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Protein

Interferon alpha-8

Gene

IFNA8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.

GO - Molecular functioni

  1. cytokine activity Source: GO_Central
  2. cytokine receptor binding Source: ProtInc
  3. type I interferon receptor binding Source: GO_Central

GO - Biological processi

  1. adaptive immune response Source: GO_Central
  2. B cell differentiation Source: GO_Central
  3. B cell proliferation Source: GO_Central
  4. blood coagulation Source: Reactome
  5. cytokine-mediated signaling pathway Source: GO_Central
  6. defense response to virus Source: UniProtKB-KW
  7. humoral immune response Source: GO_Central
  8. innate immune response Source: GO_Central
  9. natural killer cell activation involved in immune response Source: GO_Central
  10. positive regulation of peptidyl-serine phosphorylation of STAT protein Source: GO_Central
  11. regulation of MHC class I biosynthetic process Source: GO_Central
  12. regulation of type I interferon-mediated signaling pathway Source: Reactome
  13. response to exogenous dsRNA Source: GO_Central
  14. T cell activation involved in immune response Source: GO_Central
  15. type I interferon signaling pathway Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Antiviral defense

Enzyme and pathway databases

ReactomeiREACT_24938. TRAF6 mediated IRF7 activation.
REACT_24970. Factors involved in megakaryocyte development and platelet production.
REACT_25162. Interferon alpha/beta signaling.
REACT_25216. Regulation of IFNA signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon alpha-8
Short name:
IFN-alpha-8
Alternative name(s):
Interferon alpha-B
Short name:
LeIF B
Interferon alpha-B2
Gene namesi
Name:IFNA8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:5429. IFNA8.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: Reactome
  2. extracellular space Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29668.
PA88.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 23231 PublicationAdd
BLAST
Chaini24 – 189166Interferon alpha-8PRO_0000016365Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi24 ↔ 122By similarity
Disulfide bondi52 ↔ 162By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP32881.
PRIDEiP32881.

Expressioni

Gene expression databases

CleanExiHS_IFNA8.
GenevestigatoriP32881.

Organism-specific databases

HPAiHPA047557.

Interactioni

Protein-protein interaction databases

BioGridi109668. 8 interactions.
DIPiDIP-6017N.
STRINGi9606.ENSP00000369553.

Structurei

3D structure databases

ProteinModelPortaliP32881.
SMRiP32881. Positions 24-189.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alpha/beta interferon family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG87565.
GeneTreeiENSGT00760000119150.
HOGENOMiHOG000230500.
HOVERGENiHBG052086.
InParanoidiP32881.
KOiK05414.
OMAiMYEDSIL.
OrthoDBiEOG7M98HV.
PhylomeDBiP32881.
TreeFamiTF336177.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000471. Interferon_alpha/beta/delta.
[Graphical view]
PANTHERiPTHR11691. PTHR11691. 1 hit.
PfamiPF00143. Interferon. 1 hit.
[Graphical view]
PRINTSiPR00266. INTERFERONAB.
SMARTiSM00076. IFabd. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00252. INTERFERON_A_B_D. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P32881-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALTFYLLVA LVVLSYKSFS SLGCDLPQTH SLGNRRALIL LAQMRRISPF
60 70 80 90 100
SCLKDRHDFE FPQEEFDDKQ FQKAQAISVL HEMIQQTFNL FSTKDSSAAL
110 120 130 140 150
DETLLDEFYI ELDQQLNDLE SCVMQEVGVI ESPLMYEDSI LAVRKYFQRI
160 170 180
TLYLTEKKYS SCAWEVVRAE IMRSFSLSIN LQKRLKSKE
Length:189
Mass (Da):21,989
Last modified:August 13, 1987 - v1
Checksum:i83128DA2B6DBB2C1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti8 – 81L → M in CAA23806 (PubMed:6164048).Curated
Sequence conflicti8 – 81L → M in CAA23811 (PubMed:6163083).Curated
Sequence conflicti121 – 1244SCVM → VLCD in CAA23806 (PubMed:6164048).Curated
Sequence conflicti121 – 1244SCVM → VLCD in CAA23811 (PubMed:6163083).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti137 – 1371E → K.
Corresponds to variant rs3739630 [ dbSNP | Ensembl ].
VAR_021975

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03125 Genomic DNA. Translation: CAA26903.1.
K01900 mRNA. Translation: AAA52716.1.
V00545 mRNA. Translation: CAA23806.1.
V00550 mRNA. Translation: CAA23811.1.
AL353732 Genomic DNA. Translation: CAH72909.1.
CH471071 Genomic DNA. Translation: EAW58610.1.
BC104828 mRNA. Translation: AAI04829.1.
BC104830 mRNA. Translation: AAI04831.1.
CCDSiCCDS6507.1.
PIRiA93747. IVHUA4.
B61413.
D23753. IVHUI8.
RefSeqiNP_002161.2. NM_002170.3.
UniGeneiHs.73890.

