P32943 (CGS6_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
S-phase entry cyclin-6

Gene names

Name:	CLB6
Ordered Locus Names:	YGR109C
ORF Names:	G5970

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	380 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Involved in G1/S and or S phase progression. Interacts with CDC28.
Developmental stage	Maximally expressed just before cell cycle start.
Sequence similarities	Belongs to the cyclin family. Cyclin AB subfamily.

Ontologies

Keywords
Biological process	Cell cycle Cell division
Molecular function	Cyclin
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	G1/S transition of mitotic cell cycle Inferred from genetic interaction Ref.1. Source: SGD cell division Inferred from electronic annotation. Source: UniProtKB-KW premeiotic DNA replication Inferred from genetic interaction PubMed 9732268. Source: SGD regulation of S phase of mitotic cell cycle Inferred from mutant phenotype Ref.1. Source: SGD regulation of cyclin-dependent protein serine/threonine kinase activity Inferred from electronic annotation. Source: InterPro
Cellular_component	nucleus Inferred from electronic annotation. Source: InterPro
Molecular_function	cyclin-dependent protein serine/threonine kinase regulator activity Inferred from mutant phenotype Ref.1. Source: SGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 380	380	S-phase entry cyclin-6		PRO_0000080409
Experimental info
	Sequence conflict	77	1	T → S in CAA51408. Ref.2
	Sequence conflict	92	1	P → S in CAA51408. Ref.2
	Sequence conflict	109	1	I → M in CAA51408. Ref.2
	Sequence conflict	223	1	F → L in CAA49894. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P32943 [UniParc]. Last modified October 1, 1996. Version 2. Checksum: C8A4284091C64F87	FASTA	380	44,145
	10 20 30 40 50 60 MNCIPSPISE RKIQINNEDC IGKENAFHTI PRESSINLTP HSTNEKKVLS EVNSNKIDSL 70 80 90 100 110 120 QLPRGKLQRD STHLEKTRKR QLSNDSTDPI EPKTVKKIKC HQWKNLDSIE MDDPFMVAEY 130 140 150 160 170 180 TDSIFSHLYE KEIQMLPTHN YLMDTQSPYH LKSSMRALLI DWLVEVHEKF HCLPETLFLA 190 200 210 220 230 240 INLLDRFLSQ NVVKLNKLQL LCITCLFIAC KFEEVKLPKI TNFAYVTDGA ATVEGIRKAE 250 260 270 280 290 300 LFVLSSLGYN ISLPNPLNFI RRISKADNYC IETRNMAKFI MEYSICCNKF IHLKPSYLAA 310 320 330 340 350 360 MSMYIARKIK NENSKWDETF IHYSGGIDIE SDPAFKDFIS ELVEDIAVPD TNLDSLRLKY 370 380 KKPKHGMVYF KVFDWCKQKR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"CLB5 and CLB6, a new pair of B cyclins involved in DNA replication in Saccharomyces cerevisiae." Schwob E., Nasmyth K. Genes Dev. 7:1160-1175(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: K1107.
[2]	"A new pair of B-type cyclins from Saccharomyces cerevisiae that function early in the cell cycle." Kuehne C., Linder P. EMBO J. 12:3437-3447(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	Kuehne C. Submitted (JAN-1994) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION TO C-TERMINUS.
[4]	"The sequence of a 23.4 kb segment on the right arm of chromosome VII from Saccharomyces cerevisiae reveals CLB6, SPT6, RP28A and NUP57 genes, a Ty3 element and 11 new open reading frames." Hansen M., Albers M., Backes U., Coblenz A., Leuther H., Neu R., Schreer A., Schaefer B., Zimmermann M., Wolf K. Yeast 12:1273-1277(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[5]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome VII." Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E. , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K. Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679.
[6]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[7]	"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J. Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X70436 Genomic DNA. Translation: CAA49894.1. X72890 Genomic DNA. Translation: CAA51408.1. Z72894 Genomic DNA. Translation: CAA97113.1. AY693095 Genomic DNA. Translation: AAT93114.1. BK006941 Genomic DNA. Translation: DAA08201.1.
PIR	S64417.
RefSeq	NP_011623.3. NM_001181238.3.
3D structure databases
ProteinModelPortal	P32943.
SMR	P32943. Positions 114-367.
ModBase	Search...
Protein-protein interaction databases
IntAct	P32943. 8 interactions.
STRING	4932.YGR109C.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YGR109C; YGR109C; YGR109C.
GeneID	853003.
KEGG	sce:YGR109C. sce:YGR113W.
Organism-specific databases
CYGD	YGR109c.
SGD	S000003341. CLB6.
Phylogenomic databases
eggNOG	COG5024.
GeneTree	ENSGT00560000076692.
HOGENOM	HOG000000929.
KO	K02307. K06651.
OMA	SATHTEY.
OrthoDB	EOG4PG991.
Gene expression databases
Genevestigator	P32943.
GermOnline	YGR109C. Saccharomyces cerevisiae.
Family and domain databases
Gene3D	1.10.472.10. 2 hits.
InterPro	IPR013763. Cyclin-like. IPR014400. Cyclin_A/B/D/E. IPR004367. Cyclin_C-dom. IPR006671. Cyclin_N. [Graphical view]
Pfam	PF02984. Cyclin_C. 1 hit. PF00134. Cyclin_N. 1 hit. [Graphical view]
PIRSF	PIRSF001771. Cyclin_A_B_D_E. 1 hit.
SMART	SM00385. CYCLIN. 2 hits. [Graphical view]
SUPFAM	SSF47954. Cyclin_like. 2 hits.
PROSITE	PS00292. CYCLINS. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	972849.

Entry information

Entry name

CGS6_YEAST

Accession

Primary (citable) accession number: P32943
Secondary accession number(s): D6VUP0

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1993
Last sequence update:	October 1, 1996
Last modified:	May 1, 2013
This is version 104 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program