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Protein

Vacuolar protein sorting-associated protein 17

Gene

VPS17

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in vesicular protein sorting. Required for the sorting and delivery of a subset of soluble vacuolar hydrolases. Required for retention of late Golgi membrane proteins and vacuolar biogenesis. Component of the membrane-associated retromer complex which is essential in endosome-to-Golgi retrograde transport. The VPS5-VPS17 subcomplex may assemble onto the membrane to promote vesicle formation.

GO - Molecular functioni

  • phosphatidylinositol-3-phosphate binding Source: SGD

GO - Biological processi

  • endocytosis Source: GO_Central
  • protein transport Source: UniProtKB-KW
  • retrograde transport, endosome to Golgi Source: SGD
  • vesicle organization Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-33656-MONOMER.

Protein family/group databases

TCDBi9.A.63.1.1. the retromer-dependnet vacuolar protein sorting (r-vps) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Vacuolar protein sorting-associated protein 17
Alternative name(s):
Carboxypeptidase Y-deficient protein 21
Gene namesi
Name:VPS17
Synonyms:PEP21
Ordered Locus Names:YOR132W
ORF Names:O3314, YOR3314W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOR132W.
SGDiS000005658. VPS17.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: GOC
  • endosome Source: SGD
  • extrinsic component of membrane Source: GO_Central
  • retromer, tubulation complex Source: SGD
  • retromer complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 551551Vacuolar protein sorting-associated protein 17PRO_0000065892Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei544 – 5441PhosphoserineCombined sources

Post-translational modificationi

Phosphorylated on one or more serine residues.

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP32913.

PTM databases

iPTMnetiP32913.

Interactioni

Subunit structurei

Component of the retromer complex which consists of VPS29, VPS26, VPS35, VPS5 and VPS17. Component of a retromer subcomplex consisting of VPS5 and VPS17.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
VPS35P341103EBI-20366,EBI-20415
VPS5Q923317EBI-20366,EBI-20483
YIF1P538452EBI-20366,EBI-28230
YIP1P530392EBI-20366,EBI-25295

Protein-protein interaction databases

BioGridi34528. 203 interactions.
DIPiDIP-1739N.
IntActiP32913. 17 interactions.
MINTiMINT-391669.

Structurei

3D structure databases

ProteinModelPortaliP32913.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini108 – 227120PXAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili359 – 38527Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the VPS17 family.Curated
Contains 1 PX (phox homology) domain.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOGENOMiHOG000172935.
InParanoidiP32913.
OMAiRFRTTQY.
OrthoDBiEOG092C1J9Y.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiIPR001683. Phox.
IPR014461. Retromer_complex_Vps17.
[Graphical view]
PfamiPF00787. PX. 1 hit.
[Graphical view]
PIRSFiPIRSF011791. Vps17. 1 hit.
SMARTiSM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF64268. SSF64268. 1 hit.

Sequencei

Sequence statusi: Complete.

P32913-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSAVPYDPY DDLDNNPFAE PQEEDSEPAA TTTDGSSSMS EERVGTEQTA
60 70 80 90 100
ASVQDNGTAN NIQNGLGEEG NATRSKTSNE HNENQQPSQP SERVILPERS
110 120 130 140 150
DEKKKYTLLA KVTGLERFGS ATGKKENPTI IFDCSTNLPT FRKQQYKNVK
160 170 180 190 200
KSYEEFHQLF KYLNVAIQES FVPTLPSAYT TFGINSEEDR MKVTRNFQLW
210 220 230 240 250
FNRLSQDPLI IRNEEVAFFI ESDFNTYTPI NKSKSLASGL KRKTLKQLAP
260 270 280 290 300
PYDEITELAE FRPLVKSIYV VSQSLQEKLL RVSRNRKMMV QEENAFGQDF
310 320 330 340 350
VNLDEHNKLY RRYGKILTAV GDIDSIIATM DMATLYDGLE WIVRDAYAVK
360 370 380 390 400
EALTNRHFIM RNLVQAQQNS KAKQEQARRF RSRRDINPMK IDEALRQLKA
410 420 430 440 450
AAKNEQVLTL KLQRITSNMI IERKQWISWY EEWIRSSIKE FTLRKIEYER
460 470 480 490 500
KKLTLLERVR SDIRKADENG GLSRLGRHAV SNNNSDTSQT LKGDSWTGES
510 520 530 540 550
NRKSQIPINK IAHTEFDDEL FTEDDGYNSQ DSDTTSLNAR HAASLLGMST

K
Length:551
Mass (Da):63,204
Last modified:November 1, 1997 - v2
Checksum:iC709968468144A50
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti25 – 251D → G in AAA35213 (PubMed:8416961).Curated
Sequence conflicti30 – 301A → T in AAA35213 (PubMed:8416961).Curated
Sequence conflicti62 – 621I → V in AAA35213 (PubMed:8416961).Curated
Sequence conflicti68 – 681E → G in AAA35213 (PubMed:8416961).Curated
Sequence conflicti90 – 901P → S in AAA35213 (PubMed:8416961).Curated
Sequence conflicti402 – 4021A → T in AAA35213 (PubMed:8416961).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L02869 Genomic DNA. Translation: AAA35213.1.
X94335 Genomic DNA. Translation: CAA64051.1.
X90518 Genomic DNA. Translation: CAA62115.1.
Z75040 Genomic DNA. Translation: CAA99331.1.
BK006948 Genomic DNA. Translation: DAA10906.1.
PIRiS60994.
RefSeqiNP_014775.3. NM_001183551.3.

Genome annotation databases

EnsemblFungiiYOR132W; YOR132W; YOR132W.
GeneIDi854300.
KEGGisce:YOR132W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L02869 Genomic DNA. Translation: AAA35213.1.
X94335 Genomic DNA. Translation: CAA64051.1.
X90518 Genomic DNA. Translation: CAA62115.1.
Z75040 Genomic DNA. Translation: CAA99331.1.
BK006948 Genomic DNA. Translation: DAA10906.1.
PIRiS60994.
RefSeqiNP_014775.3. NM_001183551.3.

3D structure databases

ProteinModelPortaliP32913.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34528. 203 interactions.
DIPiDIP-1739N.
IntActiP32913. 17 interactions.
MINTiMINT-391669.

Protein family/group databases

TCDBi9.A.63.1.1. the retromer-dependnet vacuolar protein sorting (r-vps) family.

PTM databases

iPTMnetiP32913.

Proteomic databases

MaxQBiP32913.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYOR132W; YOR132W; YOR132W.
GeneIDi854300.
KEGGisce:YOR132W.

Organism-specific databases

EuPathDBiFungiDB:YOR132W.
SGDiS000005658. VPS17.

Phylogenomic databases

HOGENOMiHOG000172935.
InParanoidiP32913.
OMAiRFRTTQY.
OrthoDBiEOG092C1J9Y.

Enzyme and pathway databases

BioCyciYEAST:G3O-33656-MONOMER.

Miscellaneous databases

PROiP32913.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiIPR001683. Phox.
IPR014461. Retromer_complex_Vps17.
[Graphical view]
PfamiPF00787. PX. 1 hit.
[Graphical view]
PIRSFiPIRSF011791. Vps17. 1 hit.
SMARTiSM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF64268. SSF64268. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiVPS17_YEAST
AccessioniPrimary (citable) accession number: P32913
Secondary accession number(s): D6W2J0, Q12279
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: November 1, 1997
Last modified: September 7, 2016
This is version 142 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 7380 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.