P32970 (CD70_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
CD70 antigen

Alternative name(s):
CD27 ligand
Short name=CD27-L
Tumor necrosis factor ligand superfamily member 7
CD_antigen=CD70

Gene names

Name:	CD70
Synonyms:	CD27L, CD27LG, TNFSF7

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	193 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Cytokine that binds to CD27. Plays a role in T-cell activation. Induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells.
Subunit structure	Homotrimer Probable.
Subcellular location	Membrane; Single-pass type II membrane protein.
Sequence similarities	Belongs to the tumor necrosis factor family.

Ontologies

Keywords
Cellular component	Membrane
Domain	Signal-anchor Transmembrane Transmembrane helix
Molecular function	Cytokine
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell proliferation Traceable author statement Ref.2. Source: ProtInc cell-cell signaling Traceable author statement Ref.1. Source: ProtInc immune response Inferred from electronic annotation. Source: InterPro induction of apoptosis Inferred from direct assay PubMed 9177220. Source: HGNC signal transduction Traceable author statement Ref.1. Source: ProtInc
Cellular_component	extracellular space Inferred from electronic annotation. Source: UniProtKB-KW integral to plasma membrane Traceable author statement Ref.2. Source: ProtInc
Molecular_function	receptor binding Traceable author statement Ref.2Ref.1. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 193	193	CD70 antigen		PRO_0000185497
Regions
	Topological domain	1 – 17	17	Cytoplasmic Potential
	Transmembrane	18 – 38	21	Helical; Signal-anchor for type II membrane protein; Potential
	Topological domain	39 – 193	155	Extracellular Potential
Amino acid modifications
	Glycosylation	63	1	N-linked (GlcNAc...) Potential
	Glycosylation	170	1	N-linked (GlcNAc...) Potential
	Disulfide bond	133 ↔ 151		Potential
Experimental info
	Sequence conflict	154	1	A → V in AAA36175. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P32970 [UniParc]. Last modified June 6, 2002. Version 2. Checksum: 9265856E33BE4D50	FASTA	193	21,118
	10 20 30 40 50 60 MPEEGSGCSV RRRPYGCVLR AALVPLVAGL VICLVVCIQR FAQAQQQLPL ESLGWDVAEL 70 80 90 100 110 120 QLNHTGPQQD PRLYWQGGPA LGRSFLHGPE LDKGQLRIHR DGIYMVHIQV TLAICSSTTA 130 140 150 160 170 180 SRHHPTTLAV GICSPASRSI SLLRLSFHQG CTIASQRLTP LARGDTLCTN LTGTLLPSRN 190 TDETFFGVQW VRP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular and biological characterization of a ligand for CD27 defines a new family of cytokines with homology to tumor necrosis factor." Goodwin R.G., Alderson M.R., Smith C.A., Armitage R.J., Vandenbos T., Jerzy R., Tough T.W., Schoenborn M.A., David-Smith T., Hennen K., Falk B., Cosman D., Baker E., Sutherland G.R., Grabstein K.H., Farrah T., Giri J.G., Beckmann M.P. Cell 73:447-456(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: B-cell.
[2]	"The cloning of CD70 and its identification as the ligand for CD27." Bowman M.R., Crimmins M.A., Yetz-Aldape J., Kriz R., Kelleher K., Herrmann S. J. Immunol. 152:1756-1761(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L08096 mRNA. Translation: AAA36175.1. S69339 mRNA. Translation: AAB30121.1. BC000725 mRNA. Translation: AAH00725.1.
IPI	IPI00031713.
PIR	A40738. I56214.
RefSeq	NP_001243.1. NM_001252.3.
UniGene	Hs.501497. Hs.715224.
3D structure databases
ProteinModelPortal	P32970.
SMR	P32970. Positions 57-189.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000245903.
PTM databases
PhosphoSite	P32970.
Polymorphism databases
DMDM	21431837.
Proteomic databases
PaxDb	P32970.
PeptideAtlas	P32970.
PRIDE	P32970.
Protocols and materials databases
DNASU	970.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000245903; ENSP00000245903; ENSG00000125726.
GeneID	970.
KEGG	hsa:970.
UCSC	uc002mfi.3. human.
Organism-specific databases
CTD	970.
GeneCards	GC19M006583.
HGNC	HGNC:11937. CD70.
MIM	602840. gene.
neXtProt	NX_P32970.
PharmGKB	PA36627.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG46932.
HOGENOM	HOG000070045.
HOVERGEN	HBG054184.
InParanoid	P32970.
KO	K05470.
OMA	DTLCTNL.
PhylomeDB	P32970.
Gene expression databases
ArrayExpress	P32970.
Bgee	P32970.
CleanEx	HS_CD70.
Genevestigator	P32970.
GermOnline	ENSG00000125726. Homo sapiens.
Family and domain databases
Gene3D	2.60.120.40. 1 hit.
InterPro	IPR006052. TNF. IPR021184. TNF_CS. IPR008983. Tumour_necrosis_fac-like_dom. [Graphical view]
Pfam	PF00229. TNF. 1 hit. [Graphical view]
SMART	SM00207. TNF. 1 hit. [Graphical view]
SUPFAM	SSF49842. TNF_like. 1 hit.
PROSITE	PS00251. TNF_1. 1 hit. PS50049. TNF_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	970.
NextBio	4060.
SOURCE	Search...

Entry information

Entry name

CD70_HUMAN

Accession

Primary (citable) accession number: P32970
Secondary accession number(s): Q96J57

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1993
Last sequence update:	June 6, 2002
Last modified:	May 1, 2013
This is version 116 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.