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P32969 (RL9_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 148. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (7) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
60S ribosomal protein L9
Gene names
Name:RPL9
ORF Names:OK/SW-cl.103
AND
Name:RPL9P7
AND
Name:RPL9P8
AND
Name:RPL9P9
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length192 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the ribosomal protein L6P family.

Ontologies

Keywords
   Molecular functionRibonucleoprotein
Ribosomal protein
   PTMAcetylation
   Technical term3D-structure
Complete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processRNA metabolic process

Traceable author statement. Source: Reactome

SRP-dependent cotranslational protein targeting to membrane

Traceable author statement. Source: Reactome

cellular protein metabolic process

Traceable author statement. Source: Reactome

gene expression

Traceable author statement. Source: Reactome

mRNA metabolic process

Traceable author statement. Source: Reactome

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

Traceable author statement. Source: Reactome

translation

Non-traceable author statement PubMed 12962325. Source: UniProtKB

translational elongation

Traceable author statement. Source: Reactome

translational initiation

Traceable author statement. Source: Reactome

translational termination

Traceable author statement. Source: Reactome

viral life cycle

Traceable author statement. Source: Reactome

viral process

Traceable author statement. Source: Reactome

viral transcription

Traceable author statement. Source: Reactome

   Cellular_componentcytoplasm

Inferred from direct assay. Source: HPA

cytosol

Traceable author statement. Source: Reactome

cytosolic large ribosomal subunit

Inferred from direct assay PubMed 12962325. Source: UniProtKB

nucleolus

Inferred from direct assay. Source: HPA

ribosome

Traceable author statement Ref.2. Source: ProtInc

   Molecular_functionRNA binding

Traceable author statement Ref.2. Source: ProtInc

rRNA binding

Inferred from electronic annotation. Source: InterPro

structural constituent of ribosome

Non-traceable author statement PubMed 12962325. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 19219260S ribosomal protein L9
PRO_0000131097

Amino acid modifications

Modified residue1211N6-acetyllysine Ref.8

Experimental info

Sequence conflict111D → E in AAB01040. Ref.2
Sequence conflict111D → E in AAB01041. Ref.2

Secondary structure

................... 192
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P32969 [UniParc].

Last modified October 1, 1993. Version 1.
Checksum: 0249E6CA12F77934

FASTA19221,863
        10         20         30         40         50         60 
MKTILSNQTV DIPENVDITL KGRTVIVKGP RGTLRRDFNH INVELSLLGK KKKRLRVDKW 

        70         80         90        100        110        120 
WGNRKELATV RTICSHVQNM IKGVTLGFRY KMRSVYAHFP INVVIQENGS LVEIRNFLGE 

       130        140        150        160        170        180 
KYIRRVRMRP GVACSVSQAQ KDELILEGND IELVSNSAAL IQQATTVKNK DIRKFLDGIY 

