ID   CGS6_YEAST              Reviewed;         380 AA.
AC   P32943; D6VUP0;
DT   01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 2.
DT   27-MAR-2024, entry version 180.
DE   RecName: Full=S-phase entry cyclin-6;
GN   Name=CLB6; OrderedLocusNames=YGR109C; ORFNames=G5970;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=K1107;
RX   PubMed=8319908; DOI=10.1101/gad.7.7a.1160;
RA   Schwob E., Nasmyth K.;
RT   "CLB5 and CLB6, a new pair of B cyclins involved in DNA replication in
RT   Saccharomyces cerevisiae.";
RL   Genes Dev. 7:1160-1175(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8253070; DOI=10.1002/j.1460-2075.1993.tb06018.x;
RA   Kuehne C., Linder P.;
RT   "A new pair of B-type cyclins from Saccharomyces cerevisiae that function
RT   early in the cell cycle.";
RL   EMBO J. 12:3437-3447(1993).
RN   [3]
RP   SEQUENCE REVISION TO C-TERMINUS.
RA   Kuehne C.;
RL   Submitted (JAN-1994) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8905931;
RX   DOI=10.1002/(sici)1097-0061(19960930)12:12<1273::aid-yea21>3.0.co;2-j;
RA   Hansen M., Albers M., Backes U., Coblenz A., Leuther H., Neu R.,
RA   Schreer A., Schaefer B., Zimmermann M., Wolf K.;
RT   "The sequence of a 23.4 kb segment on the right arm of chromosome VII from
RT   Saccharomyces cerevisiae reveals CLB6, SPT6, RP28A and NUP57 genes, a Ty3
RT   element and 11 new open reading frames.";
RL   Yeast 12:1273-1277(1996).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=9169869;
RA   Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J.,
RA   Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M.,
RA   Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L.,
RA   Coblenz A., Coglievina M., Coissac E., Defoor E., Del Bino S., Delius H.,
RA   Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P.,
RA   Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M.,
RA   Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A.,
RA   Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K.,
RA   Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P.,
RA   Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E.,
RA   Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K.,
RA   Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A.,
RA   Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S.,
RA   Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M.,
RA   Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C.,
RA   Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M.,
RA   Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M.,
RA   Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y.,
RA   Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L.,
RA   Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D.,
RA   Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F.,
RA   Zaccaria P., Zimmermann M., Zollner A., Kleine K.;
RT   "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII.";
RL   Nature 387:81-84(1997).
RN   [6]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [7]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=17322287; DOI=10.1101/gr.6037607;
RA   Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA   Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA   Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA   Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA   LaBaer J.;
RT   "Approaching a complete repository of sequence-verified protein-encoding
RT   clones for Saccharomyces cerevisiae.";
RL   Genome Res. 17:536-543(2007).
CC   -!- FUNCTION: Involved in G1/S and or S phase progression. Interacts with
CC       CDC28.
CC   -!- INTERACTION:
CC       P32943; P00546: CDC28; NbExp=3; IntAct=EBI-2049771, EBI-4253;
CC   -!- DEVELOPMENTAL STAGE: Maximally expressed just before cell cycle start.
CC   -!- SIMILARITY: Belongs to the cyclin family. Cyclin AB subfamily.
CC       {ECO:0000305}.
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DR   EMBL; X70436; CAA49894.1; -; Genomic_DNA.
DR   EMBL; X72890; CAA51408.1; -; Genomic_DNA.
DR   EMBL; Z72894; CAA97113.1; -; Genomic_DNA.
DR   EMBL; AY693095; AAT93114.1; -; Genomic_DNA.
DR   EMBL; BK006941; DAA08201.1; -; Genomic_DNA.
DR   PIR; S64417; S64417.
DR   RefSeq; NP_011623.3; NM_001181238.3.
DR   AlphaFoldDB; P32943; -.
DR   SMR; P32943; -.
DR   BioGRID; 33353; 102.
DR   ComplexPortal; CPX-339; CLB6-CDC28 kinase complex.
DR   IntAct; P32943; 8.
DR   MINT; P32943; -.
DR   STRING; 4932.YGR109C; -.
DR   iPTMnet; P32943; -.
DR   PaxDb; 4932-YGR109C; -.
DR   PeptideAtlas; P32943; -.
DR   EnsemblFungi; YGR109C_mRNA; YGR109C; YGR109C.
DR   GeneID; 853003; -.
DR   KEGG; sce:YGR109C; -.
DR   AGR; SGD:S000003341; -.
DR   SGD; S000003341; CLB6.
DR   VEuPathDB; FungiDB:YGR109C; -.
