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P32884

- HN_NDVB

UniProt

P32884 - HN_NDVB

Protein

Hemagglutinin-neuraminidase

Gene

HN

Organism
Newcastle disease virus (strain Beaudette C/45) (NDV)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 Jan 1988)
      Previous versions | rss
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    Functioni

    Attaches the virus to sialic acid-containing cell receptors and thereby initiating infection. Binding of HN protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion By similarity.By similarity
    Neuraminidase activity ensures the efficient spread of the virus by dissociating the mature virions from the neuraminic acid containing glycoproteins.By similarity

    Catalytic activityi

    Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.

    GO - Molecular functioni

    1. exo-alpha-(2->3)-sialidase activity Source: UniProtKB-EC
    2. exo-alpha-(2->6)-sialidase activity Source: UniProtKB-EC
    3. exo-alpha-(2->8)-sialidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. viral entry into host cell Source: UniProtKB-KW
    2. virion attachment to host cell Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hemagglutinin, Hydrolase

    Keywords - Biological processi

    Host-virus interaction, Viral attachment to host cell, Virus entry into host cell

    Protein family/group databases

    CAZyiGH83. Glycoside Hydrolase Family 83.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hemagglutinin-neuraminidase (EC:3.2.1.18)
    Gene namesi
    Name:HN
    OrganismiNewcastle disease virus (strain Beaudette C/45) (NDV)
    Taxonomic identifieri11178 [NCBI]
    Taxonomic lineageiVirusesssRNA negative-strand virusesMononegaviralesParamyxoviridaeParamyxovirinaeAvulavirus
    Virus hostiGallus gallus (Chicken) [TaxID: 9031]

    Subcellular locationi

    GO - Cellular componenti

    1. host cell plasma membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW
    3. viral envelope Source: UniProtKB-KW
    4. virion membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Host cell membrane, Host membrane, Membrane, Viral envelope protein, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 577577Hemagglutinin-neuraminidasePRO_0000142607Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11Blocked amino end (Met); by host
    Glycosylationi119 – 1191N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi341 – 3411N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi433 – 4331N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi481 – 4811N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi538 – 5381N-linked (GlcNAc...); by hostSequence Analysis

    Keywords - PTMi

    Glycoprotein

    Structurei

    Secondary structure

    1
    577
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Turni130 – 1345
    Beta strandi136 – 1383
    Beta strandi144 – 1463
    Helixi148 – 1503
    Beta strandi151 – 1533
    Beta strandi168 – 1703
    Beta strandi172 – 1809
    Beta strandi185 – 1928
    Beta strandi203 – 21311
    Beta strandi219 – 22911
    Beta strandi231 – 2333
    Beta strandi235 – 2439
    Beta strandi246 – 2538
    Helixi258 – 2614
    Beta strandi270 – 2767
    Beta strandi281 – 2855
    Helixi288 – 2914
    Turni292 – 2943
    Beta strandi295 – 3006
    Beta strandi306 – 3083
    Beta strandi311 – 32010
    Helixi325 – 3284
    Turni329 – 3324
    Helixi348 – 3569
    Helixi357 – 3593
    Helixi362 – 3643
    Beta strandi368 – 37710
    Beta strandi379 – 3813
    Beta strandi387 – 3893
    Turni393 – 3953
    Beta strandi402 – 4076
    Beta strandi410 – 4156
    Beta strandi423 – 43210
    Beta strandi435 – 4384
    Beta strandi442 – 4443
    Beta strandi473 – 4786
    Beta strandi484 – 4907
    Beta strandi494 – 4974
    Beta strandi503 – 5064
    Beta strandi523 – 53412
    Turni535 – 5384
    Beta strandi539 – 54911
    Beta strandi551 – 5533
    Beta strandi555 – 56713

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1USRX-ray2.00A/B124-577[»]
    1USXX-ray2.70A/B/C124-577[»]
    ProteinModelPortaliP32884.
    SMRiP32884. Positions 124-572.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP32884.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2626IntravirionSequence AnalysisAdd
    BLAST
    Topological domaini49 – 577529Virion surfaceSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei27 – 4822HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Family and domain databases

