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P32888

- VP19_HHV11

UniProt

P32888 - VP19_HHV11

Protein

Triplex capsid protein VP19C

Gene

UL38

Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (01 Oct 1993)
      Previous versions | rss
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    Functioni

    Structural component of the T=16 icosahedral capsid. The capsid is composed of pentamers and hexamers of VP5, which are linked together by heterotrimers called triplex. These triplex are formed by a single molecule of VP19C and two copies of VP23 which bridge major capsid protein VP5 multimers together. Triplexes occupy the local threeflod positions between hexons and between hexamers and pentamers. Additionally, VP19C is required for efficient transport of VP23 to the nucleus, which is the site of capsid assembly.5 Publications

    GO - Molecular functioni

    1. DNA binding Source: InterPro

    GO - Biological processi

    1. viral capsid assembly Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Triplex capsid protein VP19C
    Alternative name(s):
    Virion protein UL38
    Gene namesi
    Name:UL38
    OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
    Taxonomic identifieri10299 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
    Virus hostiHomo sapiens (Human) [TaxID: 9606]
    ProteomesiUP000009294: Genome

    Subcellular locationi

    GO - Cellular componenti

    1. host cell nucleus Source: UniProtKB-SubCell
    2. viral capsid Source: CACAO

    Keywords - Cellular componenti

    Capsid protein, Host nucleus, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 465465Triplex capsid protein VP19CPRO_0000115712Add
    BLAST

    Interactioni

    Subunit structurei

    Interacts with VP23, VP5 and UL25.1 Publication

    Protein-protein interaction databases

    BioGridi971404. 2 interactions.
    DIPiDIP-2193N.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the herpesviridae VP19C family.Curated

    Family and domain databases

    InterProiIPR004999. Herpes_VP19C.
    [Graphical view]
    PfamiPF03327. Herpes_VP19C. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P32888-1 [UniParc]FASTAAdd to Basket

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    MKTNPLPATP SVWGGSTVEL PPTTRDTAGQ GLLRRVLRPP ISRRDGPGLP    50
    RGSGPRRAAS TLWLLGLDGT DAPPGALTPN DDTEQALDKI LRGTMRGGAA 100
    LIGSPRHHLT RQVILTDLCQ PNADRAGTLL LALRHPADLP HLAHQRAPPG 150
    RQTERLGEAW GQLMEATALG SGRAESGCTR AGLVSFNFLV AACAASYDAR 200
    DAADAVRAHV TANYRGTRVG ARLDRFSECL RAMVHTHVFP HEVMRFFGGL 250
    VSWVTQDELA SVTAVCAGPQ EAAHTGHPGR PRSAVILPAC AFVDLDAELG 300
    LGGPGAAFLY LVFTYRQRRD QELCCVYVIK SQLPPRGLEP ALERLFGRLR 350
    ITNTIHGTED MTPPAPNRNP DFPLAGLAAN PQTPRCSAGQ VTNPQFADRL 400
    YRWQPDLRGR PTARTCTYAA FAELGMMPED SPRCLHRTER FGAVSVPVVI 450
    LEGVVWRPGE WRACA 465
    Length:465
    Mass (Da):50,263
    Last modified:October 1, 1993 - v1
    Checksum:i5F00147AE29B3092
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X14112 Genomic DNA. Translation: CAA32313.1.
    PIRiB30088. WMBEZ8.
    RefSeqiNP_044640.1. NC_001806.1.

    Genome annotation databases

    GeneIDi2703359.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X14112 Genomic DNA. Translation: CAA32313.1 .
    PIRi B30088. WMBEZ8.
    RefSeqi NP_044640.1. NC_001806.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 971404. 2 interactions.
    DIPi DIP-2193N.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2703359.

    Family and domain databases

    InterProi IPR004999. Herpes_VP19C.
    [Graphical view ]
    Pfami PF03327. Herpes_VP19C. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1."
      McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P.
      J. Gen. Virol. 69:1531-1574(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Identification of the genes encoding two capsid proteins of herpes simplex virus type 1 by direct amino acid sequencing."
      Rixon F.J., Davison M.D., Davison A.J.
      J. Gen. Virol. 71:1211-1214(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    3. "The herpes simplex virus procapsid: structure, conformational changes upon maturation, and roles of the triplex proteins VP19c and VP23 in assembly."
      Trus B.L., Booy F.P., Newcomb W.W., Brown J.C., Homa F.L., Thomsen D.R., Steven A.C.
      J. Mol. Biol. 263:447-462(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    4. "Roles of triplex and scaffolding proteins in herpes simplex virus type 1 capsid formation suggested by structures of recombinant particles."
      Saad A., Zhou Z.H., Jakana J., Chiu W., Rixon F.J.
      J. Virol. 73:6821-6830(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    5. "Role of the UL25 gene product in packaging DNA into the herpes simplex virus capsid: location of UL25 product in the capsid and demonstration that it binds DNA."
      Ogasawara M., Suzutani T., Yoshida I., Azuma M.
      J. Virol. 75:1427-1436(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH UL25.
    6. "Functional analysis of the triplex proteins (VP19C and VP23) of herpes simplex virus type 1."
      Okoye M.E., Sexton G.L., Huang E., McCaffery J.M., Desai P.
      J. Virol. 80:929-940(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    7. "Mutational analysis of the herpes simplex virus triplex protein VP19C."
      Adamson W.E., McNab D., Preston V.G., Rixon F.J.
      J. Virol. 80:1537-1548(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    8. "Identification of genes encoding two capsid proteins (VP24 and VP26) of herpes simplex virus type 1."
      Davison M.D., Rixon F.J., Davison A.J.
      J. Gen. Virol. 73:2709-2713(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 1-16.

    Entry informationi

    Entry nameiVP19_HHV11
    AccessioniPrimary (citable) accession number: P32888
    Secondary accession number(s): P10222
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1993
    Last sequence update: October 1, 1993
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3