Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P32942

- ICAM3_HUMAN

UniProt

P32942 - ICAM3_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Intercellular adhesion molecule 3

Gene

ICAM3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM3 is also a ligand for integrin alpha-D/beta-2.

GO - Molecular functioni

  1. integrin binding Source: BHF-UCL
  2. receptor binding Source: ProtInc

GO - Biological processi

  1. extracellular matrix organization Source: Reactome
  2. regulation of immune response Source: Reactome
  3. single organismal cell-cell adhesion Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Enzyme and pathway databases

ReactomeiREACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
REACT_13552. Integrin cell surface interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Intercellular adhesion molecule 3
Short name:
ICAM-3
Alternative name(s):
CDw50
ICAM-R
CD_antigen: CD50
Gene namesi
Name:ICAM3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:5346. ICAM3.

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProt
  2. integral component of plasma membrane Source: ProtInc
  3. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29594.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929Sequence AnalysisAdd
BLAST
Chaini30 – 547518Intercellular adhesion molecule 3PRO_0000014794Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi52 – 521N-linked (GlcNAc...)1 Publication
Disulfide bondi53 ↔ 961 PublicationPROSITE-ProRule annotation
Glycosylationi84 – 841N-linked (GlcNAc...)1 Publication
Glycosylationi87 – 871N-linked (GlcNAc...)1 Publication
Glycosylationi91 – 911N-linked (GlcNAc...); atypical1 Publication
Glycosylationi101 – 1011N-linked (GlcNAc...)Sequence Analysis
Glycosylationi110 – 1101N-linked (GlcNAc...)1 Publication
Glycosylationi134 – 1341N-linked (GlcNAc...)1 Publication
Disulfide bondi139 ↔ 190PROSITE-ProRule annotation
Glycosylationi206 – 2061N-linked (GlcNAc...)3 Publications
Disulfide bondi241 ↔ 294PROSITE-ProRule annotation
Glycosylationi264 – 2641N-linked (GlcNAc...)Sequence Analysis
Glycosylationi295 – 2951N-linked (GlcNAc...)1 Publication
Glycosylationi308 – 3081N-linked (GlcNAc...)Sequence Analysis
Glycosylationi320 – 3201N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi336 ↔ 375PROSITE-ProRule annotation
Glycosylationi363 – 3631N-linked (GlcNAc...)3 Publications
Glycosylationi389 – 3891N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi423 ↔ 462PROSITE-ProRule annotation
Glycosylationi453 – 4531N-linked (GlcNAc...)Sequence Analysis
Glycosylationi457 – 4571N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

Upon stimulation by a physiologic stimuli becomes rapidly and transiently phosphorylated on serine residues.
N-glycosylated; glycans consist of a mixture of tri- and tetra-antennary complex-type chains and high-mannose chains.4 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP32942.
PaxDbiP32942.
PRIDEiP32942.

PTM databases

PhosphoSiteiP32942.
UniCarbKBiP32942.

Expressioni

Gene expression databases

BgeeiP32942.
CleanExiHS_ICAM3.
ExpressionAtlasiP32942. baseline and differential.
GenevestigatoriP32942.

Organism-specific databases

HPAiCAB002498.

Interactioni

Protein-protein interaction databases

BioGridi109612. 5 interactions.
IntActiP32942. 3 interactions.
MINTiMINT-1391707.
STRINGi9606.ENSP00000160262.

Structurei

Secondary structure

1
547
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi34 – 385
Beta strandi48 – 558
Beta strandi61 – 666
Beta strandi68 – 7710
Beta strandi80 – 867
Beta strandi92 – 1009
Beta strandi103 – 11311

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1T0PX-ray1.66B30-114[»]
ProteinModelPortaliP32942.
SMRiP32942. Positions 30-479.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP32942.

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini30 – 485456ExtracellularSequence AnalysisAdd
BLAST
Topological domaini511 – 54737CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei486 – 51025HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini46 – 10358Ig-like C2-type 1Add
BLAST
Domaini132 – 19766Ig-like C2-type 2Add
BLAST
Domaini234 – 30168Ig-like C2-type 3Add
BLAST
Domaini329 – 38254Ig-like C2-type 4Add
BLAST
Domaini416 – 46954Ig-like C2-type 5Add
BLAST

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. ICAM family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG146347.
GeneTreeiENSGT00530000063246.
HOGENOMiHOG000059554.
HOVERGENiHBG052074.
InParanoidiP32942.
KOiK06486.
OMAiYGPKIDR.
OrthoDBiEOG7QG43X.
PhylomeDBiP32942.
TreeFamiTF333745.

