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Protein

Peptide transporter PTR2

Gene

PTR2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Uptake of small peptides.

GO - Molecular functioni

  • dipeptide transmembrane transporter activity Source: SGD
  • peptide transmembrane transporter activity Source: SGD
  • tripeptide transmembrane transporter activity Source: SGD

GO - Biological processi

  • dipeptide transport Source: SGD
  • peptide transport Source: SGD
  • protein transport Source: UniProtKB-KW
  • tripeptide transport Source: SGD

Keywordsi

Biological processPeptide transport, Protein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-32056-MONOMER
ReactomeiR-SCE-427975 Proton/oligopeptide cotransporters
R-SCE-6798695 Neutrophil degranulation

Protein family/group databases

TCDBi2.A.17.2.2 the proton-dependent oligopeptide transporter (pot/ptr) family

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide transporter PTR2
Alternative name(s):
Peptide permease PTR2
Gene namesi
Name:PTR2
Ordered Locus Names:YKR093W
ORF Names:YKR413
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XI

Organism-specific databases

EuPathDBiFungiDB:YKR093W
SGDiS000001801 PTR2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 150ExtracellularSequence analysisAdd BLAST150
Transmembranei151 – 172HelicalSequence analysisAdd BLAST22
Topological domaini173 – 182CytoplasmicSequence analysis10
Transmembranei183 – 202HelicalSequence analysisAdd BLAST20
Topological domaini203 – 210ExtracellularSequence analysis8
Transmembranei211 – 229HelicalSequence analysisAdd BLAST19
Topological domaini230 – 267CytoplasmicSequence analysisAdd BLAST38
Transmembranei268 – 287HelicalSequence analysisAdd BLAST20
Topological domaini288 – 294ExtracellularSequence analysis7
Transmembranei295 – 316HelicalSequence analysisAdd BLAST22
Topological domaini317 – 378CytoplasmicSequence analysisAdd BLAST62
Transmembranei379 – 399HelicalSequence analysisAdd BLAST21
Topological domaini400 – 412ExtracellularSequence analysisAdd BLAST13
Transmembranei413 – 429HelicalSequence analysisAdd BLAST17
Topological domaini430 – 448CytoplasmicSequence analysisAdd BLAST19
Transmembranei449 – 466HelicalSequence analysisAdd BLAST18
Topological domaini467 – 494ExtracellularSequence analysisAdd BLAST28
Transmembranei495 – 513HelicalSequence analysisAdd BLAST19
Topological domaini514 – 526CytoplasmicSequence analysisAdd BLAST13
Transmembranei527 – 547HelicalSequence analysisAdd BLAST21
Topological domaini548 – 554ExtracellularSequence analysis7
Transmembranei555 – 577HelicalSequence analysisAdd BLAST23
Topological domaini578 – 601CytoplasmicSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000643171 – 601Peptide transporter PTR2Add BLAST601

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei37PhosphotyrosineCombined sources1
Modified residuei39PhosphoserineCombined sources1
Modified residuei45PhosphoserineCombined sources1
Modified residuei594PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP32901
PaxDbiP32901
PRIDEiP32901

PTM databases

CarbonylDBiP32901
iPTMnetiP32901

Interactioni

Protein-protein interaction databases

BioGridi34224, 115 interactors
DIPiDIP-5311N
STRINGi4932.YKR093W

Structurei

3D structure databases

ProteinModelPortaliP32901
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00530000062961
HOGENOMiHOG000161421
InParanoidiP32901
KOiK03305
OMAiATKFFEA
OrthoDBiEOG092C1LLP

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
IPR000109 POT_fam
IPR018456 PTR2_symporter_CS
PANTHERiPTHR11654 PTHR11654, 1 hit
PfamiView protein in Pfam
PF00854 PTR2, 1 hit
SUPFAMiSSF103473 SSF103473, 2 hits
PROSITEiView protein in PROSITE
PS01022 PTR2_1, 1 hit
PS01023 PTR2_2, 1 hit

Sequencei

Sequence statusi: Complete.

P32901-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLNHPSQGSD DAQDEKQGDF PVIEEEKTQA VTLKDSYVSD DVANSTERYN
60 70 80 90 100
LSPSPEDEDF EGPTEEEMQT LRHVGGKIPM RCWLIAIVEL SERFSYYGLS
110 120 130 140 150
APFQNYMEYG PNDSPKGVLS LNSQGATGLS YFFQFWCYVT PVFGGYVADT
160 170 180 190 200
FWGKYNTICC GTAIYIAGIF ILFITSIPSV GNRDSAIGGF IAAIILIGIA
210 220 230 240 250
TGMIKANLSV LIADQLPKRK PSIKVLKSGE RVIVDSNITL QNVFMFFYFM
260 270 280 290 300
INVGSLSLMA TTELEYHKGF WAAYLLPFCF FWIAVVTLIF GKKQYIQRPI
310 320 330 340 350
GDKVIAKSFK VCWILTKNKF DFNAAKPSVH PEKNYPWNDK FVDEIKRALA
360 370 380 390 400
ACKVFIFYPI YWTQYGTMIS SFITQASMME LHGIPNDFLQ AFDSIALIIF
410 420 430 440 450
IPIFEKFVYP FIRRYTPLKP ITKIFFGFMF GSFAMTWAAV LQSFVYKAGP
460 470 480 490 500
WYNEPLGHNT PNHVHVCWQI PAYVLISFSE IFASITGLEY AYSKAPASMK
510 520 530 540 550
SFIMSIFLLT NAFGSAIGCA LSPVTVDPKF TWLFTGLAVA CFISGCLFWL
560 570 580 590 600
CFRKYNDTEE EMNAMDYEEE DEFDLNPISA PKANDIEILE PMESLRSTTK

Y
Length:601
Mass (Da):68,044
Last modified:June 1, 1994 - v2
Checksum:i2BD50723B1A3B310
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti39S → T in AAC37368 (PubMed:8264579).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L11994 Unassigned DNA Translation: AAC37368.1
X73541 Genomic DNA Translation: CAA51947.1
Z28318 Genomic DNA Translation: CAA82172.1
BK006944 Genomic DNA Translation: DAA09243.1
PIRiS38171
RefSeqiNP_013019.1, NM_001179883.1

Genome annotation databases

EnsemblFungiiYKR093W; YKR093W; YKR093W
GeneIDi853968
KEGGisce:YKR093W

Similar proteinsi

Entry informationi

Entry nameiPTR2_YEAST
AccessioniPrimary (citable) accession number: P32901
Secondary accession number(s): D6VXF3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: June 1, 1994
Last modified: June 20, 2018
This is version 144 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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