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P32970

- CD70_HUMAN

UniProt

P32970 - CD70_HUMAN

Protein

CD70 antigen

Gene

CD70

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 128 (01 Oct 2014)
      Sequence version 2 (06 Jun 2002)
      Previous versions | rss
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    Functioni

    Cytokine that binds to CD27. Plays a role in T-cell activation. Induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells.

    GO - Molecular functioni

    1. protease binding Source: BHF-UCL
    2. protein binding Source: UniProtKB
    3. receptor binding Source: ProtInc

    GO - Biological processi

    1. cell-cell signaling Source: ProtInc
    2. cell proliferation Source: ProtInc
    3. extrinsic apoptotic signaling pathway Source: BHF-UCL
    4. immune response Source: InterPro
    5. signal transduction Source: ProtInc

    Keywords - Molecular functioni

    Cytokine

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    CD70 antigen
    Alternative name(s):
    CD27 ligand
    Short name:
    CD27-L
    Tumor necrosis factor ligand superfamily member 7
    CD_antigen: CD70
    Gene namesi
    Name:CD70
    Synonyms:CD27L, CD27LG, TNFSF7
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:11937. CD70.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-KW
    2. extracellular vesicular exosome Source: UniProt
    3. integral component of plasma membrane Source: ProtInc
    4. plasma membrane Source: HGNC

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA36627.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 193193CD70 antigenPRO_0000185497Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi63 – 631N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi133 ↔ 151Sequence Analysis
    Glycosylationi170 – 1701N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiP32970.
    PaxDbiP32970.
    PeptideAtlasiP32970.
    PRIDEiP32970.

    PTM databases

    PhosphoSiteiP32970.

    Expressioni

    Gene expression databases

    ArrayExpressiP32970.
    BgeeiP32970.
    CleanExiHS_CD70.
    GenevestigatoriP32970.

    Interactioni

    Subunit structurei

    Homotrimer.Curated

    Protein-protein interaction databases

    BioGridi107408. 3 interactions.
    STRINGi9606.ENSP00000245903.

    Structurei

    3D structure databases

    ProteinModelPortaliP32970.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1717CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini39 – 193155ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei18 – 3821Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the tumor necrosis factor family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG46932.
    HOGENOMiHOG000070045.
    HOVERGENiHBG054184.
    InParanoidiP32970.
    KOiK05470.
    OMAiDTLCTNL.
    PhylomeDBiP32970.
    TreeFamiTF338269.

    Family and domain databases

    Gene3Di2.60.120.40. 1 hit.
    InterProiIPR021184. TNF_CS.
    IPR006052. TNF_dom.
    IPR008983. Tumour_necrosis_fac-like_dom.
    [Graphical view]
    PfamiPF00229. TNF. 1 hit.
    [Graphical view]
    SMARTiSM00207. TNF. 1 hit.
    [Graphical view]
    SUPFAMiSSF49842. SSF49842. 1 hit.
    PROSITEiPS00251. TNF_1. 1 hit.
    PS50049. TNF_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P32970-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPEEGSGCSV RRRPYGCVLR AALVPLVAGL VICLVVCIQR FAQAQQQLPL    50
    ESLGWDVAEL QLNHTGPQQD PRLYWQGGPA LGRSFLHGPE LDKGQLRIHR 100
    DGIYMVHIQV TLAICSSTTA SRHHPTTLAV GICSPASRSI SLLRLSFHQG 150
    CTIASQRLTP LARGDTLCTN LTGTLLPSRN TDETFFGVQW VRP 193
    Length:193
    Mass (Da):21,118
    Last modified:June 6, 2002 - v2
    Checksum:i9265856E33BE4D50
    GO
    Isoform 2 (identifier: P32970-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         151-193: CTIASQRLTP...TFFGVQWVRP → LFGFWNWGLK...TDEENRGVNR

    Note: No experimental confirmation available.

    Show »
    Length:208
    Mass (Da):23,438
    Checksum:i191D07D576433B6C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti154 – 1541A → V in AAA36175. (PubMed:8387892)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei151 – 19343CTIAS…QWVRP → LFGFWNWGLKVKCFLRHLIW TAHCFIPLTQLVFMQALQSW RNHHCSHFTDEENRGVNR in isoform 2. 1 PublicationVSP_056416Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L08096 mRNA. Translation: AAA36175.1.
    S69339 mRNA. Translation: AAB30121.1.
    BT007211 mRNA. Translation: AAP35875.1.
    AK298467 mRNA. Translation: BAG60680.1.
    EF064709 Genomic DNA. Translation: ABK41892.1.
    AC008760 Genomic DNA. No translation available.
    CH471139 Genomic DNA. Translation: EAW69074.1.
    BC000725 mRNA. Translation: AAH00725.1.
    CCDSiCCDS12170.1.
    PIRiI56214. A40738.
    RefSeqiNP_001243.1. NM_001252.4.
    UniGeneiHs.501497.
    Hs.715224.

