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Protein

S-phase entry cyclin-6

Gene

CLB6

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in G1/S and or S phase progression. Interacts with CDC28.

GO - Molecular functioni

  • cyclin-dependent protein serine/threonine kinase regulator activity Source: SGD

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • G1/S transition of mitotic cell cycle Source: SGD
  • positive regulation of DNA replication Source: SGD
  • premeiotic DNA replication Source: SGD
  • regulation of cyclin-dependent protein serine/threonine kinase activity Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Cyclin

Keywords - Biological processi

Cell cycle, Cell division

Enzyme and pathway databases

BioCyciYEAST:G3O-30818-MONOMER.
ReactomeiR-SCE-113507. E2F-enabled inhibition of pre-replication complex formation.
R-SCE-113510. E2F mediated regulation of DNA replication.
R-SCE-176408. Regulation of APC/C activators between G1/S and early anaphase.
R-SCE-2980767. Activation of NIMA Kinases NEK9, NEK6, NEK7.
R-SCE-3214858. RMTs methylate histone arginines.
R-SCE-4419969. Depolymerisation of the Nuclear Lamina.
R-SCE-5687128. MAPK6/MAPK4 signaling.
R-SCE-6804114. TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest.
R-SCE-69202. Cyclin E associated events during G1/S transition.
R-SCE-69205. G1/S-Specific Transcription.
R-SCE-69229. Ubiquitin-dependent degradation of Cyclin D1.
R-SCE-69273. Cyclin A/B1 associated events during G2/M transition.
R-SCE-69478. G2/M DNA replication checkpoint.
R-SCE-69656. Cyclin A:Cdk2-associated events at S phase entry.
R-SCE-75035. Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex.

Names & Taxonomyi

Protein namesi
Recommended name:
S-phase entry cyclin-6
Gene namesi
Name:CLB6
Ordered Locus Names:YGR109C
ORF Names:G5970
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGR109C.
SGDiS000003341. CLB6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 380380S-phase entry cyclin-6PRO_0000080409Add
BLAST

PTM databases

iPTMnetiP32943.

Expressioni

Developmental stagei

Maximally expressed just before cell cycle start.

Interactioni

Protein-protein interaction databases

BioGridi33353. 51 interactions.
IntActiP32943. 8 interactions.
MINTiMINT-4808884.

Structurei

3D structure databases

ProteinModelPortaliP32943.
SMRiP32943. Positions 114-370.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cyclin family. Cyclin AB subfamily.Curated

Phylogenomic databases

GeneTreeiENSGT00760000118939.
HOGENOMiHOG000000929.
InParanoidiP32943.
KOiK06651.
OMAiHTIPRES.
OrthoDBiEOG092C2S0G.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
InterProiIPR013763. Cyclin-like.
IPR004367. Cyclin_C-dom.
IPR006671. Cyclin_N.
[Graphical view]
PfamiPF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view]
SMARTiSM00385. CYCLIN. 2 hits.
SM01332. Cyclin_C. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.
PROSITEiPS00292. CYCLINS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P32943-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNCIPSPISE RKIQINNEDC IGKENAFHTI PRESSINLTP HSTNEKKVLS
60 70 80 90 100
EVNSNKIDSL QLPRGKLQRD STHLEKTRKR QLSNDSTDPI EPKTVKKIKC
110 120 130 140 150
HQWKNLDSIE MDDPFMVAEY TDSIFSHLYE KEIQMLPTHN YLMDTQSPYH
160 170 180 190 200
LKSSMRALLI DWLVEVHEKF HCLPETLFLA INLLDRFLSQ NVVKLNKLQL
210 220 230 240 250
LCITCLFIAC KFEEVKLPKI TNFAYVTDGA ATVEGIRKAE LFVLSSLGYN
260 270 280 290 300
ISLPNPLNFI RRISKADNYC IETRNMAKFI MEYSICCNKF IHLKPSYLAA
310 320 330 340 350
MSMYIARKIK NENSKWDETF IHYSGGIDIE SDPAFKDFIS ELVEDIAVPD
360 370 380
TNLDSLRLKY KKPKHGMVYF KVFDWCKQKR
Length:380
Mass (Da):44,145
Last modified:October 1, 1996 - v2
Checksum:iC8A4284091C64F87
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti77 – 771T → S in CAA51408 (PubMed:8253070).Curated
Sequence conflicti92 – 921P → S in CAA51408 (PubMed:8253070).Curated
Sequence conflicti109 – 1091I → M in CAA51408 (PubMed:8253070).Curated
Sequence conflicti223 – 2231F → L in CAA49894 (PubMed:8319908).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70436 Genomic DNA. Translation: CAA49894.1.
X72890 Genomic DNA. Translation: CAA51408.1.
Z72894 Genomic DNA. Translation: CAA97113.1.
AY693095 Genomic DNA. Translation: AAT93114.1.
BK006941 Genomic DNA. Translation: DAA08201.1.
PIRiS64417.
RefSeqiNP_011623.3. NM_001181238.3.

