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Protein

Protein PDC2

Gene

PDC2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Essential for the synthesis of pyruvate decarboxylase. May be important for a high basal level of PDC gene expression or play a positive role in the autoregulation control of PDC1 and PDC5.

GO - Molecular functioni

GO - Biological processi

  • positive regulation of glycolytic fermentation to ethanol Source: SGD
  • positive regulation of thiamine biosynthetic process Source: SGD
  • positive regulation of transcription from RNA polymerase II promoter Source: SGD
Complete GO annotation...

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-29686-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein PDC2
Gene namesi
Name:PDC2
Ordered Locus Names:YDR081C
ORF Names:D4451
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR081C.
SGDiS000002488. PDC2.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: SGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 925925Protein PDC2PRO_0000126137Add
BLAST

Proteomic databases

MaxQBiP32896.
PeptideAtlasiP32896.

PTM databases

iPTMnetiP32896.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
THI3Q074713EBI-13004,EBI-19209

Protein-protein interaction databases

BioGridi32137. 12 interactions.
IntActiP32896. 6 interactions.
MINTiMINT-2785884.

Structurei

3D structure databases

ProteinModelPortaliP32896.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini63 – 13876HTH CENPB-typePROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi538 – 56225Asn/Ser-richAdd
BLAST
Compositional biasi890 – 8956Poly-Ala

Sequence similaritiesi

Contains 1 HTH CENPB-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00760000119149.
HOGENOMiHOG000115832.
InParanoidiP32896.
OrthoDBiEOG7BZW1V.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR004875. DDE_SF_endonuclease_dom.
IPR009057. Homeodomain-like.
IPR006600. HTH_CenpB_DNA-bd_dom.
[Graphical view]
PfamiPF03184. DDE_1. 1 hit.
PF03221. HTH_Tnp_Tc5. 1 hit.
[Graphical view]
SMARTiSM00674. CENPB. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS51253. HTH_CENPB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P32896-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSIQQRYNI CLMAERHPKW TQLELAKWAY ETFQLPKIPS QGTISRLLAR
60 70 80 90 100
KSTYMNCKEH EKDANRLRKP NNLLVRKILQ EWISQSLWNG IPITSPIIQD
110 120 130 140 150
TAQAVWHRIP AEHREGNGSF SYKWISNFLS KMDVNISVLD EELPKTPKVW
160 170 180 190 200
TFEERDVLKA YFSKIPPKDL FTLDEAFLSY NLPLDYAQYE ASSIQRRIEV
210 220 230 240 250
ATVMLCSNLD GSEKLKPVVV GKYDSYKSFR NYFPNEPNDP VSQSMLGTKM
260 270 280 290 300
AKKFDISYHS NRKAWLTSNL FHNWLVRWDK RLVAVNRKIW IVLDDSCCHR
310 320 330 340 350
IINLRLQNIK LVYTSSNSKF LPFNWGVWDE FKTRYRIQQY QALIDLQNRI
360 370 380 390 400
SKNIQNKNKS ERNECIPNGK KCLISFEQSQ LTMSNAFKFI KKAWDDIPVD
410 420 430 440 450
AIKANWKSSG LLPPEMIHLN ENVSMAFKKN EVLESVLNRL CDEYYCVKKW
460 470 480 490 500
EYEMLLDLNI ENKNTNFLST EELVESAIVE PCEPDFDTAP KGNEVHDDNF
510 520 530 540 550
DVSVFANEDD NNQNHLSMSQ ASHNPDYNSN HSNNAIENTN NRGSNNNNNN
560 570 580 590 600
NGSSNNINDN DSSVKYLQQN TVDNSTKTGN PGQPNISSME SQRNSSTTDL
610 620 630 640 650
VVDGNYDVNF NGLLNDPYNT MKQPGPLDYN VSTLIDKPNL FLSPDLDLST
660 670 680 690 700
VGVDMQLPSS EYFSEVFSSA IRNNEKAASD QNKSTDELPS STAMANSNSI
710 720 730 740 750
TTALLESRNQ AQPFDVPHMN GLLSDTSKSG HSVNSSNAIS QNSLNNFQHN
760 770 780 790 800
SASVAEASSP SITPSPVAIN STGAPARSII SAPIDSNSSA SSPSALEHLE
810 820 830 840 850
GAVSGMSPSS TTILSNLQTN INIAKSLSTI MKHAESNEIS LTKETINELN
860 870 880 890 900
FNYLTLLKRI KKTRKQLNSE SIKINSKNAQ DHLETLLSGA AAAAATSANN
910 920
LDLPTGGSNL PDSNNLHLPG NTGFF
Length:925
Mass (Da):103,944
Last modified:October 5, 2010 - v2
Checksum:i579FFF99A944E686
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti113 – 1131H → T in CAA46558 (PubMed:8264540).Curated
Sequence conflicti113 – 1131H → T in AAA34845 (Ref. 2) Curated
Sequence conflicti174 – 1741D → I in CAA46558 (PubMed:8264540).Curated
Sequence conflicti174 – 1741D → I in AAA34845 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X65608 Genomic DNA. Translation: CAA46558.1.
L19880 Genomic DNA. Translation: AAA34845.1.
X82086 Genomic DNA. Translation: CAA57608.1.
Z46796 Genomic DNA. Translation: CAA86803.1.
Z74377 Genomic DNA. Translation: CAA98900.1.
Z74378 Genomic DNA. Translation: CAA98901.1.
BK006938 Genomic DNA. Translation: DAA11928.1.
PIRiS48768.
RefSeqiNP_010366.1. NM_001180389.1.

