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P32943

- CGS6_YEAST

UniProt

P32943 - CGS6_YEAST

Protein

S-phase entry cyclin-6

Gene

CLB6

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 2 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Involved in G1/S and or S phase progression. Interacts with CDC28.

    GO - Molecular functioni

    1. cyclin-dependent protein serine/threonine kinase regulator activity Source: SGD

    GO - Biological processi

    1. cell division Source: UniProtKB-KW
    2. G1/S transition of mitotic cell cycle Source: SGD
    3. premeiotic DNA replication Source: SGD
    4. regulation of cyclin-dependent protein serine/threonine kinase activity Source: SGD

    Keywords - Molecular functioni

    Cyclin

    Keywords - Biological processi

    Cell cycle, Cell division

    Enzyme and pathway databases

    BioCyciYEAST:G3O-30818-MONOMER.
    ReactomeiREACT_188466. Regulation of APC/C activators between G1/S and early anaphase.
    REACT_188487. Cyclin A/B1 associated events during G2/M transition.
    REACT_188488. G2/M DNA replication checkpoint.
    REACT_188908. Condensation of Prometaphase Chromosomes.
    REACT_188916. MASTL Facilitates Mitotic Progression.
    REACT_205363. Cyclin B2 mediated events.
    REACT_211772. E2F-enabled inhibition of pre-replication complex formation.
    REACT_224510. Depolymerisation of the Nuclear Lamina.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    S-phase entry cyclin-6
    Gene namesi
    Name:CLB6
    Ordered Locus Names:YGR109C
    ORF Names:G5970
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome VII

    Organism-specific databases

    CYGDiYGR109c.
    SGDiS000003341. CLB6.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 380380S-phase entry cyclin-6PRO_0000080409Add
    BLAST

    Expressioni

    Developmental stagei

    Maximally expressed just before cell cycle start.

    Gene expression databases

    GenevestigatoriP32943.

    Interactioni

    Protein-protein interaction databases

    BioGridi33353. 47 interactions.
    IntActiP32943. 8 interactions.
    MINTiMINT-4808884.
    STRINGi4932.YGR109C.

    Structurei

    3D structure databases

    ProteinModelPortaliP32943.
    SMRiP32943. Positions 114-367.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cyclin family. Cyclin AB subfamily.Curated

    Phylogenomic databases

    eggNOGiCOG5024.
    GeneTreeiENSGT00750000117276.
    HOGENOMiHOG000000929.
    KOiK06651.
    OMAiHTIPRES.
    OrthoDBiEOG7FNCJX.

    Family and domain databases

    Gene3Di1.10.472.10. 2 hits.
    InterProiIPR013763. Cyclin-like.
    IPR014400. Cyclin_A/B/D/E/F.
    IPR004367. Cyclin_C-dom.
    IPR006671. Cyclin_N.
    [Graphical view]
    PfamiPF02984. Cyclin_C. 1 hit.
    PF00134. Cyclin_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001771. Cyclin_A_B_D_E. 1 hit.
    SMARTiSM00385. CYCLIN. 2 hits.
    [Graphical view]
    SUPFAMiSSF47954. SSF47954. 2 hits.
    PROSITEiPS00292. CYCLINS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P32943-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNCIPSPISE RKIQINNEDC IGKENAFHTI PRESSINLTP HSTNEKKVLS    50
    EVNSNKIDSL QLPRGKLQRD STHLEKTRKR QLSNDSTDPI EPKTVKKIKC 100
    HQWKNLDSIE MDDPFMVAEY TDSIFSHLYE KEIQMLPTHN YLMDTQSPYH 150
    LKSSMRALLI DWLVEVHEKF HCLPETLFLA INLLDRFLSQ NVVKLNKLQL 200
    LCITCLFIAC KFEEVKLPKI TNFAYVTDGA ATVEGIRKAE LFVLSSLGYN 250
    ISLPNPLNFI RRISKADNYC IETRNMAKFI MEYSICCNKF IHLKPSYLAA 300
    MSMYIARKIK NENSKWDETF IHYSGGIDIE SDPAFKDFIS ELVEDIAVPD 350
    TNLDSLRLKY KKPKHGMVYF KVFDWCKQKR 380
    Length:380
    Mass (Da):44,145
    Last modified:October 1, 1996 - v2
    Checksum:iC8A4284091C64F87
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti77 – 771T → S in CAA51408. (PubMed:8253070)Curated
    Sequence conflicti92 – 921P → S in CAA51408. (PubMed:8253070)Curated
    Sequence conflicti109 – 1091I → M in CAA51408. (PubMed:8253070)Curated
    Sequence conflicti223 – 2231F → L in CAA49894. (PubMed:8319908)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X70436 Genomic DNA. Translation: CAA49894.1.
    X72890 Genomic DNA. Translation: CAA51408.1.
    Z72894 Genomic DNA. Translation: CAA97113.1.
    AY693095 Genomic DNA. Translation: AAT93114.1.
    BK006941 Genomic DNA. Translation: DAA08201.1.
    PIRiS64417.
    RefSeqiNP_011623.3. NM_001181238.3.

