Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Vacuolar protein sorting-associated protein 17

Gene

VPS17

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in vesicular protein sorting. Required for the sorting and delivery of a subset of soluble vacuolar hydrolases. Required for retention of late Golgi membrane proteins and vacuolar biogenesis. Component of the membrane-associated retromer complex which is essential in endosome-to-Golgi retrograde transport. The VPS5-VPS17 subcomplex may assemble onto the membrane to promote vesicle formation.

Miscellaneous

Present with 7380 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • phosphatidylinositol-3-phosphate binding Source: SGD

GO - Biological processi

  • endocytosis Source: GO_Central
  • protein transport Source: UniProtKB-KW
  • retrograde transport, endosome to Golgi Source: SGD
  • vesicle organization Source: GO_Central

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-33656-MONOMER

Protein family/group databases

TCDBi9.A.63.1.1 the retromer-dependent vacuolar protein sorting (r-vps) family

Names & Taxonomyi

Protein namesi
Recommended name:
Vacuolar protein sorting-associated protein 17
Alternative name(s):
Carboxypeptidase Y-deficient protein 21
Gene namesi
Name:VPS17
Synonyms:PEP21
Ordered Locus Names:YOR132W
ORF Names:O3314, YOR3314W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOR132W
SGDiS000005658 VPS17

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000658921 – 551Vacuolar protein sorting-associated protein 17Add BLAST551

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei544PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated on one or more serine residues.

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP32913
PaxDbiP32913
PRIDEiP32913

PTM databases

iPTMnetiP32913

Interactioni

Subunit structurei

Component of the retromer complex which consists of VPS29, VPS26, VPS35, VPS5 and VPS17. Component of a retromer subcomplex consisting of VPS5 and VPS17.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi34528, 407 interactors
DIPiDIP-1739N
IntActiP32913, 22 interactors
MINTiP32913
STRINGi4932.YOR132W

Structurei

3D structure databases

ProteinModelPortaliP32913
SMRiP32913
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini108 – 227PXAdd BLAST120

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili359 – 385Sequence analysisAdd BLAST27

Sequence similaritiesi

Belongs to the VPS17 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOGENOMiHOG000172935
InParanoidiP32913
OMAiMDAGHKV
OrthoDBiEOG092C1J9Y

Family and domain databases

CDDicd06891 PX_Vps17p, 1 hit
Gene3Di1.20.1270.60, 1 hit
3.30.1520.10, 1 hit
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR001683 Phox
IPR036871 PX_dom_sf
IPR014461 Retromer_complex_Vps17
IPR037907 Vps17_PX
PfamiView protein in Pfam
PF00787 PX, 1 hit
PIRSFiPIRSF011791 Vps17, 1 hit
SMARTiView protein in SMART
SM00312 PX, 1 hit
SUPFAMiSSF64268 SSF64268, 1 hit

Sequencei

Sequence statusi: Complete.

P32913-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSAVPYDPY DDLDNNPFAE PQEEDSEPAA TTTDGSSSMS EERVGTEQTA
60 70 80 90 100
ASVQDNGTAN NIQNGLGEEG NATRSKTSNE HNENQQPSQP SERVILPERS
110 120 130 140 150
DEKKKYTLLA KVTGLERFGS ATGKKENPTI IFDCSTNLPT FRKQQYKNVK
160 170 180 190 200
KSYEEFHQLF KYLNVAIQES FVPTLPSAYT TFGINSEEDR MKVTRNFQLW
210 220 230 240 250
FNRLSQDPLI IRNEEVAFFI ESDFNTYTPI NKSKSLASGL KRKTLKQLAP
260 270 280 290 300
PYDEITELAE FRPLVKSIYV VSQSLQEKLL RVSRNRKMMV QEENAFGQDF
310 320 330 340 350
VNLDEHNKLY RRYGKILTAV GDIDSIIATM DMATLYDGLE WIVRDAYAVK
360 370 380 390 400
EALTNRHFIM RNLVQAQQNS KAKQEQARRF RSRRDINPMK IDEALRQLKA
410 420 430 440 450
AAKNEQVLTL KLQRITSNMI IERKQWISWY EEWIRSSIKE FTLRKIEYER
460 470 480 490 500
KKLTLLERVR SDIRKADENG GLSRLGRHAV SNNNSDTSQT LKGDSWTGES
510 520 530 540 550
NRKSQIPINK IAHTEFDDEL FTEDDGYNSQ DSDTTSLNAR HAASLLGMST

K
Length:551
Mass (Da):63,204
Last modified:November 1, 1997 - v2
Checksum:iC709968468144A50
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti25D → G in AAA35213 (PubMed:8416961).Curated1
Sequence conflicti30A → T in AAA35213 (PubMed:8416961).Curated1
Sequence conflicti62I → V in AAA35213 (PubMed:8416961).Curated1
Sequence conflicti68E → G in AAA35213 (PubMed:8416961).Curated1
Sequence conflicti90P → S in AAA35213 (PubMed:8416961).Curated1
Sequence conflicti402A → T in AAA35213 (PubMed:8416961).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L02869 Genomic DNA Translation: AAA35213.1
X94335 Genomic DNA Translation: CAA64051.1
X90518 Genomic DNA Translation: CAA62115.1
Z75040 Genomic DNA Translation: CAA99331.1
BK006948 Genomic DNA Translation: DAA10906.1
PIRiS60994
RefSeqiNP_014775.3, NM_001183551.3

Genome annotation databases

EnsemblFungiiYOR132W; YOR132W; YOR132W
GeneIDi854300
KEGGisce:YOR132W

Similar proteinsi

Entry informationi

Entry nameiVPS17_YEAST
AccessioniPrimary (citable) accession number: P32913
Secondary accession number(s): D6W2J0, Q12279
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: November 1, 1997
Last modified: March 28, 2018
This is version 157 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health