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P32970 (CD70_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 127. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
CD70 antigen
Alternative name(s):
CD27 ligand
Short name=CD27-L
Tumor necrosis factor ligand superfamily member 7
CD_antigen=CD70
Gene names
Name:CD70
Synonyms:CD27L, CD27LG, TNFSF7
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length193 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Cytokine that binds to CD27. Plays a role in T-cell activation. Induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells.

Subunit structure

Homotrimer Probable.

Subcellular location

Membrane; Single-pass type II membrane protein.

Sequence similarities

Belongs to the tumor necrosis factor family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 193193CD70 antigen
PRO_0000185497

Regions

Topological domain1 – 1717Cytoplasmic Potential
Transmembrane18 – 3821Helical; Signal-anchor for type II membrane protein; Potential
Topological domain39 – 193155Extracellular Potential

Amino acid modifications

Glycosylation631N-linked (GlcNAc...) Potential
Glycosylation1701N-linked (GlcNAc...) Potential
Disulfide bond133 ↔ 151 Potential

Experimental info

Sequence conflict1541A → V in AAA36175. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P32970 [UniParc].

Last modified June 6, 2002. Version 2.
Checksum: 9265856E33BE4D50

FASTA19321,118
        10         20         30         40         50         60 
MPEEGSGCSV RRRPYGCVLR AALVPLVAGL VICLVVCIQR FAQAQQQLPL ESLGWDVAEL 

        70         80         90        100        110        120 
QLNHTGPQQD PRLYWQGGPA LGRSFLHGPE LDKGQLRIHR DGIYMVHIQV TLAICSSTTA 

       130        140        150        160        170        180 
SRHHPTTLAV GICSPASRSI SLLRLSFHQG CTIASQRLTP LARGDTLCTN LTGTLLPSRN 

       190 
TDETFFGVQW VRP 

« Hide

References

« Hide 'large scale' references
[1]"Molecular and biological characterization of a ligand for CD27 defines a new family of cytokines with homology to tumor necrosis factor."
Goodwin R.G., Alderson M.R., Smith C.A., Armitage R.J., Vandenbos T., Jerzy R., Tough T.W., Schoenborn M.A., David-Smith T., Hennen K., Falk B., Cosman D., Baker E., Sutherland G.R., Grabstein K.H., Farrah T., Giri J.G., Beckmann M.P.
Cell 73:447-456(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: B-cell.
[2]"The cloning of CD70 and its identification as the ligand for CD27."
Bowman M.R., Crimmins M.A., Yetz-Aldape J., Kriz R., Kelleher K., Herrmann S.
J. Immunol. 152:1756-1761(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]Livingston R.J., Shaffer T., McFarland I., Nguyen C.P., Stanaway I.B., Rajkumar N., Johnson E.J., da Ponte S.H., Willa H., Ahearn M.O., Bertucci C., Acklestad J., Carroll A., Swanson J., Gildersleeve H.I., Nickerson D.A.
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[5]Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.
[7]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L08096 mRNA. Translation: AAA36175.1.
S69339 mRNA. Translation: AAB30121.1.
BT007211 mRNA. Translation: AAP35875.1.
EF064709 Genomic DNA. Translation: ABK41892.1.
CH471139 Genomic DNA. Translation: EAW69074.1.
BC000725 mRNA. Translation: AAH00725.1.
CCDSCCDS12170.1.
PIRA40738. I56214.
RefSeqNP_001243.1. NM_001252.4.
UniGeneHs.501497.
Hs.715224.

3D structure databases

ProteinModelPortalP32970.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid107408. 2 interactions.
STRING9606.ENSP00000245903.

PTM databases

PhosphoSiteP32970.

Polymorphism databases

DMDM21431837.

Proteomic databases

MaxQBP32970.
PaxDbP32970.
PeptideAtlasP32970.
PRIDEP32970.

Protocols and materials databases

DNASU970.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000245903; ENSP00000245903; ENSG00000125726.
GeneID970.
KEGGhsa:970.
UCSCuc002mfi.3. human.

Organism-specific databases

CTD970.
GeneCardsGC19M006583.
HGNCHGNC:11937. CD70.
MIM602840. gene.
neXtProtNX_P32970.
PharmGKBPA36627.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG46932.
HOGENOMHOG000070045.
HOVERGENHBG054184.
InParanoidP32970.
KOK05470.
OMADTLCTNL.
PhylomeDBP32970.
TreeFamTF338269.

Gene expression databases

ArrayExpressP32970.
BgeeP32970.
CleanExHS_CD70.
GenevestigatorP32970.

Family and domain databases

Gene3D2.60.120.40. 1 hit.
InterProIPR021184. TNF_CS.
IPR006052. TNF_dom.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamPF00229. TNF. 1 hit.
[Graphical view]
SMARTSM00207. TNF. 1 hit.
[Graphical view]
SUPFAMSSF49842. SSF49842. 1 hit.
PROSITEPS00251. TNF_1. 1 hit.
PS50049. TNF_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi970.
NextBio4060.
PROP32970.
SOURCESearch...

Entry information

Entry nameCD70_HUMAN
AccessionPrimary (citable) accession number: P32970
Secondary accession number(s): Q53XX4, Q96J57
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: June 6, 2002
Last modified: July 9, 2014
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM

Human cell differentiation molecules

CD nomenclature of surface proteins of human leucocytes and list of entries