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Protein

54S ribosomal protein L6, mitochondrial

Gene

MRPL6

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.2 Publications

Miscellaneous

Present with 5700 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • RNA binding Source: GO_Central
  • rRNA binding Source: UniProtKB-KW
  • structural constituent of ribosome Source: SGD

GO - Biological processi

  • mitochondrial translation Source: SGD

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein, RNA-binding, rRNA-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-31182-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
54S ribosomal protein L6, mitochondrial
Alternative name(s):
Mitochondrial large ribosomal subunit protein uL6m1 Publication
YmL16
Gene namesi
Name:MRPL6
Ordered Locus Names:YHR147C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VIII

Organism-specific databases

EuPathDBiFungiDB:YHR147C
SGDiS000001190 MRPL6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 16Mitochondrion1 PublicationAdd BLAST16
ChainiPRO_000003054617 – 21454S ribosomal protein L6, mitochondrialAdd BLAST198

Proteomic databases

MaxQBiP32904
PaxDbiP32904
PRIDEiP32904

Interactioni

Subunit structurei

Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature yeast 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 15S ribosomal RNA (15S mt-rRNA) and 34 different proteins. The 54S large subunit contains a 21S rRNA (21S mt-rRNA) and 46 different proteins.3 Publications

Protein-protein interaction databases

BioGridi36581, 232 interactors
DIPiDIP-5622N
IntActiP32904, 6 interactors
STRINGi4932.YHR147C

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J6Belectron microscopy3.20F1-214[»]
5MRCelectron microscopy3.25F17-212[»]
5MREelectron microscopy3.75F17-212[»]
5MRFelectron microscopy4.97F17-212[»]
ProteinModelPortaliP32904
SMRiP32904
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000039904
InParanoidiP32904
KOiK02933
OMAiINNMVVG
OrthoDBiEOG092C5762

Family and domain databases

Gene3Di3.90.930.12, 2 hits
InterProiView protein in InterPro
IPR000702 Ribosomal_L6
IPR020040 Ribosomal_L6_a/b-dom
IPR036789 Ribosomal_L6_a/b-dom_sf
IPR019906 Ribosomal_L6_bac-type
IPR002358 Ribosomal_L6_CS
PANTHERiPTHR11655 PTHR11655, 1 hit
PTHR11655:SF14 PTHR11655:SF14, 1 hit
PfamiView protein in Pfam
PF00347 Ribosomal_L6, 2 hits
PIRSFiPIRSF002162 Ribosomal_L6, 1 hit
PRINTSiPR00059 RIBOSOMALL6
SUPFAMiSSF56053 SSF56053, 2 hits
PROSITEiView protein in PROSITE
PS00525 RIBOSOMAL_L6_1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P32904-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFIQRRLLS QTLFLRSQVG SLPLYISPEV QVSINALSMP RIIRKGRTSM
60 70 80 90 100
NISQNITVKG PKGELSVEVP DFLHLDKDEK HGKINVTVQN SEDKHQRSMW
110 120 130 140 150
GTVRSLINNH IIGVTEGHLA VLRFVGTGYR AQLENDGKFV NVKVGASIKQ
160 170 180 190 200
GLDVPEGIVV KTPAPTSLII EGCNKQQVLL FAAKLRKFHP PEPYKGKGIY
210
VNDETIKLKD KKIK
Length:214
Mass (Da):23,889
Last modified:February 1, 1995 - v2
Checksum:i204B836742FF42E7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti19V → P AA sequence (PubMed:9151978).Curated1
Sequence conflicti27S → K AA sequence (PubMed:9151978).Curated1
Sequence conflicti201 – 214VNDET…DKKIK → GTVKQ in CAA49236 (PubMed:8358820).CuratedAdd BLAST14

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69480 Genomic DNA Translation: CAA49236.1
U10397 Genomic DNA Translation: AAB68986.1
BK006934 Genomic DNA Translation: DAA06840.1
PIRiS46764
RefSeqiNP_012017.1, NM_001179278.1

Genome annotation databases

EnsemblFungiiYHR147C; YHR147C; YHR147C
GeneIDi856552
KEGGisce:YHR147C

Similar proteinsi

Entry informationi

Entry nameiRM06_YEAST
AccessioniPrimary (citable) accession number: P32904
Secondary accession number(s): D3DL96
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: February 1, 1995
Last modified: May 23, 2018
This is version 153 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

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