Family and domain databases

Gene3Di2.60.40.10. 5 hits.
InterProiIPR003988. ICAM.
IPR013768. ICAM_N.
IPR003987. ICAM_VCAM_N.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]
PfamiPF03921. ICAM_N. 1 hit.
[Graphical view]
PRINTSiPR01473. ICAM.
PR01472. ICAMVCAM1.
SMARTiSM00409. IG. 2 hits.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P32942-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MATMVPSVLW PRACWTLLVC CLLTPGVQGQ EFLLRVEPQN PVLSAGGSLF
60 70 80 90 100
VNCSTDCPSS EKIALETSLS KELVASGMGW AAFNLSNVTG NSRILCSVYC
110 120 130 140 150
NGSQITGSSN ITVYRLPERV ELAPLPPWQP VGQNFTLRCQ VEDGSPRTSL
160 170 180 190 200
TVVLLRWEEE LSRQPAVEEP AEVTATVLAS RDDHGAPFSC RTELDMQPQG
210 220 230 240 250
LGLFVNTSAP RQLRTFVLPV TPPRLVAPRF LEVETSWPVD CTLDGLFPAS
260 270 280 290 300
EAQVYLALGD QMLNATVMNH GDTLTATATA TARADQEGAR EIVCNVTLGG
310 320 330 340 350
ERREARENLT VFSFLGPIVN LSEPTAHEGS TVTVSCMAGA RVQVTLDGVP
360 370 380 390 400
AAAPGQPAQL QLNATESDDG RSFFCSATLE VDGEFLHRNS SVQLRVLYGP
410 420 430 440 450
KIDRATCPQH LKWKDKTRHV LQCQARGNPY PELRCLKEGS SREVPVGIPF
460 470 480 490 500
FVNVTHNGTY QCQASSSRGK YTLVVVMDIE AGSSHFVPVF VAVLLTLGVV
510 520 530 540
TIVLALMYVF REHQRSGSYH VREESTYLPL TSMQPTEAMG EEPSRAE
Length:547
Mass (Da):59,541
Last modified:September 23, 2008 - v2
Checksum:i4B7BDC02F24F3031
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti60 – 601S → F in AAB24331. (PubMed:1448173)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti63 – 631I → V.
Corresponds to variant rs17697947 [ dbSNP | Ensembl ].
VAR_046547
Natural varianti115 – 1151R → G.2 Publications
Corresponds to variant rs7258015 [ dbSNP | Ensembl ].
VAR_059394
Natural varianti143 – 1431D → G.3 Publications
Corresponds to variant rs2304237 [ dbSNP | Ensembl ].
VAR_046548
Natural varianti525 – 5251S → T.
Corresponds to variant rs2230399 [ dbSNP | Ensembl ].
VAR_024498

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S50015 mRNA. Translation: AAB24331.2. Sequence problems.
X69711 mRNA. Translation: CAA49369.1.
X69819 mRNA. Translation: CAA49473.1.
DQ217937 Genomic DNA. Translation: ABB01007.1.
CH471106 Genomic DNA. Translation: EAW84092.1.
BC058903 mRNA. Translation: AAH58903.1.
CCDSiCCDS12235.1.
PIRiS28904.
RefSeqiNP_002153.2. NM_002162.3.
UniGeneiHs.654563.

Genome annotation databases

EnsembliENST00000160262; ENSP00000160262; ENSG00000076662.
GeneIDi3385.
KEGGihsa:3385.
UCSCiuc002mob.2. human.

Polymorphism databases

DMDMi206729872.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

R&D Systems' cytokine source book: ICAM-3
Functional Glycomics Gateway - Glycan Binding

ICAM-3

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S50015 mRNA. Translation: AAB24331.2 . Sequence problems.
X69711 mRNA. Translation: CAA49369.1 .
X69819 mRNA. Translation: CAA49473.1 .
DQ217937 Genomic DNA. Translation: ABB01007.1 .
CH471106 Genomic DNA. Translation: EAW84092.1 .
BC058903 mRNA. Translation: AAH58903.1 .
CCDSi CCDS12235.1.
PIRi S28904.
RefSeqi NP_002153.2. NM_002162.3.
UniGenei Hs.654563.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1T0P X-ray 1.66 B 30-114 [» ]
ProteinModelPortali P32942.
SMRi P32942. Positions 30-479.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109612. 5 interactions.
IntActi P32942. 3 interactions.
MINTi MINT-1391707.
STRINGi 9606.ENSP00000160262.

