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Protein

Tumor necrosis factor ligand superfamily member 8

Gene

TNFSF8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cytokine that binds to TNFRSF8/CD30. Induces proliferation of T-cells.

GO - Molecular functioni

  • cytokine activity Source: UniProtKB-KW
  • signaling receptor binding Source: ProtInc
  • tumor necrosis factor receptor binding Source: InterPro

GO - Biological processi

  • apoptotic process Source: ProtInc
  • CD8-positive, alpha-beta T cell differentiation Source: Ensembl
  • cell-cell signaling Source: ProtInc
  • cell proliferation Source: ProtInc
  • defense response to Gram-positive bacterium Source: Ensembl
  • immune response Source: InterPro
  • positive regulation of transcription by RNA polymerase II Source: Ensembl
  • signal transduction Source: ProtInc
  • tumor necrosis factor-mediated signaling pathway Source: Reactome

Keywordsi

Molecular functionCytokine

Enzyme and pathway databases

ReactomeiR-HSA-5669034 TNFs bind their physiological receptors

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor ligand superfamily member 8
Alternative name(s):
CD30 ligand
Short name:
CD30-L
CD_antigen: CD153
Gene namesi
Name:TNFSF8
Synonyms:CD30L, CD30LG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000106952.7
HGNCiHGNC:11938 TNFSF8
MIMi603875 gene
neXtProtiNX_P32971

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 37CytoplasmicSequence analysisAdd BLAST37
Transmembranei38 – 62Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST25
Topological domaini63 – 234ExtracellularSequence analysisAdd BLAST172

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi944
OpenTargetsiENSG00000106952
PharmGKBiPA36628

Polymorphism and mutation databases

BioMutaiTNFSF8
DMDMi416777

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001854991 – 234Tumor necrosis factor ligand superfamily member 8Add BLAST234

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi81N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi109N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi151 ↔ 177Sequence analysis
Glycosylationi153N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi189N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi201N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP32971
PeptideAtlasiP32971
PRIDEiP32971

PTM databases

iPTMnetiP32971
PhosphoSitePlusiP32971

Miscellaneous databases

PMAP-CutDBP32971

Expressioni

Gene expression databases

BgeeiENSG00000106952
CleanExiHS_TNFSF8
ExpressionAtlasiP32971 baseline and differential
GenevisibleiP32971 HS

Interactioni

Subunit structurei

Homotrimer.Curated

GO - Molecular functioni

  • cytokine activity Source: UniProtKB-KW
  • signaling receptor binding Source: ProtInc
  • tumor necrosis factor receptor binding Source: InterPro

Protein-protein interaction databases

BioGridi107382, 41 interactors
DIPiDIP-2929N
IntActiP32971, 2 interactors
STRINGi9606.ENSP00000223795

Structurei

3D structure databases

ProteinModelPortaliP32971
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tumor necrosis factor family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHE9 Eukaryota
ENOG4111CQK LUCA
GeneTreeiENSGT00390000011719
HOGENOMiHOG000136320
HOVERGENiHBG055267
InParanoidiP32971
KOiK05471
OMAiWAYLQVS
OrthoDBiEOG091G0HNM
PhylomeDBiP32971
TreeFamiTF335780

Family and domain databases

Gene3Di2.60.120.40, 1 hit
InterProiView protein in InterPro
IPR021185 TNF_CD30_ligand_type
IPR021184 TNF_CS
IPR006052 TNF_dom
IPR008983 Tumour_necrosis_fac-like_dom
PfamiView protein in Pfam
PF00229 TNF, 1 hit
PIRSFiPIRSF019548 TNF_CD30_ligand_type, 1 hit
SMARTiView protein in SMART
SM00207 TNF, 1 hit
SUPFAMiSSF49842 SSF49842, 1 hit
PROSITEiView protein in PROSITE
PS00251 TNF_1, 1 hit
PS50049 TNF_2, 1 hit

Sequencei

Sequence statusi: Complete.

P32971-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPGLQQALN GMAPPGDTAM HVPAGSVASH LGTTSRSYFY LTTATLALCL
60 70 80 90 100
VFTVATIMVL VVQRTDSIPN SPDNVPLKGG NCSEDLLCIL KRAPFKKSWA
110 120 130 140 150
YLQVAKHLNK TKLSWNKDGI LHGVRYQDGN LVIQFPGLYF IICQLQFLVQ
160 170 180 190 200
CPNNSVDLKL ELLINKHIKK QALVTVCESG MQTKHVYQNL SQFLLDYLQV
210 220 230
NTTISVNVDT FQYIDTSTFP LENVLSIFLY SNSD
Length:234
Mass (Da):26,017
Last modified:October 1, 1993 - v1
Checksum:iC653615682305B1B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L09753 mRNA Translation: AAA74594.1
AF006384
, AF006381, AF006382, AF006383 Genomic DNA Translation: AAB97877.1
CCDSiCCDS6810.1
PIRiA40710
RefSeqiNP_001235.1, NM_001244.3
UniGeneiHs.494901
Hs.654445

Genome annotation databases

EnsembliENST00000223795; ENSP00000223795; ENSG00000106952
GeneIDi944
KEGGihsa:944

Similar proteinsi

Entry informationi

Entry nameiTNFL8_HUMAN
AccessioniPrimary (citable) accession number: P32971
Secondary accession number(s): O43404
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: May 23, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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