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Protein

Trafficking protein particle complex II-specific subunit 65

Gene

TRS65

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Specific subunit of the TRAPP II complex, a highly conserved vesicle tethering complex that functions in the late Golgi as a guanine nucleotide exchanger (GEF) for the Golgi YPT1 GTPase. TRS65 plays a role in the YPT GEF activity of TRAPP II in concert with the two other TRAPP II-specific subunits TRS120 and TRS130. Involved in cell wall (1-->6)-beta-glucan synthesis.3 Publications

Miscellaneous

Present with 1660 molecules/cell in log phase SD medium.1 Publication

Pathwayi: beta-glucan biosynthesis

This protein is involved in the pathway beta-glucan biosynthesis, which is part of Glycan metabolism.
View all proteins of this organism that are known to be involved in the pathway beta-glucan biosynthesis and in Glycan metabolism.

GO - Biological processi

  • beta-glucan biosynthetic process Source: UniProtKB-UniPathway
  • cellular protein-containing complex assembly Source: SGD
  • cell wall organization Source: UniProtKB-KW
  • intra-Golgi vesicle-mediated transport Source: SGD

Keywordsi

Biological processCell wall biogenesis/degradation, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-30864-MONOMER
UniPathwayiUPA00636

Names & Taxonomyi

Protein namesi
Recommended name:
Trafficking protein particle complex II-specific subunit 65
Short name:
TRAPP II-specific subunit 65
Alternative name(s):
Beta-glucan synthesis-associated protein TRS65
Killer toxin-resistance protein 11
Transport protein particle 65 kDa subunit
Gene namesi
Name:TRS65
Synonyms:KRE11
Ordered Locus Names:YGR166W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGR166W
SGDiS000003398 TRS65

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000843281 – 560Trafficking protein particle complex II-specific subunit 65Add BLAST560

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei393PhosphoserineCombined sources1
Modified residuei398PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP32893
PaxDbiP32893
PRIDEiP32893

PTM databases

iPTMnetiP32893

Interactioni

Subunit structurei

Part of the multisubunit TRAPP (transport protein particle) II complex composed of BET3, BET5, TRS20, TRS23, TRS31, TRS33, TRS65, TRS120 and TRS130. Interacts directly with TRS120 and TRS130.4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
TRS130Q036603EBI-9900,EBI-19461

Protein-protein interaction databases

BioGridi33418, 253 interactors
DIPiDIP-5104N
IntActiP32893, 10 interactors
MINTiP32893
STRINGi4932.YGR166W

Structurei

3D structure databases

ProteinModelPortaliP32893
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

InParanoidiP32893
KOiK20311
OMAiNVVMNNG
OrthoDBiEOG092C1NZF

Family and domain databases

InterProiView protein in InterPro
IPR024662 Trs65
PfamiView protein in Pfam
PF12735 Trs65, 1 hit

Sequencei

Sequence statusi: Complete.

P32893-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MECFVPLRCD LDGSNIEQLR QSHLSRKFII FDEQLNLWLW FQGNSQENKR
60 70 80 90 100
FVLQNMIILI NEAQVTRTST IDDYFTQVEN NENLWRLKND CCSKILFKSN
110 120 130 140 150
VVMNNGYNNQ IKFVFEYKSV DANFNNQDSL QDPQAKYTLD KYSSEEILPS
160 170 180 190 200
FEPVYSWSSA ATKSSKNTNN HLEKNNRATH RVSSKNSEVH EADVSRNPNT
210 220 230 240 250
FTLKLQYPIF SLLNMRLRNI SLKSEHCILS SLDFQTSKAS EQLTKKFIYP
260 270 280 290 300
QEHNSFLKLN FQEISYKLID GTSQIELDPI CPLKVPLTAF SYDSISATFK
310 320 330 340 350
LVLLPKSTQP HRVKITLAYE LELHPNLKLP VRTSWETEVT LKRSMPISST
360 370 380 390 400
SSQYSSNNNN TNHSASFNGA ANNVNSGGLA NLRLGGVSSS RFSLGAASTT
410 420 430 440 450
SLVNSKLSNV KFKFINSNIK VIKGEKFTMR LQIINSSSSP LDLVVYYNNT
460 470 480 490 500
INPIPSANNV RNSNGINNCG MNNGTIPNSP LTLENQYQLH NKYRKIAEGI
510 520 530 540 550
ILLSNDYKIP VVPPRETYFA DLRFIGIMSG YYGTLSGLKV LDLNTNELIE
560
VGNGASVLIQ
Length:560
Mass (Da):63,368
Last modified:October 1, 1993 - v1
Checksum:i9039A2CEBB1F8316
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L10667 Genomic DNA Translation: AAA34727.1
Z72951 Genomic DNA Translation: CAA97191.1
BK006941 Genomic DNA Translation: DAA08260.1
PIRiS42158
RefSeqiNP_011682.1, NM_001181295.1

Genome annotation databases

EnsemblFungiiYGR166W; YGR166W; YGR166W
GeneIDi853076
KEGGisce:YGR166W

Similar proteinsi

Entry informationi

Entry nameiTRS65_YEAST
AccessioniPrimary (citable) accession number: P32893
Secondary accession number(s): D6VUU9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: May 23, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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