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P32943

- CGS6_YEAST

UniProt

P32943 - CGS6_YEAST

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Protein

S-phase entry cyclin-6

Gene

CLB6

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Involved in G1/S and or S phase progression. Interacts with CDC28.

GO - Molecular functioni

  1. cyclin-dependent protein serine/threonine kinase regulator activity Source: SGD

GO - Biological processi

  1. cell division Source: UniProtKB-KW
  2. G1/S transition of mitotic cell cycle Source: SGD
  3. premeiotic DNA replication Source: SGD
  4. regulation of cyclin-dependent protein serine/threonine kinase activity Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Cyclin

Keywords - Biological processi

Cell cycle, Cell division

Enzyme and pathway databases

BioCyciYEAST:G3O-30818-MONOMER.
ReactomeiREACT_188466. Regulation of APC/C activators between G1/S and early anaphase.
REACT_188487. Cyclin A/B1 associated events during G2/M transition.
REACT_188488. G2/M DNA replication checkpoint.
REACT_188908. Condensation of Prometaphase Chromosomes.
REACT_188916. MASTL Facilitates Mitotic Progression.
REACT_205363. Cyclin B2 mediated events.
REACT_211772. E2F-enabled inhibition of pre-replication complex formation.
REACT_224510. Depolymerisation of the Nuclear Lamina.

Names & Taxonomyi

Protein namesi
Recommended name:
S-phase entry cyclin-6
Gene namesi
Name:CLB6
Ordered Locus Names:YGR109C
ORF Names:G5970
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VII

Organism-specific databases

CYGDiYGR109c.
SGDiS000003341. CLB6.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 380380S-phase entry cyclin-6PRO_0000080409Add
BLAST

Expressioni

Developmental stagei

Maximally expressed just before cell cycle start.

Gene expression databases

GenevestigatoriP32943.

Interactioni

Protein-protein interaction databases

BioGridi33353. 49 interactions.
IntActiP32943. 8 interactions.
MINTiMINT-4808884.
STRINGi4932.YGR109C.

Structurei

3D structure databases

ProteinModelPortaliP32943.
SMRiP32943. Positions 114-367.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cyclin family. Cyclin AB subfamily.Curated

Phylogenomic databases

eggNOGiCOG5024.
GeneTreeiENSGT00760000118939.
HOGENOMiHOG000000929.
InParanoidiP32943.
KOiK06651.
OMAiHTIPRES.
OrthoDBiEOG7FNCJX.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
InterProiIPR013763. Cyclin-like.
IPR014400. Cyclin_A/B/D/E/F.
IPR004367. Cyclin_C-dom.
IPR006671. Cyclin_N.
[Graphical view]
PfamiPF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view]
PIRSFiPIRSF001771. Cyclin_A_B_D_E. 1 hit.
SMARTiSM00385. CYCLIN. 2 hits.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.
PROSITEiPS00292. CYCLINS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P32943-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNCIPSPISE RKIQINNEDC IGKENAFHTI PRESSINLTP HSTNEKKVLS
60 70 80 90 100
EVNSNKIDSL QLPRGKLQRD STHLEKTRKR QLSNDSTDPI EPKTVKKIKC
110 120 130 140 150
HQWKNLDSIE MDDPFMVAEY TDSIFSHLYE KEIQMLPTHN YLMDTQSPYH
160 170 180 190 200
LKSSMRALLI DWLVEVHEKF HCLPETLFLA INLLDRFLSQ NVVKLNKLQL
210 220 230 240 250
LCITCLFIAC KFEEVKLPKI TNFAYVTDGA ATVEGIRKAE LFVLSSLGYN
260 270 280 290 300
ISLPNPLNFI RRISKADNYC IETRNMAKFI MEYSICCNKF IHLKPSYLAA
310 320 330 340 350
MSMYIARKIK NENSKWDETF IHYSGGIDIE SDPAFKDFIS ELVEDIAVPD
360 370 380
TNLDSLRLKY KKPKHGMVYF KVFDWCKQKR
Length:380
Mass (Da):44,145
Last modified:October 1, 1996 - v2
Checksum:iC8A4284091C64F87
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti77 – 771T → S in CAA51408. (PubMed:8253070)Curated
Sequence conflicti92 – 921P → S in CAA51408. (PubMed:8253070)Curated
Sequence conflicti109 – 1091I → M in CAA51408. (PubMed:8253070)Curated
Sequence conflicti223 – 2231F → L in CAA49894. (PubMed:8319908)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X70436 Genomic DNA. Translation: CAA49894.1.
X72890 Genomic DNA. Translation: CAA51408.1.
Z72894 Genomic DNA. Translation: CAA97113.1.
AY693095 Genomic DNA. Translation: AAT93114.1.
BK006941 Genomic DNA. Translation: DAA08201.1.
PIRiS64417.
RefSeqiNP_011623.3. NM_001181238.3.

