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P32881 (IFNA8_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 132. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Interferon alpha-8

Short name=IFN-alpha-8
Alternative name(s):
Interferon alpha-B
Short name=LeIF B
Interferon alpha-B2
Gene names
Name:IFNA8
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length189 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.

Subcellular location

Secreted.

Sequence similarities

Belongs to the alpha/beta interferon family.

Ontologies

Keywords
   Biological processAntiviral defense
   Cellular componentSecreted
   Coding sequence diversityPolymorphism
   DomainSignal
   Molecular functionCytokine
   PTMDisulfide bond
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processB cell differentiation

Inferred from Biological aspect of Ancestor. Source: RefGenome

B cell proliferation

Inferred from Biological aspect of Ancestor. Source: RefGenome

T cell activation involved in immune response

Inferred from Biological aspect of Ancestor. Source: RefGenome

adaptive immune response

Inferred from Biological aspect of Ancestor. Source: RefGenome

blood coagulation

Traceable author statement. Source: Reactome

cytokine-mediated signaling pathway

Inferred from Biological aspect of Ancestor. Source: RefGenome

defense response to virus

Inferred from electronic annotation. Source: UniProtKB-KW

humoral immune response

Inferred from Biological aspect of Ancestor. Source: RefGenome

innate immune response

Inferred from Biological aspect of Ancestor. Source: RefGenome

natural killer cell activation involved in immune response

Inferred from Biological aspect of Ancestor. Source: RefGenome

positive regulation of peptidyl-serine phosphorylation of STAT protein

Inferred from Biological aspect of Ancestor. Source: RefGenome

regulation of MHC class I biosynthetic process

Inferred from Biological aspect of Ancestor. Source: RefGenome

regulation of type I interferon-mediated signaling pathway

Traceable author statement. Source: Reactome

response to exogenous dsRNA

Inferred from Biological aspect of Ancestor. Source: RefGenome

type I interferon signaling pathway

Traceable author statement. Source: Reactome

   Cellular_componentextracellular region

Traceable author statement. Source: Reactome

extracellular space

Inferred from Biological aspect of Ancestor. Source: RefGenome

   Molecular_functioncytokine activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

cytokine receptor binding

Traceable author statement Ref.4. Source: ProtInc

type I interferon receptor binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Ref.8
Chain24 – 189166Interferon alpha-8
PRO_0000016365

Amino acid modifications

Disulfide bond24 ↔ 122 By similarity
Disulfide bond52 ↔ 162 By similarity

Natural variations

Natural variant1371E → K.
Corresponds to variant rs3739630 [ dbSNP | Ensembl ].
VAR_021975

Experimental info

Sequence conflict81L → M in CAA23806. Ref.3
Sequence conflict81L → M in CAA23811. Ref.4
Sequence conflict121 – 1244SCVM → VLCD in CAA23806. Ref.3
Sequence conflict121 – 1244SCVM → VLCD in CAA23811. Ref.4

Sequences

Sequence LengthMass (Da)Tools
P32881 [UniParc].

Last modified August 13, 1987. Version 1.
Checksum: 83128DA2B6DBB2C1

FASTA18921,989
        10         20         30         40         50         60 
MALTFYLLVA LVVLSYKSFS SLGCDLPQTH SLGNRRALIL LAQMRRISPF SCLKDRHDFE 

        70         80         90        100        110        120 
FPQEEFDDKQ FQKAQAISVL HEMIQQTFNL FSTKDSSAAL DETLLDEFYI ELDQQLNDLE 

       130        140        150        160        170        180 
SCVMQEVGVI ESPLMYEDSI LAVRKYFQRI TLYLTEKKYS SCAWEVVRAE IMRSFSLSIN 


