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P32901

- PTR2_YEAST

UniProt

P32901 - PTR2_YEAST

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Protein
Peptide transporter PTR2
Gene
PTR2, YKR093W, YKR413
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Uptake of small peptides.

GO - Molecular functioni

  1. dipeptide transporter activity Source: SGD
  2. peptide transporter activity Source: SGD
  3. tripeptide transporter activity Source: SGD

GO - Biological processi

  1. dipeptide transport Source: SGD
  2. peptide transport Source: SGD
  3. protein transport Source: UniProtKB-KW
  4. tripeptide transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Peptide transport, Protein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-32056-MONOMER.

Protein family/group databases

TCDBi2.A.17.2.2. the proton-dependent oligopeptide transporter (pot/ptr) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide transporter PTR2
Alternative name(s):
Peptide permease PTR2
Gene namesi
Name:PTR2
Ordered Locus Names:YKR093W
ORF Names:YKR413
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XI

Organism-specific databases

CYGDiYKR093w.
SGDiS000001801. PTR2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 150150Extracellular Reviewed prediction
Add
BLAST
Transmembranei151 – 17222Helical; Reviewed prediction
Add
BLAST
Topological domaini173 – 18210Cytoplasmic Reviewed prediction
Transmembranei183 – 20220Helical; Reviewed prediction
Add
BLAST
Topological domaini203 – 2108Extracellular Reviewed prediction
Transmembranei211 – 22919Helical; Reviewed prediction
Add
BLAST
Topological domaini230 – 26738Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei268 – 28720Helical; Reviewed prediction
Add
BLAST
Topological domaini288 – 2947Extracellular Reviewed prediction
Transmembranei295 – 31622Helical; Reviewed prediction
Add
BLAST
Topological domaini317 – 37862Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei379 – 39921Helical; Reviewed prediction
Add
BLAST
Topological domaini400 – 41213Extracellular Reviewed prediction
Add
BLAST
Transmembranei413 – 42917Helical; Reviewed prediction
Add
BLAST
Topological domaini430 – 44819Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei449 – 46618Helical; Reviewed prediction
Add
BLAST
Topological domaini467 – 49428Extracellular Reviewed prediction
Add
BLAST
Transmembranei495 – 51319Helical; Reviewed prediction
Add
BLAST
Topological domaini514 – 52613Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei527 – 54721Helical; Reviewed prediction
Add
BLAST
Topological domaini548 – 5547Extracellular Reviewed prediction
Transmembranei555 – 57723Helical; Reviewed prediction
Add
BLAST
Topological domaini578 – 60124Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 601601Peptide transporter PTR2
PRO_0000064317Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei37 – 371Phosphotyrosine1 Publication
Modified residuei39 – 391Phosphoserine2 Publications
Modified residuei45 – 451Phosphoserine1 Publication
Modified residuei594 – 5941Phosphoserine2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP32901.
PaxDbiP32901.

Expressioni

Gene expression databases

GenevestigatoriP32901.

Interactioni

Protein-protein interaction databases

BioGridi34224. 40 interactions.
DIPiDIP-5311N.
MINTiMINT-524464.
STRINGi4932.YKR093W.

Structurei

3D structure databases

ProteinModelPortaliP32901.
SMRiP32901. Positions 89-561.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG3104.
GeneTreeiENSGT00530000062961.
HOGENOMiHOG000161421.
KOiK03305.
OMAiGVKPCTS.
OrthoDBiEOG70PC6N.

Family and domain databases

InterProiIPR016196. MFS_dom_general_subst_transpt.
IPR000109. POT_fam.
IPR018456. PTR2_symporter_CS.
[Graphical view]
PANTHERiPTHR11654. PTHR11654. 1 hit.
PfamiPF00854. PTR2. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
PROSITEiPS01022. PTR2_1. 1 hit.
PS01023. PTR2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P32901-1 [UniParc]FASTAAdd to Basket