PTM databases

PhosphoSitei P32942.
UniCarbKBi P32942.

Polymorphism databases

DMDMi 206729872.

Proteomic databases

MaxQBi P32942.
PaxDbi P32942.
PRIDEi P32942.

Protocols and materials databases

DNASUi 3385.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000160262 ; ENSP00000160262 ; ENSG00000076662 .
GeneIDi 3385.
KEGGi hsa:3385.
UCSCi uc002mob.2. human.

Organism-specific databases

CTDi 3385.
GeneCardsi GC19M010444.
H-InvDB HIX0014743.
HGNCi HGNC:5346. ICAM3.
HPAi CAB002498.
MIMi 146631. gene.
neXtProti NX_P32942.
PharmGKBi PA29594.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG146347.
GeneTreei ENSGT00530000063246.
HOGENOMi HOG000059554.
HOVERGENi HBG052074.
InParanoidi P32942.
KOi K06486.
OMAi YGPKIDR.
OrthoDBi EOG7QG43X.
PhylomeDBi P32942.
TreeFami TF333745.

Enzyme and pathway databases

Reactomei REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
REACT_13552. Integrin cell surface interactions.

Miscellaneous databases

EvolutionaryTracei P32942.
GeneWikii ICAM3.
GenomeRNAii 3385.
NextBioi 13392.
PROi P32942.
SOURCEi Search...

Gene expression databases

Bgeei P32942.
CleanExi HS_ICAM3.
ExpressionAtlasi P32942. baseline and differential.
Genevestigatori P32942.

Family and domain databases

Gene3Di 2.60.40.10. 5 hits.
InterProi IPR003988. ICAM.
IPR013768. ICAM_N.
IPR003987. ICAM_VCAM_N.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view ]
Pfami PF03921. ICAM_N. 1 hit.
[Graphical view ]
PRINTSi PR01473. ICAM.
PR01472. ICAMVCAM1.
SMARTi SM00409. IG. 2 hits.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of ICAM-3, a third ligand for LFA-1, constitutively expressed on resting leukocytes."
    Fawcett J., Holness C.L., Needham L.A., Turley H., Gatter K.C., Mason D.Y., Simmons D.L.
    Nature 360:481-484(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS AND GLY-115 GLY-143.
  2. "Cloning and characterization of a new intercellular adhesion molecule ICAM-R."
    Vazeux R., Hoffman P.A., Tomita J.K., Dickinson E.S., Jasman R.L., St John T., Gallatin W.M.
    Nature 360:485-488(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS GLY-115 AND GLY-143.
  3. "Cloning and expression of intercellular adhesion molecule 3 reveals strong homology to other immunoglobulin family counter-receptors for lymphocyte function-associated antigen 1."
    de Fougerolles A.R., Kilckstein L.B., Springer T.A.
    J. Exp. Med. 177:1187-1192(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS GLY-115 AND GLY-143.
  4. "Genetic variation in immune response genes."
    Tan J., Ong R., Hibberd M.L., Seielstad M.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  7. Cited for: PROTEIN SEQUENCE OF 197-217; 269-293 AND 338-365.
  8. "Structural study of N-linked oligosaccharides of human intercellular adhesion molecule-3 (CD50)."
    Funatsu O., Sato T., Kotovuori P., Gahmberg C.G., Ikekita M., Furukawa K.
    Eur. J. Biochem. 268:1020-1029(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE OF N-LINKED CARBOHYDRATES.
  9. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
    Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
    J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-206 AND ASN-363.
    Tissue: Plasma.
  10. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-206 AND ASN-363.
    Tissue: Liver.
  11. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
    Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
    Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-84; ASN-87; ASN-91; ASN-134; ASN-206; ASN-295 AND ASN-363.
    Tissue: Leukemic T-cell.
  12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  14. "An atomic resolution view of ICAM recognition in a complex between the binding domains of ICAM-3 and integrin alphaLbeta2."
    Song G., Yang Y., Liu J.-H., Casasnovas J.M., Shimaoka M., Springer T.A., Wang J.-H.
    Proc. Natl. Acad. Sci. U.S.A. 102:3366-3371(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.66 ANGSTROMS) OF 30-115 IN COMPLEX WITH INTEGRIN ALPHALBETA2, DISULFIDE BOND, GLYCOSYLATION AT ASN-52 AND ASN-110.

Entry informationi

Entry nameiICAM3_HUMAN
AccessioniPrimary (citable) accession number: P32942
Secondary accession number(s): Q6PD68
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: September 23, 2008
Last modified: October 29, 2014
This is version 156 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3