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Protein

Cytokine receptor common subunit beta

Gene

CSF2RB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

BioCyciZFISH:ENSG00000100368-MONOMER.
ReactomeiR-HSA-114604. GPVI-mediated activation cascade.
R-HSA-392451. G beta:gamma signalling through PI3Kgamma.
R-HSA-512988. Interleukin-3, 5 and GM-CSF signaling.
R-HSA-5673001. RAF/MAP kinase cascade.
R-HSA-5683826. Surfactant metabolism.
R-HSA-5688849. Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5).
R-HSA-5688890. Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4).
R-HSA-912526. Interleukin receptor SHC signaling.
SignaLinkiP32927.
SIGNORiP32927.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytokine receptor common subunit beta
Alternative name(s):
CDw131
GM-CSF/IL-3/IL-5 receptor common beta subunit
CD_antigen: CD131
Gene namesi
Name:CSF2RB
Synonyms:IL3RB, IL5RB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:2436. CSF2RB.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini17 – 443ExtracellularSequence analysisAdd BLAST427
Transmembranei444 – 460HelicalSequence analysisAdd BLAST17
Topological domaini461 – 897CytoplasmicSequence analysisAdd BLAST437

GO - Cellular componenti

  • granulocyte macrophage colony-stimulating factor receptor complex Source: UniProtKB
  • integral component of plasma membrane Source: UniProtKB
  • intracellular Source: GOC
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Pulmonary surfactant metabolism dysfunction 5 (SMDP5)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress.
See also OMIM:614370

Organism-specific databases

DisGeNETi1439.
MalaCardsiCSF2RB.
MIMi614370. phenotype.
OpenTargetsiENSG00000100368.
Orphaneti264675. Congenital pulmonary alveolar proteinosis.
PharmGKBiPA26939.

Chemistry databases

ChEMBLiCHEMBL2364169.
DrugBankiDB00020. Sargramostim.

Polymorphism and mutation databases

BioMutaiCSF2RB.
DMDMi1345923.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_000001086217 – 897Cytokine receptor common subunit betaAdd BLAST881

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi35 ↔ 45
Glycosylationi58N-linked (GlcNAc...)2 Publications1
Disulfide bondi75 ↔ 96
Disulfide bondi86 ↔ 91
Glycosylationi191N-linked (GlcNAc...)2 Publications1
Disulfide bondi250 ↔ 260
Disulfide bondi289 ↔ 306
Glycosylationi346N-linked (GlcNAc...)Sequence analysis1
Modified residuei766PhosphotyrosineBy similarity1

Post-translational modificationi

May be phosphorylated by LYN.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP32927.
PeptideAtlasiP32927.
PRIDEiP32927.

PTM databases

iPTMnetiP32927.
PhosphoSitePlusiP32927.

Expressioni

Gene expression databases

BgeeiENSG00000100368.
CleanExiHS_CSF2RB.
ExpressionAtlasiP32927. baseline and differential.
GenevisibleiP32927. HS.

Organism-specific databases

HPAiCAB010251.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit. The beta subunit is common to the IL3, IL5 and GM-CSF receptors. The signaling GM-CSF receptor complex is a dodecamer of two head-to-head hexamers of two alpha, two beta, and two ligand subunits. Interacts with TMEM102; this interaction occurs preferentially in the absence of CSF2. Interacts with LYN (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
CSF2P041412EBI-1809771,EBI-1809826
IL5P051132EBI-1809771,EBI-2435811
IL5RAQ013443EBI-1809771,EBI-1759442
ITGB1P055565EBI-1809771,EBI-703066
JAK2O606744EBI-1809771,EBI-518647

Protein-protein interaction databases

BioGridi107826. 15 interactors.
DIPiDIP-127N.
IntActiP32927. 15 interactors.
MINTiMINT-105697.
STRINGi9606.ENSP00000384053.

