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P32901 (PTR2_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 110. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Peptide transporter PTR2
Alternative name(s):
Peptide permease PTR2
Gene names
Name:PTR2
Ordered Locus Names:YKR093W
ORF Names:YKR413
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length601 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Uptake of small peptides.

Subcellular location

Membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the PTR2/POT transporter (TC 2.A.17) family. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 601601Peptide transporter PTR2
PRO_0000064317

Regions

Topological domain1 – 150150Extracellular Potential
Transmembrane151 – 17222Helical; Potential
Topological domain173 – 18210Cytoplasmic Potential
Transmembrane183 – 20220Helical; Potential
Topological domain203 – 2108Extracellular Potential
Transmembrane211 – 22919Helical; Potential
Topological domain230 – 26738Cytoplasmic Potential
Transmembrane268 – 28720Helical; Potential
Topological domain288 – 2947Extracellular Potential
Transmembrane295 – 31622Helical; Potential
Topological domain317 – 37862Cytoplasmic Potential
Transmembrane379 – 39921Helical; Potential
Topological domain400 – 41213Extracellular Potential
Transmembrane413 – 42917Helical; Potential
Topological domain430 – 44819Cytoplasmic Potential
Transmembrane449 – 46618Helical; Potential
Topological domain467 – 49428Extracellular Potential
Transmembrane495 – 51319Helical; Potential
Topological domain514 – 52613Cytoplasmic Potential
Transmembrane527 – 54721Helical; Potential
Topological domain548 – 5547Extracellular Potential
Transmembrane555 – 57723Helical; Potential
Topological domain578 – 60124Cytoplasmic Potential

Amino acid modifications

Modified residue371Phosphotyrosine Ref.6
Modified residue391Phosphoserine Ref.6 Ref.8
Modified residue451Phosphoserine Ref.6
Modified residue5941Phosphoserine Ref.6 Ref.8

Experimental info

Sequence conflict391S → T in AAC37368. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P32901 [UniParc].

Last modified June 1, 1994. Version 2.
Checksum: 2BD50723B1A3B310

FASTA60168,044
        10         20         30         40         50         60 
MLNHPSQGSD DAQDEKQGDF PVIEEEKTQA VTLKDSYVSD DVANSTERYN LSPSPEDEDF 

        70         80         90        100        110        120 
EGPTEEEMQT LRHVGGKIPM RCWLIAIVEL SERFSYYGLS APFQNYMEYG PNDSPKGVLS 

       130        140        150        160        170        180 
LNSQGATGLS YFFQFWCYVT PVFGGYVADT FWGKYNTICC GTAIYIAGIF ILFITSIPSV 

       190        200        210        220        230        240 
GNRDSAIGGF IAAIILIGIA TGMIKANLSV LIADQLPKRK PSIKVLKSGE RVIVDSNITL 

       250        260        270        280        290        300 
QNVFMFFYFM INVGSLSLMA TTELEYHKGF WAAYLLPFCF FWIAVVTLIF GKKQYIQRPI 

       310        320        330        340        350        360 
GDKVIAKSFK VCWILTKNKF DFNAAKPSVH PEKNYPWNDK FVDEIKRALA ACKVFIFYPI 

       370        380        390        400        410        420 
YWTQYGTMIS SFITQASMME LHGIPNDFLQ AFDSIALIIF IPIFEKFVYP FIRRYTPLKP 

       430        440        450        460        470        480 
ITKIFFGFMF GSFAMTWAAV LQSFVYKAGP WYNEPLGHNT PNHVHVCWQI PAYVLISFSE 

       490        500        510        520        530        540 
IFASITGLEY AYSKAPASMK SFIMSIFLLT NAFGSAIGCA LSPVTVDPKF TWLFTGLAVA 

       550        560        570        580        590        600 
CFISGCLFWL CFRKYNDTEE EMNAMDYEEE DEFDLNPISA PKANDIEILE PMESLRSTTK 


Y 

« Hide

References

« Hide 'large scale' references
[1]"Isolation and characterization of a Saccharomyces cerevisiae peptide transport gene."
Perry J.R., Basrai M.A., Steiner H.-Y., Naider F., Becker J.M.
Mol. Cell. Biol. 14:104-115(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The complete sequence of a 15,820 bp segment of Saccharomyces cerevisiae chromosome XI contains the UBI2 and MPL1 genes and three new open reading frames."
Bou G., Esteban P.F., Baladron V., Gonzalez G.A., Cantalejo J.G., Remacha M.A., Jimenez A., del Rey F., Ballesta J.P.G., Revuelta J.L.
Yeast 9:1349-1354(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Complete DNA sequence of yeast chromosome XI."
Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C. expand/collapse author list , Domdey H., Duesterhoeft A., Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H., Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L., Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M., Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H., Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J., Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H., Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J., Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S., Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F., Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R., Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W., Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M., Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C., Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H., Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L., van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S., von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M., Becker I., Mewes H.-W.
Nature 369:371-378(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[4]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[5]"A global topology map of the Saccharomyces cerevisiae membrane proteome."
Kim H., Melen K., Oesterberg M., von Heijne G.
Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
Strain: ATCC 208353 / W303-1A.
[6]"Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-37; SER-39; SER-45 AND SER-594, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Strain: ADR376.
[7]"A multidimensional chromatography technology for in-depth phosphoproteome analysis."
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[8]"Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-39 AND SER-594, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L11994 Unassigned DNA. Translation: AAC37368.1.
X73541 Genomic DNA. Translation: CAA51947.1.
Z28318 Genomic DNA. Translation: CAA82172.1.
BK006944 Genomic DNA. Translation: DAA09243.1.
PIRS38171.
RefSeqNP_013019.1. NM_001179883.1.

3D structure databases

ProteinModelPortalP32901.
SMRP32901. Positions 89-542.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid34224. 40 interactions.
DIPDIP-5311N.
MINTMINT-524464.
STRING4932.YKR093W.

Protein family/group databases

TCDB2.A.17.2.2. the proton-dependent oligopeptide transporter (pot) family.

Proteomic databases

PaxDbP32901.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYKR093W; YKR093W; YKR093W.
GeneID853968.
KEGGsce:YKR093W.

Organism-specific databases

CYGDYKR093w.
SGDS000001801. PTR2.

Phylogenomic databases

eggNOGCOG3104.
GeneTreeENSGT00530000062961.
HOGENOMHOG000161421.
KOK03305.
OMAPESHGPK.
OrthoDBEOG70PC6N.

Enzyme and pathway databases

BioCycYEAST:G3O-32056-MONOMER.

Gene expression databases

GenevestigatorP32901.

Family and domain databases

InterProIPR016196. MFS_dom_general_subst_transpt.
IPR000109. POT_fam.
IPR018456. PTR2_symporter_CS.
[Graphical view]
PANTHERPTHR11654. PTHR11654. 1 hit.
PfamPF00854. PTR2. 1 hit.
[Graphical view]
SUPFAMSSF103473. SSF103473. 2 hits.
PROSITEPS01022. PTR2_1. 1 hit.
PS01023. PTR2_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio975407.
PROP32901.

Entry information

Entry namePTR2_YEAST
AccessionPrimary (citable) accession number: P32901
Secondary accession number(s): D6VXF3
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: June 1, 1994
Last modified: April 16, 2014
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome XI

Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families