    Genome annotation databases

    EnsemblFungiiYGR109C; YGR109C; YGR109C.
    GeneIDi853003.
    KEGGisce:YGR109C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X70436 Genomic DNA. Translation: CAA49894.1 .
    X72890 Genomic DNA. Translation: CAA51408.1 .
    Z72894 Genomic DNA. Translation: CAA97113.1 .
    AY693095 Genomic DNA. Translation: AAT93114.1 .
    BK006941 Genomic DNA. Translation: DAA08201.1 .
    PIRi S64417.
    RefSeqi NP_011623.3. NM_001181238.3.

    3D structure databases

    ProteinModelPortali P32943.
    SMRi P32943. Positions 114-367.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 33353. 47 interactions.
    IntActi P32943. 8 interactions.
    MINTi MINT-4808884.
    STRINGi 4932.YGR109C.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YGR109C ; YGR109C ; YGR109C .
    GeneIDi 853003.
    KEGGi sce:YGR109C.

    Organism-specific databases

    CYGDi YGR109c.
    SGDi S000003341. CLB6.

    Phylogenomic databases

    eggNOGi COG5024.
    GeneTreei ENSGT00750000117276.
    HOGENOMi HOG000000929.
    KOi K06651.
    OMAi HTIPRES.
    OrthoDBi EOG7FNCJX.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-30818-MONOMER.
    Reactomei REACT_188466. Regulation of APC/C activators between G1/S and early anaphase.
    REACT_188487. Cyclin A/B1 associated events during G2/M transition.
    REACT_188488. G2/M DNA replication checkpoint.
    REACT_188908. Condensation of Prometaphase Chromosomes.
    REACT_188916. MASTL Facilitates Mitotic Progression.
    REACT_205363. Cyclin B2 mediated events.
    REACT_211772. E2F-enabled inhibition of pre-replication complex formation.
    REACT_224510. Depolymerisation of the Nuclear Lamina.

    Miscellaneous databases

    NextBioi 972849.

    Gene expression databases

    Genevestigatori P32943.

    Family and domain databases

    Gene3Di 1.10.472.10. 2 hits.
    InterProi IPR013763. Cyclin-like.
    IPR014400. Cyclin_A/B/D/E/F.
    IPR004367. Cyclin_C-dom.
    IPR006671. Cyclin_N.
    [Graphical view ]
    Pfami PF02984. Cyclin_C. 1 hit.
    PF00134. Cyclin_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001771. Cyclin_A_B_D_E. 1 hit.
    SMARTi SM00385. CYCLIN. 2 hits.
    [Graphical view ]
    SUPFAMi SSF47954. SSF47954. 2 hits.
    PROSITEi PS00292. CYCLINS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "CLB5 and CLB6, a new pair of B cyclins involved in DNA replication in Saccharomyces cerevisiae."
      Schwob E., Nasmyth K.
      Genes Dev. 7:1160-1175(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: K1107.
    2. "A new pair of B-type cyclins from Saccharomyces cerevisiae that function early in the cell cycle."
      Kuehne C., Linder P.
      EMBO J. 12:3437-3447(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. Kuehne C.
      Submitted (JAN-1994) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION TO C-TERMINUS.
    4. "The sequence of a 23.4 kb segment on the right arm of chromosome VII from Saccharomyces cerevisiae reveals CLB6, SPT6, RP28A and NUP57 genes, a Ty3 element and 11 new open reading frames."
      Hansen M., Albers M., Backes U., Coblenz A., Leuther H., Neu R., Schreer A., Schaefer B., Zimmermann M., Wolf K.
      Yeast 12:1273-1277(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    5. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
      Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E.
      , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
      Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    6. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    7. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.

    Entry informationi

    Entry nameiCGS6_YEAST
    AccessioniPrimary (citable) accession number: P32943
    Secondary accession number(s): D6VUP0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1993
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 116 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome VII
      Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

    External Data

    Dasty 3