ID   SIGM2_REOVJ             Reviewed;         418 AA.
AC   P32922;
DT   01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1993, sequence version 1.
DT   27-MAR-2024, entry version 69.
DE   RecName: Full=Inner capsid protein sigma-2;
DE            Short=Sigma2;
GN   Name=S2;
OS   Reovirus type 2 (strain D5/Jones) (T2J) (Mammalian orthoreovirus 2).
OC   Viruses; Riboviria; Orthornavirae; Duplornaviricota; Resentoviricetes;
OC   Reovirales; Spinareoviridae; Orthoreovirus; Mammalian orthoreovirus.
OX   NCBI_TaxID=10885;
OH   NCBI_TaxID=40674; Mammalia.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=1920614; DOI=10.1128/jvi.65.11.5721-5731.1991;
RA   Dermody T.S., Schiff L.A., Nibert M.L., Coombs K.M., Fields B.N.;
RT   "The S2 gene nucleotide sequences of prototype strains of the three
RT   reovirus serotypes: characterization of reovirus core protein sigma 2.";
RL   J. Virol. 65:5721-5731(1991).
CC   -!- FUNCTION: Inner capsid (core) component.
CC   -!- SUBUNIT: Interacts with protein mu-NS; in viral inclusions.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000305}. Note=Found in the inner
CC       capsid (150 copies).
CC   -!- SIMILARITY: Belongs to the orthoreovirus sigma-1 protein family.
CC       {ECO:0000305}.
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DR   EMBL; L19775; AAA47248.1; -; Genomic_RNA.
DR   PIR; B41306; FOXRJS.
DR   SMR; P32922; -.
DR   Proteomes; UP000006370; Genome.
DR   GO; GO:0039625; C:viral inner capsid; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.287.1520; -; 1.
DR   InterPro; IPR004317; Sigma_1_2_reovir.
DR   Pfam; PF03084; Sigma_1_2; 1.
PE   3: Inferred from homology;
KW   Capsid protein; Inner capsid protein; Virion.
FT   CHAIN           1..418
FT                   /note="Inner capsid protein sigma-2"
FT                   /id="PRO_0000222750"
SQ   SEQUENCE   418 AA;  47045 MW;  E3D4351F55524213 CRC64;
     MARAAFLFKT VGFGGLQNVP INDELASHLL RAGNSPWQLT QFLDWISLGR GLATSALVPT
     AGSRYYQMSC LLSGTLQIPF RPNHRWGDVR FLRLVWSAPT LDGLVIAPPP ILAQPAIQAQ
     ADRAYDCDDY PFLARDPRFK HRVYQQLSAI TLLNLTGFGP ISYVRVDEDM WSGDVSQLLM
     NYFGHTFAEI AYTLCQASAN RPWEHDGTYA RMTQIVLSLF WLSYVGVIHQ HNTYRTFYFQ
     CNRRGDAAEV WILSCSLTHS AQIRAGNRSL FVMPTSPDWN MDVNLILSST LTGCLCSGSQ
     LPLIDNNSVP NVSRNIHGWT GRGGNQLHGF QVRRMITEYC DRLRRDGVMT PAQQMQIEAL
     GDQTQQFKRD KLEAWALEDD QYNRAHPNST MFRTKPFTNA QWGRGNTAAT SAAIAALI
//