    Gene3Di2.120.10.10. 1 hit.
    InterProiIPR000665. Hemagglutn-neuramid.
    IPR016285. Hemagglutn-neuramid_paramyxo.
    IPR011040. Sialidases.
    [Graphical view]
    PfamiPF00423. HN. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001072. Hemagglut-neuramid_paramyxoV. 1 hit.
    SUPFAMiSSF50939. SSF50939. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P32884-1 [UniParc]FASTAAdd to Basket

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    MDRAVSQVAL ENDEREAKNT WRLIFRIAIL LLTVVTLATS VASLVYSMGA    50
    STPSDLVGIP TRISRAEEKI TSALGSNQDV VDRIYKQVAL ESPLALLNTE 100
    TTIMNAITSL SYQINGAANN SGWGAPIHDP DFIGGIGKEL IVDDASDVTS 150
    FYPSAFQEHL NFIPAPTTGS GCTRIPSFDM SATHYCYTHN VILSGCRDHS 200
    HSHQYLALGV LRTTATGRIF FSTLRSISLD DTQNRKSCSV SATPLGCDML 250
    CSKVTETEEE DYNSAVPTLM AHGRLGFDGQ YHEKDLDVTT LFEDWVANYP 300
    GVGGGSFIDG RVWFSVYGGL KPNSPSDTVQ EGKYVIYKRY NDTCPDEQDY 350
    QIRMAKSSYK PGRFGGKRIQ QAILSIKVST SLGEDPVLTV PPNTVTLMGA 400
    EGRILTVGTS HFLYQRGSSY FSPALLYPMT VSNKTATLHS PYTFNAFTRP 450
    GSIPCQASAR CPNSCVTGVY TDPYPLIFYR NHTLRGVFGT MLDSEQARLN 500
    PTSAVFDSTS RSRITRVSSS STKAAYTTST CFKVVKTNKT YCLSIAEISN 550
    TLFGEFRIVP LLVEILKNDG VREARSG 577
    Length:577
    Mass (Da):63,142
    Last modified:January 1, 1988 - v1
    Checksum:i1D4C52B4887EC1A1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X04355 Genomic RNA. Translation: CAA27880.1.
    M24710 Genomic RNA. Translation: AAA46660.1.
    PIRiF46328.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X04355 Genomic RNA. Translation: CAA27880.1 .
    M24710 Genomic RNA. Translation: AAA46660.1 .
    PIRi F46328.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1USR X-ray 2.00 A/B 124-577 [» ]
    1USX X-ray 2.70 A/B/C 124-577 [» ]
    ProteinModelPortali P32884.
    SMRi P32884. Positions 124-572.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi GH83. Glycoside Hydrolase Family 83.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    EvolutionaryTracei P32884.

    Family and domain databases

    Gene3Di 2.120.10.10. 1 hit.
    InterProi IPR000665. Hemagglutn-neuramid.
    IPR016285. Hemagglutn-neuramid_paramyxo.
    IPR011040. Sialidases.
    [Graphical view ]
    Pfami PF00423. HN. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001072. Hemagglut-neuramid_paramyxoV. 1 hit.
    SUPFAMi SSF50939. SSF50939. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence analysis of the haemagglutinin-neuraminidase gene of Newcastle disease virus."
      Millar N.S., Chambers P., Emmerson P.T.
      J. Gen. Virol. 67:1917-1927(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    2. "Newcastle disease virus evolution. I. Multiple lineages defined by sequence variability of the hemagglutinin-neuraminidase gene."
      Sakaguchi T., Toyoda T., Gotoh B., Inocencio N.M., Kuma K., Miyata T., Nagai Y.
      Virology 169:260-272(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

    Entry informationi

    Entry nameiHN_NDVB
    AccessioniPrimary (citable) accession number: P32884
    Secondary accession number(s): P06158
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1988
    Last sequence update: January 1, 1988
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3