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Protein

Eukaryotic translation initiation factor eIF-1

Gene

SUI1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Additional factor that functions in concert with eIF-2 and the initiator tRNA in directing the ribosome to the proper start site of translation.

GO - Molecular functioni

  • ribosomal small subunit binding Source: SGD
  • translation initiation factor activity Source: SGD
  • translation initiation factor binding Source: SGD

GO - Biological processi

  • formation of translation preinitiation complex Source: SGD
  • maintenance of translational fidelity Source: SGD
  • regulation of translation Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Protein biosynthesis, Translation regulation

Enzyme and pathway databases

BioCyciYEAST:G3O-33241-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor eIF-1
Alternative name(s):
Protein translation factor SUI1
Gene namesi
Name:SUI1
Synonyms:RFR1
Ordered Locus Names:YNL244C
ORF Names:N0905
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNL244C.
SGDiS000005188. SUI1.

Subcellular locationi

GO - Cellular componenti

  • eukaryotic 43S preinitiation complex Source: SGD
  • multi-eIF complex Source: SGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001305662 – 108Eukaryotic translation initiation factor eIF-1Add BLAST107

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP32911.
PRIDEiP32911.

PTM databases

iPTMnetiP32911.

Interactioni

Subunit structurei

The factors eIF-1, eIF-2, eIF-3, TIF5/eIF-5 and methionyl-tRNAi form a multifactor complex (MFC) that may bind to the 40S ribosome. Interacts with NIP1.1 Publication

GO - Molecular functioni

  • translation initiation factor binding Source: SGD

Protein-protein interaction databases

BioGridi35595. 64 interactors.
DIPiDIP-1471N.
IntActiP32911. 10 interactors.
MINTiMINT-391861.

Structurei

Secondary structure

1108
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi25 – 31Combined sources7
Beta strandi34 – 36Combined sources3
Beta strandi39 – 43Combined sources5
Helixi51 – 62Combined sources12
Beta strandi66 – 69Combined sources4
Beta strandi77 – 83Combined sources7
Helixi85 – 96Combined sources12
Beta strandi103 – 105Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2OGHNMR-A1-108[»]
3J80electron microscopy3.75j1-108[»]
3J81electron microscopy4.00m1-108[»]
3JAMelectron microscopy3.46j1-108[»]
3JAPelectron microscopy4.90m1-108[»]
3JAQelectron microscopy6.00m1-108[»]
ProteinModelPortaliP32911.
SMRiP32911.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP32911.

Family & Domainsi

Sequence similaritiesi

Belongs to the SUI1 family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000015789.
HOGENOMiHOG000279813.
InParanoidiP32911.
KOiK03113.
OMAiNIHIRIQ.
OrthoDBiEOG092C585A.

Family and domain databases

CDDicd11566. eIF1_SUI1. 1 hit.
Gene3Di3.30.780.10. 1 hit.
InterProiIPR001950. SUI1.
IPR005874. SUI1_euk.
[Graphical view]
PfamiPF01253. SUI1. 1 hit.
[Graphical view]
PIRSFiPIRSF004499. SUI1_euk. 1 hit.
SUPFAMiSSF55159. SSF55159. 1 hit.
TIGRFAMsiTIGR01160. SUI1_MOF2. 1 hit.
PROSITEiPS50296. SUI1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P32911-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIENLKSFD PFADTGDDET ATSNYIHIRI QQRNGRKTLT TVQGVPEEYD
60 70 80 90 100
LKRILKVLKK DFACNGNIVK DPEMGEIIQL QGDQRAKVCE FMISQLGLQK

KNIKIHGF
Length:108
Mass (Da):12,312
Last modified:October 1, 1993 - v1
Checksum:i03ECB94F3EF3A417
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M77514 Genomic DNA. Translation: AAA35131.1.
X96722 Genomic DNA. Translation: CAA65499.1.
Z71520 Genomic DNA. Translation: CAA96150.1.
BK006947 Genomic DNA. Translation: DAA10315.1.
PIRiS31245.
RefSeqiNP_014155.1. NM_001183082.1.

Genome annotation databases

EnsemblFungiiYNL244C; YNL244C; YNL244C.
GeneIDi855477.
KEGGisce:YNL244C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M77514 Genomic DNA. Translation: AAA35131.1.
X96722 Genomic DNA. Translation: CAA65499.1.
Z71520 Genomic DNA. Translation: CAA96150.1.
BK006947 Genomic DNA. Translation: DAA10315.1.
PIRiS31245.
RefSeqiNP_014155.1. NM_001183082.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2OGHNMR-A1-108[»]
3J80electron microscopy3.75j1-108[»]
3J81electron microscopy4.00m1-108[»]
3JAMelectron microscopy3.46j1-108[»]
3JAPelectron microscopy4.90m1-108[»]
3JAQelectron microscopy6.00m1-108[»]
ProteinModelPortaliP32911.
SMRiP32911.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35595. 64 interactors.
DIPiDIP-1471N.
IntActiP32911. 10 interactors.
MINTiMINT-391861.

PTM databases

iPTMnetiP32911.

Proteomic databases

MaxQBiP32911.
PRIDEiP32911.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYNL244C; YNL244C; YNL244C.
GeneIDi855477.
KEGGisce:YNL244C.

Organism-specific databases

EuPathDBiFungiDB:YNL244C.
SGDiS000005188. SUI1.

Phylogenomic databases

GeneTreeiENSGT00390000015789.
HOGENOMiHOG000279813.
InParanoidiP32911.
KOiK03113.
OMAiNIHIRIQ.
OrthoDBiEOG092C585A.

Enzyme and pathway databases

BioCyciYEAST:G3O-33241-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP32911.
PROiP32911.

Family and domain databases

CDDicd11566. eIF1_SUI1. 1 hit.
Gene3Di3.30.780.10. 1 hit.
InterProiIPR001950. SUI1.
IPR005874. SUI1_euk.
[Graphical view]
PfamiPF01253. SUI1. 1 hit.
[Graphical view]
PIRSFiPIRSF004499. SUI1_euk. 1 hit.
SUPFAMiSSF55159. SSF55159. 1 hit.
TIGRFAMsiTIGR01160. SUI1_MOF2. 1 hit.
PROSITEiPS50296. SUI1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSUI1_YEAST
AccessioniPrimary (citable) accession number: P32911
Secondary accession number(s): D6W0U9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: November 2, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Translation initiation factors
    List of translation initiation factor entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  5. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.