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P32971

- TNFL8_HUMAN

UniProt

P32971 - TNFL8_HUMAN

Protein

Tumor necrosis factor ligand superfamily member 8

Gene

TNFSF8

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 1 (01 Oct 1993)
      Previous versions | rss
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    Functioni

    Cytokine that binds to TNFRSF8/CD30. Induces proliferation of T-cells.

    GO - Molecular functioni

    1. receptor binding Source: ProtInc

    GO - Biological processi

    1. apoptotic process Source: ProtInc
    2. CD8-positive, alpha-beta T cell differentiation Source: Ensembl
    3. cell-cell signaling Source: ProtInc
    4. cell proliferation Source: ProtInc
    5. defense response to Gram-positive bacterium Source: Ensembl
    6. immune response Source: InterPro
    7. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    8. signal transduction Source: ProtInc

    Keywords - Molecular functioni

    Cytokine

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tumor necrosis factor ligand superfamily member 8
    Alternative name(s):
    CD30 ligand
    Short name:
    CD30-L
    CD_antigen: CD153
    Gene namesi
    Name:TNFSF8
    Synonyms:CD30L, CD30LG
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:11938. TNFSF8.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-KW
    2. integral component of plasma membrane Source: ProtInc

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA36628.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 234234Tumor necrosis factor ligand superfamily member 8PRO_0000185499Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi81 – 811N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi109 – 1091N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi151 ↔ 177Sequence Analysis
    Glycosylationi153 – 1531N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi189 – 1891N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi201 – 2011N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP32971.
    PRIDEiP32971.

    PTM databases

    PhosphoSiteiP32971.

    Miscellaneous databases

    PMAP-CutDBP32971.

    Expressioni

    Gene expression databases

    ArrayExpressiP32971.
    BgeeiP32971.
    CleanExiHS_TNFSF8.
    GenevestigatoriP32971.

    Interactioni

    Subunit structurei

    Homotrimer.Curated

    Protein-protein interaction databases

    BioGridi107382. 1 interaction.
    DIPiDIP-2929N.
    STRINGi9606.ENSP00000223795.

    Structurei

    3D structure databases

    ProteinModelPortaliP32971.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3737CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini63 – 234172ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei38 – 6225Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the tumor necrosis factor family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG40848.
    HOGENOMiHOG000136320.
    HOVERGENiHBG055267.
    InParanoidiP32971.
    KOiK05471.
    OMAiWAYLQVS.
    OrthoDBiEOG7DZ8M6.
    PhylomeDBiP32971.
    TreeFamiTF335780.

    Family and domain databases

    Gene3Di2.60.120.40. 1 hit.
    InterProiIPR021185. TNF_CD30_ligand_type.
    IPR021184. TNF_CS.
    IPR006052. TNF_dom.
    IPR008983. Tumour_necrosis_fac-like_dom.
    [Graphical view]
    PfamiPF00229. TNF. 1 hit.
    [Graphical view]
    PIRSFiPIRSF019548. TNF_CD30_ligand_type. 1 hit.
    SMARTiSM00207. TNF. 1 hit.
    [Graphical view]
    SUPFAMiSSF49842. SSF49842. 1 hit.
    PROSITEiPS00251. TNF_1. 1 hit.
    PS50049. TNF_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P32971-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDPGLQQALN GMAPPGDTAM HVPAGSVASH LGTTSRSYFY LTTATLALCL    50
    VFTVATIMVL VVQRTDSIPN SPDNVPLKGG NCSEDLLCIL KRAPFKKSWA 100
    YLQVAKHLNK TKLSWNKDGI LHGVRYQDGN LVIQFPGLYF IICQLQFLVQ 150
    CPNNSVDLKL ELLINKHIKK QALVTVCESG MQTKHVYQNL SQFLLDYLQV 200
    NTTISVNVDT FQYIDTSTFP LENVLSIFLY SNSD 234
    Length:234
    Mass (Da):26,017
    Last modified:October 1, 1993 - v1
    Checksum:iC653615682305B1B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L09753 mRNA. Translation: AAA74594.1.
    AF006384
    , AF006381, AF006382, AF006383 Genomic DNA. Translation: AAB97877.1.
    CCDSiCCDS6810.1.
    PIRiA40710.
    RefSeqiNP_001235.1. NM_001244.3.
    UniGeneiHs.494901.
    Hs.654445.

