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P32881

- IFNA8_HUMAN

UniProt

P32881 - IFNA8_HUMAN

Protein

Interferon alpha-8

Gene

IFNA8

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 137 (01 Oct 2014)
      Sequence version 1 (13 Aug 1987)
      Previous versions | rss
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    Functioni

    Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.

    GO - Molecular functioni

    1. cytokine activity Source: RefGenome
    2. cytokine receptor binding Source: ProtInc
    3. type I interferon receptor binding Source: RefGenome

    GO - Biological processi

    1. adaptive immune response Source: RefGenome
    2. B cell differentiation Source: RefGenome
    3. B cell proliferation Source: RefGenome
    4. blood coagulation Source: Reactome
    5. cytokine-mediated signaling pathway Source: RefGenome
    6. defense response to virus Source: UniProtKB-KW
    7. humoral immune response Source: RefGenome
    8. innate immune response Source: RefGenome
    9. natural killer cell activation involved in immune response Source: RefGenome
    10. positive regulation of peptidyl-serine phosphorylation of STAT protein Source: RefGenome
    11. regulation of MHC class I biosynthetic process Source: RefGenome
    12. regulation of type I interferon-mediated signaling pathway Source: Reactome
    13. response to exogenous dsRNA Source: RefGenome
    14. T cell activation involved in immune response Source: RefGenome
    15. type I interferon signaling pathway Source: Reactome

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Antiviral defense

    Enzyme and pathway databases

    ReactomeiREACT_24938. TRAF6 mediated IRF7 activation.
    REACT_24970. Factors involved in megakaryocyte development and platelet production.
    REACT_25162. Interferon alpha/beta signaling.
    REACT_25216. Regulation of IFNA signaling.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interferon alpha-8
    Short name:
    IFN-alpha-8
    Alternative name(s):
    Interferon alpha-B
    Short name:
    LeIF B
    Interferon alpha-B2
    Gene namesi
    Name:IFNA8
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:5429. IFNA8.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: Reactome
    2. extracellular space Source: RefGenome

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29668.
    PA88.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 23231 PublicationAdd
    BLAST
    Chaini24 – 189166Interferon alpha-8PRO_0000016365Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi24 ↔ 122By similarity
    Disulfide bondi52 ↔ 162By similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiP32881.
    PRIDEiP32881.

    Expressioni

    Gene expression databases

    CleanExiHS_IFNA8.
    GenevestigatoriP32881.

    Organism-specific databases

    HPAiHPA047557.

    Interactioni

    Protein-protein interaction databases

    BioGridi109668. 1 interaction.
    DIPiDIP-6017N.
    STRINGi9606.ENSP00000369553.

    Structurei

    3D structure databases

    ProteinModelPortaliP32881.
    SMRiP32881. Positions 24-189.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alpha/beta interferon family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG87565.
    HOGENOMiHOG000230500.
    HOVERGENiHBG052086.
    InParanoidiP32881.
    KOiK05414.
    OMAiMYEDSIL.
    OrthoDBiEOG7M98HV.
    PhylomeDBiP32881.
    TreeFamiTF336177.

    Family and domain databases

    Gene3Di1.20.1250.10. 1 hit.
    InterProiIPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR000471. Interferon_alpha/beta/delta.
    [Graphical view]
    PANTHERiPTHR11691. PTHR11691. 1 hit.
    PfamiPF00143. Interferon. 1 hit.
    [Graphical view]
    PRINTSiPR00266. INTERFERONAB.
    SMARTiSM00076. IFabd. 1 hit.
    [Graphical view]
    SUPFAMiSSF47266. SSF47266. 1 hit.
    PROSITEiPS00252. INTERFERON_A_B_D. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P32881-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALTFYLLVA LVVLSYKSFS SLGCDLPQTH SLGNRRALIL LAQMRRISPF    50
    SCLKDRHDFE FPQEEFDDKQ FQKAQAISVL HEMIQQTFNL FSTKDSSAAL 100
    DETLLDEFYI ELDQQLNDLE SCVMQEVGVI ESPLMYEDSI LAVRKYFQRI 150
    TLYLTEKKYS SCAWEVVRAE IMRSFSLSIN LQKRLKSKE 189
    Length:189
    Mass (Da):21,989
    Last modified:August 13, 1987 - v1
    Checksum:i83128DA2B6DBB2C1
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti8 – 81L → M in CAA23806. (PubMed:6164048)Curated
    Sequence conflicti8 – 81L → M in CAA23811. (PubMed:6163083)Curated
    Sequence conflicti121 – 1244SCVM → VLCD in CAA23806. (PubMed:6164048)Curated
    Sequence conflicti121 – 1244SCVM → VLCD in CAA23811. (PubMed:6163083)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti137 – 1371E → K.
    Corresponds to variant rs3739630 [ dbSNP | Ensembl ].
    VAR_021975

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X03125 Genomic DNA. Translation: CAA26903.1.
    K01900 mRNA. Translation: AAA52716.1.
    V00545 mRNA. Translation: CAA23806.1.
    V00550 mRNA. Translation: CAA23811.1.
    AL353732 Genomic DNA. Translation: CAH72909.1.
    CH471071 Genomic DNA. Translation: EAW58610.1.
    BC104828 mRNA. Translation: AAI04829.1.
    BC104830 mRNA. Translation: AAI04831.1.
    CCDSiCCDS6507.1.
    PIRiA93747. IVHUA4.
    B61413.
    D23753. IVHUI8.
    RefSeqiNP_002161.2. NM_002170.3.
    UniGeneiHs.73890.