LQKRLKSKE 

« Hide

References

« Hide 'large scale' references
[1]"Structural relationship of human interferon alpha genes and pseudogenes."
Henco K., Brosius J., Fujisawa A., Fujisawa J., Haynes J.R., Hochstadt J., Kovacic T., Pasek M., Schamboeck A., Schmid J., Todokoro K., Waelchli M., Nagata S., Weissmann C.
J. Mol. Biol. 185:227-260(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Cloning of eukaryotic genes in single-strand phage vectors: the human interferon genes."
Bowden D.W., Mao J., Gill T., Hsiao K., Lillquist J.S., Testa D., Vovis G.F.
Gene 27:87-99(1984) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Bacterial synthesis of a novel human leukocyte interferon."
Yelverton E., Leung D., Weck P., Gray P.W., Goeddel D.V.
Nucleic Acids Res. 9:731-741(1981) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]"The structure of eight distinct cloned human leukocyte interferon cDNAs."
Goeddel D.V., Leung D.W., Dull T.J., Gross M., Lawn R.M., McCandliss R., Seeburg P.H., Ullrich A., Yelverton E., Gray P.W.
Nature 290:20-26(1981) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[5]"DNA sequence and analysis of human chromosome 9."
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. expand/collapse author list , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[8]"Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes."
Nyman T.A., Toeloe H., Parkkinen J., Kalkkinen N.
Biochem. J. 329:295-302(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 24-53.
[9]"Interferon-alpha 8b is the only variant of interferon-alpha 8 identified in a large human population."
Hussain M., Gill D.S., Liao M.-J., Testa D.
J. Interferon Cytokine Res. 16:523-529(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: ABSENCE OF POLYMORPHISM.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X03125 Genomic DNA. Translation: CAA26903.1.
K01900 mRNA. Translation: AAA52716.1.
V00545 mRNA. Translation: CAA23806.1.
V00550 mRNA. Translation: CAA23811.1.
AL353732 Genomic DNA. Translation: CAH72909.1.
CH471071 Genomic DNA. Translation: EAW58610.1.
BC104828 mRNA. Translation: AAI04829.1.
BC104830 mRNA. Translation: AAI04831.1.
PIRIVHUA4. A93747.
B61413.
IVHUI8. D23753.
RefSeqNP_002161.2. NM_002170.3.
UniGeneHs.73890.

3D structure databases

ProteinModelPortalP32881.
SMRP32881. Positions 24-189.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid109668. 1 interaction.
DIPDIP-6017N.
STRING9606.ENSP00000369553.

Polymorphism databases

DMDM417188.

Proteomic databases

PaxDbP32881.
PRIDEP32881.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000380205; ENSP00000369553; ENSG00000120242.
GeneID3445.
KEGGhsa:3445.
UCSCuc003zpc.1. human.

Organism-specific databases

CTD3445.
GeneCardsGC09P021409.
HGNCHGNC:5429. IFNA8.
HPAHPA047557.
MIM147568. gene.
neXtProtNX_P32881.
PharmGKBPA29668.
PA88.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG87565.
HOGENOMHOG000230500.
HOVERGENHBG052086.
InParanoidP32881.
KOK05414.
OMAMYEDSIL.
OrthoDBEOG7M98HV.
PhylomeDBP32881.
TreeFamTF336177.

Enzyme and pathway databases

ReactomeREACT_604. Hemostasis.
REACT_6900. Immune System.

Gene expression databases

CleanExHS_IFNA8.
GenevestigatorP32881.

Family and domain databases

Gene3D1.20.1250.10. 1 hit.
InterProIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR015589. Interferon_alpha.
IPR000471. Interferon_alpha/beta/delta.
[Graphical view]
PANTHERPTHR11691. PTHR11691. 1 hit.
PTHR11691:SF9. PTHR11691:SF9. 1 hit.
PfamPF00143. Interferon. 1 hit.
[Graphical view]
PRINTSPR00266. INTERFERONAB.
SMARTSM00076. IFabd. 1 hit.
[Graphical view]
SUPFAMSSF47266. SSF47266. 1 hit.
PROSITEPS00252. INTERFERON_A_B_D. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiIFNA8.
GenomeRNAi3445.
NextBio13576.
PROP32881.
SOURCESearch...

Entry information

Entry nameIFNA8_HUMAN
AccessionPrimary (citable) accession number: P32881
Secondary accession number(s): P01565 expand/collapse secondary AC list , P09236, Q5VWV7, Q5VYQ3
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: August 13, 1987
Last modified: April 16, 2014
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM