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Protein

60S ribosomal protein L9

Gene

RPL9

more
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • RNA binding Source: ProtInc
  • rRNA binding Source: InterPro
  • structural constituent of ribosome Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciZFISH:ENSG00000169653-MONOMER.
ReactomeiR-HSA-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-HSA-156902. Peptide chain elongation.
R-HSA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-HSA-192823. Viral mRNA Translation.
R-HSA-2408557. Selenocysteine synthesis.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
R-HSA-72689. Formation of a pool of free 40S subunits.
R-HSA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-HSA-72764. Eukaryotic Translation Termination.
R-HSA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-HSA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L9
Gene namesi
Name:RPL9
ORF Names:OK/SW-cl.103
AND
Name:RPL9P7
AND
Name:RPL9P8
AND
Name:RPL9P9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:10369. RPL9.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: HPA
  • cytosol Source: Reactome
  • cytosolic large ribosomal subunit Source: UniProtKB
  • extracellular matrix Source: BHF-UCL
  • focal adhesion Source: UniProtKB
  • membrane Source: UniProtKB
  • nucleolus Source: HPA
  • nucleus Source: UniProtKB
  • ribosome Source: ProtInc
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi6133.
OpenTargetsiENSG00000163682.
PharmGKBiPA34769.

Polymorphism and mutation databases

BioMutaiRPL9.
DMDMi417677.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001310971 – 19260S ribosomal protein L9Add BLAST192

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei121N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP32969.
PaxDbiP32969.
PeptideAtlasiP32969.
PRIDEiP32969.
TopDownProteomicsiP32969.

2D gel databases

SWISS-2DPAGEP32969.

PTM databases

iPTMnetiP32969.
PhosphoSitePlusiP32969.
SwissPalmiP32969.

Expressioni

Gene expression databases

BgeeiENSG00000163682.
CleanExiHS_RPL9.
ExpressionAtlasiP32969. baseline and differential.
GenevisibleiP32969. HS.

Organism-specific databases

HPAiHPA003372.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CALCOCO2Q131373EBI-358122,EBI-739580
CCDC184Q52MB25EBI-358122,EBI-10179526
CEP76Q8TAP65EBI-358122,EBI-742887
DHPSP493666EBI-358122,EBI-741925
FAM9BQ8IZU03EBI-358122,EBI-10175124
HEL-S-70V9HW803EBI-358122,EBI-10175326
HMBOX1Q6NT763EBI-358122,EBI-2549423
HOMEZQ8IX15-33EBI-358122,EBI-10172004
KXD1Q9BQD33EBI-358122,EBI-739657
MTUS2Q5JR593EBI-358122,EBI-742948
PNMA2Q9UL425EBI-358122,EBI-302355
SPERTQ8NA613EBI-358122,EBI-741724
TIFAQ96CG35EBI-358122,EBI-740711
TRIM37O949723EBI-358122,EBI-741602
ZBTB14O438293EBI-358122,EBI-10176632
ZBTB7BO151563EBI-358122,EBI-740434
ZBTB8AQ96BR95EBI-358122,EBI-742740

Protein-protein interaction databases

BioGridi112053. 169 interactors.
IntActiP32969. 52 interactors.
MINTiMINT-5000985.
STRINGi9606.ENSP00000346022.

Structurei

Secondary structure

1192
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi8 – 10Combined sources3
Beta strandi17 – 21Combined sources5
Beta strandi24 – 29Combined sources6
Beta strandi32 – 37Combined sources6
Beta strandi44 – 48Combined sources5
Beta strandi50 – 52Combined sources3
Beta strandi54 – 58Combined sources5
Beta strandi61 – 63Combined sources3
Helixi65 – 85Combined sources21

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CQLNMR-A1-87[»]
4UG0electron microscopy-LH1-192[»]
4V6Xelectron microscopy5.00CH1-192[»]
5AJ0electron microscopy3.50AH1-192[»]
ProteinModelPortaliP32969.
SMRiP32969.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP32969.

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L6P family.Curated

Phylogenomic databases

eggNOGiKOG3255. Eukaryota.
COG0097. LUCA.
GeneTreeiENSGT00390000015224.
HOGENOMiHOG000039905.
HOVERGENiHBG000942.
InParanoidiP32969.
KOiK02940.
OMAiLRVRKWF.
OrthoDBiEOG091G0R6Z.
PhylomeDBiP32969.
TreeFamiTF300033.

Family and domain databases

Gene3Di3.90.930.12. 2 hits.
InterProiIPR000702. Ribosomal_L6.
IPR020040. Ribosomal_L6_a/b-dom.
IPR002359. Ribosomal_L6_CS2.
[Graphical view]
PANTHERiPTHR11655. PTHR11655. 1 hit.
PfamiPF00347. Ribosomal_L6. 2 hits.
[Graphical view]
PIRSFiPIRSF002162. Ribosomal_L6. 1 hit.
SUPFAMiSSF56053. SSF56053. 2 hits.
PROSITEiPS00700. RIBOSOMAL_L6_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P32969-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTILSNQTV DIPENVDITL KGRTVIVKGP RGTLRRDFNH INVELSLLGK
60 70 80 90 100
KKKRLRVDKW WGNRKELATV RTICSHVQNM IKGVTLGFRY KMRSVYAHFP
110 120 130 140 150
INVVIQENGS LVEIRNFLGE KYIRRVRMRP GVACSVSQAQ KDELILEGND
160 170 180 190
IELVSNSAAL IQQATTVKNK DIRKFLDGIY VSEKGTVQQA DE
Length:192
Mass (Da):21,863
Last modified:October 1, 1993 - v1
Checksum:i0249E6CA12F77934
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti11D → E in AAB01040 (PubMed:8597601).Curated1
Sequence conflicti11D → E in AAB01041 (PubMed:8597601).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14531 mRNA. Translation: BAA03401.1.
U09953 mRNA. Translation: AAB01040.1.
U09954 Genomic DNA. Translation: AAB01041.1.
U21138 mRNA. Translation: AAA63752.1.
AB062431 mRNA. Translation: BAB93494.1.
BC000483 mRNA. Translation: AAH00483.1.
BC004156 mRNA. Translation: AAH04156.1.
BC004206 mRNA. Translation: AAH04206.1.
BC007967 mRNA. Translation: AAH07967.1.
BC012149 mRNA. Translation: AAH12149.1.
BC031906 mRNA. Translation: AAH31906.1.
BC066318 mRNA. Translation: AAH66318.1.
BC070214 mRNA. Translation: AAH70214.1.
AB007169 Genomic DNA. Translation: BAA25830.1.
CCDSiCCDS3452.1.
PIRiS65792.
RefSeqiNP_000652.2. NM_000661.4.
NP_001020092.1. NM_001024921.3.
UniGeneiHs.412370.
Hs.513083.
Hs.730597.

Genome annotation databases

EnsembliENST00000295955; ENSP00000346022; ENSG00000163682.
ENST00000449470; ENSP00000400467; ENSG00000163682.
GeneIDi6133.
KEGGihsa:6133.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14531 mRNA. Translation: BAA03401.1.
U09953 mRNA. Translation: AAB01040.1.
U09954 Genomic DNA. Translation: AAB01041.1.
U21138 mRNA. Translation: AAA63752.1.
AB062431 mRNA. Translation: BAB93494.1.
BC000483 mRNA. Translation: AAH00483.1.
BC004156 mRNA. Translation: AAH04156.1.
BC004206 mRNA. Translation: AAH04206.1.
BC007967 mRNA. Translation: AAH07967.1.
BC012149 mRNA. Translation: AAH12149.1.
BC031906 mRNA. Translation: AAH31906.1.
BC066318 mRNA. Translation: AAH66318.1.
BC070214 mRNA. Translation: AAH70214.1.
AB007169 Genomic DNA. Translation: BAA25830.1.
CCDSiCCDS3452.1.
PIRiS65792.
RefSeqiNP_000652.2. NM_000661.4.
NP_001020092.1. NM_001024921.3.
UniGeneiHs.412370.
Hs.513083.
Hs.730597.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CQLNMR-A1-87[»]
4UG0electron microscopy-LH1-192[»]
4V6Xelectron microscopy5.00CH1-192[»]
5AJ0electron microscopy3.50AH1-192[»]
ProteinModelPortaliP32969.
SMRiP32969.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112053. 169 interactors.
IntActiP32969. 52 interactors.
MINTiMINT-5000985.
STRINGi9606.ENSP00000346022.

PTM databases

iPTMnetiP32969.
PhosphoSitePlusiP32969.
SwissPalmiP32969.

Polymorphism and mutation databases

BioMutaiRPL9.
DMDMi417677.

2D gel databases

SWISS-2DPAGEP32969.

Proteomic databases

EPDiP32969.
PaxDbiP32969.
PeptideAtlasiP32969.
PRIDEiP32969.
TopDownProteomicsiP32969.

Protocols and materials databases

DNASUi6133.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295955; ENSP00000346022; ENSG00000163682.
ENST00000449470; ENSP00000400467; ENSG00000163682.
GeneIDi6133.
KEGGihsa:6133.

Organism-specific databases

CTDi6133.
DisGeNETi6133.
GeneCardsiRPL9.
RPL9P7.
RPL9P8.
RPL9P9.
HGNCiHGNC:10369. RPL9.
HPAiHPA003372.
MIMi603686. gene.
neXtProtiNX_P32969.
OpenTargetsiENSG00000163682.
PharmGKBiPA34769.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3255. Eukaryota.
COG0097. LUCA.
GeneTreeiENSGT00390000015224.
HOGENOMiHOG000039905.
HOVERGENiHBG000942.
InParanoidiP32969.
KOiK02940.
OMAiLRVRKWF.
OrthoDBiEOG091G0R6Z.
PhylomeDBiP32969.
TreeFamiTF300033.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000169653-MONOMER.
ReactomeiR-HSA-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-HSA-156902. Peptide chain elongation.
R-HSA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-HSA-192823. Viral mRNA Translation.
R-HSA-2408557. Selenocysteine synthesis.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
R-HSA-72689. Formation of a pool of free 40S subunits.
R-HSA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-HSA-72764. Eukaryotic Translation Termination.
R-HSA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-HSA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

ChiTaRSiRPL9. human.
EvolutionaryTraceiP32969.
GeneWikiiRPL9.
GenomeRNAii6133.
PROiP32969.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000163682.
CleanExiHS_RPL9.
ExpressionAtlasiP32969. baseline and differential.
GenevisibleiP32969. HS.

Family and domain databases

Gene3Di3.90.930.12. 2 hits.
InterProiIPR000702. Ribosomal_L6.
IPR020040. Ribosomal_L6_a/b-dom.
IPR002359. Ribosomal_L6_CS2.
[Graphical view]
PANTHERiPTHR11655. PTHR11655. 1 hit.
PfamiPF00347. Ribosomal_L6. 2 hits.
[Graphical view]
PIRSFiPIRSF002162. Ribosomal_L6. 1 hit.
SUPFAMiSSF56053. SSF56053. 2 hits.
PROSITEiPS00700. RIBOSOMAL_L6_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRL9_HUMAN
AccessioniPrimary (citable) accession number: P32969
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: November 30, 2016
This is version 176 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  3. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Ribosomal proteins
    Ribosomal proteins families and list of entries
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.