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Protein

Interferon alpha-8

Gene

IFNA8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.

GO - Molecular functioni

  • cytokine activity Source: GO_Central
  • cytokine receptor binding Source: ProtInc
  • type I interferon receptor binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processAntiviral defense

Enzyme and pathway databases

ReactomeiR-HSA-909733. Interferon alpha/beta signaling.
R-HSA-912694. Regulation of IFNA signaling.
R-HSA-933541. TRAF6 mediated IRF7 activation.
R-HSA-983231. Factors involved in megakaryocyte development and platelet production.

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon alpha-8
Short name:
IFN-alpha-8
Alternative name(s):
Interferon alpha-B
Short name:
LeIF B
Interferon alpha-B2
Gene namesi
Name:IFNA8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000120242.3.
HGNCiHGNC:5429. IFNA8.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi3445.
OpenTargetsiENSG00000120242.
PharmGKBiPA29668.
PA88.

Polymorphism and mutation databases

BioMutaiIFNA8.
DMDMi417188.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 231 PublicationAdd BLAST23
ChainiPRO_000001636524 – 189Interferon alpha-8Add BLAST166

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi24 ↔ 122By similarity
Disulfide bondi52 ↔ 162By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP32881.
PeptideAtlasiP32881.
PRIDEiP32881.

Expressioni

Gene expression databases

BgeeiENSG00000120242.
CleanExiHS_IFNA8.
GenevisibleiP32881. HS.

Organism-specific databases

HPAiHPA047557.

Interactioni

GO - Molecular functioni

  • cytokine activity Source: GO_Central
  • cytokine receptor binding Source: ProtInc
  • type I interferon receptor binding Source: GO_Central

Protein-protein interaction databases

BioGridi109668. 10 interactors.
DIPiDIP-6017N.
STRINGi9606.ENSP00000369553.

Structurei

3D structure databases

ProteinModelPortaliP32881.
SMRiP32881.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alpha/beta interferon family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J735. Eukaryota.
ENOG410ZH91. LUCA.
GeneTreeiENSGT00760000119150.
HOGENOMiHOG000230500.
HOVERGENiHBG052086.
InParanoidiP32881.
KOiK05414.
OMAiMYEDSIL.
OrthoDBiEOG091G0MJ6.
PhylomeDBiP32881.
TreeFamiTF336177.

Family and domain databases

CDDicd00095. IFab. 1 hit.
InterProiView protein in InterPro
IPR009079. 4_helix_cytokine-like_core.
IPR000471. Interferon_alpha/beta/delta.
PANTHERiPTHR11691. PTHR11691. 1 hit.
PfamiView protein in Pfam
PF00143. Interferon. 1 hit.
PRINTSiPR00266. INTERFERONAB.
SMARTiView protein in SMART
SM00076. IFabd. 1 hit.
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiView protein in PROSITE
PS00252. INTERFERON_A_B_D. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P32881-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALTFYLLVA LVVLSYKSFS SLGCDLPQTH SLGNRRALIL LAQMRRISPF
60 70 80 90 100
SCLKDRHDFE FPQEEFDDKQ FQKAQAISVL HEMIQQTFNL FSTKDSSAAL
110 120 130 140 150
DETLLDEFYI ELDQQLNDLE SCVMQEVGVI ESPLMYEDSI LAVRKYFQRI
160 170 180
TLYLTEKKYS SCAWEVVRAE IMRSFSLSIN LQKRLKSKE
Length:189
Mass (Da):21,989
Last modified:August 13, 1987 - v1
Checksum:i83128DA2B6DBB2C1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti8L → M in CAA23806 (PubMed:6164048).Curated1
Sequence conflicti8L → M in CAA23811 (PubMed:6163083).Curated1
Sequence conflicti121 – 124SCVM → VLCD in CAA23806 (PubMed:6164048).Curated4
Sequence conflicti121 – 124SCVM → VLCD in CAA23811 (PubMed:6163083).Curated4

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_021975137E → K. Corresponds to variant dbSNP:rs3739630Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03125 Genomic DNA. Translation: CAA26903.1.
K01900 mRNA. Translation: AAA52716.1.
V00545 mRNA. Translation: CAA23806.1.
V00550 mRNA. Translation: CAA23811.1.
AL353732 Genomic DNA. No translation available.
CH471071 Genomic DNA. Translation: EAW58610.1.
BC104828 mRNA. Translation: AAI04829.1.
BC104830 mRNA. Translation: AAI04831.1.
CCDSiCCDS6507.1.
PIRiA93747. IVHUA4.
B61413.
D23753. IVHUI8.
RefSeqiNP_002161.2. NM_002170.3.
UniGeneiHs.73890.

Genome annotation databases

EnsembliENST00000380205; ENSP00000369553; ENSG00000120242.
GeneIDi3445.
KEGGihsa:3445.
UCSCiuc003zpc.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiIFNA8_HUMAN
AccessioniPrimary (citable) accession number: P32881
Secondary accession number(s): P01565
, P09236, Q5VWV7, Q5VYQ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: August 13, 1987
Last modified: September 27, 2017
This is version 157 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families