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Protein

54S ribosomal protein L6, mitochondrial

Gene

MRPL6

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Indispensable for mitochondrial function.

GO - Molecular functioni

  • RNA binding Source: GO_Central
  • rRNA binding Source: UniProtKB-KW
  • structural constituent of ribosome Source: SGD

GO - Biological processi

  • mitochondrial translation Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Keywords - Ligandi

RNA-binding, rRNA-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-31182-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
54S ribosomal protein L6, mitochondrial
Alternative name(s):
YmL16
Gene namesi
Name:MRPL6
Ordered Locus Names:YHR147C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VIII

Organism-specific databases

EuPathDBiFungiDB:YHR147C.
SGDiS000001190. MRPL6.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial large ribosomal subunit Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 16Mitochondrion1 PublicationAdd BLAST16
ChainiPRO_000003054617 – 21454S ribosomal protein L6, mitochondrialAdd BLAST198

Proteomic databases

MaxQBiP32904.
PRIDEiP32904.

Interactioni

Subunit structurei

Component of the mitochondrial large ribosomal subunit. Mature mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S subunit contains at least 33 different proteins and 1 molecule of RNA (15S). The 54S subunit contains at least 45 different proteins and 1 molecule of RNA (21S).2 Publications

Protein-protein interaction databases

BioGridi36581. 13 interactors.
DIPiDIP-5622N.
IntActiP32904. 5 interactors.
MINTiMINT-503396.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J6Belectron microscopy3.20F1-214[»]
ProteinModelPortaliP32904.
SMRiP32904.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L6P family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000039904.
InParanoidiP32904.
KOiK02933.
OMAiPQPNRIV.
OrthoDBiEOG092C5762.

Family and domain databases

Gene3Di3.90.930.12. 2 hits.
InterProiIPR000702. Ribosomal_L6.
IPR020040. Ribosomal_L6_a/b-dom.
IPR019906. Ribosomal_L6_bac-type.
IPR002358. Ribosomal_L6_CS.
[Graphical view]
PANTHERiPTHR11655. PTHR11655. 2 hits.
PfamiPF00347. Ribosomal_L6. 2 hits.
[Graphical view]
PIRSFiPIRSF002162. Ribosomal_L6. 1 hit.
PRINTSiPR00059. RIBOSOMALL6.
SUPFAMiSSF56053. SSF56053. 2 hits.
PROSITEiPS00525. RIBOSOMAL_L6_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P32904-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFIQRRLLS QTLFLRSQVG SLPLYISPEV QVSINALSMP RIIRKGRTSM
60 70 80 90 100
NISQNITVKG PKGELSVEVP DFLHLDKDEK HGKINVTVQN SEDKHQRSMW
110 120 130 140 150
GTVRSLINNH IIGVTEGHLA VLRFVGTGYR AQLENDGKFV NVKVGASIKQ
160 170 180 190 200
GLDVPEGIVV KTPAPTSLII EGCNKQQVLL FAAKLRKFHP PEPYKGKGIY
210
VNDETIKLKD KKIK
Length:214
Mass (Da):23,889
Last modified:February 1, 1995 - v2
Checksum:i204B836742FF42E7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti19V → P AA sequence (PubMed:9151978).Curated1
Sequence conflicti27S → K AA sequence (PubMed:9151978).Curated1
Sequence conflicti201 – 214VNDET…DKKIK → GTVKQ in CAA49236 (PubMed:8358820).CuratedAdd BLAST14

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69480 Genomic DNA. Translation: CAA49236.1.
U10397 Genomic DNA. Translation: AAB68986.1.
BK006934 Genomic DNA. Translation: DAA06840.1.
PIRiS46764.
RefSeqiNP_012017.1. NM_001179278.1.

Genome annotation databases

EnsemblFungiiYHR147C; YHR147C; YHR147C.
GeneIDi856552.
KEGGisce:YHR147C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69480 Genomic DNA. Translation: CAA49236.1.
U10397 Genomic DNA. Translation: AAB68986.1.
BK006934 Genomic DNA. Translation: DAA06840.1.
PIRiS46764.
RefSeqiNP_012017.1. NM_001179278.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J6Belectron microscopy3.20F1-214[»]
ProteinModelPortaliP32904.
SMRiP32904.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36581. 13 interactors.
DIPiDIP-5622N.
IntActiP32904. 5 interactors.
MINTiMINT-503396.

Proteomic databases

MaxQBiP32904.
PRIDEiP32904.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYHR147C; YHR147C; YHR147C.
GeneIDi856552.
KEGGisce:YHR147C.

Organism-specific databases

EuPathDBiFungiDB:YHR147C.
SGDiS000001190. MRPL6.

Phylogenomic databases

HOGENOMiHOG000039904.
InParanoidiP32904.
KOiK02933.
OMAiPQPNRIV.
OrthoDBiEOG092C5762.

Enzyme and pathway databases

BioCyciYEAST:G3O-31182-MONOMER.

Miscellaneous databases

PROiP32904.

Family and domain databases

Gene3Di3.90.930.12. 2 hits.
InterProiIPR000702. Ribosomal_L6.
IPR020040. Ribosomal_L6_a/b-dom.
IPR019906. Ribosomal_L6_bac-type.
IPR002358. Ribosomal_L6_CS.
[Graphical view]
PANTHERiPTHR11655. PTHR11655. 2 hits.
PfamiPF00347. Ribosomal_L6. 2 hits.
[Graphical view]
PIRSFiPIRSF002162. Ribosomal_L6. 1 hit.
PRINTSiPR00059. RIBOSOMALL6.
SUPFAMiSSF56053. SSF56053. 2 hits.
PROSITEiPS00525. RIBOSOMAL_L6_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRM06_YEAST
AccessioniPrimary (citable) accession number: P32904
Secondary accession number(s): D3DL96
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: February 1, 1995
Last modified: November 2, 2016
This is version 141 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 5700 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  5. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.