Structurei

Secondary structure

1897
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi28 – 32Combined sources5
Beta strandi34 – 37Combined sources4
Beta strandi39 – 50Combined sources12
Helixi51 – 54Combined sources4
Beta strandi59 – 66Combined sources8
Beta strandi69 – 72Combined sources4
Beta strandi75 – 77Combined sources3
Beta strandi88 – 99Combined sources12
Beta strandi108 – 117Combined sources10
Beta strandi121 – 126Combined sources6
Helixi127 – 129Combined sources3
Beta strandi137 – 144Combined sources8
Beta strandi147 – 153Combined sources7
Beta strandi162 – 164Combined sources3
Helixi166 – 168Combined sources3
Beta strandi169 – 177Combined sources9
Helixi182 – 184Combined sources3
Beta strandi186 – 197Combined sources12
Turni199 – 201Combined sources3
Beta strandi207 – 216Combined sources10
Beta strandi218 – 221Combined sources4
Beta strandi233 – 236Combined sources4
Beta strandi246 – 252Combined sources7
Beta strandi254 – 265Combined sources12
Helixi266 – 269Combined sources4
Beta strandi274 – 279Combined sources6
Beta strandi292 – 295Combined sources4
Turni298 – 300Combined sources3
Beta strandi301 – 309Combined sources9
Turni313 – 315Combined sources3
Beta strandi318 – 325Combined sources8
Beta strandi330 – 333Combined sources4
Helixi334 – 336Combined sources3
Beta strandi337 – 339Combined sources3
Beta strandi344 – 348Combined sources5
Beta strandi350 – 352Combined sources3
Beta strandi355 – 359Combined sources5
Beta strandi365 – 367Combined sources3
Beta strandi370 – 377Combined sources8
Beta strandi379 – 381Combined sources3
Helixi383 – 385Combined sources3
Beta strandi388 – 393Combined sources6
Beta strandi395 – 398Combined sources4
Beta strandi405 – 407Combined sources3
Beta strandi409 – 416Combined sources8
Beta strandi418 – 420Combined sources3
Beta strandi432 – 436Combined sources5
Helixi442 – 466Combined sources25

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1C8PNMR-A338-438[»]
1EGJX-ray2.80A338-438[»]
1GH7X-ray3.00A/B25-437[»]
2GYSX-ray2.70A/B25-437[»]
2NA8NMR-A432-473[»]
2NA9NMR-A432-473[»]
4NKQX-ray3.30A25-438[»]
5DWUX-ray3.97A17-240[»]
B241-443[»]
ProteinModelPortaliP32927.
SMRiP32927.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP32927.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini133 – 240Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST108
Domaini339 – 436Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST98

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi425 – 429WSXWS motif5
Motifi474 – 482Box 1 motif9

Domaini

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation.

Sequence similaritiesi

Contains 2 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGEX. Eukaryota.
ENOG4112BQP. LUCA.
GeneTreeiENSGT00510000048963.
HOGENOMiHOG000113049.
HOVERGENiHBG052113.
InParanoidiP32927.
KOiK04738.
OMAiCRWADTQ.
OrthoDBiEOG091G05K0.
PhylomeDBiP32927.
TreeFamiTF337996.