    Genome annotation databases

    EnsembliENST00000245903; ENSP00000245903; ENSG00000125726.
    ENST00000423145; ENSP00000395294; ENSG00000125726.
    GeneIDi970.
    KEGGihsa:970.
    UCSCiuc002mfi.3. human.

    Polymorphism databases

    DMDMi21431837.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L08096 mRNA. Translation: AAA36175.1 .
    S69339 mRNA. Translation: AAB30121.1 .
    BT007211 mRNA. Translation: AAP35875.1 .
    AK298467 mRNA. Translation: BAG60680.1 .
    EF064709 Genomic DNA. Translation: ABK41892.1 .
    AC008760 Genomic DNA. No translation available.
    CH471139 Genomic DNA. Translation: EAW69074.1 .
    BC000725 mRNA. Translation: AAH00725.1 .
    CCDSi CCDS12170.1.
    PIRi I56214. A40738.
    RefSeqi NP_001243.1. NM_001252.4.
    UniGenei Hs.501497.
    Hs.715224.

    3D structure databases

    ProteinModelPortali P32970.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107408. 3 interactions.
    STRINGi 9606.ENSP00000245903.

    PTM databases

    PhosphoSitei P32970.

    Polymorphism databases

    DMDMi 21431837.

    Proteomic databases

    MaxQBi P32970.
    PaxDbi P32970.
    PeptideAtlasi P32970.
    PRIDEi P32970.

    Protocols and materials databases

    DNASUi 970.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000245903 ; ENSP00000245903 ; ENSG00000125726 .
    ENST00000423145 ; ENSP00000395294 ; ENSG00000125726 .
    GeneIDi 970.
    KEGGi hsa:970.
    UCSCi uc002mfi.3. human.

    Organism-specific databases

    CTDi 970.
    GeneCardsi GC19M006583.
    HGNCi HGNC:11937. CD70.
    MIMi 602840. gene.
    neXtProti NX_P32970.
    PharmGKBi PA36627.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG46932.
    HOGENOMi HOG000070045.
    HOVERGENi HBG054184.
    InParanoidi P32970.
    KOi K05470.
    OMAi DTLCTNL.
    PhylomeDBi P32970.
    TreeFami TF338269.

    Miscellaneous databases

    GenomeRNAii 970.
    NextBioi 4060.
    PROi P32970.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P32970.
    Bgeei P32970.
    CleanExi HS_CD70.
    Genevestigatori P32970.

    Family and domain databases

    Gene3Di 2.60.120.40. 1 hit.
    InterProi IPR021184. TNF_CS.
    IPR006052. TNF_dom.
    IPR008983. Tumour_necrosis_fac-like_dom.
    [Graphical view ]
    Pfami PF00229. TNF. 1 hit.
    [Graphical view ]
    SMARTi SM00207. TNF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49842. SSF49842. 1 hit.
    PROSITEi PS00251. TNF_1. 1 hit.
    PS50049. TNF_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular and biological characterization of a ligand for CD27 defines a new family of cytokines with homology to tumor necrosis factor."
      Goodwin R.G., Alderson M.R., Smith C.A., Armitage R.J., Vandenbos T., Jerzy R., Tough T.W., Schoenborn M.A., David-Smith T., Hennen K., Falk B., Cosman D., Baker E., Sutherland G.R., Grabstein K.H., Farrah T., Giri J.G., Beckmann M.P.
      Cell 73:447-456(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: B-cell.
    2. "The cloning of CD70 and its identification as the ligand for CD27."
      Bowman M.R., Crimmins M.A., Yetz-Aldape J., Kriz R., Kelleher K., Herrmann S.
      J. Immunol. 152:1756-1761(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    6. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Kidney.
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiCD70_HUMAN
    AccessioniPrimary (citable) accession number: P32970
    Secondary accession number(s): B4DPR8, Q53XX4, Q96J57
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1993
    Last sequence update: June 6, 2002
    Last modified: October 1, 2014
    This is version 128 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3