P32868 (SIG1S_REOVJ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein sigma-1-small
Short name=Sigma1s

Alternative name(s):
Sigma-s
Sigma1NS
Sigma1bNS
p14

Gene names

Name:

S1

Organism

Reovirus type 2 (strain D5/Jones) (T2J) (Mammalian orthoreovirus 2) [Complete proteome]

Taxonomic identifier

10885 [NCBI]

Taxonomic lineage

Viruses › dsRNA viruses › Reoviridae › Spinareovirinae › Orthoreovirus › Mammalian orthoreovirus › Mammalian orthoreovirus 2

Virus host

Mammalia [TaxID: 40674]

Protein attributes

Sequence length	125 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Sequence similarities

Belongs to the orthoreovirus sigma-1s protein family.

Ontologies

Keywords
Biological process	Host G2/M cell cycle arrest by virus Host-virus interaction Modulation of host cell cycle by virus
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	suppression by virus of G2/M transition of host mitotic cell cycle Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 125	125	Protein sigma-1-small		PRO_0000222756

Sequences

	Sequence		Length	Mass (Da)
	P32868 [UniParc]. Last modified October 1, 1993. Version 1. Checksum: 71AFD9523EB8A789	FASTA	125	14,560
	10 20 30 40 50 60 MENQPTRNTR SRKLRNKLKT SLLMSTGSVT SLIQSKDNWV DYLYACQPLN RELVRTAIEL 70 80 90 100 110 120 IDSSEMSPAY RLALAESIRV YPSWVTESML QNSELASWIQ SRIISLSEHQ DWKLKYQPLL MTLDH

References

[1]	"Sequences of the S1 genes of the three serotypes of reovirus." Cashdollar L.W., Chmelo R.A., Wiener J.R., Joklik W.K. Proc. Natl. Acad. Sci. U.S.A. 82:24-28(1985) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
[2]	"Structure of the reovirus cell-attachment protein: a model for the domain organization of sigma 1." Nibert M.L., Dermody T.S., Fields B.N. J. Virol. 64:2976-2989(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	M10261 Genomic RNA. Translation: AAA66880.1. M35964 Genomic RNA. Translation: AAA47252.1.
PIR	D34829.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR003478. Capsid_sigma_1s. [Graphical view]
Pfam	PF02454. Sigma_1s. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SIG1S_REOVJ

Accession

Primary (citable) accession number: P32868
Secondary accession number(s): Q6LDZ2

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1993
Last sequence update:	October 1, 1993
Last modified:	April 3, 2013
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program