Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P32888 (VP19_HHV11) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Triplex capsid protein VP19C
Alternative name(s):
Virion protein UL38
Gene names
Name:UL38
OrganismHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) [Reference proteome]
Taxonomic identifier10299 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostHomo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length465 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Structural component of the T=16 icosahedral capsid. The capsid is composed of pentamers and hexamers of VP5, which are linked together by heterotrimers called triplex. These triplex are formed by a single molecule of VP19C and two copies of VP23 which bridge major capsid protein VP5 multimers together. Triplexes occupy the local threeflod positions between hexons and between hexamers and pentamers. Additionally, VP19C is required for efficient transport of VP23 to the nucleus, which is the site of capsid assembly. Ref.2 Ref.3 Ref.4 Ref.6 Ref.7

Subunit structure

Interacts with VP23, VP5 and UL25. Ref.5

Subcellular location

Virion. Host nucleus.

Sequence similarities

Belongs to the herpesviridae VP19C family.

Ontologies

Keywords
   Cellular componentCapsid protein
Host nucleus
Virion
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processviral capsid assembly

Inferred from electronic annotation. Source: InterPro

   Cellular_componenthost cell nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

viral capsid

Inferred from direct assay PubMed 23408623. Source: CACAO

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 465465Triplex capsid protein VP19C
PRO_0000115712

Sequences

Sequence LengthMass (Da)Tools
P32888 [UniParc].

Last modified October 1, 1993. Version 1.
Checksum: 5F00147AE29B3092

FASTA46550,263
        10         20         30         40         50         60 
MKTNPLPATP SVWGGSTVEL PPTTRDTAGQ GLLRRVLRPP ISRRDGPGLP RGSGPRRAAS 

        70         80         90        100        110        120 
TLWLLGLDGT DAPPGALTPN DDTEQALDKI LRGTMRGGAA LIGSPRHHLT RQVILTDLCQ 

       130        140        150        160        170        180 
PNADRAGTLL LALRHPADLP HLAHQRAPPG RQTERLGEAW GQLMEATALG SGRAESGCTR 

       190        200        210        220        230        240 
AGLVSFNFLV AACAASYDAR DAADAVRAHV TANYRGTRVG ARLDRFSECL RAMVHTHVFP 

       250        260        270        280        290        300 
HEVMRFFGGL VSWVTQDELA SVTAVCAGPQ EAAHTGHPGR PRSAVILPAC AFVDLDAELG 

       310        320        330        340        350        360 
LGGPGAAFLY LVFTYRQRRD QELCCVYVIK SQLPPRGLEP ALERLFGRLR ITNTIHGTED 

       370        380        390        400        410        420 
MTPPAPNRNP DFPLAGLAAN PQTPRCSAGQ VTNPQFADRL YRWQPDLRGR PTARTCTYAA 

       430        440        450        460 
FAELGMMPED SPRCLHRTER FGAVSVPVVI LEGVVWRPGE WRACA 

« Hide

References

[1]"The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1."
McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P.
J. Gen. Virol. 69:1531-1574(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Identification of the genes encoding two capsid proteins of herpes simplex virus type 1 by direct amino acid sequencing."
Rixon F.J., Davison M.D., Davison A.J.
J. Gen. Virol. 71:1211-1214(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[3]"The herpes simplex virus procapsid: structure, conformational changes upon maturation, and roles of the triplex proteins VP19c and VP23 in assembly."
Trus B.L., Booy F.P., Newcomb W.W., Brown J.C., Homa F.L., Thomsen D.R., Steven A.C.
J. Mol. Biol. 263:447-462(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[4]"Roles of triplex and scaffolding proteins in herpes simplex virus type 1 capsid formation suggested by structures of recombinant particles."
Saad A., Zhou Z.H., Jakana J., Chiu W., Rixon F.J.
J. Virol. 73:6821-6830(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[5]"Role of the UL25 gene product in packaging DNA into the herpes simplex virus capsid: location of UL25 product in the capsid and demonstration that it binds DNA."
Ogasawara M., Suzutani T., Yoshida I., Azuma M.
J. Virol. 75:1427-1436(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH UL25.
[6]"Functional analysis of the triplex proteins (VP19C and VP23) of herpes simplex virus type 1."
Okoye M.E., Sexton G.L., Huang E., McCaffery J.M., Desai P.
J. Virol. 80:929-940(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[7]"Mutational analysis of the herpes simplex virus triplex protein VP19C."
Adamson W.E., McNab D., Preston V.G., Rixon F.J.
J. Virol. 80:1537-1548(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[8]"Identification of genes encoding two capsid proteins (VP24 and VP26) of herpes simplex virus type 1."
Davison M.D., Rixon F.J., Davison A.J.
J. Gen. Virol. 73:2709-2713(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 1-16.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X14112 Genomic DNA. Translation: CAA32313.1.
PIRWMBEZ8. B30088.
RefSeqNP_044640.1. NC_001806.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid971404. 2 interactions.
DIPDIP-2193N.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2703359.

Phylogenomic databases

ProtClustDBPHA3261.

Family and domain databases

InterProIPR004999. Herpes_VP19C.
[Graphical view]
PfamPF03327. Herpes_VP19C. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameVP19_HHV11
AccessionPrimary (citable) accession number: P32888
Secondary accession number(s): P10222
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: February 19, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families