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Protein

Eukaryotic translation initiation factor eIF-1

Gene

SUI1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Additional factor that functions in concert with eIF-2 and the initiator tRNA in directing the ribosome to the proper start site of translation.

GO - Molecular functioni

  • ribosomal small subunit binding Source: SGD
  • translation initiation factor activity Source: SGD
  • translation initiation factor binding Source: SGD

GO - Biological processi

  • formation of translation preinitiation complex Source: SGD
  • maintenance of translational fidelity Source: SGD
  • regulation of translation Source: UniProtKB-KW

Keywordsi

Biological processProtein biosynthesis, Translation regulation

Enzyme and pathway databases

BioCyciYEAST:G3O-33241-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor eIF-1
Alternative name(s):
Protein translation factor SUI1
Gene namesi
Name:SUI1
Synonyms:RFR1
Ordered Locus Names:YNL244C
ORF Names:N0905
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNL244C
SGDiS000005188 SUI1

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001305662 – 108Eukaryotic translation initiation factor eIF-1Add BLAST107

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP32911
PaxDbiP32911
PRIDEiP32911

PTM databases

iPTMnetiP32911

Interactioni

Subunit structurei

The factors eIF-1, eIF-2, eIF-3, TIF5/eIF-5 and methionyl-tRNAi form a multifactor complex (MFC) that may bind to the 40S ribosome. Interacts with NIP1.1 Publication

GO - Molecular functioni

  • translation initiation factor binding Source: SGD

Protein-protein interaction databases

BioGridi35595, 65 interactors
DIPiDIP-1471N
IntActiP32911, 63 interactors
MINTiP32911
STRINGi4932.YNL244C

Structurei

Secondary structure

1108
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi26 – 32Combined sources7
Beta strandi34 – 36Combined sources3
Beta strandi38 – 44Combined sources7
Beta strandi47 – 49Combined sources3
Helixi51 – 62Combined sources12
Beta strandi67 – 69Combined sources3
Turni72 – 74Combined sources3
Beta strandi77 – 83Combined sources7
Helixi86 – 94Combined sources9
Beta strandi100 – 105Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2OGHNMR-A1-108[»]
2RVHNMR-A1-108[»]
3J80electron microscopy3.75j1-108[»]
3J81electron microscopy4.00m1-108[»]
3JAMelectron microscopy3.46j1-108[»]
3JAPelectron microscopy4.90m1-108[»]
3JAQelectron microscopy6.00m1-108[»]
ProteinModelPortaliP32911
SMRiP32911
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP32911

Family & Domainsi

Sequence similaritiesi

Belongs to the SUI1 family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000015789
HOGENOMiHOG000279813
InParanoidiP32911
KOiK03113
OMAiDKIHIRI
OrthoDBiEOG092C585A

Family and domain databases

CDDicd11566 eIF1_SUI1, 1 hit
InterProiView protein in InterPro
IPR001950 SUI1
IPR036877 SUI1_dom_sf
IPR005874 SUI1_euk
PfamiView protein in Pfam
PF01253 SUI1, 1 hit
PIRSFiPIRSF004499 SUI1_euk, 1 hit
SUPFAMiSSF55159 SSF55159, 1 hit
TIGRFAMsiTIGR01160 SUI1_MOF2, 1 hit
PROSITEiView protein in PROSITE
PS50296 SUI1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P32911-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIENLKSFD PFADTGDDET ATSNYIHIRI QQRNGRKTLT TVQGVPEEYD
60 70 80 90 100
LKRILKVLKK DFACNGNIVK DPEMGEIIQL QGDQRAKVCE FMISQLGLQK

KNIKIHGF
Length:108
Mass (Da):12,312
Last modified:October 1, 1993 - v1
Checksum:i03ECB94F3EF3A417
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M77514 Genomic DNA Translation: AAA35131.1
X96722 Genomic DNA Translation: CAA65499.1
Z71520 Genomic DNA Translation: CAA96150.1
BK006947 Genomic DNA Translation: DAA10315.1
PIRiS31245
RefSeqiNP_014155.1, NM_001183082.1

Genome annotation databases

EnsemblFungiiYNL244C; YNL244C; YNL244C
GeneIDi855477
KEGGisce:YNL244C

Similar proteinsi

Entry informationi

Entry nameiSUI1_YEAST
AccessioniPrimary (citable) accession number: P32911
Secondary accession number(s): D6W0U9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: May 23, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health