Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Tumor necrosis factor ligand superfamily member 8

Gene

TNFSF8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Cytokine that binds to TNFRSF8/CD30. Induces proliferation of T-cells.

GO - Molecular functioni

  • receptor binding Source: ProtInc

GO - Biological processi

  • apoptotic process Source: ProtInc
  • CD8-positive, alpha-beta T cell differentiation Source: Ensembl
  • cell-cell signaling Source: ProtInc
  • cell proliferation Source: ProtInc
  • defense response to Gram-positive bacterium Source: Ensembl
  • immune response Source: InterPro
  • positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  • signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor ligand superfamily member 8
Alternative name(s):
CD30 ligand
Short name:
CD30-L
CD_antigen: CD153
Gene namesi
Name:TNFSF8
Synonyms:CD30L, CD30LG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:11938. TNFSF8.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3737CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei38 – 6225Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST
Topological domaini63 – 234172ExtracellularSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • extracellular space Source: UniProtKB-KW
  • integral component of plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36628.

Polymorphism and mutation databases

BioMutaiTNFSF8.
DMDMi416777.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 234234Tumor necrosis factor ligand superfamily member 8PRO_0000185499Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi81 – 811N-linked (GlcNAc...)Sequence Analysis
Glycosylationi109 – 1091N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi151 ↔ 177Sequence Analysis
Glycosylationi153 – 1531N-linked (GlcNAc...)Sequence Analysis
Glycosylationi189 – 1891N-linked (GlcNAc...)Sequence Analysis
Glycosylationi201 – 2011N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP32971.
PRIDEiP32971.

PTM databases

PhosphoSiteiP32971.

Miscellaneous databases

PMAP-CutDBP32971.

Expressioni

Gene expression databases

BgeeiP32971.
CleanExiHS_TNFSF8.
ExpressionAtlasiP32971. baseline and differential.
GenevisibleiP32971. HS.

Interactioni

Subunit structurei

Homotrimer.Curated

Protein-protein interaction databases

BioGridi107382. 43 interactions.
DIPiDIP-2929N.
STRINGi9606.ENSP00000223795.

Structurei

3D structure databases

ProteinModelPortaliP32971.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tumor necrosis factor family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG40848.
HOGENOMiHOG000136320.
HOVERGENiHBG055267.
InParanoidiP32971.
KOiK05471.
OMAiWAYLQVS.
OrthoDBiEOG7DZ8M6.
PhylomeDBiP32971.
TreeFamiTF335780.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR021185. TNF_CD30_ligand_type.
IPR021184. TNF_CS.
IPR006052. TNF_dom.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00229. TNF. 1 hit.
[Graphical view]
PIRSFiPIRSF019548. TNF_CD30_ligand_type. 1 hit.
SMARTiSM00207. TNF. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS00251. TNF_1. 1 hit.
PS50049. TNF_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P32971-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPGLQQALN GMAPPGDTAM HVPAGSVASH LGTTSRSYFY LTTATLALCL
60 70 80 90 100
VFTVATIMVL VVQRTDSIPN SPDNVPLKGG NCSEDLLCIL KRAPFKKSWA
110 120 130 140 150
YLQVAKHLNK TKLSWNKDGI LHGVRYQDGN LVIQFPGLYF IICQLQFLVQ
160 170 180 190 200
CPNNSVDLKL ELLINKHIKK QALVTVCESG MQTKHVYQNL SQFLLDYLQV
210 220 230
NTTISVNVDT FQYIDTSTFP LENVLSIFLY SNSD
Length:234
Mass (Da):26,017
Last modified:October 1, 1993 - v1
Checksum:iC653615682305B1B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L09753 mRNA. Translation: AAA74594.1.
AF006384
, AF006381, AF006382, AF006383 Genomic DNA. Translation: AAB97877.1.
CCDSiCCDS6810.1.
PIRiA40710.
RefSeqiNP_001235.1. NM_001244.3.
UniGeneiHs.494901.
Hs.654445.

Genome annotation databases

EnsembliENST00000223795; ENSP00000223795; ENSG00000106952.
GeneIDi944.
KEGGihsa:944.
UCSCiuc004bji.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L09753 mRNA. Translation: AAA74594.1.
AF006384
, AF006381, AF006382, AF006383 Genomic DNA. Translation: AAB97877.1.
CCDSiCCDS6810.1.
PIRiA40710.
RefSeqiNP_001235.1. NM_001244.3.
UniGeneiHs.494901.
Hs.654445.

3D structure databases

ProteinModelPortaliP32971.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107382. 43 interactions.
DIPiDIP-2929N.
STRINGi9606.ENSP00000223795.

PTM databases

PhosphoSiteiP32971.

Polymorphism and mutation databases

BioMutaiTNFSF8.
DMDMi416777.

Proteomic databases

PaxDbiP32971.
PRIDEiP32971.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000223795; ENSP00000223795; ENSG00000106952.
GeneIDi944.
KEGGihsa:944.
UCSCiuc004bji.2. human.

Organism-specific databases

CTDi944.
GeneCardsiGC09M117656.
HGNCiHGNC:11938. TNFSF8.
MIMi603875. gene.
neXtProtiNX_P32971.
PharmGKBiPA36628.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG40848.
HOGENOMiHOG000136320.
HOVERGENiHBG055267.
InParanoidiP32971.
KOiK05471.
OMAiWAYLQVS.
OrthoDBiEOG7DZ8M6.
PhylomeDBiP32971.
TreeFamiTF335780.

Miscellaneous databases

GenomeRNAii944.
NextBioi3914.
PMAP-CutDBP32971.
PROiP32971.
SOURCEiSearch...

Gene expression databases

BgeeiP32971.
CleanExiHS_TNFSF8.
ExpressionAtlasiP32971. baseline and differential.
GenevisibleiP32971. HS.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR021185. TNF_CD30_ligand_type.
IPR021184. TNF_CS.
IPR006052. TNF_dom.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00229. TNF. 1 hit.
[Graphical view]
PIRSFiPIRSF019548. TNF_CD30_ligand_type. 1 hit.
SMARTiSM00207. TNF. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS00251. TNF_1. 1 hit.
PS50049. TNF_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "CD30 antigen, a marker for Hodgkin's lymphoma, is a receptor whose ligand defines an emerging family of cytokines with homology to TNF."
    Smith C.A., Gruess H.-J., Davis T., Anderson D., Farrah T., Baker E., Sutherland G.R., Brannan C.I., Copeland N.G., Jenkins N.A., Grabstein K.H., Gliniak B., McAlister I.B., Fanslow W., Alderson M., Falk B., Gimpsel S., Gillis S.
    , Din W.S., Goodwin R.G., Armitage R.J.
    Cell 73:1349-1360(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Characterisation of the human CD30 ligand gene structure."
    Croager E.J., Abraham L.J.
    Biochim. Biophys. Acta 1353:231-235(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiTNFL8_HUMAN
AccessioniPrimary (citable) accession number: P32971
Secondary accession number(s): O43404
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: June 24, 2015
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.