DR   eggNOG; KOG0653; Eukaryota.
DR   GeneTree; ENSGT00940000176489; -.
DR   HOGENOM; CLU_020695_12_4_1; -.
DR   InParanoid; P32943; -.
DR   OMA; ENSKWDE; -.
DR   OrthoDB; 5474295at2759; -.
DR   BioCyc; YEAST:G3O-30818-MONOMER; -.
DR   Reactome; R-SCE-69017; CDK-mediated phosphorylation and removal of Cdc6.
DR   Reactome; R-SCE-69202; Cyclin E associated events during G1/S transition.
DR   BioGRID-ORCS; 853003; 0 hits in 10 CRISPR screens.
DR   PRO; PR:P32943; -.
DR   Proteomes; UP000002311; Chromosome VII.
DR   RNAct; P32943; Protein.
DR   GO; GO:0000307; C:cyclin-dependent protein kinase holoenzyme complex; IPI:ComplexPortal.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005816; C:spindle pole body; IBA:GO_Central.
DR   GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IDA:SGD.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0000082; P:G1/S transition of mitotic cell cycle; IMP:SGD.
DR   GO; GO:0044772; P:mitotic cell cycle phase transition; IBA:GO_Central.
DR   GO; GO:0045740; P:positive regulation of DNA replication; IGI:SGD.
DR   GO; GO:0006279; P:premeiotic DNA replication; IMP:SGD.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IMP:ComplexPortal.
DR   GO; GO:0032880; P:regulation of protein localization; IMP:SGD.
DR   GO; GO:0001932; P:regulation of protein phosphorylation; IDA:SGD.
DR   CDD; cd20568; CYCLIN_CLBs_yeast_rpt1; 1.
DR   CDD; cd20512; CYCLIN_CLBs_yeast_rpt2; 1.
DR   Gene3D; 1.10.472.10; Cyclin-like; 2.
DR   InterPro; IPR039361; Cyclin.
DR   InterPro; IPR013763; Cyclin-like_dom.
DR   InterPro; IPR036915; Cyclin-like_sf.
DR   InterPro; IPR046965; Cyclin_A/B-like.
DR   InterPro; IPR004367; Cyclin_C-dom.
DR   InterPro; IPR006671; Cyclin_N.
DR   InterPro; IPR048258; Cyclins_cyclin-box.
DR   PANTHER; PTHR10177; CYCLINS; 1.
DR   PANTHER; PTHR10177:SF587; S-PHASE ENTRY CYCLIN-5-RELATED; 1.
DR   Pfam; PF02984; Cyclin_C; 1.
DR   Pfam; PF00134; Cyclin_N; 1.
DR   PIRSF; PIRSF001771; Cyclin_A_B_D_E; 1.
DR   SMART; SM00385; CYCLIN; 2.
DR   SMART; SM01332; Cyclin_C; 1.
DR   SUPFAM; SSF47954; Cyclin-like; 2.
DR   PROSITE; PS00292; CYCLINS; 1.
PE   1: Evidence at protein level;
KW   Cell cycle; Cell division; Cyclin; Reference proteome.
FT   CHAIN           1..380
FT                   /note="S-phase entry cyclin-6"
FT                   /id="PRO_0000080409"
FT   REGION          63..91
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        68..91
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        77
FT                   /note="T -> S (in Ref. 2; CAA51408)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        92
FT                   /note="P -> S (in Ref. 2; CAA51408)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        109
FT                   /note="I -> M (in Ref. 2; CAA51408)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        223
FT                   /note="F -> L (in Ref. 1; CAA49894)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   380 AA;  44145 MW;  C8A4284091C64F87 CRC64;
     MNCIPSPISE RKIQINNEDC IGKENAFHTI PRESSINLTP HSTNEKKVLS EVNSNKIDSL
     QLPRGKLQRD STHLEKTRKR QLSNDSTDPI EPKTVKKIKC HQWKNLDSIE MDDPFMVAEY
     TDSIFSHLYE KEIQMLPTHN YLMDTQSPYH LKSSMRALLI DWLVEVHEKF HCLPETLFLA
     INLLDRFLSQ NVVKLNKLQL LCITCLFIAC KFEEVKLPKI TNFAYVTDGA ATVEGIRKAE
     LFVLSSLGYN ISLPNPLNFI RRISKADNYC IETRNMAKFI MEYSICCNKF IHLKPSYLAA
     MSMYIARKIK NENSKWDETF IHYSGGIDIE SDPAFKDFIS ELVEDIAVPD TNLDSLRLKY
     KKPKHGMVYF KVFDWCKQKR
//