Genome annotation databases

EnsemblFungiiYGR109C; YGR109C; YGR109C.
GeneIDi853003.
KEGGisce:YGR109C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X70436 Genomic DNA. Translation: CAA49894.1 .
X72890 Genomic DNA. Translation: CAA51408.1 .
Z72894 Genomic DNA. Translation: CAA97113.1 .
AY693095 Genomic DNA. Translation: AAT93114.1 .
BK006941 Genomic DNA. Translation: DAA08201.1 .
PIRi S64417.
RefSeqi NP_011623.3. NM_001181238.3.

3D structure databases

ProteinModelPortali P32943.
SMRi P32943. Positions 114-367.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 33353. 49 interactions.
IntActi P32943. 8 interactions.
MINTi MINT-4808884.
STRINGi 4932.YGR109C.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YGR109C ; YGR109C ; YGR109C .
GeneIDi 853003.
KEGGi sce:YGR109C.

Organism-specific databases

CYGDi YGR109c.
SGDi S000003341. CLB6.

Phylogenomic databases

eggNOGi COG5024.
GeneTreei ENSGT00760000118939.
HOGENOMi HOG000000929.
InParanoidi P32943.
KOi K06651.
OMAi HTIPRES.
OrthoDBi EOG7FNCJX.

Enzyme and pathway databases

BioCyci YEAST:G3O-30818-MONOMER.
Reactomei REACT_188466. Regulation of APC/C activators between G1/S and early anaphase.
REACT_188487. Cyclin A/B1 associated events during G2/M transition.
REACT_188488. G2/M DNA replication checkpoint.
REACT_188908. Condensation of Prometaphase Chromosomes.
REACT_188916. MASTL Facilitates Mitotic Progression.
REACT_205363. Cyclin B2 mediated events.
REACT_211772. E2F-enabled inhibition of pre-replication complex formation.
REACT_224510. Depolymerisation of the Nuclear Lamina.

Miscellaneous databases

NextBioi 972849.

Gene expression databases

Genevestigatori P32943.

Family and domain databases

Gene3Di 1.10.472.10. 2 hits.
InterProi IPR013763. Cyclin-like.
IPR014400. Cyclin_A/B/D/E/F.
IPR004367. Cyclin_C-dom.
IPR006671. Cyclin_N.
[Graphical view ]
Pfami PF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF001771. Cyclin_A_B_D_E. 1 hit.
SMARTi SM00385. CYCLIN. 2 hits.
[Graphical view ]
SUPFAMi SSF47954. SSF47954. 2 hits.
PROSITEi PS00292. CYCLINS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "CLB5 and CLB6, a new pair of B cyclins involved in DNA replication in Saccharomyces cerevisiae."
    Schwob E., Nasmyth K.
    Genes Dev. 7:1160-1175(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: K1107.
  2. "A new pair of B-type cyclins from Saccharomyces cerevisiae that function early in the cell cycle."
    Kuehne C., Linder P.
    EMBO J. 12:3437-3447(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. Kuehne C.
    Submitted (JAN-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION TO C-TERMINUS.
  4. "The sequence of a 23.4 kb segment on the right arm of chromosome VII from Saccharomyces cerevisiae reveals CLB6, SPT6, RP28A and NUP57 genes, a Ty3 element and 11 new open reading frames."
    Hansen M., Albers M., Backes U., Coblenz A., Leuther H., Neu R., Schreer A., Schaefer B., Zimmermann M., Wolf K.
    Yeast 12:1273-1277(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  5. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
    Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E.
    , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
    Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  6. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  7. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.

Entry informationi

Entry nameiCGS6_YEAST
AccessioniPrimary (citable) accession number: P32943
Secondary accession number(s): D6VUP0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

External Data

Dasty 3