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Protein

U3 small nucleolar ribonucleoprotein protein IMP3

Gene

IMP3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for the early cleavages at sites A0, A1 and A2 during 18S ribosomal pre-RNA processing.2 Publications

GO - Molecular functioni

  • snoRNA binding Source: SGD

GO - Biological processi

  • ribosomal small subunit biogenesis Source: SGD
  • rRNA methylation Source: Reactome
  • rRNA processing Source: SGD

Keywordsi

Molecular functionRibonucleoprotein, RNA-binding, rRNA-binding
Biological processRibosome biogenesis, rRNA processing

Enzyme and pathway databases

BioCyciYEAST:G3O-31183-MONOMER
ReactomeiR-SCE-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Names & Taxonomyi

Protein namesi
Recommended name:
U3 small nucleolar ribonucleoprotein protein IMP3
Short name:
U3 snoRNP protein IMP3
Alternative name(s):
Interacting with MPP10 protein 3
Gene namesi
Name:IMP3
Ordered Locus Names:YHR148W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VIII

Organism-specific databases

EuPathDBiFungiDB:YHR148W
SGDiS000001191 IMP3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001327121 – 183U3 small nucleolar ribonucleoprotein protein IMP3Add BLAST183

Proteomic databases

MaxQBiP32899
PaxDbiP32899
PRIDEiP32899

Interactioni

Subunit structurei

Component of a heterotrimeric complex containing IMP3, IMP4 and MPP10. Interacts with MPP10. Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3.2 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi36582, 27 interactors
DIPiDIP-5009N
IntActiP32899, 23 interactors
MINTiP32899
STRINGi4932.YHR148W

Structurei

Secondary structure

1183
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi29 – 35Combined sources7
Helixi41 – 62Combined sources22
Helixi69 – 84Combined sources16
Helixi94 – 96Combined sources3
Helixi97 – 100Combined sources4
Helixi103 – 107Combined sources5
Helixi111 – 117Combined sources7
Beta strandi120 – 123Combined sources4
Helixi124 – 132Combined sources9
Beta strandi136 – 138Combined sources3
Turni152 – 156Combined sources5
Beta strandi158 – 160Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5WLCelectron microscopy3.80LZ1-183[»]
5WXMX-ray2.30A/B26-183[»]
5WYJelectron microscopy8.70MA1-183[»]
5WYKelectron microscopy4.50MA1-183[»]
ProteinModelPortaliP32899
SMRiP32899
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini109 – 175S4 RNA-bindingPROSITE-ProRule annotationAdd BLAST67

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00550000075090
HOGENOMiHOG000213883
InParanoidiP32899
KOiK14560
OMAiKVDFLNW
OrthoDBiEOG092C4Y4I

Family and domain databases

CDDicd00165 S4, 1 hit
Gene3Di3.10.290.10, 1 hit
InterProiView protein in InterPro
IPR022801 Ribosomal_S4/S9
IPR001912 Ribosomal_S4/S9_N
IPR002942 S4_RNA-bd
IPR036986 S4_RNA-bd_sf
PANTHERiPTHR11831 PTHR11831, 1 hit
PfamiView protein in Pfam
PF00163 Ribosomal_S4, 1 hit
PF01479 S4, 1 hit
SMARTiView protein in SMART
SM01390 Ribosomal_S4, 1 hit
SM00363 S4, 1 hit
PROSITEiView protein in PROSITE
PS50889 S4, 1 hit

Sequencei

Sequence statusi: Complete.

P32899-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVRKLKHHEQ KLLKKVDFLE WKQDQGHRDT QVMRTYHIQN REDYHKYNRI
60 70 80 90 100
CGDIRRLANK LSLLPPTDPF RRKHEQLLLD KLYAMGVLTT KSKISDLENK
110 120 130 140 150
VTVSAICRRR LPVIMHRLKM AETIQDAVKF IEQGHVRVGP NLINDPAYLV
160 170 180
TRNMEDYVTW VDNSKIKKTL LRYRNQIDDF DFS
Length:183
Mass (Da):21,885
Last modified:October 1, 1993 - v1
Checksum:i2CA16A3425691DBD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69480 Genomic DNA Translation: CAA49237.1
U10397 Genomic DNA Translation: AAB68981.1
AY558388 Genomic DNA Translation: AAS56714.1
BK006934 Genomic DNA Translation: DAA06841.1
PIRiS33911
RefSeqiNP_012018.1, NM_001179279.1

Genome annotation databases

EnsemblFungiiYHR148W; YHR148W; YHR148W
GeneIDi856553
KEGGisce:YHR148W

Similar proteinsi

Entry informationi

Entry nameiIMP3_YEAST
AccessioniPrimary (citable) accession number: P32899
Secondary accession number(s): D3DL97
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: May 23, 2018
This is version 159 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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