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P32872

- ALDHY_YEASX

UniProt

P32872 - ALDHY_YEASX

Protein

Aldehyde dehydrogenase 2, mitochondrial

Gene

ALD2

Organism
Saccharomyces cerevisiae (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 1 (01 Oct 1993)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    An aldehyde + NAD+ + H2O = a carboxylate + NADH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei198 – 1981Transition state stabilizerBy similarity
    Active sitei297 – 2971Proton acceptorPROSITE-ProRule annotation
    Active sitei331 – 3311NucleophilePROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi274 – 2796NADBy similarity

    GO - Molecular functioni

    1. aldehyde dehydrogenase (NAD) activity Source: UniProtKB-EC

    GO - Biological processi

    1. ethanol catabolic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    UniPathwayiUPA00780; UER00768.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aldehyde dehydrogenase 2, mitochondrial (EC:1.2.1.3)
    Gene namesi
    Name:ALD2
    Synonyms:ALDH2
    OrganismiSaccharomyces cerevisiae (Baker's yeast)
    Taxonomic identifieri4932 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 2121MitochondrionAdd
    BLAST
    Chaini22 – 511490Aldehyde dehydrogenase 2, mitochondrialPRO_0000007164Add
    BLAST

    Proteomic databases

    PRIDEiP32872.

    Expressioni

    Gene expression databases

    GenevestigatoriP32872.

    Structurei

    3D structure databases

    ProteinModelPortaliP32872.
    SMRiP32872. Positions 44-510.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the aldehyde dehydrogenase family.Curated

    Keywords - Domaini

    Transit peptide

    Family and domain databases

    Gene3Di3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    [Graphical view]
    PfamiPF00171. Aldedh. 1 hit.
    [Graphical view]
    SUPFAMiSSF53720. SSF53720. 1 hit.
    PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P32872-1 [UniParc]FASTAAdd to Basket

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    MSKSKTKTDK RNQSSLSRIK LSALHYCMSD AEPSIAYLQD NSAFINNEWH    50
    NLVLEKIFPV YNPSTEEDIT QVSEKSQHDS TEEDITQVSE KSQHDDDKAV 100
    VDISERGRLL NILADLIERD RDILAAIEHL DNGKPFDEAY LLDLASVLKE 150
    LRYTAGWADK LHGTLRFAIT IPTFQDLRFL RYTRHEPVGV CGEIIPWNIP 200
    LLMYIWKIGP ALAAGNTVVL KPEELTPLTA LTVATLIKEA GFPPGVVNVV 250
    SGYGPTAGAA CLSHKDNDKL AFTGSTLVGK VVMKAAAKSN LKKVTLELGG 300
    KSPMIVFIDA DLDWAVENAH FGVFFNQGQC CIAQSRITVH ESIYDEIVER 350
    DLEKAKKQVL GNPFESDTRY GPQILKIEFD SIPRLINSAK AEGAKVLCGG 400
    GRDDSCVGYY IQPTVFADVT DEMRIAKEEI FGPVITISRF KSVDEAIKRV 450
    DNTKYGLAAY VFTKDKAIRI SAALKAGTVW VNCVHVASYQ IPFGGNKNSG 500
    MGRELGEYGL E 511
    Length:511
    Mass (Da):56,466
    Last modified:October 1, 1993 - v1
    Checksum:i70EDAE951B84EE4A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z17314 Genomic DNA. Translation: CAA78962.1.
    PIRiS31308.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z17314 Genomic DNA. Translation: CAA78962.1 .
    PIRi S31308.

    3D structure databases

    ProteinModelPortali P32872.
    SMRi P32872. Positions 44-510.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P32872.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00780 ; UER00768 .

    Gene expression databases

    Genevestigatori P32872.

    Family and domain databases

    Gene3Di 3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    [Graphical view ]
    Pfami PF00171. Aldedh. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53720. SSF53720. 1 hit.
    PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Thielen J.
      Thesis (1993), Heinrich-Heine University / Duesseldorf, Germany
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiALDHY_YEASX
    AccessioniPrimary (citable) accession number: P32872
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1993
    Last sequence update: October 1, 1993
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Caution

    Is not present in yeast genome.Curated

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3