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P32899

- IMP3_YEAST

UniProt

P32899 - IMP3_YEAST

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Protein

U3 small nucleolar ribonucleoprotein protein IMP3

Gene

IMP3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Required for the early cleavages at sites A0, A1 and A2 during 18S ribosomal pre-RNA processing.2 Publications

GO - Molecular functioni

  1. rRNA binding Source: UniProtKB-KW
  2. snoRNA binding Source: SGD

GO - Biological processi

  1. ribosome biogenesis Source: SGD
  2. rRNA processing Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Biological processi

Ribosome biogenesis, rRNA processing

Keywords - Ligandi

RNA-binding, rRNA-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-31183-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
U3 small nucleolar ribonucleoprotein protein IMP3
Short name:
U3 snoRNP protein IMP3
Alternative name(s):
Interacting with MPP10 protein 3
Gene namesi
Name:IMP3
Ordered Locus Names:YHR148W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VIII

Organism-specific databases

CYGDiYHR148w.
SGDiS000001191. IMP3.

Subcellular locationi

Nucleusnucleolus 1 Publication

GO - Cellular componenti

  1. Mpp10 complex Source: SGD
  2. small-subunit processome Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 183183U3 small nucleolar ribonucleoprotein protein IMP3PRO_0000132712Add
BLAST

Proteomic databases

MaxQBiP32899.
PaxDbiP32899.
PeptideAtlasiP32899.

Expressioni

Gene expression databases

GenevestigatoriP32899.

Interactioni

Subunit structurei

Component of a heterotrimeric complex containing IMP3, IMP4 and MPP10. Interacts with MPP10. Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
MPP10P470833EBI-9237,EBI-11168

Protein-protein interaction databases

BioGridi36582. 48 interactions.
DIPiDIP-5009N.
IntActiP32899. 14 interactions.
MINTiMINT-8285260.
STRINGi4932.YHR148W.

Structurei

3D structure databases

ProteinModelPortaliP32899.
SMRiP32899. Positions 21-166.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini109 – 17567S4 RNA-bindingPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ribosomal protein S4P family.Curated
Contains 1 S4 RNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0522.
GeneTreeiENSGT00550000075090.
HOGENOMiHOG000213883.
InParanoidiP32899.
KOiK14560.
OMAiKKVDFLN.
OrthoDBiEOG74N5V2.

Family and domain databases

Gene3Di3.10.290.10. 1 hit.
InterProiIPR022801. Ribosomal_S4/S9.
IPR001912. Ribosomal_S4/S9_N.
IPR002942. S4_RNA-bd.
[Graphical view]
PANTHERiPTHR11831. PTHR11831. 1 hit.
PfamiPF00163. Ribosomal_S4. 1 hit.
PF01479. S4. 1 hit.
[Graphical view]
SMARTiSM00363. S4. 1 hit.
[Graphical view]
PROSITEiPS50889. S4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P32899-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVRKLKHHEQ KLLKKVDFLE WKQDQGHRDT QVMRTYHIQN REDYHKYNRI
60 70 80 90 100
CGDIRRLANK LSLLPPTDPF RRKHEQLLLD KLYAMGVLTT KSKISDLENK
110 120 130 140 150
VTVSAICRRR LPVIMHRLKM AETIQDAVKF IEQGHVRVGP NLINDPAYLV
160 170 180
TRNMEDYVTW VDNSKIKKTL LRYRNQIDDF DFS
Length:183
Mass (Da):21,885
Last modified:October 1, 1993 - v1
Checksum:i2CA16A3425691DBD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69480 Genomic DNA. Translation: CAA49237.1.
U10397 Genomic DNA. Translation: AAB68981.1.
AY558388 Genomic DNA. Translation: AAS56714.1.
BK006934 Genomic DNA. Translation: DAA06841.1.
PIRiS33911.
RefSeqiNP_012018.1. NM_001179279.1.

Genome annotation databases

EnsemblFungiiYHR148W; YHR148W; YHR148W.
GeneIDi856553.
KEGGisce:YHR148W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69480 Genomic DNA. Translation: CAA49237.1 .
U10397 Genomic DNA. Translation: AAB68981.1 .
AY558388 Genomic DNA. Translation: AAS56714.1 .
BK006934 Genomic DNA. Translation: DAA06841.1 .
PIRi S33911.
RefSeqi NP_012018.1. NM_001179279.1.

3D structure databases

ProteinModelPortali P32899.
SMRi P32899. Positions 21-166.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 36582. 48 interactions.
DIPi DIP-5009N.
IntActi P32899. 14 interactions.
MINTi MINT-8285260.
STRINGi 4932.YHR148W.

Proteomic databases

MaxQBi P32899.
PaxDbi P32899.
PeptideAtlasi P32899.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YHR148W ; YHR148W ; YHR148W .
GeneIDi 856553.
KEGGi sce:YHR148W.

Organism-specific databases

CYGDi YHR148w.
SGDi S000001191. IMP3.

Phylogenomic databases

eggNOGi COG0522.
GeneTreei ENSGT00550000075090.
HOGENOMi HOG000213883.
InParanoidi P32899.
KOi K14560.
OMAi KKVDFLN.
OrthoDBi EOG74N5V2.

Enzyme and pathway databases

BioCyci YEAST:G3O-31183-MONOMER.

Miscellaneous databases

NextBioi 982363.
PROi P32899.

Gene expression databases

Genevestigatori P32899.

Family and domain databases

Gene3Di 3.10.290.10. 1 hit.
InterProi IPR022801. Ribosomal_S4/S9.
IPR001912. Ribosomal_S4/S9_N.
IPR002942. S4_RNA-bd.
[Graphical view ]
PANTHERi PTHR11831. PTHR11831. 1 hit.
Pfami PF00163. Ribosomal_S4. 1 hit.
PF01479. S4. 1 hit.
[Graphical view ]
SMARTi SM00363. S4. 1 hit.
[Graphical view ]
PROSITEi PS50889. S4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and analysis of the nuclear gene MRP-L6 coding for a putative mitochondrial ribosomal protein from Saccharomyces cerevisiae."
    Schwank S., Harrer R., Schueller H.-J., Schweizer E.
    Curr. Genet. 24:136-140(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  5. "Imp3p and Imp4p, two specific components of the U3 small nucleolar ribonucleoprotein that are essential for pre-18S rRNA processing."
    Lee S.J., Baserga S.J.
    Mol. Cell. Biol. 19:5441-5452(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  6. Cited for: IDENTIFICATION IN SSU PROCESSOME BY MASS SPECTROMETRY.
  7. "Imp3p and Imp4p mediate formation of essential U3-precursor rRNA (pre-rRNA) duplexes, possibly to recruit the small subunit processome to the pre-rRNA."
    Gerczei T., Correll C.C.
    Proc. Natl. Acad. Sci. U.S.A. 101:15301-15306(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH MPP10.

Entry informationi

Entry nameiIMP3_YEAST
AccessioniPrimary (citable) accession number: P32899
Secondary accession number(s): D3DL97
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: October 29, 2014
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Ribosomal proteins
    Ribosomal proteins families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

External Data

Dasty 3