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P32884

- HN_NDVB

UniProt

P32884 - HN_NDVB

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Protein
Hemagglutinin-neuraminidase
Gene
HN
Organism
Newcastle disease virus (strain Beaudette C/45) (NDV)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Attaches the virus to sialic acid-containing cell receptors and thereby initiating infection. Binding of HN protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion By similarity.
Neuraminidase activity ensures the efficient spread of the virus by dissociating the mature virions from the neuraminic acid containing glycoproteins By similarity.

Catalytic activityi

Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.

GO - Molecular functioni

  1. exo-alpha-(2->3)-sialidase activity Source: UniProtKB-EC
  2. exo-alpha-(2->6)-sialidase activity Source: UniProtKB-EC
  3. exo-alpha-(2->8)-sialidase activity Source: UniProtKB-EC

GO - Biological processi

  1. viral entry into host cell Source: UniProtKB-KW
  2. virion attachment to host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hemagglutinin, Hydrolase

Keywords - Biological processi

Host-virus interaction, Viral attachment to host cell, Virus entry into host cell

Protein family/group databases

CAZyiGH83. Glycoside Hydrolase Family 83.

Names & Taxonomyi

Protein namesi
Recommended name:
Hemagglutinin-neuraminidase (EC:3.2.1.18)
Gene namesi
Name:HN
OrganismiNewcastle disease virus (strain Beaudette C/45) (NDV)
Taxonomic identifieri11178 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesMononegaviralesParamyxoviridaeParamyxovirinaeAvulavirus
Virus hostiGallus gallus (Chicken) [TaxID: 9031]

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2626Intravirion Reviewed prediction
Add
BLAST
Transmembranei27 – 4822Helical; Reviewed prediction
Add
BLAST
Topological domaini49 – 577529Virion surface Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. host cell plasma membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
  3. viral envelope Source: UniProtKB-KW
  4. virion membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Host cell membrane, Host membrane, Membrane, Viral envelope protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 577577Hemagglutinin-neuraminidase
PRO_0000142607Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11Blocked amino end (Met); by host
Glycosylationi119 – 1191N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi341 – 3411N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi433 – 4331N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi481 – 4811N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi538 – 5381N-linked (GlcNAc...); by host Reviewed prediction

Keywords - PTMi

Glycoprotein

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni130 – 1345
Beta strandi136 – 1383
Beta strandi144 – 1463
Helixi148 – 1503
Beta strandi151 – 1533
Beta strandi168 – 1703
Beta strandi172 – 1809
Beta strandi185 – 1928
Beta strandi203 – 21311
Beta strandi219 – 22911
Beta strandi231 – 2333
Beta strandi235 – 2439
Beta strandi246 – 2538
Helixi258 – 2614
Beta strandi270 – 2767
Beta strandi281 – 2855
Helixi288 – 2914
Turni292 – 2943
Beta strandi295 – 3006
Beta strandi306 – 3083
Beta strandi311 – 32010
Helixi325 – 3284
Turni329 – 3324
Helixi348 – 3569
Helixi357 – 3593
Helixi362 – 3643
Beta strandi368 – 37710
Beta strandi379 – 3813
Beta strandi387 – 3893
Turni393 – 3953
Beta strandi402 – 4076
Beta strandi410 – 4156
Beta strandi423 – 43210
Beta strandi435 – 4384
Beta strandi442 – 4443
Beta strandi473 – 4786
Beta strandi484 – 4907
Beta strandi494 – 4974
Beta strandi503 – 5064
Beta strandi523 – 53412
Turni535 – 5384
Beta strandi539 – 54911
Beta strandi551 – 5533
Beta strandi555 – 56713

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1USRX-ray2.00A/B124-577[»]
1USXX-ray2.70A/B/C124-577[»]
ProteinModelPortaliP32884.
SMRiP32884. Positions 124-572.

