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Protein

Peptide transporter PTR2

Gene

PTR2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Uptake of small peptides.

GO - Molecular functioni

  • dipeptide transporter activity Source: SGD
  • peptide transporter activity Source: SGD
  • tripeptide transporter activity Source: SGD

GO - Biological processi

  • dipeptide transport Source: SGD
  • peptide transport Source: SGD
  • protein transport Source: UniProtKB-KW
  • tripeptide transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Peptide transport, Protein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-32056-MONOMER.
ReactomeiR-SCE-427975. Proton/oligopeptide cotransporters.
R-SCE-6798695. Neutrophil degranulation.

Protein family/group databases

TCDBi2.A.17.2.2. the proton-dependent oligopeptide transporter (pot/ptr) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide transporter PTR2
Alternative name(s):
Peptide permease PTR2
Gene namesi
Name:PTR2
Ordered Locus Names:YKR093W
ORF Names:YKR413
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XI

Organism-specific databases

EuPathDBiFungiDB:YKR093W.
SGDiS000001801. PTR2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 150ExtracellularSequence analysisAdd BLAST150
Transmembranei151 – 172HelicalSequence analysisAdd BLAST22
Topological domaini173 – 182CytoplasmicSequence analysis10
Transmembranei183 – 202HelicalSequence analysisAdd BLAST20
Topological domaini203 – 210ExtracellularSequence analysis8
Transmembranei211 – 229HelicalSequence analysisAdd BLAST19
Topological domaini230 – 267CytoplasmicSequence analysisAdd BLAST38
Transmembranei268 – 287HelicalSequence analysisAdd BLAST20
Topological domaini288 – 294ExtracellularSequence analysis7
Transmembranei295 – 316HelicalSequence analysisAdd BLAST22
Topological domaini317 – 378CytoplasmicSequence analysisAdd BLAST62
Transmembranei379 – 399HelicalSequence analysisAdd BLAST21
Topological domaini400 – 412ExtracellularSequence analysisAdd BLAST13
Transmembranei413 – 429HelicalSequence analysisAdd BLAST17
Topological domaini430 – 448CytoplasmicSequence analysisAdd BLAST19
Transmembranei449 – 466HelicalSequence analysisAdd BLAST18
Topological domaini467 – 494ExtracellularSequence analysisAdd BLAST28
Transmembranei495 – 513HelicalSequence analysisAdd BLAST19
Topological domaini514 – 526CytoplasmicSequence analysisAdd BLAST13
Transmembranei527 – 547HelicalSequence analysisAdd BLAST21
Topological domaini548 – 554ExtracellularSequence analysis7
Transmembranei555 – 577HelicalSequence analysisAdd BLAST23
Topological domaini578 – 601CytoplasmicSequence analysisAdd BLAST24

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000643171 – 601Peptide transporter PTR2Add BLAST601

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei37PhosphotyrosineCombined sources1
Modified residuei39PhosphoserineCombined sources1
Modified residuei45PhosphoserineCombined sources1
Modified residuei594PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP32901.
PRIDEiP32901.

PTM databases

iPTMnetiP32901.

Interactioni

Protein-protein interaction databases

BioGridi34224. 39 interactors.
DIPiDIP-5311N.
MINTiMINT-524464.

