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Protein

Serine/threonine-protein phosphatase PPQ

Gene

PPQ1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Phosphatase involved in the regulation of protein synthesis. Affects translational accuracy.

Miscellaneous

Present with 319 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi301Manganese 1By similarity1
Metal bindingi303Manganese 1By similarity1
Metal bindingi329Manganese 1By similarity1
Metal bindingi329Manganese 2By similarity1
Metal bindingi361Manganese 2By similarity1
Active sitei362Proton donorBy similarity1
Metal bindingi410Manganese 2By similarity1
Metal bindingi485Manganese 2By similarity1

GO - Molecular functioni

GO - Biological processi

  • negative regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion Source: SGD
  • protein dephosphorylation Source: SGD

Keywordsi

Molecular functionHydrolase, Protein phosphatase
LigandManganese, Metal-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-34074-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase PPQ (EC:3.1.3.16)
Gene namesi
Name:PPQ1
Synonyms:SAL6
Ordered Locus Names:YPL179W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPL179W.
SGDiS000006100. PPQ1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000588931 – 549Serine/threonine-protein phosphatase PPQAdd BLAST549

Proteomic databases

MaxQBiP32945.
PRIDEiP32945.

PTM databases

iPTMnetiP32945.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SDS22P360473EBI-13787,EBI-16783

Protein-protein interaction databases

BioGridi36003. 156 interactors.
DIPiDIP-5504N.
IntActiP32945. 3 interactors.
MINTiMINT-564004.
STRINGi4932.YPL179W.

Structurei

3D structure databases

ProteinModelPortaliP32945.
SMRiP32945.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi113 – 219Ser-richAdd BLAST107

Sequence similaritiesi

Belongs to the PPP phosphatase family. PP-Z subfamily.Curated

Phylogenomic databases

GeneTreeiENSGT00900000142047.
HOGENOMiHOG000172697.
InParanoidiP32945.
KOiK06269.
OrthoDBiEOG092C37EX.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiView protein in InterPro
IPR004843. Calcineurin-like_PHP_ApaH.
IPR029052. Metallo-depent_PP-like.
IPR011159. PPPtase_PPZ/Ppq1.
IPR006186. Ser/Thr-sp_prot-phosphatase.
IPR031675. STPPase_N.
PfamiView protein in Pfam
PF00149. Metallophos. 1 hit.
PF16891. STPPase_N. 1 hit.
PIRSFiPIRSF000909. PPPtase_PPZ. 1 hit.
PRINTSiPR00114. STPHPHTASE.
SMARTiView protein in SMART
SM00156. PP2Ac. 1 hit.
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiView protein in PROSITE
PS00125. SER_THR_PHOSPHATASE. 1 hit.

Sequencei

Sequence statusi: Complete.

P32945-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRSPSRSNN NFAVPNCSTN SNSSQQQLTT PSDDLNSNEP NDPDDSRSLP
60 70 80 90 100
TIKKFNNKHS INNYNTLASA GKNNNNKRAS NDNLLIPGEN AHKQKIYTKD
110 120 130 140 150
ENLKSLYLDI DVSVAKALSS SATAPKLINT ARTSSTTTAT TSNNILTSPS
160 170 180 190 200
YRESNYSSPS SYSFSSYYSS ATSASSSTSS FLKSSGLSSR VKSPSSSVKA
210 220 230 240 250
GSFGAPSSPT SGIPNPKSSK KPIFLRRYSH DTSSNEGLDI DVAIEKLLQV
260 270 280 290 300
GESREITKTS KKKNFPFHSW EIQLICYHAR EIFLNQPTLL RLQAPIKVVG
310 320 330 340 350
DVHGQFNDLL RILKLSGVPS DTNYLFLGDY VDRGKNSLET ILLLLCYKIK
360 370 380 390 400
YKDNFFMLRG NHESANVTKM YGFYDECKRR LSSKVWKMFV DVFNTLPLAA
410 420 430 440 450
IIQDKIFCVH GGISPDLHDM KQIEKVARPT DIPESGLVTD LLWSDPDPQV
460 470 480 490 500
TDWSENDRGV SYTFSKRNVL DFCAKFKFDL ILRGHMVVED GYEFFARKKF
510 520 530 540
VTIFSAPNYC GEFHNWGAVM SVTTGMMCSF ELLKPRALKN KKKLYKTKV
Length:549
Mass (Da):61,420
Last modified:October 1, 1993 - v1
Checksum:i1E26D05E2865A8C1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75485 Genomic DNA. Translation: CAA53214.1.
U00795 Genomic DNA. Translation: AAC48924.1.
Z73535 Genomic DNA. Translation: CAA97886.1.
S39958 Genomic DNA. Translation: AAB22461.1.
BK006949 Genomic DNA. Translation: DAA11255.1.
PIRiS39533.
RefSeqiNP_015146.1. NM_001183993.1.

Genome annotation databases

EnsemblFungiiYPL179W; YPL179W; YPL179W.
GeneIDi855923.
KEGGisce:YPL179W.

Similar proteinsi

Entry informationi

Entry nameiPPQ1_YEAST
AccessioniPrimary (citable) accession number: P32945
Secondary accession number(s): D6W3I9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: October 25, 2017
This is version 158 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names