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P32901

- PTR2_YEAST

UniProt

P32901 - PTR2_YEAST

Protein

Peptide transporter PTR2

Gene

PTR2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 2 (01 Jun 1994)
      Previous versions | rss
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    Functioni

    Uptake of small peptides.

    GO - Molecular functioni

    1. dipeptide transporter activity Source: SGD
    2. peptide transporter activity Source: SGD
    3. tripeptide transporter activity Source: SGD

    GO - Biological processi

    1. dipeptide transport Source: SGD
    2. peptide transport Source: SGD
    3. protein transport Source: UniProtKB-KW
    4. tripeptide transport Source: SGD

    Keywords - Biological processi

    Peptide transport, Protein transport, Transport

    Enzyme and pathway databases

    BioCyciYEAST:G3O-32056-MONOMER.

    Protein family/group databases

    TCDBi2.A.17.2.2. the proton-dependent oligopeptide transporter (pot/ptr) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peptide transporter PTR2
    Alternative name(s):
    Peptide permease PTR2
    Gene namesi
    Name:PTR2
    Ordered Locus Names:YKR093W
    ORF Names:YKR413
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XI

    Organism-specific databases

    CYGDiYKR093w.
    SGDiS000001801. PTR2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: SGD

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 601601Peptide transporter PTR2PRO_0000064317Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei37 – 371Phosphotyrosine1 Publication
    Modified residuei39 – 391Phosphoserine2 Publications
    Modified residuei45 – 451Phosphoserine1 Publication
    Modified residuei594 – 5941Phosphoserine2 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP32901.
    PaxDbiP32901.

    Expressioni

    Gene expression databases

    GenevestigatoriP32901.

    Interactioni

    Protein-protein interaction databases

    BioGridi34224. 40 interactions.
    DIPiDIP-5311N.
    MINTiMINT-524464.
    STRINGi4932.YKR093W.

    Structurei

    3D structure databases

    ProteinModelPortaliP32901.
    SMRiP32901. Positions 89-561.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 150150ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini173 – 18210CytoplasmicSequence Analysis
    Topological domaini203 – 2108ExtracellularSequence Analysis
    Topological domaini230 – 26738CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini288 – 2947ExtracellularSequence Analysis
    Topological domaini317 – 37862CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini400 – 41213ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini430 – 44819CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini467 – 49428ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini514 – 52613CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini548 – 5547ExtracellularSequence Analysis
    Topological domaini578 – 60124CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei151 – 17222HelicalSequence AnalysisAdd
    BLAST
    Transmembranei183 – 20220HelicalSequence AnalysisAdd
    BLAST
    Transmembranei211 – 22919HelicalSequence AnalysisAdd
    BLAST
    Transmembranei268 – 28720HelicalSequence AnalysisAdd
    BLAST
    Transmembranei295 – 31622HelicalSequence AnalysisAdd
    BLAST
    Transmembranei379 – 39921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei413 – 42917HelicalSequence AnalysisAdd
    BLAST
    Transmembranei449 – 46618HelicalSequence AnalysisAdd
    BLAST
    Transmembranei495 – 51319HelicalSequence AnalysisAdd
    BLAST
    Transmembranei527 – 54721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei555 – 57723HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG3104.
    GeneTreeiENSGT00530000062961.
    HOGENOMiHOG000161421.
    KOiK03305.
    OMAiGVKPCTS.
    OrthoDBiEOG70PC6N.

    Family and domain databases

    InterProiIPR016196. MFS_dom_general_subst_transpt.
    IPR000109. POT_fam.
    IPR018456. PTR2_symporter_CS.
    [Graphical view]
    PANTHERiPTHR11654. PTHR11654. 1 hit.
    PfamiPF00854. PTR2. 1 hit.
    [Graphical view]
    SUPFAMiSSF103473. SSF103473. 2 hits.
    PROSITEiPS01022. PTR2_1. 1 hit.
    PS01023. PTR2_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P32901-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLNHPSQGSD DAQDEKQGDF PVIEEEKTQA VTLKDSYVSD DVANSTERYN    50
    LSPSPEDEDF EGPTEEEMQT LRHVGGKIPM RCWLIAIVEL SERFSYYGLS 100
    APFQNYMEYG PNDSPKGVLS LNSQGATGLS YFFQFWCYVT PVFGGYVADT 150
    FWGKYNTICC GTAIYIAGIF ILFITSIPSV GNRDSAIGGF IAAIILIGIA 200
    TGMIKANLSV LIADQLPKRK PSIKVLKSGE RVIVDSNITL QNVFMFFYFM 250
    INVGSLSLMA TTELEYHKGF WAAYLLPFCF FWIAVVTLIF GKKQYIQRPI 300
    GDKVIAKSFK VCWILTKNKF DFNAAKPSVH PEKNYPWNDK FVDEIKRALA 350
    ACKVFIFYPI YWTQYGTMIS SFITQASMME LHGIPNDFLQ AFDSIALIIF 400
    IPIFEKFVYP FIRRYTPLKP ITKIFFGFMF GSFAMTWAAV LQSFVYKAGP 450
    WYNEPLGHNT PNHVHVCWQI PAYVLISFSE IFASITGLEY AYSKAPASMK 500
    SFIMSIFLLT NAFGSAIGCA LSPVTVDPKF TWLFTGLAVA CFISGCLFWL 550
    CFRKYNDTEE EMNAMDYEEE DEFDLNPISA PKANDIEILE PMESLRSTTK 600
    Y 601
    Length:601
    Mass (Da):68,044
    Last modified:June 1, 1994 - v2
    Checksum:i2BD50723B1A3B310
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti39 – 391S → T in AAC37368. (PubMed:8264579)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L11994 Unassigned DNA. Translation: AAC37368.1.
    X73541 Genomic DNA. Translation: CAA51947.1.
    Z28318 Genomic DNA. Translation: CAA82172.1.
    BK006944 Genomic DNA. Translation: DAA09243.1.
    PIRiS38171.
    RefSeqiNP_013019.1. NM_001179883.1.