       190 
VSEKGTVQQA DE 

« Hide

References

« Hide 'large scale' references
[1]"A new human ribosomal protein sequence, homologue of rat L9."
Hori N., Murakawa K., Matoba R., Fukushima A., Okubo K., Matsubara K.
Nucleic Acids Res. 21:4395-4395(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.
[2]"Structural organization and chromosomal localization of the human ribosomal protein L9 gene."
Mazuruk K., Schoen T.J., Chader G.J., Iwata T., Rodriguez I.R.
Biochim. Biophys. Acta 1305:151-162(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Retina.
[3]"Human homolog of rat ribosomal protein L9."
Williams J.H., Pearse M.J., Power D.A.
Submitted (FEB-1995) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]"Identification of immuno-peptidmics that are recognized by tumor-reactive CTL generated from TIL of colon cancer patients."
Shichijo S., Itoh K.
Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Colon adenocarcinoma.
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain, Muscle, Placenta and Uterus.
[6]Bienvenut W.V., Bilsland A.E., Keith W.N.
Submitted (JAN-2010) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 1-21; 36-51; 94-115; 142-168 AND 174-184, IDENTIFICATION BY MASS SPECTROMETRY.
Tissue: Colon carcinoma.
[7]"A map of 75 human ribosomal protein genes."
Kenmochi N., Kawaguchi T., Rozen S., Davis E., Goodman N., Hudson T.J., Tanaka T., Page D.C.
Genome Res. 8:509-523(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 146-192.
[8]"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-121, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[9]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[10]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[11]"Solution structure of the N-terminal domain of human ribosomal protein L9."
RIKEN structural genomics initiative (RSGI)
Submitted (NOV-2005) to the PDB data bank
Cited for: STRUCTURE BY NMR OF 1-87.
[12]"Structures of the human and Drosophila 80S ribosome."
Anger A.M., Armache J.P., Berninghausen O., Habeck M., Subklewe M., Wilson D.N., Beckmann R.
Nature 497:80-85(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY ELECTRON MICROSCOPY (5.0 ANGSTROMS) OF 80S RIBOSOME.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D14531 mRNA. Translation: BAA03401.1.
U09953 mRNA. Translation: AAB01040.1.
U09954 Genomic DNA. Translation: AAB01041.1.
U21138 mRNA. Translation: AAA63752.1.
AB062431 mRNA. Translation: BAB93494.1.
BC000483 mRNA. Translation: AAH00483.1.
BC004156 mRNA. Translation: AAH04156.1.
BC004206 mRNA. Translation: AAH04206.1.
BC007967 mRNA. Translation: AAH07967.1.
BC012149 mRNA. Translation: AAH12149.1.
BC031906 mRNA. Translation: AAH31906.1.
BC066318 mRNA. Translation: AAH66318.1.
BC070214 mRNA. Translation: AAH70214.1.
AB007169 Genomic DNA. Translation: BAA25830.1.
PIRS65792.
RefSeqNP_000652.2. NM_000661.4.
NP_001020092.1. NM_001024921.2.
XP_005262718.1. XM_005262661.1.
UniGeneHs.412370.
Hs.513083.
Hs.730597.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2CQLNMR-A1-87[»]
3J3Belectron microscopy5.00H1-192[»]
ProteinModelPortalP32969.
SMRP32969. Positions 1-191.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid112053. 105 interactions.
IntActP32969. 17 interactions.
MINTMINT-5000985.
STRING9606.ENSP00000346022.

PTM databases

PhosphoSiteP32969.

Polymorphism databases

DMDM417677.

2D gel databases

SWISS-2DPAGEP32969.

Proteomic databases

PaxDbP32969.
PeptideAtlasP32969.
PRIDEP32969.

Protocols and materials databases

DNASU6133.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000295955; ENSP00000346022; ENSG00000163682.
ENST00000449470; ENSP00000400467; ENSG00000163682.
GeneID6133.
KEGGhsa:6133.
UCSCuc003gub.3. human.

Organism-specific databases

CTD6133.
HGNCHGNC:10369. RPL9.
HPAHPA003372.
MIM603686. gene.
neXtProtNX_P32969.
PharmGKBPA34769.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0097.
HOGENOMHOG000039905.
HOVERGENHBG000942.
InParanoidP32969.
KOK02940.
OMALKVVYSH.
OrthoDBEOG7353Z4.
PhylomeDBP32969.
TreeFamTF300033.

Enzyme and pathway databases

ReactomeREACT_116125. Disease.
REACT_17015. Metabolism of proteins.
REACT_1762. 3' -UTR-mediated translational regulation.
REACT_21257. Metabolism of RNA.
REACT_71. Gene Expression.

Gene expression databases

BgeeP32969.
CleanExHS_RPL9.
GenevestigatorP32969.

Family and domain databases

Gene3D3.90.930.12. 2 hits.
InterProIPR000702. Ribosomal_L6.
IPR020040. Ribosomal_L6_a/b-dom.
IPR002359. Ribosomal_L6_CS2.
[Graphical view]
PANTHERPTHR11655. PTHR11655. 1 hit.
PfamPF00347. Ribosomal_L6. 2 hits.
[Graphical view]
PIRSFPIRSF002162. Ribosomal_L6. 1 hit.
SUPFAMSSF56053. SSF56053. 2 hits.
PROSITEPS00700. RIBOSOMAL_L6_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP32969.
GeneWikiRPL9.
GenomeRNAi6133.
NextBio23821.
PROP32969.
SOURCESearch...

Entry information

Entry nameRL9_HUMAN
AccessionPrimary (citable) accession number: P32969
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: April 16, 2014
This is version 148 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Ribosomal proteins

Ribosomal proteins families and list of entries

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome X

Human chromosome X: entries, gene names and cross-references to MIM

Human chromosome 15

Human chromosome 15: entries, gene names and cross-references to MIM

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM