P32903 (PMP1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Plasma membrane ATPase proteolipid 1

Gene names

Name:	PMP1
Ordered Locus Names:	YCR024C-A
ORF Names:	YCR24C-A

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	40 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Monomer and homodimer. Associated with the 100 kDa subunit of the plasma membrane H+-ATPase.
Subcellular location	Cell membrane.
Miscellaneous	Present with 124000 molecules/cell in log phase SD medium.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	cation transport Inferred from genetic interaction PubMed 8063750. Source: SGD
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from direct assay Ref.1. Source: SGD
Molecular_function	enzyme regulator activity Inferred from mutant phenotype PubMed 8063750. Source: SGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Propeptide	1 – 2	2			PRO_0000022071
	Chain	3 – 40	38	Plasma membrane ATPase proteolipid 1		PRO_0000022072
Regions
	Transmembrane	3 – 26	24	Helical; Potential
	Topological domain	27 – 40	14	Cytoplasmic Potential

Sequences

	Sequence		Length	Mass (Da)
	P32903 [UniParc]. Last modified October 1, 1993. Version 1. Checksum: B3497C1A828B5426	FASTA	40	4,501
	10 20 30 40 MTLPGGVILV FILVGLACIA IIATIIYRKW QARQRGLQRF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Purification and complete sequence of a small proteolipid associated with the plasma membrane H(+)-ATPase of Saccharomyces cerevisiae." Navarre C., Ghislain M., Leterme S., Ferroud C., Dufour J.-P., Goffeau A. J. Biol. Chem. 267:6425-6428(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 3-40.
[2]	"The complete DNA sequence of yeast chromosome III." Oliver S.G., van der Aart Q.J.M., Agostoni-Carbone M.L., Aigle M., Alberghina L., Alexandraki D., Antoine G., Anwar R., Ballesta J.P.G., Benit P., Berben G., Bergantino E., Biteau N., Bolle P.-A., Bolotin-Fukuhara M., Brown A., Brown A.J.P., Buhler J.-M. , Carcano C., Carignani G., Cederberg H., Chanet R., Contreras R., Crouzet M., Daignan-Fornier B., Defoor E., Delgado M.D., Demolder J., Doira C., Dubois E., Dujon B., Duesterhoeft A., Erdmann D., Esteban M., Fabre F., Fairhead C., Faye G., Feldmann H., Fiers W., Francingues-Gaillard M.-C., Franco L., Frontali L., Fukuhara H., Fuller L.J., Galland P., Gent M.E., Gigot D., Gilliquet V., Glansdorff N., Goffeau A., Grenson M., Grisanti P., Grivell L.A., de Haan M., Haasemann M., Hatat D., Hoenicka J., Hegemann J.H., Herbert C.J., Hilger F., Hohmann S., Hollenberg C.P., Huse K., Iborra F., Indge K.J., Isono K., Jacq C., Jacquet M., James C.M., Jauniaux J.-C., Jia Y., Jimenez A., Kelly A., Kleinhans U., Kreisl P., Lanfranchi G., Lewis C., van der Linden C.G., Lucchini G., Lutzenkirchen K., Maat M.J., Mallet L., Mannhaupt G., Martegani E., Mathieu A., Maurer C.T.C., McConnell D., McKee R.A., Messenguy F., Mewes H.-W., Molemans F., Montague M.A., Muzi Falconi M., Navas L., Newlon C.S., Noone D., Pallier C., Panzeri L., Pearson B.M., Perea J., Philippsen P., Pierard A., Planta R.J., Plevani P., Poetsch B., Pohl F.M., Purnelle B., Ramezani Rad M., Rasmussen S.W., Raynal A., Remacha M.A., Richterich P., Roberts A.B., Rodriguez F., Sanz E., Schaaff-Gerstenschlaeger I., Scherens B., Schweitzer B., Shu Y., Skala J., Slonimski P.P., Sor F., Soustelle C., Spiegelberg R., Stateva L.I., Steensma H.Y., Steiner S., Thierry A., Thireos G., Tzermia M., Urrestarazu L.A., Valle G., Vetter I., van Vliet-Reedijk J.C., Voet M., Volckaert G., Vreken P., Wang H., Warmington J.R., von Wettstein D., Wicksteed B.L., Wilson C., Wurst H., Xu G., Yoshikawa A., Zimmermann F.K., Sgouros J.G. Nature 357:38-46(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[3]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[4]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M77845 Genomic DNA. Translation: AAA34883.1. X59720 Genomic DNA. Translation: CAC42976.1. BK006937 Genomic DNA. Translation: DAA07504.1.
PIR	S31269.
RefSeq	NP_058137.1. NM_001178739.1.
3D structure databases
ProteinModelPortal	P32903.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-2538N.
IntAct	P32903. 18 interactions.
MINT	MINT-1354879.
STRING	4932.YCR024C-A.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YCR024C-A; YCR024C-A; YCR024C-A.
GeneID	850389.
KEGG	sce:YCR024C-A.
Organism-specific databases
CYGD	YCR024c-a.
SGD	S000000619. PMP1.
Phylogenomic databases
GeneTree	ENSGT00390000006089.
HOGENOM	HOG000000839.
OrthoDB	EOG42C1KH.
Gene expression databases
Genevestigator	P32903.
GermOnline	YCR024C-A. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR012589. ATPase_proteolipid. [Graphical view]
Pfam	PF08114. PMP1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	965906.

Entry information

Entry name

PMP1_YEAST

Accession

Primary (citable) accession number: P32903
Secondary accession number(s): D6VR35, Q76PA9

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1993
Last sequence update:	October 1, 1993
Last modified:	April 3, 2013
This is version 87 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program