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P32970

- CD70_HUMAN

UniProt

P32970 - CD70_HUMAN

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Protein
CD70 antigen
Gene
CD70, CD27L, CD27LG, TNFSF7
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Cytokine that binds to CD27. Plays a role in T-cell activation. Induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells.

GO - Molecular functioni

  1. protease binding Source: BHF-UCL
  2. protein binding Source: UniProtKB
  3. receptor binding Source: ProtInc
Complete GO annotation...

GO - Biological processi

  1. cell proliferation Source: ProtInc
  2. cell-cell signaling Source: ProtInc
  3. extrinsic apoptotic signaling pathway Source: BHF-UCL
  4. immune response Source: InterPro
  5. signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Names & Taxonomyi

Protein namesi
Recommended name:
CD70 antigen
Alternative name(s):
CD27 ligand
Short name:
CD27-L
Tumor necrosis factor ligand superfamily member 7
CD_antigen: CD70
Gene namesi
Name:CD70
Synonyms:CD27L, CD27LG, TNFSF7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:11937. CD70.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1717Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei18 – 3821Helical; Signal-anchor for type II membrane protein; Reviewed prediction
Add
BLAST
Topological domaini39 – 193155Extracellular Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
  2. extracellular vesicular exosome Source: UniProt
  3. integral component of plasma membrane Source: ProtInc
  4. plasma membrane Source: HGNC
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36627.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 193193CD70 antigen
PRO_0000185497Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi63 – 631N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi133 ↔ 151 Reviewed prediction
Glycosylationi170 – 1701N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP32970.
PaxDbiP32970.
PeptideAtlasiP32970.
PRIDEiP32970.

PTM databases

PhosphoSiteiP32970.

Expressioni

Gene expression databases

ArrayExpressiP32970.
BgeeiP32970.
CleanExiHS_CD70.
GenevestigatoriP32970.

Interactioni

Subunit structurei

Homotrimer Inferred.

Protein-protein interaction databases

BioGridi107408. 2 interactions.
STRINGi9606.ENSP00000245903.

Structurei

3D structure databases

ProteinModelPortaliP32970.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG46932.
HOGENOMiHOG000070045.
HOVERGENiHBG054184.
InParanoidiP32970.
KOiK05470.
OMAiDTLCTNL.
PhylomeDBiP32970.
TreeFamiTF338269.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR021184. TNF_CS.
IPR006052. TNF_dom.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00229. TNF. 1 hit.
[Graphical view]
SMARTiSM00207. TNF. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS00251. TNF_1. 1 hit.
PS50049. TNF_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P32970-1 [UniParc]FASTAAdd to Basket

« Hide

MPEEGSGCSV RRRPYGCVLR AALVPLVAGL VICLVVCIQR FAQAQQQLPL    50
ESLGWDVAEL QLNHTGPQQD PRLYWQGGPA LGRSFLHGPE LDKGQLRIHR 100
DGIYMVHIQV TLAICSSTTA SRHHPTTLAV GICSPASRSI SLLRLSFHQG 150
CTIASQRLTP LARGDTLCTN LTGTLLPSRN TDETFFGVQW VRP 193
Length:193
Mass (Da):21,118
Last modified:June 6, 2002 - v2
Checksum:i9265856E33BE4D50
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti154 – 1541A → V in AAA36175. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L08096 mRNA. Translation: AAA36175.1.
S69339 mRNA. Translation: AAB30121.1.
BT007211 mRNA. Translation: AAP35875.1.
EF064709 Genomic DNA. Translation: ABK41892.1.
CH471139 Genomic DNA. Translation: EAW69074.1.
BC000725 mRNA. Translation: AAH00725.1.
CCDSiCCDS12170.1.
PIRiI56214. A40738.
RefSeqiNP_001243.1. NM_001252.4.
UniGeneiHs.501497.
Hs.715224.

Genome annotation databases

EnsembliENST00000245903; ENSP00000245903; ENSG00000125726.
GeneIDi970.
KEGGihsa:970.
UCSCiuc002mfi.3. human.

Polymorphism databases

DMDMi21431837.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L08096 mRNA. Translation: AAA36175.1 .
S69339 mRNA. Translation: AAB30121.1 .
BT007211 mRNA. Translation: AAP35875.1 .
EF064709 Genomic DNA. Translation: ABK41892.1 .
CH471139 Genomic DNA. Translation: EAW69074.1 .
BC000725 mRNA. Translation: AAH00725.1 .
CCDSi CCDS12170.1.
PIRi I56214. A40738.
RefSeqi NP_001243.1. NM_001252.4.
UniGenei Hs.501497.
Hs.715224.

3D structure databases

ProteinModelPortali P32970.
ModBasei Search...

Protein-protein interaction databases

BioGridi 107408. 2 interactions.
STRINGi 9606.ENSP00000245903.

PTM databases

PhosphoSitei P32970.

Polymorphism databases

DMDMi 21431837.

Proteomic databases

MaxQBi P32970.
PaxDbi P32970.
PeptideAtlasi P32970.
PRIDEi P32970.

Protocols and materials databases

DNASUi 970.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000245903 ; ENSP00000245903 ; ENSG00000125726 .
GeneIDi 970.
KEGGi hsa:970.
UCSCi uc002mfi.3. human.

Organism-specific databases

CTDi 970.
GeneCardsi GC19M006583.
HGNCi HGNC:11937. CD70.
MIMi 602840. gene.
neXtProti NX_P32970.
PharmGKBi PA36627.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG46932.
HOGENOMi HOG000070045.
HOVERGENi HBG054184.
InParanoidi P32970.
KOi K05470.
OMAi DTLCTNL.
PhylomeDBi P32970.
TreeFami TF338269.

Miscellaneous databases

GenomeRNAii 970.
NextBioi 4060.
PROi P32970.
SOURCEi Search...

Gene expression databases

ArrayExpressi P32970.
Bgeei P32970.
CleanExi HS_CD70.
Genevestigatori P32970.

Family and domain databases

Gene3Di 2.60.120.40. 1 hit.
InterProi IPR021184. TNF_CS.
IPR006052. TNF_dom.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view ]
Pfami PF00229. TNF. 1 hit.
[Graphical view ]
SMARTi SM00207. TNF. 1 hit.
[Graphical view ]
SUPFAMi SSF49842. SSF49842. 1 hit.
PROSITEi PS00251. TNF_1. 1 hit.
PS50049. TNF_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular and biological characterization of a ligand for CD27 defines a new family of cytokines with homology to tumor necrosis factor."
    Goodwin R.G., Alderson M.R., Smith C.A., Armitage R.J., Vandenbos T., Jerzy R., Tough T.W., Schoenborn M.A., David-Smith T., Hennen K., Falk B., Cosman D., Baker E., Sutherland G.R., Grabstein K.H., Farrah T., Giri J.G., Beckmann M.P.
    Cell 73:447-456(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: B-cell.
  2. "The cloning of CD70 and its identification as the ligand for CD27."
    Bowman M.R., Crimmins M.A., Yetz-Aldape J., Kriz R., Kelleher K., Herrmann S.
    J. Immunol. 152:1756-1761(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCD70_HUMAN
AccessioniPrimary (citable) accession number: P32970
Secondary accession number(s): Q53XX4, Q96J57
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: June 6, 2002
Last modified: July 9, 2014
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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