Family and domain databases

CDDicd00063. FN3. 2 hits.
Gene3Di2.60.40.10. 4 hits.
InterProiIPR003961. FN3_dom.
IPR003531. Hempt_rcpt_S_F1_CS.
IPR013783. Ig-like_fold.
IPR011365. IL3_rcpt_beta.
IPR015373. Interferon/interleukin_rcp_dom.
IPR015321. TypeI_recpt_CBD.
[Graphical view]
PfamiPF09240. IL6Ra-bind. 1 hit.
PF09294. Interfer-bind. 1 hit.
[Graphical view]
PIRSFiPIRSF001956. IL3R_beta_c. 1 hit.
SMARTiSM00060. FN3. 2 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 4 hits.
PROSITEiPS50853. FN3. 2 hits.
PS01355. HEMATOPO_REC_S_F1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P32927-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVLAQGLLSM ALLALCWERS LAGAEETIPL QTLRCYNDYT SHITCRWADT
60 70 80 90 100
QDAQRLVNVT LIRRVNEDLL EPVSCDLSDD MPWSACPHPR CVPRRCVIPC
110 120 130 140 150
QSFVVTDVDY FSFQPDRPLG TRLTVTLTQH VQPPEPRDLQ ISTDQDHFLL
160 170 180 190 200
TWSVALGSPQ SHWLSPGDLE FEVVYKRLQD SWEDAAILLS NTSQATLGPE
210 220 230 240 250
HLMPSSTYVA RVRTRLAPGS RLSGRPSKWS PEVCWDSQPG DEAQPQNLEC
260 270 280 290 300
FFDGAAVLSC SWEVRKEVAS SVSFGLFYKP SPDAGEEECS PVLREGLGSL
310 320 330 340 350
HTRHHCQIPV PDPATHGQYI VSVQPRRAEK HIKSSVNIQM APPSLNVTKD
360 370 380 390 400
GDSYSLRWET MKMRYEHIDH TFEIQYRKDT ATWKDSKTET LQNAHSMALP
410 420 430 440 450
ALEPSTRYWA RVRVRTSRTG YNGIWSEWSE ARSWDTESVL PMWVLALIVI
460 470 480 490 500
FLTIAVLLAL RFCGIYGYRL RRKWEEKIPN PSKSHLFQNG SAELWPPGSM
510 520 530 540 550
SAFTSGSPPH QGPWGSRFPE LEGVFPVGFG DSEVSPLTIE DPKHVCDPPS
560 570 580 590 600
GPDTTPAASD LPTEQPPSPQ PGPPAASHTP EKQASSFDFN GPYLGPPHSR
610 620 630 640 650
SLPDILGQPE PPQEGGSQKS PPPGSLEYLC LPAGGQVQLV PLAQAMGPGQ
660 670 680 690 700
AVEVERRPSQ GAAGSPSLES GGGPAPPALG PRVGGQDQKD SPVAIPMSSG
710 720 730 740 750
DTEDPGVASG YVSSADLVFT PNSGASSVSL VPSLGLPSDQ TPSLCPGLAS
760 770 780 790 800
GPPGAPGPVK SGFEGYVELP PIEGRSPRSP RNNPVPPEAK SPVLNPGERP
810 820 830 840 850
ADVSPTSPQP EGLLVLQQVG DYCFLPGLGP GPLSLRSKPS SPGPGPEIKN
860 870 880 890
LDQAFQVKKP PGQAVPQVPV IQLFKALKQQ DYLSLPPWEV NKPGEVC
Length:897
Mass (Da):97,336
Last modified:February 1, 1996 - v2
Checksum:i3398E37FDB8F393A
GO
Isoform 2 (identifier: P32927-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     285-285: G → GSAVLLR

Show »
Length:903
Mass (Da):97,976
Checksum:iAE8FFF1721CD63F2
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_042521249E → Q.Corresponds to variant rs16845dbSNPEnsembl.1
Natural variantiVAR_014801603P → T.1 PublicationCorresponds to variant rs1801122dbSNPEnsembl.1
Natural variantiVAR_014802647G → V.Corresponds to variant rs1801115dbSNPEnsembl.1
Natural variantiVAR_014803652V → M.Corresponds to variant rs1801114dbSNPEnsembl.1
Natural variantiVAR_042522696P → S.Corresponds to variant rs16997517dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_032798285G → GSAVLLR in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M59941 mRNA. Translation: AAA18171.1.
CR456428 mRNA. Translation: CAG30314.1.
AL008637, AL133392 Genomic DNA. Translation: CAI17999.1.
AL008637, AL133392 Genomic DNA. Translation: CAQ10744.1.
CH471095 Genomic DNA. Translation: EAW60125.1.
CH471095 Genomic DNA. Translation: EAW60126.1.
CCDSiCCDS13936.1. [P32927-1]
PIRiA39255.
RefSeqiNP_000386.1. NM_000395.2. [P32927-1]
XP_005261397.1. XM_005261340.3. [P32927-2]
UniGeneiHs.592192.

