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P32872

- ALDHY_YEASX

UniProt

P32872 - ALDHY_YEASX

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Protein

Aldehyde dehydrogenase 2, mitochondrial

Gene

ALD2

Organism
Saccharomyces cerevisiae (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei198 – 1981Transition state stabilizerBy similarity
Active sitei297 – 2971Proton acceptorPROSITE-ProRule annotation
Active sitei331 – 3311NucleophilePROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi274 – 2796NADBy similarity

GO - Molecular functioni

  1. aldehyde dehydrogenase (NAD) activity Source: UniProtKB-EC

GO - Biological processi

  1. ethanol catabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

UniPathwayiUPA00780; UER00768.

Names & Taxonomyi

Protein namesi
Recommended name:
Aldehyde dehydrogenase 2, mitochondrial (EC:1.2.1.3)
Gene namesi
Name:ALD2
Synonyms:ALDH2
OrganismiSaccharomyces cerevisiae (Baker's yeast)
Taxonomic identifieri4932 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Subcellular locationi

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2121MitochondrionAdd
BLAST
Chaini22 – 511490Aldehyde dehydrogenase 2, mitochondrialPRO_0000007164Add
BLAST

Proteomic databases

PRIDEiP32872.

Expressioni

Gene expression databases

GenevestigatoriP32872.

Structurei

3D structure databases

ProteinModelPortaliP32872.
SMRiP32872. Positions 44-510.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Keywords - Domaini

Transit peptide

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P32872-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSKSKTKTDK RNQSSLSRIK LSALHYCMSD AEPSIAYLQD NSAFINNEWH
60 70 80 90 100
NLVLEKIFPV YNPSTEEDIT QVSEKSQHDS TEEDITQVSE KSQHDDDKAV
110 120 130 140 150
VDISERGRLL NILADLIERD RDILAAIEHL DNGKPFDEAY LLDLASVLKE
160 170 180 190 200
LRYTAGWADK LHGTLRFAIT IPTFQDLRFL RYTRHEPVGV CGEIIPWNIP
210 220 230 240 250
LLMYIWKIGP ALAAGNTVVL KPEELTPLTA LTVATLIKEA GFPPGVVNVV
260 270 280 290 300
SGYGPTAGAA CLSHKDNDKL AFTGSTLVGK VVMKAAAKSN LKKVTLELGG
310 320 330 340 350
KSPMIVFIDA DLDWAVENAH FGVFFNQGQC CIAQSRITVH ESIYDEIVER
360 370 380 390 400
DLEKAKKQVL GNPFESDTRY GPQILKIEFD SIPRLINSAK AEGAKVLCGG
410 420 430 440 450
GRDDSCVGYY IQPTVFADVT DEMRIAKEEI FGPVITISRF KSVDEAIKRV
460 470 480 490 500
DNTKYGLAAY VFTKDKAIRI SAALKAGTVW VNCVHVASYQ IPFGGNKNSG
510
MGRELGEYGL E
Length:511
Mass (Da):56,466
Last modified:October 1, 1993 - v1
Checksum:i70EDAE951B84EE4A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z17314 Genomic DNA. Translation: CAA78962.1.
PIRiS31308.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z17314 Genomic DNA. Translation: CAA78962.1 .
PIRi S31308.

3D structure databases

ProteinModelPortali P32872.
SMRi P32872. Positions 44-510.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P32872.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00780 ; UER00768 .

Gene expression databases

Genevestigatori P32872.

Family and domain databases

Gene3Di 3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view ]
Pfami PF00171. Aldedh. 1 hit.
[Graphical view ]
SUPFAMi SSF53720. SSF53720. 1 hit.
PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Thielen J.
    Thesis (1993), Heinrich-Heine University / Duesseldorf, Germany
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiALDHY_YEASX
AccessioniPrimary (citable) accession number: P32872
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: October 29, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Caution

Is not present in yeast genome.Curated

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3