    Genome annotation databases

    EnsembliENST00000223795; ENSP00000223795; ENSG00000106952.
    GeneIDi944.
    KEGGihsa:944.
    UCSCiuc004bji.2. human.

    Polymorphism databases

    DMDMi416777.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L09753 mRNA. Translation: AAA74594.1 .
    AF006384
    , AF006381 , AF006382 , AF006383 Genomic DNA. Translation: AAB97877.1 .
    CCDSi CCDS6810.1.
    PIRi A40710.
    RefSeqi NP_001235.1. NM_001244.3.
    UniGenei Hs.494901.
    Hs.654445.

    3D structure databases

    ProteinModelPortali P32971.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107382. 1 interaction.
    DIPi DIP-2929N.
    STRINGi 9606.ENSP00000223795.

    PTM databases

    PhosphoSitei P32971.

    Polymorphism databases

    DMDMi 416777.

    Proteomic databases

    PaxDbi P32971.
    PRIDEi P32971.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000223795 ; ENSP00000223795 ; ENSG00000106952 .
    GeneIDi 944.
    KEGGi hsa:944.
    UCSCi uc004bji.2. human.

    Organism-specific databases

    CTDi 944.
    GeneCardsi GC09M117656.
    HGNCi HGNC:11938. TNFSF8.
    MIMi 603875. gene.
    neXtProti NX_P32971.
    PharmGKBi PA36628.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG40848.
    HOGENOMi HOG000136320.
    HOVERGENi HBG055267.
    InParanoidi P32971.
    KOi K05471.
    OMAi WAYLQVS.
    OrthoDBi EOG7DZ8M6.
    PhylomeDBi P32971.
    TreeFami TF335780.

    Miscellaneous databases

    GenomeRNAii 944.
    NextBioi 3914.
    PMAP-CutDB P32971.
    PROi P32971.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P32971.
    Bgeei P32971.
    CleanExi HS_TNFSF8.
    Genevestigatori P32971.

    Family and domain databases

    Gene3Di 2.60.120.40. 1 hit.
    InterProi IPR021185. TNF_CD30_ligand_type.
    IPR021184. TNF_CS.
    IPR006052. TNF_dom.
    IPR008983. Tumour_necrosis_fac-like_dom.
    [Graphical view ]
    Pfami PF00229. TNF. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF019548. TNF_CD30_ligand_type. 1 hit.
    SMARTi SM00207. TNF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49842. SSF49842. 1 hit.
    PROSITEi PS00251. TNF_1. 1 hit.
    PS50049. TNF_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "CD30 antigen, a marker for Hodgkin's lymphoma, is a receptor whose ligand defines an emerging family of cytokines with homology to TNF."
      Smith C.A., Gruess H.-J., Davis T., Anderson D., Farrah T., Baker E., Sutherland G.R., Brannan C.I., Copeland N.G., Jenkins N.A., Grabstein K.H., Gliniak B., McAlister I.B., Fanslow W., Alderson M., Falk B., Gimpsel S., Gillis S.
      , Din W.S., Goodwin R.G., Armitage R.J.
      Cell 73:1349-1360(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Characterisation of the human CD30 ligand gene structure."
      Croager E.J., Abraham L.J.
      Biochim. Biophys. Acta 1353:231-235(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiTNFL8_HUMAN
    AccessioniPrimary (citable) accession number: P32971
    Secondary accession number(s): O43404
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1993
    Last sequence update: October 1, 1993
    Last modified: October 1, 2014
    This is version 112 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3