    Genome annotation databases

    EnsemblFungiiYKR093W; YKR093W; YKR093W.
    GeneIDi853968.
    KEGGisce:YKR093W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L11994 Unassigned DNA. Translation: AAC37368.1 .
    X73541 Genomic DNA. Translation: CAA51947.1 .
    Z28318 Genomic DNA. Translation: CAA82172.1 .
    BK006944 Genomic DNA. Translation: DAA09243.1 .
    PIRi S38171.
    RefSeqi NP_013019.1. NM_001179883.1.

    3D structure databases

    ProteinModelPortali P32901.
    SMRi P32901. Positions 89-561.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 34224. 40 interactions.
    DIPi DIP-5311N.
    MINTi MINT-524464.
    STRINGi 4932.YKR093W.

    Protein family/group databases

    TCDBi 2.A.17.2.2. the proton-dependent oligopeptide transporter (pot/ptr) family.

    Proteomic databases

    MaxQBi P32901.
    PaxDbi P32901.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YKR093W ; YKR093W ; YKR093W .
    GeneIDi 853968.
    KEGGi sce:YKR093W.

    Organism-specific databases

    CYGDi YKR093w.
    SGDi S000001801. PTR2.

    Phylogenomic databases

    eggNOGi COG3104.
    GeneTreei ENSGT00530000062961.
    HOGENOMi HOG000161421.
    KOi K03305.
    OMAi GVKPCTS.
    OrthoDBi EOG70PC6N.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-32056-MONOMER.

    Miscellaneous databases

    NextBioi 975407.
    PROi P32901.

    Gene expression databases

    Genevestigatori P32901.

    Family and domain databases

    InterProi IPR016196. MFS_dom_general_subst_transpt.
    IPR000109. POT_fam.
    IPR018456. PTR2_symporter_CS.
    [Graphical view ]
    PANTHERi PTHR11654. PTHR11654. 1 hit.
    Pfami PF00854. PTR2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF103473. SSF103473. 2 hits.
    PROSITEi PS01022. PTR2_1. 1 hit.
    PS01023. PTR2_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of a Saccharomyces cerevisiae peptide transport gene."
      Perry J.R., Basrai M.A., Steiner H.-Y., Naider F., Becker J.M.
      Mol. Cell. Biol. 14:104-115(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The complete sequence of a 15,820 bp segment of Saccharomyces cerevisiae chromosome XI contains the UBI2 and MPL1 genes and three new open reading frames."
      Bou G., Esteban P.F., Baladron V., Gonzalez G.A., Cantalejo J.G., Remacha M.A., Jimenez A., del Rey F., Ballesta J.P.G., Revuelta J.L.
      Yeast 9:1349-1354(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Complete DNA sequence of yeast chromosome XI."
      Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C.
      , Domdey H., Duesterhoeft A., Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H., Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L., Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M., Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H., Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J., Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H., Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J., Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S., Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F., Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R., Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W., Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M., Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C., Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H., Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L., van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S., von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M., Becker I., Mewes H.-W.
      Nature 369:371-378(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    4. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    5. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
      Kim H., Melen K., Oesterberg M., von Heijne G.
      Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
      Strain: ATCC 208353 / W303-1A.
    6. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
      Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
      J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-37; SER-39; SER-45 AND SER-594, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Strain: ADR376.
    7. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-39 AND SER-594, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiPTR2_YEAST
    AccessioniPrimary (citable) accession number: P32901
    Secondary accession number(s): D6VXF3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1993
    Last sequence update: June 1, 1994
    Last modified: October 1, 2014
    This is version 114 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome XI
      Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

    External Data

    Dasty 3