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Protein

Rod outer segment membrane protein 1

Gene

Rom1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

May function as an adhesion molecule involved in stabilization and compaction of outer segment disks or in the maintenance of the curvature of the rim. It is essential for disk morphogenesis.

GO - Biological processi

  • camera-type eye photoreceptor cell differentiation Source: MGI
  • cell adhesion Source: UniProtKB-KW
  • regulation of gene expression Source: MGI
  • retina morphogenesis in camera-type eye Source: MGI
  • retina vasculature development in camera-type eye Source: MGI
  • visual perception Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Rod outer segment membrane protein 1
Short name:
ROSP1
Gene namesi
Name:Rom1
Synonyms:Rom-1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:97998. Rom1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1919CytoplasmicSequence analysisAdd
BLAST
Transmembranei20 – 4425HelicalSequence analysisAdd
BLAST
Topological domaini45 – 6420LumenalSequence analysisAdd
BLAST
Transmembranei65 – 8420HelicalSequence analysisAdd
BLAST
Topological domaini85 – 10218CytoplasmicSequence analysisAdd
BLAST
Transmembranei103 – 12523HelicalSequence analysisAdd
BLAST
Topological domaini126 – 263138LumenalSequence analysisAdd
BLAST
Transmembranei264 – 28623HelicalSequence analysisAdd
BLAST
Topological domaini287 – 35165CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • photoreceptor outer segment Source: MGI
  • photoreceptor outer segment membrane Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 351351Rod outer segment membrane protein 1PRO_0000168112Add
BLAST

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP32958.
PRIDEiP32958.

PTM databases

iPTMnetiP32958.
PhosphoSiteiP32958.

Expressioni

Tissue specificityi

Retina (photoreceptor). In rim region of ROS (rod outer segment) disks.

Gene expression databases

BgeeiP32958.
CleanExiMM_ROM1.
GenevisibleiP32958. MM.

Interactioni

Subunit structurei

Homodimer; disulfide-linked. Probably forms a complex with a PRPH2 homodimer. Other proteins could associate with this complex in rods.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000093961.

Structurei

3D structure databases

ProteinModelPortaliP32958.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PRPH2/ROM1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3882. Eukaryota.
ENOG4111IRY. LUCA.
GeneTreeiENSGT00390000016192.
HOGENOMiHOG000026780.
HOVERGENiHBG004964.
InParanoidiP32958.
KOiK17344.
OMAiCCNPHSP.
OrthoDBiEOG7T1RBG.
PhylomeDBiP32958.
TreeFamiTF331684.

Family and domain databases

InterProiIPR000830. Peripherin/rom-1.
IPR018498. Peripherin/rom-1_CS.
IPR018499. Tetraspanin/Peripherin.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PRINTSiPR00218. PERIPHERNRDS.
SUPFAMiSSF48652. SSF48652. 2 hits.
PROSITEiPS00930. RDS_ROM1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P32958-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPVLPVVLP LQPRIRLAQG IWLLSWLLAL VGGLTLLCSG HLLVQLGHLG
60 70 80 90 100
TFLAPSCSFP ALPQTALAAG TVALGTGLGG AGASRASLDA AQYPPWRGVL
110 120 130 140 150
TPLLAVGTAA GGGLLTLALG LALALPVSLN QGLEEGLEAA LAHYKDTEVP
160 170 180 190 200
GRCQAKRLMD ELQLRYHCCG RHGYKDWFGV QWVSNRYLDP SDQDVVDRIQ
210 220 230 240 250
SNVEGLYLID GVPFSCCNPH SPRPCLQSQL SDPYAHPLFD PRQPNLNLWA
260 270 280 290 300
QGCHEVLLEH LQGLSGTLGS ILAVTLLLQI LVLLGLRYLQ TALEGLGGVI
310 320 330 340 350
DGEGEAQGYL FPGGLKDILK TAWLQGGLAH KPAPEEAPPD EEPPKEVLAE

A
Length:351
Mass (Da):37,265
Last modified:October 1, 1993 - v1
Checksum:i64CB47F552886394
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96760 Genomic DNA. Translation: AAA40063.1.
BC014827 mRNA. Translation: AAH14827.1.
CCDSiCCDS29559.1.
PIRiI68620.
RefSeqiNP_033099.3. NM_009073.4.
UniGeneiMm.426094.

Genome annotation databases

EnsembliENSMUST00000096242; ENSMUSP00000093961; ENSMUSG00000071648.
GeneIDi19881.
KEGGimmu:19881.
UCSCiuc008goc.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96760 Genomic DNA. Translation: AAA40063.1.
BC014827 mRNA. Translation: AAH14827.1.
CCDSiCCDS29559.1.
PIRiI68620.
RefSeqiNP_033099.3. NM_009073.4.
UniGeneiMm.426094.

3D structure databases

ProteinModelPortaliP32958.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000093961.

PTM databases

iPTMnetiP32958.
PhosphoSiteiP32958.

Proteomic databases

PaxDbiP32958.
PRIDEiP32958.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000096242; ENSMUSP00000093961; ENSMUSG00000071648.
GeneIDi19881.
KEGGimmu:19881.
UCSCiuc008goc.2. mouse.

Organism-specific databases

CTDi6094.
MGIiMGI:97998. Rom1.

Phylogenomic databases

eggNOGiKOG3882. Eukaryota.
ENOG4111IRY. LUCA.
GeneTreeiENSGT00390000016192.
HOGENOMiHOG000026780.
HOVERGENiHBG004964.
InParanoidiP32958.
KOiK17344.
OMAiCCNPHSP.
OrthoDBiEOG7T1RBG.
PhylomeDBiP32958.
TreeFamiTF331684.

Miscellaneous databases

PROiP32958.
SOURCEiSearch...

Gene expression databases

BgeeiP32958.
CleanExiMM_ROM1.
GenevisibleiP32958. MM.

Family and domain databases

InterProiIPR000830. Peripherin/rom-1.
IPR018498. Peripherin/rom-1_CS.
IPR018499. Tetraspanin/Peripherin.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PRINTSiPR00218. PERIPHERNRDS.
SUPFAMiSSF48652. SSF48652. 2 hits.
PROSITEiPS00930. RDS_ROM1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of the human and murine ROM1 genes: genomic organization and sequence conservation."
    Bascom R.A., Schappert K.T., McInnes R.R.
    Hum. Mol. Genet. 2:385-391(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.

Entry informationi

Entry nameiROM1_MOUSE
AccessioniPrimary (citable) accession number: P32958
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: June 8, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.