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P32899

- IMP3_YEAST

UniProt

P32899 - IMP3_YEAST

Protein

U3 small nucleolar ribonucleoprotein protein IMP3

Gene

IMP3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 128 (01 Oct 2014)
      Sequence version 1 (01 Oct 1993)
      Previous versions | rss
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    Functioni

    Required for the early cleavages at sites A0, A1 and A2 during 18S ribosomal pre-RNA processing.2 Publications

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. rRNA binding Source: UniProtKB-KW
    3. snoRNA binding Source: SGD

    GO - Biological processi

    1. ribosome biogenesis Source: SGD
    2. rRNA processing Source: SGD

    Keywords - Molecular functioni

    Ribonucleoprotein

    Keywords - Biological processi

    Ribosome biogenesis, rRNA processing

    Keywords - Ligandi

    RNA-binding, rRNA-binding

    Enzyme and pathway databases

    BioCyciYEAST:G3O-31183-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    U3 small nucleolar ribonucleoprotein protein IMP3
    Short name:
    U3 snoRNP protein IMP3
    Alternative name(s):
    Interacting with MPP10 protein 3
    Gene namesi
    Name:IMP3
    Ordered Locus Names:YHR148W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome VIII

    Organism-specific databases

    CYGDiYHR148w.
    SGDiS000001191. IMP3.

    Subcellular locationi

    Nucleusnucleolus 1 Publication

    GO - Cellular componenti

    1. Mpp10 complex Source: SGD
    2. small-subunit processome Source: SGD

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 183183U3 small nucleolar ribonucleoprotein protein IMP3PRO_0000132712Add
    BLAST

    Proteomic databases

    MaxQBiP32899.
    PaxDbiP32899.
    PeptideAtlasiP32899.

    Expressioni

    Gene expression databases

    GenevestigatoriP32899.

    Interactioni

    Subunit structurei

    Component of a heterotrimeric complex containing IMP3, IMP4 and MPP10. Interacts with MPP10. Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    MPP10P470833EBI-9237,EBI-11168

    Protein-protein interaction databases

    BioGridi36582. 48 interactions.
    DIPiDIP-5009N.
    IntActiP32899. 14 interactions.
    MINTiMINT-8285260.
    STRINGi4932.YHR148W.

    Structurei

    3D structure databases

    ProteinModelPortaliP32899.
    SMRiP32899. Positions 1-167.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini109 – 17567S4 RNA-bindingPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ribosomal protein S4P family.Curated
    Contains 1 S4 RNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0522.
    GeneTreeiENSGT00550000075090.
    HOGENOMiHOG000213883.
    KOiK14560.
    OMAiKKVDFLN.
    OrthoDBiEOG74N5V2.

    Family and domain databases

    Gene3Di3.10.290.10. 1 hit.
    InterProiIPR022801. Ribosomal_S4/S9.
    IPR001912. Ribosomal_S4/S9_N.
    IPR002942. S4_RNA-bd.
    [Graphical view]
    PANTHERiPTHR11831. PTHR11831. 1 hit.
    PfamiPF00163. Ribosomal_S4. 1 hit.
    PF01479. S4. 1 hit.
    [Graphical view]
    SMARTiSM00363. S4. 1 hit.
    [Graphical view]
    PROSITEiPS50889. S4. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P32899-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVRKLKHHEQ KLLKKVDFLE WKQDQGHRDT QVMRTYHIQN REDYHKYNRI    50
    CGDIRRLANK LSLLPPTDPF RRKHEQLLLD KLYAMGVLTT KSKISDLENK 100
    VTVSAICRRR LPVIMHRLKM AETIQDAVKF IEQGHVRVGP NLINDPAYLV 150
    TRNMEDYVTW VDNSKIKKTL LRYRNQIDDF DFS 183
    Length:183
    Mass (Da):21,885
    Last modified:October 1, 1993 - v1
    Checksum:i2CA16A3425691DBD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X69480 Genomic DNA. Translation: CAA49237.1.
    U10397 Genomic DNA. Translation: AAB68981.1.
    AY558388 Genomic DNA. Translation: AAS56714.1.
    BK006934 Genomic DNA. Translation: DAA06841.1.
    PIRiS33911.
    RefSeqiNP_012018.1. NM_001179279.1.