« Hide

MLNHPSQGSD DAQDEKQGDF PVIEEEKTQA VTLKDSYVSD DVANSTERYN    50
LSPSPEDEDF EGPTEEEMQT LRHVGGKIPM RCWLIAIVEL SERFSYYGLS 100
APFQNYMEYG PNDSPKGVLS LNSQGATGLS YFFQFWCYVT PVFGGYVADT 150
FWGKYNTICC GTAIYIAGIF ILFITSIPSV GNRDSAIGGF IAAIILIGIA 200
TGMIKANLSV LIADQLPKRK PSIKVLKSGE RVIVDSNITL QNVFMFFYFM 250
INVGSLSLMA TTELEYHKGF WAAYLLPFCF FWIAVVTLIF GKKQYIQRPI 300
GDKVIAKSFK VCWILTKNKF DFNAAKPSVH PEKNYPWNDK FVDEIKRALA 350
ACKVFIFYPI YWTQYGTMIS SFITQASMME LHGIPNDFLQ AFDSIALIIF 400
IPIFEKFVYP FIRRYTPLKP ITKIFFGFMF GSFAMTWAAV LQSFVYKAGP 450
WYNEPLGHNT PNHVHVCWQI PAYVLISFSE IFASITGLEY AYSKAPASMK 500
SFIMSIFLLT NAFGSAIGCA LSPVTVDPKF TWLFTGLAVA CFISGCLFWL 550
CFRKYNDTEE EMNAMDYEEE DEFDLNPISA PKANDIEILE PMESLRSTTK 600
Y 601
Length:601
Mass (Da):68,044
Last modified:June 1, 1994 - v2
Checksum:i2BD50723B1A3B310
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti39 – 391S → T in AAC37368. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L11994 Unassigned DNA. Translation: AAC37368.1.
X73541 Genomic DNA. Translation: CAA51947.1.
Z28318 Genomic DNA. Translation: CAA82172.1.
BK006944 Genomic DNA. Translation: DAA09243.1.
PIRiS38171.
RefSeqiNP_013019.1. NM_001179883.1.

Genome annotation databases

EnsemblFungiiYKR093W; YKR093W; YKR093W.
GeneIDi853968.
KEGGisce:YKR093W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L11994 Unassigned DNA. Translation: AAC37368.1 .
X73541 Genomic DNA. Translation: CAA51947.1 .
Z28318 Genomic DNA. Translation: CAA82172.1 .
BK006944 Genomic DNA. Translation: DAA09243.1 .
PIRi S38171.
RefSeqi NP_013019.1. NM_001179883.1.

3D structure databases

ProteinModelPortali P32901.
SMRi P32901. Positions 89-561.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 34224. 40 interactions.
DIPi DIP-5311N.
MINTi MINT-524464.
STRINGi 4932.YKR093W.

Protein family/group databases

TCDBi 2.A.17.2.2. the proton-dependent oligopeptide transporter (pot/ptr) family.

Proteomic databases

MaxQBi P32901.
PaxDbi P32901.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YKR093W ; YKR093W ; YKR093W .
GeneIDi 853968.
KEGGi sce:YKR093W.

Organism-specific databases

CYGDi YKR093w.
SGDi S000001801. PTR2.

Phylogenomic databases

eggNOGi COG3104.
GeneTreei ENSGT00530000062961.
HOGENOMi HOG000161421.
KOi K03305.
OMAi GVKPCTS.
OrthoDBi EOG70PC6N.

Enzyme and pathway databases

BioCyci YEAST:G3O-32056-MONOMER.

Miscellaneous databases

NextBioi 975407.
PROi P32901.

Gene expression databases

Genevestigatori P32901.

Family and domain databases

InterProi IPR016196. MFS_dom_general_subst_transpt.
IPR000109. POT_fam.
IPR018456. PTR2_symporter_CS.
[Graphical view ]
PANTHERi PTHR11654. PTHR11654. 1 hit.
Pfami PF00854. PTR2. 1 hit.
[Graphical view ]
SUPFAMi SSF103473. SSF103473. 2 hits.
PROSITEi PS01022. PTR2_1. 1 hit.
PS01023. PTR2_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of a Saccharomyces cerevisiae peptide transport gene."
    Perry J.R., Basrai M.A., Steiner H.-Y., Naider F., Becker J.M.
    Mol. Cell. Biol. 14:104-115(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The complete sequence of a 15,820 bp segment of Saccharomyces cerevisiae chromosome XI contains the UBI2 and MPL1 genes and three new open reading frames."
    Bou G., Esteban P.F., Baladron V., Gonzalez G.A., Cantalejo J.G., Remacha M.A., Jimenez A., del Rey F., Ballesta J.P.G., Revuelta J.L.
    Yeast 9:1349-1354(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Complete DNA sequence of yeast chromosome XI."
    Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C.
    , Domdey H., Duesterhoeft A., Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H., Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L., Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M., Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H., Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J., Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H., Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J., Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S., Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F., Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R., Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W., Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M., Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C., Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H., Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L., van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S., von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M., Becker I., Mewes H.-W.
    Nature 369:371-378(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  5. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.
  6. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
    Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
    J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-37; SER-39; SER-45 AND SER-594, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ADR376.
  7. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-39 AND SER-594, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPTR2_YEAST
AccessioniPrimary (citable) accession number: P32901
Secondary accession number(s): D6VXF3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: June 1, 1994
Last modified: September 3, 2014
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

External Data

Dasty 3

Similar proteinsi