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Protein

Protein PDC2

Gene

PDC2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Essential for the synthesis of pyruvate decarboxylase. May be important for a high basal level of PDC gene expression or play a positive role in the autoregulation control of PDC1 and PDC5.

Miscellaneous

Present with 572 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • RNA polymerase II proximal promoter sequence-specific DNA binding Source: SGD

GO - Biological processi

  • positive regulation of glycolytic fermentation to ethanol Source: SGD
  • positive regulation of thiamine biosynthetic process Source: SGD
  • positive regulation of transcription by RNA polymerase II Source: SGD

Keywordsi

Molecular functionDNA-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-29686-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Protein PDC2
Gene namesi
Name:PDC2
Ordered Locus Names:YDR081C
ORF Names:D4451
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi

Organism-specific databases

EuPathDBiFungiDB:YDR081C
SGDiS000002488 PDC2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001261371 – 925Protein PDC2Add BLAST925

Proteomic databases

MaxQBiP32896
PaxDbiP32896
PRIDEiP32896

PTM databases

iPTMnetiP32896

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
THI3Q074713EBI-13004,EBI-19209

Protein-protein interaction databases

BioGridi32137, 351 interactors
IntActiP32896, 6 interactors
MINTiP32896
STRINGi4932.YDR081C

Structurei

3D structure databases

ProteinModelPortaliP32896
SMRiP32896
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini63 – 138HTH CENPB-typePROSITE-ProRule annotationAdd BLAST76

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi538 – 562Asn/Ser-richAdd BLAST25
Compositional biasi890 – 895Poly-Ala6

Phylogenomic databases

GeneTreeiENSGT00760000119149
HOGENOMiHOG000115832
InParanoidiP32896
OMAiEHREGNG
OrthoDBiEOG092C1XHR

Family and domain databases

InterProiView protein in InterPro
IPR004875 DDE_SF_endonuclease_dom
IPR009057 Homeobox-like_sf
IPR006600 HTH_CenpB_DNA-bd_dom
PfamiView protein in Pfam
PF03184 DDE_1, 1 hit
PF03221 HTH_Tnp_Tc5, 1 hit
SMARTiView protein in SMART
SM00674 CENPB, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS51253 HTH_CENPB, 1 hit

Sequencei

Sequence statusi: Complete.

P32896-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSIQQRYNI CLMAERHPKW TQLELAKWAY ETFQLPKIPS QGTISRLLAR
60 70 80 90 100
KSTYMNCKEH EKDANRLRKP NNLLVRKILQ EWISQSLWNG IPITSPIIQD
110 120 130 140 150
TAQAVWHRIP AEHREGNGSF SYKWISNFLS KMDVNISVLD EELPKTPKVW
160 170 180 190 200
TFEERDVLKA YFSKIPPKDL FTLDEAFLSY NLPLDYAQYE ASSIQRRIEV
210 220 230 240 250
ATVMLCSNLD GSEKLKPVVV GKYDSYKSFR NYFPNEPNDP VSQSMLGTKM
260 270 280 290 300
AKKFDISYHS NRKAWLTSNL FHNWLVRWDK RLVAVNRKIW IVLDDSCCHR
310 320 330 340 350
IINLRLQNIK LVYTSSNSKF LPFNWGVWDE FKTRYRIQQY QALIDLQNRI
360 370 380 390 400
SKNIQNKNKS ERNECIPNGK KCLISFEQSQ LTMSNAFKFI KKAWDDIPVD
410 420 430 440 450
AIKANWKSSG LLPPEMIHLN ENVSMAFKKN EVLESVLNRL CDEYYCVKKW
460 470 480 490 500
EYEMLLDLNI ENKNTNFLST EELVESAIVE PCEPDFDTAP KGNEVHDDNF
510 520 530 540 550
DVSVFANEDD NNQNHLSMSQ ASHNPDYNSN HSNNAIENTN NRGSNNNNNN
560 570 580 590 600
NGSSNNINDN DSSVKYLQQN TVDNSTKTGN PGQPNISSME SQRNSSTTDL
610 620 630 640 650
VVDGNYDVNF NGLLNDPYNT MKQPGPLDYN VSTLIDKPNL FLSPDLDLST
660 670 680 690 700
VGVDMQLPSS EYFSEVFSSA IRNNEKAASD QNKSTDELPS STAMANSNSI
710 720 730 740 750
TTALLESRNQ AQPFDVPHMN GLLSDTSKSG HSVNSSNAIS QNSLNNFQHN
760 770 780 790 800
SASVAEASSP SITPSPVAIN STGAPARSII SAPIDSNSSA SSPSALEHLE
810 820 830 840 850
GAVSGMSPSS TTILSNLQTN INIAKSLSTI MKHAESNEIS LTKETINELN
860 870 880 890 900
FNYLTLLKRI KKTRKQLNSE SIKINSKNAQ DHLETLLSGA AAAAATSANN
910 920
LDLPTGGSNL PDSNNLHLPG NTGFF
Length:925
Mass (Da):103,944
Last modified:October 5, 2010 - v2
Checksum:i579FFF99A944E686
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti113H → T in CAA46558 (PubMed:8264540).Curated1
Sequence conflicti113H → T in AAA34845 (Ref. 2) Curated1
Sequence conflicti174D → I in CAA46558 (PubMed:8264540).Curated1
Sequence conflicti174D → I in AAA34845 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X65608 Genomic DNA Translation: CAA46558.1
L19880 Genomic DNA Translation: AAA34845.1
X82086 Genomic DNA Translation: CAA57608.1
Z46796 Genomic DNA Translation: CAA86803.1
Z74377 Genomic DNA Translation: CAA98900.1
Z74378 Genomic DNA Translation: CAA98901.1
BK006938 Genomic DNA Translation: DAA11928.1
PIRiS48768
RefSeqiNP_010366.1, NM_001180389.1

Genome annotation databases

EnsemblFungiiYDR081C; YDR081C; YDR081C
GeneIDi851654
KEGGisce:YDR081C

Similar proteinsi

Entry informationi

Entry nameiPDC2_YEAST
AccessioniPrimary (citable) accession number: P32896
Secondary accession number(s): D6VS68, E9PAG9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 5, 2010
Last modified: May 23, 2018
This is version 153 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

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