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Protein

CD70 antigen

Gene

CD70

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cytokine that binds to CD27. Plays a role in T-cell activation. Induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells.

GO - Molecular functioni

  • cytokine activity Source: UniProtKB-KW
  • protease binding Source: BHF-UCL
  • signaling receptor binding Source: ProtInc
  • tumor necrosis factor receptor binding Source: InterPro

GO - Biological processi

  • cell-cell signaling Source: ProtInc
  • cell proliferation Source: ProtInc
  • extrinsic apoptotic signaling pathway Source: BHF-UCL
  • immune response Source: InterPro
  • signal transduction Source: ProtInc
  • tumor necrosis factor-mediated signaling pathway Source: Reactome

Keywordsi

Molecular functionCytokine

Enzyme and pathway databases

ReactomeiR-HSA-5669034 TNFs bind their physiological receptors
SIGNORiP32970

Names & Taxonomyi

Protein namesi
Recommended name:
CD70 antigen
Alternative name(s):
CD27 ligand
Short name:
CD27-L
Tumor necrosis factor ligand superfamily member 7
CD_antigen: CD70
Gene namesi
Name:CD70
Synonyms:CD27L, CD27LG, TNFSF7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000125726.10
HGNCiHGNC:11937 CD70
MIMi602840 gene
neXtProtiNX_P32970

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 17CytoplasmicSequence analysisAdd BLAST17
Transmembranei18 – 38Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini39 – 193ExtracellularSequence analysisAdd BLAST155

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi970
OpenTargetsiENSG00000125726
PharmGKBiPA36627

Polymorphism and mutation databases

BioMutaiCD70
DMDMi21431837

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001854971 – 193CD70 antigenAdd BLAST193

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi63N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi133 ↔ 151Sequence analysis
Glycosylationi170N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiP32970
PaxDbiP32970
PeptideAtlasiP32970
PRIDEiP32970

PTM databases

iPTMnetiP32970
PhosphoSitePlusiP32970
SwissPalmiP32970

Expressioni

Gene expression databases

BgeeiENSG00000125726
CleanExiHS_CD70
ExpressionAtlasiP32970 baseline and differential
GenevisibleiP32970 HS

Organism-specific databases

HPAiHPA046582

Interactioni

Subunit structurei

Homotrimer.Curated

GO - Molecular functioni

  • cytokine activity Source: UniProtKB-KW
  • protease binding Source: BHF-UCL
  • signaling receptor binding Source: ProtInc
  • tumor necrosis factor receptor binding Source: InterPro

Protein-protein interaction databases

BioGridi107408, 86 interactors
STRINGi9606.ENSP00000245903

Structurei

3D structure databases

ProteinModelPortaliP32970
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tumor necrosis factor family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IY7F Eukaryota
ENOG41119T2 LUCA
GeneTreeiENSGT00390000006744
HOGENOMiHOG000070045
HOVERGENiHBG054184
InParanoidiP32970
KOiK05470
OMAiQVTLANC
OrthoDBiEOG091G0QAO
PhylomeDBiP32970
TreeFamiTF338269

Family and domain databases

Gene3Di2.60.120.40, 1 hit
InterProiView protein in InterPro
IPR021184 TNF_CS
IPR006052 TNF_dom
IPR008983 Tumour_necrosis_fac-like_dom
PfamiView protein in Pfam
PF00229 TNF, 1 hit
SMARTiView protein in SMART
SM00207 TNF, 1 hit
SUPFAMiSSF49842 SSF49842, 1 hit
PROSITEiView protein in PROSITE
PS00251 TNF_1, 1 hit
PS50049 TNF_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P32970-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPEEGSGCSV RRRPYGCVLR AALVPLVAGL VICLVVCIQR FAQAQQQLPL
60 70 80 90 100
ESLGWDVAEL QLNHTGPQQD PRLYWQGGPA LGRSFLHGPE LDKGQLRIHR
110 120 130 140 150
DGIYMVHIQV TLAICSSTTA SRHHPTTLAV GICSPASRSI SLLRLSFHQG
160 170 180 190
CTIASQRLTP LARGDTLCTN LTGTLLPSRN TDETFFGVQW VRP
Length:193
Mass (Da):21,118
Last modified:June 6, 2002 - v2
Checksum:i9265856E33BE4D50
GO
Isoform 2 (identifier: P32970-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     151-193: CTIASQRLTP...TFFGVQWVRP → LFGFWNWGLK...TDEENRGVNR

Note: No experimental confirmation available.
Show »
Length:208
Mass (Da):23,438
Checksum:i191D07D576433B6C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti154A → V in AAA36175 (PubMed:8387892).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_056416151 – 193CTIAS…QWVRP → LFGFWNWGLKVKCFLRHLIW TAHCFIPLTQLVFMQALQSW RNHHCSHFTDEENRGVNR in isoform 2. 1 PublicationAdd BLAST43

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08096 mRNA Translation: AAA36175.1
S69339 mRNA Translation: AAB30121.1
BT007211 mRNA Translation: AAP35875.1
AK298467 mRNA Translation: BAG60680.1
EF064709 Genomic DNA Translation: ABK41892.1
AC008760 Genomic DNA No translation available.
CH471139 Genomic DNA Translation: EAW69074.1
BC000725 mRNA Translation: AAH00725.1
CCDSiCCDS12170.1 [P32970-1]
CCDS82283.1 [P32970-2]
PIRiI56214 A40738
RefSeqiNP_001243.1, NM_001252.4 [P32970-1]
NP_001317261.1, NM_001330332.1 [P32970-2]
UniGeneiHs.501497
Hs.715224

Genome annotation databases

EnsembliENST00000245903; ENSP00000245903; ENSG00000125726 [P32970-1]
ENST00000423145; ENSP00000395294; ENSG00000125726 [P32970-2]
GeneIDi970
KEGGihsa:970
UCSCiuc002mfi.3 human [P32970-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCD70_HUMAN
AccessioniPrimary (citable) accession number: P32970
Secondary accession number(s): B4DPR8, Q53XX4, Q96J57
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: June 6, 2002
Last modified: May 23, 2018
This is version 155 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health