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Protein

37S ribosomal protein MRP4, mitochondrial

Gene

MRP4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.2 Publications

Miscellaneous

Present with 6890 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • structural constituent of ribosome Source: SGD

GO - Biological processi

  • mitochondrial translation Source: SGD
  • translation Source: GO_Central

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciYEAST:G3O-31027-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
37S ribosomal protein MRP4, mitochondrial
Alternative name(s):
Mitochondrial small ribosomal subunit protein uS2m1 Publication
Gene namesi
Name:MRP4
Synonyms:MRP4A
Ordered Locus Names:YHL004W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VIII

Organism-specific databases

EuPathDBiFungiDB:YHL004W.
SGDiS000000996. MRP4.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial small ribosomal subunit Source: SGD

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 25MitochondrionSequence analysisAdd BLAST25
ChainiPRO_000013434526 – 39437S ribosomal protein MRP4, mitochondrialAdd BLAST369

Proteomic databases

MaxQBiP32902.
PRIDEiP32902.

Interactioni

Subunit structurei

Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature yeast 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 15S ribosomal RNA (15S mt-rRNA) and 34 different proteins. The 54S large subunit contains a 21S rRNA (21S mt-rRNA) and 46 different proteins.3 Publications

Protein-protein interaction databases

BioGridi36421. 83 interactors.
DIPiDIP-5035N.
IntActiP32902. 69 interactors.
MINTiMINT-482507.
STRINGi4932.YHL004W.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5MRCelectron microscopy3.25BB128-393[»]
5MREelectron microscopy3.75BB128-393[»]
5MRFelectron microscopy4.97BB128-393[»]
ProteinModelPortaliP32902.
SMRiP32902.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

GeneTreeiENSGT00390000017382.
HOGENOMiHOG000248605.
InParanoidiP32902.
KOiK02967.
OMAiPVENRNC.
OrthoDBiEOG092C3LR5.

Family and domain databases

CDDicd01425. RPS2. 1 hit.
HAMAPiMF_00291_B. Ribosomal_S2_B. 1 hit.
InterProiView protein in InterPro
IPR001865. Ribosomal_S2.
IPR005706. Ribosomal_S2_bac/mit/plastid.
IPR018130. Ribosomal_S2_CS.
IPR023591. Ribosomal_S2_flav_dom.
PANTHERiPTHR12534. PTHR12534. 1 hit.
PfamiView protein in Pfam
PF00318. Ribosomal_S2. 1 hit.
PRINTSiPR00395. RIBOSOMALS2.
SUPFAMiSSF52313. SSF52313. 1 hit.
TIGRFAMsiTIGR01011. rpsB_bact. 1 hit.
PROSITEiView protein in PROSITE
PS00962. RIBOSOMAL_S2_1. 1 hit.
PS00963. RIBOSOMAL_S2_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P32902-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQRHVFARNF RRLSLLRNPS LTKRFQSSAS GAANTPNNND EVMLLQQKLL
60 70 80 90 100
YDEIRSELKS LSQVPEDEIL PELKKSLEQD KLSDKEQQLE AELSDFFRNY
110 120 130 140 150
ALLNKLFDSK TLDGQSSTTT AAATPTKPYP NLIPSANDKP YSSQELFLRQ
160 170 180 190 200
LNHSMRTAKL GATISKVYYP HKDIFYPPLP ENITVESLMS AGVHLGQSTS
210 220 230 240 250
LWRSSTQSYI YGEYKGIHII DLNQTLSYLK RAAKVVEGVS ESGGIILFLG
260 270 280 290 300
TRQGQKRGLE EAAKKTHGYY VSTRWIPGTL TNSTEISGIW EKQEIDSNDN
310 320 330 340 350
PTERALSPNE TSKQVKPDLL VVLNPTENRN ALLEAIKSRV PTIAIIDTDS
360 370 380 390
EPSLVTYPIP GNDDSLRSVN FLLGVLARAG QRGLQNRLAR NNEK
Length:394
Mass (Da):44,152
Last modified:October 1, 1993 - v1
Checksum:i81A1CB33134BC559
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M82841 Genomic DNA. Translation: AAA34793.1.
U10555 Genomic DNA. Translation: AAB68428.1.
AY558385 Genomic DNA. Translation: AAS56711.1.
BK006934 Genomic DNA. Translation: DAA06683.1.
PIRiA42115.
RefSeqiNP_011859.1. NM_001179084.1.

Genome annotation databases

EnsemblFungiiYHL004W; YHL004W; YHL004W.
GeneIDi856384.
KEGGisce:YHL004W.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiRT04_YEAST
AccessioniPrimary (citable) accession number: P32902
Secondary accession number(s): D3DKR0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: July 5, 2017
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  5. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names