Structurei

3D structure databases

ProteinModelPortaliP32901.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00530000062961.
HOGENOMiHOG000161421.
InParanoidiP32901.
KOiK03305.
OMAiPSFNKGT.
OrthoDBiEOG092C1LLP.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
IPR000109. POT_fam.
IPR018456. PTR2_symporter_CS.
[Graphical view]
PANTHERiPTHR11654. PTHR11654. 1 hit.
PfamiPF00854. PTR2. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
PROSITEiPS01022. PTR2_1. 1 hit.
PS01023. PTR2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P32901-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLNHPSQGSD DAQDEKQGDF PVIEEEKTQA VTLKDSYVSD DVANSTERYN
60 70 80 90 100
LSPSPEDEDF EGPTEEEMQT LRHVGGKIPM RCWLIAIVEL SERFSYYGLS
110 120 130 140 150
APFQNYMEYG PNDSPKGVLS LNSQGATGLS YFFQFWCYVT PVFGGYVADT
160 170 180 190 200
FWGKYNTICC GTAIYIAGIF ILFITSIPSV GNRDSAIGGF IAAIILIGIA
210 220 230 240 250
TGMIKANLSV LIADQLPKRK PSIKVLKSGE RVIVDSNITL QNVFMFFYFM
260 270 280 290 300
INVGSLSLMA TTELEYHKGF WAAYLLPFCF FWIAVVTLIF GKKQYIQRPI
310 320 330 340 350
GDKVIAKSFK VCWILTKNKF DFNAAKPSVH PEKNYPWNDK FVDEIKRALA
360 370 380 390 400
ACKVFIFYPI YWTQYGTMIS SFITQASMME LHGIPNDFLQ AFDSIALIIF
410 420 430 440 450
IPIFEKFVYP FIRRYTPLKP ITKIFFGFMF GSFAMTWAAV LQSFVYKAGP
460 470 480 490 500
WYNEPLGHNT PNHVHVCWQI PAYVLISFSE IFASITGLEY AYSKAPASMK
510 520 530 540 550
SFIMSIFLLT NAFGSAIGCA LSPVTVDPKF TWLFTGLAVA CFISGCLFWL
560 570 580 590 600
CFRKYNDTEE EMNAMDYEEE DEFDLNPISA PKANDIEILE PMESLRSTTK

Y
Length:601
Mass (Da):68,044
Last modified:June 1, 1994 - v2
Checksum:i2BD50723B1A3B310
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti39S → T in AAC37368 (PubMed:8264579).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L11994 Unassigned DNA. Translation: AAC37368.1.
X73541 Genomic DNA. Translation: CAA51947.1.
Z28318 Genomic DNA. Translation: CAA82172.1.
BK006944 Genomic DNA. Translation: DAA09243.1.
PIRiS38171.
RefSeqiNP_013019.1. NM_001179883.1.

Genome annotation databases

EnsemblFungiiYKR093W; YKR093W; YKR093W.
GeneIDi853968.
KEGGisce:YKR093W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L11994 Unassigned DNA. Translation: AAC37368.1.
X73541 Genomic DNA. Translation: CAA51947.1.
Z28318 Genomic DNA. Translation: CAA82172.1.
BK006944 Genomic DNA. Translation: DAA09243.1.
PIRiS38171.
RefSeqiNP_013019.1. NM_001179883.1.

3D structure databases

ProteinModelPortaliP32901.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34224. 39 interactors.
DIPiDIP-5311N.
MINTiMINT-524464.

Protein family/group databases

TCDBi2.A.17.2.2. the proton-dependent oligopeptide transporter (pot/ptr) family.

PTM databases

iPTMnetiP32901.

Proteomic databases

MaxQBiP32901.
PRIDEiP32901.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYKR093W; YKR093W; YKR093W.
GeneIDi853968.
KEGGisce:YKR093W.

Organism-specific databases

EuPathDBiFungiDB:YKR093W.
SGDiS000001801. PTR2.

Phylogenomic databases

GeneTreeiENSGT00530000062961.
HOGENOMiHOG000161421.
InParanoidiP32901.
KOiK03305.
OMAiPSFNKGT.
OrthoDBiEOG092C1LLP.

Enzyme and pathway databases

BioCyciYEAST:G3O-32056-MONOMER.
ReactomeiR-SCE-427975. Proton/oligopeptide cotransporters.
R-SCE-6798695. Neutrophil degranulation.

Miscellaneous databases

PROiP32901.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
IPR000109. POT_fam.
IPR018456. PTR2_symporter_CS.
[Graphical view]
PANTHERiPTHR11654. PTHR11654. 1 hit.
PfamiPF00854. PTR2. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
PROSITEiPS01022. PTR2_1. 1 hit.
PS01023. PTR2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPTR2_YEAST
AccessioniPrimary (citable) accession number: P32901
Secondary accession number(s): D6VXF3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: June 1, 1994
Last modified: November 30, 2016
This is version 134 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.