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P32970

- CD70_HUMAN

UniProt

P32970 - CD70_HUMAN

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Protein

CD70 antigen

Gene

CD70

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Cytokine that binds to CD27. Plays a role in T-cell activation. Induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells.

GO - Molecular functioni

  1. protease binding Source: BHF-UCL
  2. receptor binding Source: ProtInc

GO - Biological processi

  1. cell-cell signaling Source: ProtInc
  2. cell proliferation Source: ProtInc
  3. extrinsic apoptotic signaling pathway Source: BHF-UCL
  4. immune response Source: InterPro
  5. signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Names & Taxonomyi

Protein namesi
Recommended name:
CD70 antigen
Alternative name(s):
CD27 ligand
Short name:
CD27-L
Tumor necrosis factor ligand superfamily member 7
CD_antigen: CD70
Gene namesi
Name:CD70
Synonyms:CD27L, CD27LG, TNFSF7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:11937. CD70.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
  2. extracellular vesicular exosome Source: UniProt
  3. integral component of plasma membrane Source: ProtInc
  4. plasma membrane Source: HGNC
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36627.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 193193CD70 antigenPRO_0000185497Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi63 – 631N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi133 ↔ 151Sequence Analysis
Glycosylationi170 – 1701N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP32970.
PaxDbiP32970.
PeptideAtlasiP32970.
PRIDEiP32970.

PTM databases

PhosphoSiteiP32970.

Expressioni

Gene expression databases

BgeeiP32970.
CleanExiHS_CD70.
ExpressionAtlasiP32970. baseline and differential.
GenevestigatoriP32970.

Interactioni

Subunit structurei

Homotrimer.Curated

Protein-protein interaction databases

BioGridi107408. 3 interactions.
STRINGi9606.ENSP00000245903.

Structurei

3D structure databases

ProteinModelPortaliP32970.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1717CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini39 – 193155ExtracellularSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei18 – 3821Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the tumor necrosis factor family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG46932.
GeneTreeiENSGT00390000006744.
HOGENOMiHOG000070045.
HOVERGENiHBG054184.
InParanoidiP32970.
KOiK05470.
OMAiDTLCTNL.
PhylomeDBiP32970.
TreeFamiTF338269.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR021184. TNF_CS.
IPR006052. TNF_dom.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00229. TNF. 1 hit.
[Graphical view]
SMARTiSM00207. TNF. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS00251. TNF_1. 1 hit.
PS50049. TNF_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P32970-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPEEGSGCSV RRRPYGCVLR AALVPLVAGL VICLVVCIQR FAQAQQQLPL
60 70 80 90 100
ESLGWDVAEL QLNHTGPQQD PRLYWQGGPA LGRSFLHGPE LDKGQLRIHR
110 120 130 140 150
DGIYMVHIQV TLAICSSTTA SRHHPTTLAV GICSPASRSI SLLRLSFHQG
160 170 180 190
CTIASQRLTP LARGDTLCTN LTGTLLPSRN TDETFFGVQW VRP
Length:193
Mass (Da):21,118
Last modified:June 6, 2002 - v2
Checksum:i9265856E33BE4D50
GO
Isoform 2 (identifier: P32970-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     151-193: CTIASQRLTP...TFFGVQWVRP → LFGFWNWGLK...TDEENRGVNR

Note: No experimental confirmation available.

Show »
Length:208
Mass (Da):23,438
Checksum:i191D07D576433B6C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti154 – 1541A → V in AAA36175. (PubMed:8387892)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei151 – 19343CTIAS…QWVRP → LFGFWNWGLKVKCFLRHLIW TAHCFIPLTQLVFMQALQSW RNHHCSHFTDEENRGVNR in isoform 2. 1 PublicationVSP_056416Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L08096 mRNA. Translation: AAA36175.1.
S69339 mRNA. Translation: AAB30121.1.
BT007211 mRNA. Translation: AAP35875.1.
AK298467 mRNA. Translation: BAG60680.1.
EF064709 Genomic DNA. Translation: ABK41892.1.
AC008760 Genomic DNA. No translation available.
CH471139 Genomic DNA. Translation: EAW69074.1.
BC000725 mRNA. Translation: AAH00725.1.
CCDSiCCDS12170.1. [P32970-1]
PIRiI56214. A40738.
RefSeqiNP_001243.1. NM_001252.4.
UniGeneiHs.501497.
Hs.715224.

