Reviewed, UniProtKB/Swiss-Prot P32872 (ALDHY_YEAST)

Names and origin

Protein names

Recommended name:
    Aldehyde dehydrogenase 2, mitochondrial
    EC=1.2.1.3

Gene names

Name:	ALD2
Synonyms:	ALDH2

Organism

Saccharomyces cerevisiae (Baker's yeast)

Taxonomic identifier

4932 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	511 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	An aldehyde + NAD+ + H2O = an acid + NADH.
Pathway	Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2.
Subcellular location	Mitochondrion matrix Potential.
Sequence similarities	Belongs to the aldehyde dehydrogenase family.
Caution	Is not present in yeast genome.

Ontologies

Keywords
Cellular component	Mitochondrion
Domain	Transit peptide
Ligand	NAD
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitochondrial matrix Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	aldehyde dehydrogenase (NAD) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 21	21	Mitochondrion
	Chain	22 – 511	490	Aldehyde dehydrogenase 2, mitochondrial		PRO_0000007164
Regions
	Nucleotide binding	274 – 279	6	NAD By similarity
Sites
	Active site	297	1	Proton acceptor By similarity
	Active site	331	1	Nucleophile By similarity
	Site	198	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	P32872-1 [UniParc]. Last modified October 1, 1993. Version 1. Checksum: 70EDAE951B84EE4A	FASTA	511	56,466
	10 20 30 40 50 60 MSKSKTKTDK RNQSSLSRIK LSALHYCMSD AEPSIAYLQD NSAFINNEWH NLVLEKIFPV 70 80 90 100 110 120 YNPSTEEDIT QVSEKSQHDS TEEDITQVSE KSQHDDDKAV VDISERGRLL NILADLIERD 130 140 150 160 170 180 RDILAAIEHL DNGKPFDEAY LLDLASVLKE LRYTAGWADK LHGTLRFAIT IPTFQDLRFL 190 200 210 220 230 240 RYTRHEPVGV CGEIIPWNIP LLMYIWKIGP ALAAGNTVVL KPEELTPLTA LTVATLIKEA 250 260 270 280 290 300 GFPPGVVNVV SGYGPTAGAA CLSHKDNDKL AFTGSTLVGK VVMKAAAKSN LKKVTLELGG 310 320 330 340 350 360 KSPMIVFIDA DLDWAVENAH FGVFFNQGQC CIAQSRITVH ESIYDEIVER DLEKAKKQVL 370 380 390 400 410 420 GNPFESDTRY GPQILKIEFD SIPRLINSAK AEGAKVLCGG GRDDSCVGYY IQPTVFADVT 430 440 450 460 470 480 DEMRIAKEEI FGPVITISRF KSVDEAIKRV DNTKYGLAAY VFTKDKAIRI SAALKAGTVW 490 500 510 VNCVHVASYQ IPFGGNKNSG MGRELGEYGL E

References

[1]	Thielen J. Thesis (1993), Heinrich-Heine University / Duesseldorf, Germany Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z17314 Genomic DNA. Translation: CAA78962.1.
PIR	S31308.
3D structure databases
SMR	P32872. Positions 44-510.
ModBase	Search...
Enzyme and pathway databases
BRENDA	1.2.1.3. 250.
Gene expression databases
Genevestigator	P32872.
Family and domain databases
InterPro	IPR016161. Ald_DH/histidinol_DH. IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ALDHY_YEAST

Accession

Primary (citable) accession number: P32872

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1993
Last sequence update:	October 1, 1993
Last modified:	January 19, 2010
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)