Genome annotation databases

EnsembliENST00000403662; ENSP00000384053; ENSG00000100368. [P32927-1]
ENST00000406230; ENSP00000385271; ENSG00000100368. [P32927-2]
GeneIDi1439.
KEGGihsa:1439.
UCSCiuc003aqa.5. human. [P32927-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M59941 mRNA. Translation: AAA18171.1.
CR456428 mRNA. Translation: CAG30314.1.
AL008637, AL133392 Genomic DNA. Translation: CAI17999.1.
AL008637, AL133392 Genomic DNA. Translation: CAQ10744.1.
CH471095 Genomic DNA. Translation: EAW60125.1.
CH471095 Genomic DNA. Translation: EAW60126.1.
CCDSiCCDS13936.1. [P32927-1]
PIRiA39255.
RefSeqiNP_000386.1. NM_000395.2. [P32927-1]
XP_005261397.1. XM_005261340.3. [P32927-2]
UniGeneiHs.592192.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1C8PNMR-A338-438[»]
1EGJX-ray2.80A338-438[»]
1GH7X-ray3.00A/B25-437[»]
2GYSX-ray2.70A/B25-437[»]
2NA8NMR-A432-473[»]
2NA9NMR-A432-473[»]
4NKQX-ray3.30A25-438[»]
5DWUX-ray3.97A17-240[»]
B241-443[»]
ProteinModelPortaliP32927.
SMRiP32927.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107826. 15 interactors.
DIPiDIP-127N.
IntActiP32927. 15 interactors.
MINTiMINT-105697.
STRINGi9606.ENSP00000384053.

Chemistry databases

ChEMBLiCHEMBL2364169.
DrugBankiDB00020. Sargramostim.

PTM databases

iPTMnetiP32927.
PhosphoSitePlusiP32927.

Polymorphism and mutation databases

BioMutaiCSF2RB.
DMDMi1345923.

Proteomic databases

PaxDbiP32927.
PeptideAtlasiP32927.
PRIDEiP32927.

Protocols and materials databases

DNASUi1439.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000403662; ENSP00000384053; ENSG00000100368. [P32927-1]
ENST00000406230; ENSP00000385271; ENSG00000100368. [P32927-2]
GeneIDi1439.
KEGGihsa:1439.
UCSCiuc003aqa.5. human. [P32927-1]

Organism-specific databases

CTDi1439.
DisGeNETi1439.
GeneCardsiCSF2RB.
HGNCiHGNC:2436. CSF2RB.
HPAiCAB010251.
MalaCardsiCSF2RB.
MIMi138981. gene.
614370. phenotype.
neXtProtiNX_P32927.
OpenTargetsiENSG00000100368.
Orphaneti264675. Congenital pulmonary alveolar proteinosis.
PharmGKBiPA26939.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGEX. Eukaryota.
ENOG4112BQP. LUCA.
GeneTreeiENSGT00510000048963.
HOGENOMiHOG000113049.
HOVERGENiHBG052113.
InParanoidiP32927.
KOiK04738.
OMAiCRWADTQ.
OrthoDBiEOG091G05K0.
PhylomeDBiP32927.
TreeFamiTF337996.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000100368-MONOMER.
ReactomeiR-HSA-114604. GPVI-mediated activation cascade.
R-HSA-392451. G beta:gamma signalling through PI3Kgamma.
R-HSA-512988. Interleukin-3, 5 and GM-CSF signaling.
R-HSA-5673001. RAF/MAP kinase cascade.
R-HSA-5683826. Surfactant metabolism.
R-HSA-5688849. Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5).
R-HSA-5688890. Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4).
R-HSA-912526. Interleukin receptor SHC signaling.
SignaLinkiP32927.
SIGNORiP32927.

Miscellaneous databases

ChiTaRSiCSF2RB. human.
EvolutionaryTraceiP32927.
GenomeRNAii1439.
PROiP32927.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000100368.
CleanExiHS_CSF2RB.
ExpressionAtlasiP32927. baseline and differential.
GenevisibleiP32927. HS.

Family and domain databases

CDDicd00063. FN3. 2 hits.
Gene3Di2.60.40.10. 4 hits.
InterProiIPR003961. FN3_dom.
IPR003531. Hempt_rcpt_S_F1_CS.
IPR013783. Ig-like_fold.
IPR011365. IL3_rcpt_beta.
IPR015373. Interferon/interleukin_rcp_dom.
IPR015321. TypeI_recpt_CBD.
[Graphical view]
PfamiPF09240. IL6Ra-bind. 1 hit.
PF09294. Interfer-bind. 1 hit.
[Graphical view]
PIRSFiPIRSF001956. IL3R_beta_c. 1 hit.
SMARTiSM00060. FN3. 2 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 4 hits.
PROSITEiPS50853. FN3. 2 hits.
PS01355. HEMATOPO_REC_S_F1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIL3RB_HUMAN
AccessioniPrimary (citable) accession number: P32927
Secondary accession number(s): Q5JZI1, Q6ICE0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: February 1, 1996
Last modified: November 30, 2016
This is version 178 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.