Genome annotation databases

EnsembliENST00000245903; ENSP00000245903; ENSG00000125726. [P32970-1]
ENST00000423145; ENSP00000395294; ENSG00000125726. [P32970-2]
GeneIDi970.
KEGGihsa:970.
UCSCiuc002mfi.3. human. [P32970-1]

Polymorphism databases

DMDMi21431837.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L08096 mRNA. Translation: AAA36175.1 .
S69339 mRNA. Translation: AAB30121.1 .
BT007211 mRNA. Translation: AAP35875.1 .
AK298467 mRNA. Translation: BAG60680.1 .
EF064709 Genomic DNA. Translation: ABK41892.1 .
AC008760 Genomic DNA. No translation available.
CH471139 Genomic DNA. Translation: EAW69074.1 .
BC000725 mRNA. Translation: AAH00725.1 .
CCDSi CCDS12170.1. [P32970-1 ]
PIRi I56214. A40738.
RefSeqi NP_001243.1. NM_001252.4.
UniGenei Hs.501497.
Hs.715224.

3D structure databases

ProteinModelPortali P32970.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107408. 3 interactions.
STRINGi 9606.ENSP00000245903.

PTM databases

PhosphoSitei P32970.

Polymorphism databases

DMDMi 21431837.

Proteomic databases

MaxQBi P32970.
PaxDbi P32970.
PeptideAtlasi P32970.
PRIDEi P32970.

Protocols and materials databases

DNASUi 970.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000245903 ; ENSP00000245903 ; ENSG00000125726 . [P32970-1 ]
ENST00000423145 ; ENSP00000395294 ; ENSG00000125726 . [P32970-2 ]
GeneIDi 970.
KEGGi hsa:970.
UCSCi uc002mfi.3. human. [P32970-1 ]

Organism-specific databases

CTDi 970.
GeneCardsi GC19M006583.
HGNCi HGNC:11937. CD70.
MIMi 602840. gene.
neXtProti NX_P32970.
PharmGKBi PA36627.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG46932.
GeneTreei ENSGT00390000006744.
HOGENOMi HOG000070045.
HOVERGENi HBG054184.
InParanoidi P32970.
KOi K05470.
OMAi DTLCTNL.
PhylomeDBi P32970.
TreeFami TF338269.

Miscellaneous databases

GenomeRNAii 970.
NextBioi 35473943.
PROi P32970.
SOURCEi Search...

Gene expression databases

Bgeei P32970.
CleanExi HS_CD70.
ExpressionAtlasi P32970. baseline and differential.
Genevestigatori P32970.

Family and domain databases

Gene3Di 2.60.120.40. 1 hit.
InterProi IPR021184. TNF_CS.
IPR006052. TNF_dom.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view ]
Pfami PF00229. TNF. 1 hit.
[Graphical view ]
SMARTi SM00207. TNF. 1 hit.
[Graphical view ]
SUPFAMi SSF49842. SSF49842. 1 hit.
PROSITEi PS00251. TNF_1. 1 hit.
PS50049. TNF_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular and biological characterization of a ligand for CD27 defines a new family of cytokines with homology to tumor necrosis factor."
    Goodwin R.G., Alderson M.R., Smith C.A., Armitage R.J., Vandenbos T., Jerzy R., Tough T.W., Schoenborn M.A., David-Smith T., Hennen K., Falk B., Cosman D., Baker E., Sutherland G.R., Grabstein K.H., Farrah T., Giri J.G., Beckmann M.P.
    Cell 73:447-456(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: B-cell.
  2. "The cloning of CD70 and its identification as the ligand for CD27."
    Bowman M.R., Crimmins M.A., Yetz-Aldape J., Kriz R., Kelleher K., Herrmann S.
    J. Immunol. 152:1756-1761(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  6. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Kidney.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCD70_HUMAN
AccessioniPrimary (citable) accession number: P32970
Secondary accession number(s): B4DPR8, Q53XX4, Q96J57
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: June 6, 2002
Last modified: October 29, 2014
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3