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P32872

- ALDHY_YEASX

UniProt

P32872 - ALDHY_YEASX

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Protein
Aldehyde dehydrogenase 2, mitochondrial
Gene
ALD2, ALDH2
Organism
Saccharomyces cerevisiae (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei198 – 1981Transition state stabilizer By similarity
Active sitei297 – 2971Proton acceptor By similarity
Active sitei331 – 3311Nucleophile By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi274 – 2796NAD By similarity

GO - Molecular functioni

  1. aldehyde dehydrogenase (NAD) activity Source: UniProtKB-EC

GO - Biological processi

  1. ethanol catabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

UniPathwayiUPA00780; UER00768.

Names & Taxonomyi

Protein namesi
Recommended name:
Aldehyde dehydrogenase 2, mitochondrial (EC:1.2.1.3)
Gene namesi
Name:ALD2
Synonyms:ALDH2
OrganismiSaccharomyces cerevisiae (Baker's yeast)
Taxonomic identifieri4932 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Subcellular locationi

Mitochondrion matrix Reviewed prediction

GO - Cellular componenti

  1. mitochondrial matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2121Mitochondrion
Add
BLAST
Chaini22 – 511490Aldehyde dehydrogenase 2, mitochondrial
PRO_0000007164Add
BLAST

Proteomic databases

PRIDEiP32872.

Expressioni

Gene expression databases

GenevestigatoriP32872.

Structurei

3D structure databases

ProteinModelPortaliP32872.
SMRiP32872. Positions 44-510.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P32872-1 [UniParc]FASTAAdd to Basket

« Hide

MSKSKTKTDK RNQSSLSRIK LSALHYCMSD AEPSIAYLQD NSAFINNEWH    50
NLVLEKIFPV YNPSTEEDIT QVSEKSQHDS TEEDITQVSE KSQHDDDKAV 100
VDISERGRLL NILADLIERD RDILAAIEHL DNGKPFDEAY LLDLASVLKE 150
LRYTAGWADK LHGTLRFAIT IPTFQDLRFL RYTRHEPVGV CGEIIPWNIP 200
LLMYIWKIGP ALAAGNTVVL KPEELTPLTA LTVATLIKEA GFPPGVVNVV 250
SGYGPTAGAA CLSHKDNDKL AFTGSTLVGK VVMKAAAKSN LKKVTLELGG 300
KSPMIVFIDA DLDWAVENAH FGVFFNQGQC CIAQSRITVH ESIYDEIVER 350
DLEKAKKQVL GNPFESDTRY GPQILKIEFD SIPRLINSAK AEGAKVLCGG 400
GRDDSCVGYY IQPTVFADVT DEMRIAKEEI FGPVITISRF KSVDEAIKRV 450
DNTKYGLAAY VFTKDKAIRI SAALKAGTVW VNCVHVASYQ IPFGGNKNSG 500
MGRELGEYGL E 511
Length:511
Mass (Da):56,466
Last modified:October 1, 1993 - v1
Checksum:i70EDAE951B84EE4A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z17314 Genomic DNA. Translation: CAA78962.1.
PIRiS31308.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z17314 Genomic DNA. Translation: CAA78962.1 .
PIRi S31308.

3D structure databases

ProteinModelPortali P32872.
SMRi P32872. Positions 44-510.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P32872.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00780 ; UER00768 .

Gene expression databases

Genevestigatori P32872.

Family and domain databases

Gene3Di 3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view ]
Pfami PF00171. Aldedh. 1 hit.
[Graphical view ]
SUPFAMi SSF53720. SSF53720. 1 hit.
PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Thielen J.
    Thesis (1993), Heinrich-Heine University / Duesseldorf, Germany
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiALDHY_YEASX
AccessioniPrimary (citable) accession number: P32872
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: June 11, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Caution

Is not present in yeast genome.

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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