databases

BioMutaiTNFSF8.
DMDMi416777.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001854991 – 234Tumor necrosis factor ligand superfamily member 8Add BLAST234

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi81N-linked (GlcNAc...)Sequence analysis1
Glycosylationi109N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi151 ↔ 177Sequence analysis
Glycosylationi153N-linked (GlcNAc...)Sequence analysis1
Glycosylationi189N-linked (GlcNAc...)Sequence analysis1
Glycosylationi201N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP32971.
PeptideAtlasiP32971.
PRIDEiP32971.

PTM databases

iPTMnetiP32971.
PhosphoSitePlusiP32971.

Miscellaneous databases

PMAP-CutDBP32971.

Expressioni

Gene expression databases

BgeeiENSG00000106952.
CleanExiHS_TNFSF8.
ExpressionAtlasiP32971. baseline and differential.
GenevisibleiP32971. HS.

Interactioni

Subunit structurei

Homotrimer.Curated

GO - Molecular functioni

  • receptor binding Source: ProtInc

Protein-protein interaction databases

BioGridi107382. 37 interactors.
DIPiDIP-2929N.
STRINGi9606.ENSP00000223795.

Structurei

3D structure databases

ProteinModelPortaliP32971.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tumor necrosis factor family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHE9. Eukaryota.
ENOG4111CQK. LUCA.
GeneTreeiENSGT00390000011719.
HOGENOMiHOG000136320.
HOVERGENiHBG055267.
InParanoidiP32971.
KOiK05471.
OMAiWAYLQVS.
OrthoDBiEOG091G0HNM.
PhylomeDBiP32971.
TreeFamiTF335780.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR021185. TNF_CD30_ligand_type.
IPR021184. TNF_CS.
IPR006052. TNF_dom.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00229. TNF. 1 hit.
[Graphical view]
PIRSFiPIRSF019548. TNF_CD30_ligand_type. 1 hit.
SMARTiSM00207. TNF. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS00251. TNF_1. 1 hit.
PS50049. TNF_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P32971-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPGLQQALN GMAPPGDTAM HVPAGSVASH LGTTSRSYFY LTTATLALCL
60 70 80 90 100
VFTVATIMVL VVQRTDSIPN SPDNVPLKGG NCSEDLLCIL KRAPFKKSWA
110 120 130 140 150
YLQVAKHLNK TKLSWNKDGI LHGVRYQDGN LVIQFPGLYF IICQLQFLVQ
160 170 180 190 200
CPNNSVDLKL ELLINKHIKK QALVTVCESG MQTKHVYQNL SQFLLDYLQV
210 220 230
NTTISVNVDT FQYIDTSTFP LENVLSIFLY SNSD
Length:234
Mass (Da):26,017
Last modified:October 1, 1993 - v1
Checksum:iC653615682305B1B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L09753 mRNA. Translation: AAA74594.1.
AF006384
, AF006381, AF006382, AF006383 Genomic DNA. Translation: AAB97877.1.
CCDSiCCDS6810.1.
PIRiA40710.
RefSeqiNP_001235.1. NM_001244.3.
UniGeneiHs.494901.
Hs.654445.

Genome annotation databases

EnsembliENST00000223795; ENSP00000223795; ENSG00000106952.
GeneIDi944.
KEGGihsa:944.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L09753 mRNA. Translation: AAA74594.1.
AF006384
, AF006381, AF006382, AF006383 Genomic DNA. Translation: AAB97877.1.
CCDSiCCDS6810.1.
PIRiA40710.
RefSeqiNP_001235.1. NM_001244.3.
UniGeneiHs.494901.
Hs.654445.

3D structure databases

ProteinModelPortaliP32971.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107382. 37 interactors.
DIPiDIP-2929N.
STRINGi9606.ENSP00000223795.

PTM databases

iPTMnetiP32971.
PhosphoSitePlusiP32971.

Polymorphism and mutation databases

BioMutaiTNFSF8.
DMDMi416777.

Proteomic databases

PaxDbiP32971.
PeptideAtlasiP32971.
PRIDEiP32971.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000223795; ENSP00000223795; ENSG00000106952.
GeneIDi944.
KEGGihsa:944.

Organism-specific databases

CTDi944.
DisGeNETi944.
GeneCardsiTNFSF8.
HGNCiHGNC:11938. TNFSF8.
MIMi603875. gene.
neXtProtiNX_P32971.
OpenTargetsiENSG00000106952.
PharmGKBiPA36628.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHE9. Eukaryota.
ENOG4111CQK. LUCA.
GeneTreeiENSGT00390000011719.
HOGENOMiHOG000136320.
HOVERGENiHBG055267.
InParanoidiP32971.
KOiK05471.
OMAiWAYLQVS.
OrthoDBiEOG091G0HNM.
PhylomeDBiP32971.
TreeFamiTF335780.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000106952-MONOMER.
ReactomeiR-HSA-5669034. TNFs bind their physiological receptors.

Miscellaneous databases

GenomeRNAii944.
PMAP-CutDBP32971.
PROiP32971.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000106952.
CleanExiHS_TNFSF8.
ExpressionAtlasiP32971. baseline and differential.
GenevisibleiP32971. HS.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR021185. TNF_CD30_ligand_type.
IPR021184. TNF_CS.
IPR006052. TNF_dom.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00229. TNF. 1 hit.
[Graphical view]
PIRSFiPIRSF019548. TNF_CD30_ligand_type. 1 hit.
SMARTiSM00207. TNF. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS00251. TNF_1. 1 hit.
PS50049. TNF_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTNFL8_HUMAN
AccessioniPrimary (citable) accession number: P32971
Secondary accession number(s): O43404
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: November 30, 2016
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.