Genome annotation databases

EnsemblFungiiYGR109C; YGR109C; YGR109C.
GeneIDi853003.
KEGGisce:YGR109C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70436 Genomic DNA. Translation: CAA49894.1.
X72890 Genomic DNA. Translation: CAA51408.1.
Z72894 Genomic DNA. Translation: CAA97113.1.
AY693095 Genomic DNA. Translation: AAT93114.1.
BK006941 Genomic DNA. Translation: DAA08201.1.
PIRiS64417.
RefSeqiNP_011623.3. NM_001181238.3.

3D structure databases

ProteinModelPortaliP32943.
SMRiP32943. Positions 114-370.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33353. 51 interactions.
IntActiP32943. 8 interactions.
MINTiMINT-4808884.

PTM databases

iPTMnetiP32943.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYGR109C; YGR109C; YGR109C.
GeneIDi853003.
KEGGisce:YGR109C.

Organism-specific databases

EuPathDBiFungiDB:YGR109C.
SGDiS000003341. CLB6.

Phylogenomic databases

GeneTreeiENSGT00760000118939.
HOGENOMiHOG000000929.
InParanoidiP32943.
KOiK06651.
OMAiHTIPRES.
OrthoDBiEOG092C2S0G.

Enzyme and pathway databases

BioCyciYEAST:G3O-30818-MONOMER.
ReactomeiR-SCE-113507. E2F-enabled inhibition of pre-replication complex formation.
R-SCE-113510. E2F mediated regulation of DNA replication.
R-SCE-176408. Regulation of APC/C activators between G1/S and early anaphase.
R-SCE-2980767. Activation of NIMA Kinases NEK9, NEK6, NEK7.
R-SCE-3214858. RMTs methylate histone arginines.
R-SCE-4419969. Depolymerisation of the Nuclear Lamina.
R-SCE-5687128. MAPK6/MAPK4 signaling.
R-SCE-6804114. TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest.
R-SCE-69202. Cyclin E associated events during G1/S transition.
R-SCE-69205. G1/S-Specific Transcription.
R-SCE-69229. Ubiquitin-dependent degradation of Cyclin D1.
R-SCE-69273. Cyclin A/B1 associated events during G2/M transition.
R-SCE-69478. G2/M DNA replication checkpoint.
R-SCE-69656. Cyclin A:Cdk2-associated events at S phase entry.
R-SCE-75035. Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex.

Miscellaneous databases

PROiP32943.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
InterProiIPR013763. Cyclin-like.
IPR004367. Cyclin_C-dom.
IPR006671. Cyclin_N.
[Graphical view]
PfamiPF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view]
SMARTiSM00385. CYCLIN. 2 hits.
SM01332. Cyclin_C. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.
PROSITEiPS00292. CYCLINS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCGS6_YEAST
AccessioniPrimary (citable) accession number: P32943
Secondary accession number(s): D6VUP0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1996
Last modified: September 7, 2016
This is version 132 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.