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P32899 (IMP3_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 125. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
U3 small nucleolar ribonucleoprotein protein IMP3

Short name=U3 snoRNP protein IMP3
Alternative name(s):
Interacting with MPP10 protein 3
Gene names
Name:IMP3
Ordered Locus Names:YHR148W
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length183 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Required for the early cleavages at sites A0, A1 and A2 during 18S ribosomal pre-RNA processing. Ref.5 Ref.7

Subunit structure

Component of a heterotrimeric complex containing IMP3, IMP4 and MPP10. Interacts with MPP10. Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3. Ref.6 Ref.7

Subcellular location

Nucleusnucleolus Ref.5.

Sequence similarities

Belongs to the ribosomal protein S4P family.

Contains 1 S4 RNA-binding domain.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

MPP10P470833EBI-9237,EBI-11168

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 183183U3 small nucleolar ribonucleoprotein protein IMP3
PRO_0000132712

Regions

Domain109 – 17567S4 RNA-binding

Sequences

Sequence LengthMass (Da)Tools
P32899 [UniParc].

Last modified October 1, 1993. Version 1.
Checksum: 2CA16A3425691DBD

FASTA18321,885
        10         20         30         40         50         60 
MVRKLKHHEQ KLLKKVDFLE WKQDQGHRDT QVMRTYHIQN REDYHKYNRI CGDIRRLANK 

        70         80         90        100        110        120 
LSLLPPTDPF RRKHEQLLLD KLYAMGVLTT KSKISDLENK VTVSAICRRR LPVIMHRLKM 

       130        140        150        160        170        180 
AETIQDAVKF IEQGHVRVGP NLINDPAYLV TRNMEDYVTW VDNSKIKKTL LRYRNQIDDF 


DFS 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning and analysis of the nuclear gene MRP-L6 coding for a putative mitochondrial ribosomal protein from Saccharomyces cerevisiae."
Schwank S., Harrer R., Schueller H.-J., Schweizer E.
Curr. Genet. 24:136-140(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII."
Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z., Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T., Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P. expand/collapse author list , Louis E.J., Macri C., Mardis E., Menezes S., Mouser L., Nhan M., Rifkin L., Riles L., St Peter H., Trevaskis E., Vaughan K., Vignati D., Wilcox L., Wohldman P., Waterston R., Wilson R., Vaudin M.
Science 265:2077-2082(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae."
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. expand/collapse author list , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J.
Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[5]"Imp3p and Imp4p, two specific components of the U3 small nucleolar ribonucleoprotein that are essential for pre-18S rRNA processing."
Lee S.J., Baserga S.J.
Mol. Cell. Biol. 19:5441-5452(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.
[6]"A large nucleolar U3 ribonucleoprotein required for 18S ribosomal RNA biogenesis."
Dragon F., Gallagher J.E.G., Compagnone-Post P.A., Mitchell B.M., Porwancher K.A., Wehner K.A., Wormsley S., Settlage R.E., Shabanowitz J., Osheim Y., Beyer A.L., Hunt D.F., Baserga S.J.
Nature 417:967-970(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION IN SSU PROCESSOME BY MASS SPECTROMETRY.
[7]"Imp3p and Imp4p mediate formation of essential U3-precursor rRNA (pre-rRNA) duplexes, possibly to recruit the small subunit processome to the pre-rRNA."
Gerczei T., Correll C.C.
Proc. Natl. Acad. Sci. U.S.A. 101:15301-15306(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH MPP10.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X69480 Genomic DNA. Translation: CAA49237.1.
U10397 Genomic DNA. Translation: AAB68981.1.
AY558388 Genomic DNA. Translation: AAS56714.1.
BK006934 Genomic DNA. Translation: DAA06841.1.
PIRS33911.
RefSeqNP_012018.1. NM_001179279.1.

3D structure databases

ProteinModelPortalP32899.
SMRP32899. Positions 21-166.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid36582. 48 interactions.
DIPDIP-5009N.
IntActP32899. 14 interactions.
MINTMINT-8285260.
STRING4932.YHR148W.

Proteomic databases

PaxDbP32899.
PeptideAtlasP32899.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYHR148W; YHR148W; YHR148W.
GeneID856553.
KEGGsce:YHR148W.

Organism-specific databases

CYGDYHR148w.
SGDS000001191. IMP3.

Phylogenomic databases

eggNOGCOG0522.
GeneTreeENSGT00550000075090.
HOGENOMHOG000213883.
KOK14560.
OMAKKVDFLN.
OrthoDBEOG74N5V2.

Enzyme and pathway databases

BioCycYEAST:G3O-31183-MONOMER.

Gene expression databases

GenevestigatorP32899.

Family and domain databases

Gene3D3.10.290.10. 1 hit.
InterProIPR022801. Ribosomal_S4/S9.
IPR001912. Ribosomal_S4/S9_N.
IPR002942. S4_RNA-bd.
[Graphical view]
PANTHERPTHR11831. PTHR11831. 1 hit.
PfamPF00163. Ribosomal_S4. 1 hit.
PF01479. S4. 1 hit.
[Graphical view]
SMARTSM00363. S4. 1 hit.
[Graphical view]
PROSITEPS50889. S4. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio982363.
PROP32899.

Entry information

Entry nameIMP3_YEAST
AccessionPrimary (citable) accession number: P32899
Secondary accession number(s): D3DL97
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: April 16, 2014
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome VIII

Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families

Ribosomal proteins

Ribosomal proteins families and list of entries