    Genome annotation databases

    EnsembliENST00000380205; ENSP00000369553; ENSG00000120242.
    GeneIDi3445.
    KEGGihsa:3445.
    UCSCiuc003zpc.1. human.

    Polymorphism databases

    DMDMi417188.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X03125 Genomic DNA. Translation: CAA26903.1 .
    K01900 mRNA. Translation: AAA52716.1 .
    V00545 mRNA. Translation: CAA23806.1 .
    V00550 mRNA. Translation: CAA23811.1 .
    AL353732 Genomic DNA. Translation: CAH72909.1 .
    CH471071 Genomic DNA. Translation: EAW58610.1 .
    BC104828 mRNA. Translation: AAI04829.1 .
    BC104830 mRNA. Translation: AAI04831.1 .
    CCDSi CCDS6507.1.
    PIRi A93747. IVHUA4.
    B61413.
    D23753. IVHUI8.
    RefSeqi NP_002161.2. NM_002170.3.
    UniGenei Hs.73890.

    3D structure databases

    ProteinModelPortali P32881.
    SMRi P32881. Positions 24-189.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109668. 1 interaction.
    DIPi DIP-6017N.
    STRINGi 9606.ENSP00000369553.

    Polymorphism databases

    DMDMi 417188.

    Proteomic databases

    PaxDbi P32881.
    PRIDEi P32881.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000380205 ; ENSP00000369553 ; ENSG00000120242 .
    GeneIDi 3445.
    KEGGi hsa:3445.
    UCSCi uc003zpc.1. human.

    Organism-specific databases

    CTDi 3445.
    GeneCardsi GC09P021409.
    HGNCi HGNC:5429. IFNA8.
    HPAi HPA047557.
    MIMi 147568. gene.
    neXtProti NX_P32881.
    PharmGKBi PA29668.
    PA88.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG87565.
    HOGENOMi HOG000230500.
    HOVERGENi HBG052086.
    InParanoidi P32881.
    KOi K05414.
    OMAi MYEDSIL.
    OrthoDBi EOG7M98HV.
    PhylomeDBi P32881.
    TreeFami TF336177.

    Enzyme and pathway databases

    Reactomei REACT_24938. TRAF6 mediated IRF7 activation.
    REACT_24970. Factors involved in megakaryocyte development and platelet production.
    REACT_25162. Interferon alpha/beta signaling.
    REACT_25216. Regulation of IFNA signaling.

    Miscellaneous databases

    GeneWikii IFNA8.
    GenomeRNAii 3445.
    NextBioi 13576.
    PROi P32881.
    SOURCEi Search...

    Gene expression databases

    CleanExi HS_IFNA8.
    Genevestigatori P32881.

    Family and domain databases

    Gene3Di 1.20.1250.10. 1 hit.
    InterProi IPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR000471. Interferon_alpha/beta/delta.
    [Graphical view ]
    PANTHERi PTHR11691. PTHR11691. 1 hit.
    Pfami PF00143. Interferon. 1 hit.
    [Graphical view ]
    PRINTSi PR00266. INTERFERONAB.
    SMARTi SM00076. IFabd. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47266. SSF47266. 1 hit.
    PROSITEi PS00252. INTERFERON_A_B_D. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Cloning of eukaryotic genes in single-strand phage vectors: the human interferon genes."
      Bowden D.W., Mao J., Gill T., Hsiao K., Lillquist J.S., Testa D., Vovis G.F.
      Gene 27:87-99(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Bacterial synthesis of a novel human leukocyte interferon."
      Yelverton E., Leung D., Weck P., Gray P.W., Goeddel D.V.
      Nucleic Acids Res. 9:731-741(1981) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "The structure of eight distinct cloned human leukocyte interferon cDNAs."
      Goeddel D.V., Leung D.W., Dull T.J., Gross M., Lawn R.M., McCandliss R., Seeburg P.H., Ullrich A., Yelverton E., Gray P.W.
      Nature 290:20-26(1981) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    5. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    8. "Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes."
      Nyman T.A., Toeloe H., Parkkinen J., Kalkkinen N.
      Biochem. J. 329:295-302(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 24-53.
    9. "Interferon-alpha 8b is the only variant of interferon-alpha 8 identified in a large human population."
      Hussain M., Gill D.S., Liao M.-J., Testa D.
      J. Interferon Cytokine Res. 16:523-529(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: ABSENCE OF POLYMORPHISM.

    Entry informationi

    Entry nameiIFNA8_HUMAN
    AccessioniPrimary (citable) accession number: P32881
    Secondary accession number(s): P01565
    , P09236, Q5VWV7, Q5VYQ3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: August 13, 1987
    Last modified: October 1, 2014
    This is version 137 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3