Miscellaneous databases

EvolutionaryTraceiP32884.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di2.120.10.10. 1 hit.
InterProiIPR000665. Hemagglutn-neuramid.
IPR016285. Hemagglutn-neuramid_paramyxo.
IPR011040. Sialidases.
[Graphical view]
PfamiPF00423. HN. 1 hit.
[Graphical view]
PIRSFiPIRSF001072. Hemagglut-neuramid_paramyxoV. 1 hit.
SUPFAMiSSF50939. SSF50939. 1 hit.

Sequencei

Sequence statusi: Complete.

P32884-1 [UniParc]FASTAAdd to Basket

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MDRAVSQVAL ENDEREAKNT WRLIFRIAIL LLTVVTLATS VASLVYSMGA    50
STPSDLVGIP TRISRAEEKI TSALGSNQDV VDRIYKQVAL ESPLALLNTE 100
TTIMNAITSL SYQINGAANN SGWGAPIHDP DFIGGIGKEL IVDDASDVTS 150
FYPSAFQEHL NFIPAPTTGS GCTRIPSFDM SATHYCYTHN VILSGCRDHS 200
HSHQYLALGV LRTTATGRIF FSTLRSISLD DTQNRKSCSV SATPLGCDML 250
CSKVTETEEE DYNSAVPTLM AHGRLGFDGQ YHEKDLDVTT LFEDWVANYP 300
GVGGGSFIDG RVWFSVYGGL KPNSPSDTVQ EGKYVIYKRY NDTCPDEQDY 350
QIRMAKSSYK PGRFGGKRIQ QAILSIKVST SLGEDPVLTV PPNTVTLMGA 400
EGRILTVGTS HFLYQRGSSY FSPALLYPMT VSNKTATLHS PYTFNAFTRP 450
GSIPCQASAR CPNSCVTGVY TDPYPLIFYR NHTLRGVFGT MLDSEQARLN 500
PTSAVFDSTS RSRITRVSSS STKAAYTTST CFKVVKTNKT YCLSIAEISN 550
TLFGEFRIVP LLVEILKNDG VREARSG 577
Length:577
Mass (Da):63,142
Last modified:January 1, 1988 - v1
Checksum:i1D4C52B4887EC1A1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X04355 Genomic RNA. Translation: CAA27880.1.
M24710 Genomic RNA. Translation: AAA46660.1.
PIRiF46328.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X04355 Genomic RNA. Translation: CAA27880.1 .
M24710 Genomic RNA. Translation: AAA46660.1 .
PIRi F46328.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1USR X-ray 2.00 A/B 124-577 [» ]
1USX X-ray 2.70 A/B/C 124-577 [» ]
ProteinModelPortali P32884.
SMRi P32884. Positions 124-572.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GH83. Glycoside Hydrolase Family 83.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei P32884.

Family and domain databases

Gene3Di 2.120.10.10. 1 hit.
InterProi IPR000665. Hemagglutn-neuramid.
IPR016285. Hemagglutn-neuramid_paramyxo.
IPR011040. Sialidases.
[Graphical view ]
Pfami PF00423. HN. 1 hit.
[Graphical view ]
PIRSFi PIRSF001072. Hemagglut-neuramid_paramyxoV. 1 hit.
SUPFAMi SSF50939. SSF50939. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Nucleotide sequence analysis of the haemagglutinin-neuraminidase gene of Newcastle disease virus."
    Millar N.S., Chambers P., Emmerson P.T.
    J. Gen. Virol. 67:1917-1927(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  2. "Newcastle disease virus evolution. I. Multiple lineages defined by sequence variability of the hemagglutinin-neuraminidase gene."
    Sakaguchi T., Toyoda T., Gotoh B., Inocencio N.M., Kuma K., Miyata T., Nagai Y.
    Virology 169:260-272(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiHN_NDVB
AccessioniPrimary (citable) accession number: P32884
Secondary accession number(s): P06158
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: April 16, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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