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P32872 (ALDHY_YEASX) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Aldehyde dehydrogenase 2, mitochondrial

EC=1.2.1.3
Gene names
Name:ALD2
Synonyms:ALDH2
OrganismSaccharomyces cerevisiae (Baker's yeast)
Taxonomic identifier4932 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length511 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Pathway

Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2.

Subcellular location

Mitochondrion matrix Potential.

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

Caution

Is not present in yeast genome.

Ontologies

Keywords
   Cellular componentMitochondrion
   DomainTransit peptide
   LigandNAD
   Molecular functionOxidoreductase
Gene Ontology (GO)
   Biological_processethanol catabolic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentmitochondrial matrix

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionaldehyde dehydrogenase (NAD) activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 2121Mitochondrion
Chain22 – 511490Aldehyde dehydrogenase 2, mitochondrial
PRO_0000007164

Regions

Nucleotide binding274 – 2796NAD By similarity

Sites

Active site2971Proton acceptor By similarity
Active site3311Nucleophile By similarity
Site1981Transition state stabilizer By similarity

Sequences

Sequence LengthMass (Da)Tools
P32872 [UniParc].

Last modified October 1, 1993. Version 1.
Checksum: 70EDAE951B84EE4A

FASTA51156,466
        10         20         30         40         50         60 
MSKSKTKTDK RNQSSLSRIK LSALHYCMSD AEPSIAYLQD NSAFINNEWH NLVLEKIFPV 

        70         80         90        100        110        120 
YNPSTEEDIT QVSEKSQHDS TEEDITQVSE KSQHDDDKAV VDISERGRLL NILADLIERD 

       130        140        150        160        170        180 
RDILAAIEHL DNGKPFDEAY LLDLASVLKE LRYTAGWADK LHGTLRFAIT IPTFQDLRFL 

       190        200        210        220        230        240 
RYTRHEPVGV CGEIIPWNIP LLMYIWKIGP ALAAGNTVVL KPEELTPLTA LTVATLIKEA 

       250        260        270        280        290        300 
GFPPGVVNVV SGYGPTAGAA CLSHKDNDKL AFTGSTLVGK VVMKAAAKSN LKKVTLELGG 

       310        320        330        340        350        360 
KSPMIVFIDA DLDWAVENAH FGVFFNQGQC CIAQSRITVH ESIYDEIVER DLEKAKKQVL 

       370        380        390        400        410        420 
GNPFESDTRY GPQILKIEFD SIPRLINSAK AEGAKVLCGG GRDDSCVGYY IQPTVFADVT 

       430        440        450        460        470        480 
DEMRIAKEEI FGPVITISRF KSVDEAIKRV DNTKYGLAAY VFTKDKAIRI SAALKAGTVW 

       490        500        510 
VNCVHVASYQ IPFGGNKNSG MGRELGEYGL E 

« Hide

References

[1]Thielen J.
Thesis (1993), Heinrich-Heine University / Duesseldorf, Germany
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z17314 Genomic DNA. Translation: CAA78962.1.
PIRS31308.

3D structure databases

ProteinModelPortalP32872.
SMRP32872. Positions 44-510.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP32872.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00780; UER00768.

Gene expression databases

GenevestigatorP32872.

Family and domain databases

Gene3D3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMSSF53720. SSF53720. 1 hit.
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameALDHY_YEASX
AccessionPrimary (citable) accession number: P32872
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: October 16, 2013
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways