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P32888

- VP19_HHV11

UniProt

P32888 - VP19_HHV11

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Protein
Triplex capsid protein VP19C
Gene
UL38
Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Structural component of the T=16 icosahedral capsid. The capsid is composed of pentamers and hexamers of VP5, which are linked together by heterotrimers called triplex. These triplex are formed by a single molecule of VP19C and two copies of VP23 which bridge major capsid protein VP5 multimers together. Triplexes occupy the local threeflod positions between hexons and between hexamers and pentamers. Additionally, VP19C is required for efficient transport of VP23 to the nucleus, which is the site of capsid assembly.5 Publications

GO - Molecular functioni

  1. DNA binding Source: InterPro

GO - Biological processi

  1. viral capsid assembly Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Triplex capsid protein VP19C
Alternative name(s):
Virion protein UL38
Gene namesi
Name:UL38
OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifieri10299 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
ProteomesiUP000009294: Genome

Subcellular locationi

GO - Cellular componenti

  1. host cell nucleus Source: UniProtKB-SubCell
  2. viral capsid Source: CACAO
Complete GO annotation...

Keywords - Cellular componenti

Capsid protein, Host nucleus, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 465465Triplex capsid protein VP19C
PRO_0000115712Add
BLAST

Interactioni

Subunit structurei

Interacts with VP23, VP5 and UL25.1 Publication

Protein-protein interaction databases

BioGridi971404. 2 interactions.
DIPiDIP-2193N.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiIPR004999. Herpes_VP19C.
[Graphical view]
PfamiPF03327. Herpes_VP19C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P32888-1 [UniParc]FASTAAdd to Basket

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MKTNPLPATP SVWGGSTVEL PPTTRDTAGQ GLLRRVLRPP ISRRDGPGLP    50
RGSGPRRAAS TLWLLGLDGT DAPPGALTPN DDTEQALDKI LRGTMRGGAA 100
LIGSPRHHLT RQVILTDLCQ PNADRAGTLL LALRHPADLP HLAHQRAPPG 150
RQTERLGEAW GQLMEATALG SGRAESGCTR AGLVSFNFLV AACAASYDAR 200
DAADAVRAHV TANYRGTRVG ARLDRFSECL RAMVHTHVFP HEVMRFFGGL 250
VSWVTQDELA SVTAVCAGPQ EAAHTGHPGR PRSAVILPAC AFVDLDAELG 300
LGGPGAAFLY LVFTYRQRRD QELCCVYVIK SQLPPRGLEP ALERLFGRLR 350
ITNTIHGTED MTPPAPNRNP DFPLAGLAAN PQTPRCSAGQ VTNPQFADRL 400
YRWQPDLRGR PTARTCTYAA FAELGMMPED SPRCLHRTER FGAVSVPVVI 450
LEGVVWRPGE WRACA 465
Length:465
Mass (Da):50,263
Last modified:October 1, 1993 - v1
Checksum:i5F00147AE29B3092
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X14112 Genomic DNA. Translation: CAA32313.1.
PIRiB30088. WMBEZ8.
RefSeqiNP_044640.1. NC_001806.1.

Genome annotation databases

GeneIDi2703359.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X14112 Genomic DNA. Translation: CAA32313.1 .
PIRi B30088. WMBEZ8.
RefSeqi NP_044640.1. NC_001806.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 971404. 2 interactions.
DIPi DIP-2193N.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2703359.

Family and domain databases

InterProi IPR004999. Herpes_VP19C.
[Graphical view ]
Pfami PF03327. Herpes_VP19C. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1."
    McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P.
    J. Gen. Virol. 69:1531-1574(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Identification of the genes encoding two capsid proteins of herpes simplex virus type 1 by direct amino acid sequencing."
    Rixon F.J., Davison M.D., Davison A.J.
    J. Gen. Virol. 71:1211-1214(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  3. "The herpes simplex virus procapsid: structure, conformational changes upon maturation, and roles of the triplex proteins VP19c and VP23 in assembly."
    Trus B.L., Booy F.P., Newcomb W.W., Brown J.C., Homa F.L., Thomsen D.R., Steven A.C.
    J. Mol. Biol. 263:447-462(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  4. "Roles of triplex and scaffolding proteins in herpes simplex virus type 1 capsid formation suggested by structures of recombinant particles."
    Saad A., Zhou Z.H., Jakana J., Chiu W., Rixon F.J.
    J. Virol. 73:6821-6830(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  5. "Role of the UL25 gene product in packaging DNA into the herpes simplex virus capsid: location of UL25 product in the capsid and demonstration that it binds DNA."
    Ogasawara M., Suzutani T., Yoshida I., Azuma M.
    J. Virol. 75:1427-1436(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH UL25.
  6. "Functional analysis of the triplex proteins (VP19C and VP23) of herpes simplex virus type 1."
    Okoye M.E., Sexton G.L., Huang E., McCaffery J.M., Desai P.
    J. Virol. 80:929-940(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  7. "Mutational analysis of the herpes simplex virus triplex protein VP19C."
    Adamson W.E., McNab D., Preston V.G., Rixon F.J.
    J. Virol. 80:1537-1548(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  8. "Identification of genes encoding two capsid proteins (VP24 and VP26) of herpes simplex virus type 1."
    Davison M.D., Rixon F.J., Davison A.J.
    J. Gen. Virol. 73:2709-2713(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 1-16.

Entry informationi

Entry nameiVP19_HHV11
AccessioniPrimary (citable) accession number: P32888
Secondary accession number(s): P10222
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: May 14, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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