Genome annotation databases

EnsemblFungiiYDR081C; YDR081C; YDR081C.
GeneIDi851654.
KEGGisce:YDR081C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X65608 Genomic DNA. Translation: CAA46558.1.
L19880 Genomic DNA. Translation: AAA34845.1.
X82086 Genomic DNA. Translation: CAA57608.1.
Z46796 Genomic DNA. Translation: CAA86803.1.
Z74377 Genomic DNA. Translation: CAA98900.1.
Z74378 Genomic DNA. Translation: CAA98901.1.
BK006938 Genomic DNA. Translation: DAA11928.1.
PIRiS48768.
RefSeqiNP_010366.1. NM_001180389.1.

3D structure databases

ProteinModelPortaliP32896.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32137. 12 interactions.
IntActiP32896. 6 interactions.
MINTiMINT-2785884.

PTM databases

iPTMnetiP32896.

Proteomic databases

MaxQBiP32896.
PeptideAtlasiP32896.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDR081C; YDR081C; YDR081C.
GeneIDi851654.
KEGGisce:YDR081C.

Organism-specific databases

EuPathDBiFungiDB:YDR081C.
SGDiS000002488. PDC2.

Phylogenomic databases

GeneTreeiENSGT00760000119149.
HOGENOMiHOG000115832.
InParanoidiP32896.
OrthoDBiEOG7BZW1V.

Enzyme and pathway databases

BioCyciYEAST:G3O-29686-MONOMER.

Miscellaneous databases

PROiP32896.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR004875. DDE_SF_endonuclease_dom.
IPR009057. Homeodomain-like.
IPR006600. HTH_CenpB_DNA-bd_dom.
[Graphical view]
PfamiPF03184. DDE_1. 1 hit.
PF03221. HTH_Tnp_Tc5. 1 hit.
[Graphical view]
SMARTiSM00674. CENPB. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS51253. HTH_CENPB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterisation of PDC2, a gene necessary for high level expression of pyruvate decarboxylase structural genes in Saccharomyces cerevisiae."
    Hohmann S.
    Mol. Gen. Genet. 241:657-666(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Cloning and characterization of PDC2, a gene essential for the synthesis of pyruvate decarboxylase in Saccharomyces cerevisiae."
    Raghuram V., Lobo Z., Maitra P.K.
    Submitted (JUN-1993) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Analysis of a 32.8 kb segment of yeast chromosome IV reveals 21 open reading frames, including TPS2, PPH3, RAD55, SED1, PDC2, AFR1, SSS1, SLU7 and a tRNA for arginine."
    Coster F., Jonniaux J.-L., Goffeau A.
    Yeast 11:673-679(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV."
    Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T.
    , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P.
    Nature 387:75-78(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  5. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  7. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPDC2_YEAST
AccessioniPrimary (citable) accession number: P32896
Secondary accession number(s): D6VS68, E9PAG9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 5, 2010
Last modified: June 8, 2016
This is version 136 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 572 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.