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P32971

- TNFL8_HUMAN

UniProt

P32971 - TNFL8_HUMAN

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Protein
Tumor necrosis factor ligand superfamily member 8
Gene
TNFSF8, CD30L, CD30LG
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Cytokine that binds to TNFRSF8/CD30. Induces proliferation of T-cells.

GO - Molecular functioni

  1. receptor binding Source: ProtInc

GO - Biological processi

  1. CD8-positive, alpha-beta T cell differentiation Source: Ensembl
  2. apoptotic process Source: ProtInc
  3. cell proliferation Source: ProtInc
  4. cell-cell signaling Source: ProtInc
  5. defense response to Gram-positive bacterium Source: Ensembl
  6. immune response Source: InterPro
  7. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  8. signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor ligand superfamily member 8
Alternative name(s):
CD30 ligand
Short name:
CD30-L
CD_antigen: CD153
Gene namesi
Name:TNFSF8
Synonyms:CD30L, CD30LG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:11938. TNFSF8.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3737Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei38 – 6225Helical; Signal-anchor for type II membrane protein; Reviewed prediction
Add
BLAST
Topological domaini63 – 234172Extracellular Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
  2. integral component of plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36628.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 234234Tumor necrosis factor ligand superfamily member 8
PRO_0000185499Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi81 – 811N-linked (GlcNAc...) Reviewed prediction
Glycosylationi109 – 1091N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi151 ↔ 177 Reviewed prediction
Glycosylationi153 – 1531N-linked (GlcNAc...) Reviewed prediction
Glycosylationi189 – 1891N-linked (GlcNAc...) Reviewed prediction
Glycosylationi201 – 2011N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP32971.
PRIDEiP32971.

PTM databases

PhosphoSiteiP32971.

Miscellaneous databases

PMAP-CutDBP32971.

Expressioni

Gene expression databases

ArrayExpressiP32971.
BgeeiP32971.
CleanExiHS_TNFSF8.
GenevestigatoriP32971.

Interactioni

Subunit structurei

Homotrimer Inferred.

Protein-protein interaction databases

BioGridi107382. 1 interaction.
DIPiDIP-2929N.
STRINGi9606.ENSP00000223795.

Structurei

3D structure databases

ProteinModelPortaliP32971.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG40848.
HOGENOMiHOG000136320.
HOVERGENiHBG055267.
InParanoidiP32971.
KOiK05471.
OMAiWAYLQVS.
OrthoDBiEOG7DZ8M6.
PhylomeDBiP32971.
TreeFamiTF335780.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR021185. TNF_CD30_ligand_type.
IPR021184. TNF_CS.
IPR006052. TNF_dom.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00229. TNF. 1 hit.
[Graphical view]
PIRSFiPIRSF019548. TNF_CD30_ligand_type. 1 hit.
SMARTiSM00207. TNF. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS00251. TNF_1. 1 hit.
PS50049. TNF_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P32971-1 [UniParc]FASTAAdd to Basket

« Hide

MDPGLQQALN GMAPPGDTAM HVPAGSVASH LGTTSRSYFY LTTATLALCL    50
VFTVATIMVL VVQRTDSIPN SPDNVPLKGG NCSEDLLCIL KRAPFKKSWA 100
YLQVAKHLNK TKLSWNKDGI LHGVRYQDGN LVIQFPGLYF IICQLQFLVQ 150
CPNNSVDLKL ELLINKHIKK QALVTVCESG MQTKHVYQNL SQFLLDYLQV 200
NTTISVNVDT FQYIDTSTFP LENVLSIFLY SNSD 234
Length:234
Mass (Da):26,017
Last modified:October 1, 1993 - v1
Checksum:iC653615682305B1B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L09753 mRNA. Translation: AAA74594.1.
AF006384
, AF006381, AF006382, AF006383 Genomic DNA. Translation: AAB97877.1.
CCDSiCCDS6810.1.
PIRiA40710.
RefSeqiNP_001235.1. NM_001244.3.
UniGeneiHs.494901.
Hs.654445.

Genome annotation databases

EnsembliENST00000223795; ENSP00000223795; ENSG00000106952.
GeneIDi944.
KEGGihsa:944.
UCSCiuc004bji.2. human.

Polymorphism databases

DMDMi416777.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L09753 mRNA. Translation: AAA74594.1 .
AF006384
, AF006381 , AF006382 , AF006383 Genomic DNA. Translation: AAB97877.1 .
CCDSi CCDS6810.1.
PIRi A40710.
RefSeqi NP_001235.1. NM_001244.3.
UniGenei Hs.494901.
Hs.654445.

3D structure databases

ProteinModelPortali P32971.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107382. 1 interaction.
DIPi DIP-2929N.
STRINGi 9606.ENSP00000223795.

PTM databases

PhosphoSitei P32971.

Polymorphism databases

DMDMi 416777.

Proteomic databases

PaxDbi P32971.
PRIDEi P32971.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000223795 ; ENSP00000223795 ; ENSG00000106952 .
GeneIDi 944.
KEGGi hsa:944.
UCSCi uc004bji.2. human.

Organism-specific databases

CTDi 944.
GeneCardsi GC09M117656.
HGNCi HGNC:11938. TNFSF8.
MIMi 603875. gene.
neXtProti NX_P32971.
PharmGKBi PA36628.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG40848.
HOGENOMi HOG000136320.
HOVERGENi HBG055267.
InParanoidi P32971.
KOi K05471.
OMAi WAYLQVS.
OrthoDBi EOG7DZ8M6.
PhylomeDBi P32971.
TreeFami TF335780.

Miscellaneous databases

GenomeRNAii 944.
NextBioi 3914.
PMAP-CutDB P32971.
PROi P32971.
SOURCEi Search...

Gene expression databases

ArrayExpressi P32971.
Bgeei P32971.
CleanExi HS_TNFSF8.
Genevestigatori P32971.

Family and domain databases

Gene3Di 2.60.120.40. 1 hit.
InterProi IPR021185. TNF_CD30_ligand_type.
IPR021184. TNF_CS.
IPR006052. TNF_dom.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view ]
Pfami PF00229. TNF. 1 hit.
[Graphical view ]
PIRSFi PIRSF019548. TNF_CD30_ligand_type. 1 hit.
SMARTi SM00207. TNF. 1 hit.
[Graphical view ]
SUPFAMi SSF49842. SSF49842. 1 hit.
PROSITEi PS00251. TNF_1. 1 hit.
PS50049. TNF_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "CD30 antigen, a marker for Hodgkin's lymphoma, is a receptor whose ligand defines an emerging family of cytokines with homology to TNF."
    Smith C.A., Gruess H.-J., Davis T., Anderson D., Farrah T., Baker E., Sutherland G.R., Brannan C.I., Copeland N.G., Jenkins N.A., Grabstein K.H., Gliniak B., McAlister I.B., Fanslow W., Alderson M., Falk B., Gimpsel S., Gillis S.
    , Din W.S., Goodwin R.G., Armitage R.J.
    Cell 73:1349-1360(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Characterisation of the human CD30 ligand gene structure."
    Croager E.J., Abraham L.J.
    Biochim. Biophys. Acta 1353:231-235(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiTNFL8_HUMAN
AccessioniPrimary (citable) accession number: P32971
Secondary accession number(s): O43404
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: July 9, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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