Genome annotation databases

EnsembliENST00000380205; ENSP00000369553; ENSG00000120242.
GeneIDi3445.
KEGGihsa:3445.
UCSCiuc003zpc.1. human.

Polymorphism databases

DMDMi417188.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03125 Genomic DNA. Translation: CAA26903.1.
K01900 mRNA. Translation: AAA52716.1.
V00545 mRNA. Translation: CAA23806.1.
V00550 mRNA. Translation: CAA23811.1.
AL353732 Genomic DNA. Translation: CAH72909.1.
CH471071 Genomic DNA. Translation: EAW58610.1.
BC104828 mRNA. Translation: AAI04829.1.
BC104830 mRNA. Translation: AAI04831.1.
CCDSiCCDS6507.1.
PIRiA93747. IVHUA4.
B61413.
D23753. IVHUI8.
RefSeqiNP_002161.2. NM_002170.3.
UniGeneiHs.73890.

3D structure databases

ProteinModelPortaliP32881.
SMRiP32881. Positions 24-189.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109668. 8 interactions.
DIPiDIP-6017N.
STRINGi9606.ENSP00000369553.

Polymorphism databases

DMDMi417188.

Proteomic databases

PaxDbiP32881.
PRIDEiP32881.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000380205; ENSP00000369553; ENSG00000120242.
GeneIDi3445.
KEGGihsa:3445.
UCSCiuc003zpc.1. human.

Organism-specific databases

CTDi3445.
GeneCardsiGC09P021409.
HGNCiHGNC:5429. IFNA8.
HPAiHPA047557.
MIMi147568. gene.
neXtProtiNX_P32881.
PharmGKBiPA29668.
PA88.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG87565.
GeneTreeiENSGT00760000119150.
HOGENOMiHOG000230500.
HOVERGENiHBG052086.
InParanoidiP32881.
KOiK05414.
OMAiMYEDSIL.
OrthoDBiEOG7M98HV.
PhylomeDBiP32881.
TreeFamiTF336177.

Enzyme and pathway databases

ReactomeiREACT_24938. TRAF6 mediated IRF7 activation.
REACT_24970. Factors involved in megakaryocyte development and platelet production.
REACT_25162. Interferon alpha/beta signaling.
REACT_25216. Regulation of IFNA signaling.

Miscellaneous databases

GeneWikiiIFNA8.
GenomeRNAii3445.
NextBioi13576.
PROiP32881.
SOURCEiSearch...

Gene expression databases

CleanExiHS_IFNA8.
GenevestigatoriP32881.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000471. Interferon_alpha/beta/delta.
[Graphical view]
PANTHERiPTHR11691. PTHR11691. 1 hit.
PfamiPF00143. Interferon. 1 hit.
[Graphical view]
PRINTSiPR00266. INTERFERONAB.
SMARTiSM00076. IFabd. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00252. INTERFERON_A_B_D. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Cloning of eukaryotic genes in single-strand phage vectors: the human interferon genes."
    Bowden D.W., Mao J., Gill T., Hsiao K., Lillquist J.S., Testa D., Vovis G.F.
    Gene 27:87-99(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Bacterial synthesis of a novel human leukocyte interferon."
    Yelverton E., Leung D., Weck P., Gray P.W., Goeddel D.V.
    Nucleic Acids Res. 9:731-741(1981) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "The structure of eight distinct cloned human leukocyte interferon cDNAs."
    Goeddel D.V., Leung D.W., Dull T.J., Gross M., Lawn R.M., McCandliss R., Seeburg P.H., Ullrich A., Yelverton E., Gray P.W.
    Nature 290:20-26(1981) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  5. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  8. "Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes."
    Nyman T.A., Toeloe H., Parkkinen J., Kalkkinen N.
    Biochem. J. 329:295-302(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 24-53.
  9. "Interferon-alpha 8b is the only variant of interferon-alpha 8 identified in a large human population."
    Hussain M., Gill D.S., Liao M.-J., Testa D.
    J. Interferon Cytokine Res. 16:523-529(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: ABSENCE OF POLYMORPHISM.

Entry informationi

Entry nameiIFNA8_HUMAN
AccessioniPrimary (citable) accession number: P32881
Secondary accession number(s): P01565
, P09236, Q5VWV7, Q5VYQ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: August 13, 1987
Last modified: February 4, 2015
This is version 140 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.