    Genome annotation databases

    EnsemblFungiiYHR148W; YHR148W; YHR148W.
    GeneIDi856553.
    KEGGisce:YHR148W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X69480 Genomic DNA. Translation: CAA49237.1 .
    U10397 Genomic DNA. Translation: AAB68981.1 .
    AY558388 Genomic DNA. Translation: AAS56714.1 .
    BK006934 Genomic DNA. Translation: DAA06841.1 .
    PIRi S33911.
    RefSeqi NP_012018.1. NM_001179279.1.

    3D structure databases

    ProteinModelPortali P32899.
    SMRi P32899. Positions 1-167.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 36582. 48 interactions.
    DIPi DIP-5009N.
    IntActi P32899. 14 interactions.
    MINTi MINT-8285260.
    STRINGi 4932.YHR148W.

    Proteomic databases

    MaxQBi P32899.
    PaxDbi P32899.
    PeptideAtlasi P32899.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YHR148W ; YHR148W ; YHR148W .
    GeneIDi 856553.
    KEGGi sce:YHR148W.

    Organism-specific databases

    CYGDi YHR148w.
    SGDi S000001191. IMP3.

    Phylogenomic databases

    eggNOGi COG0522.
    GeneTreei ENSGT00550000075090.
    HOGENOMi HOG000213883.
    KOi K14560.
    OMAi KKVDFLN.
    OrthoDBi EOG74N5V2.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-31183-MONOMER.

    Miscellaneous databases

    NextBioi 982363.
    PROi P32899.

    Gene expression databases

    Genevestigatori P32899.

    Family and domain databases

    Gene3Di 3.10.290.10. 1 hit.
    InterProi IPR022801. Ribosomal_S4/S9.
    IPR001912. Ribosomal_S4/S9_N.
    IPR002942. S4_RNA-bd.
    [Graphical view ]
    PANTHERi PTHR11831. PTHR11831. 1 hit.
    Pfami PF00163. Ribosomal_S4. 1 hit.
    PF01479. S4. 1 hit.
    [Graphical view ]
    SMARTi SM00363. S4. 1 hit.
    [Graphical view ]
    PROSITEi PS50889. S4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and analysis of the nuclear gene MRP-L6 coding for a putative mitochondrial ribosomal protein from Saccharomyces cerevisiae."
      Schwank S., Harrer R., Schueller H.-J., Schweizer E.
      Curr. Genet. 24:136-140(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    5. "Imp3p and Imp4p, two specific components of the U3 small nucleolar ribonucleoprotein that are essential for pre-18S rRNA processing."
      Lee S.J., Baserga S.J.
      Mol. Cell. Biol. 19:5441-5452(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    6. Cited for: IDENTIFICATION IN SSU PROCESSOME BY MASS SPECTROMETRY.
    7. "Imp3p and Imp4p mediate formation of essential U3-precursor rRNA (pre-rRNA) duplexes, possibly to recruit the small subunit processome to the pre-rRNA."
      Gerczei T., Correll C.C.
      Proc. Natl. Acad. Sci. U.S.A. 101:15301-15306(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH MPP10.

    Entry informationi

    Entry nameiIMP3_YEAST
    AccessioniPrimary (citable) accession number: P32899
    Secondary accession number(s): D3DL97
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1993
    Last sequence update: October 1, 1993
    Last modified: October 1, 2014
    This is version 128 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Ribosomal proteins
      Ribosomal proteins families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families
    3. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    4. Yeast chromosome VIII
      Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

    External Data

    Dasty 3