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Protein

Rab proteins geranylgeranyltransferase component A

Gene

MRS6

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.

Miscellaneous

Present with 23800 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • GDP-dissociation inhibitor activity Source: InterPro
  • GTPase activator activity Source: UniProtKB-KW
  • oxidoreductase activity Source: InterPro
  • Rab GTPase binding Source: SGD

GO - Biological processi

  • activation of GTPase activity Source: SGD
  • ER to Golgi vesicle-mediated transport Source: SGD
  • protein geranylgeranylation Source: SGD
  • protein targeting to membrane Source: SGD
  • small GTPase mediated signal transduction Source: InterPro

Keywordsi

Molecular functionGTPase activation

Enzyme and pathway databases

BioCyciYEAST:G3O-33838-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Rab proteins geranylgeranyltransferase component A
Alternative name(s):
Rab escort protein
Short name:
REP
Gene namesi
Name:MRS6
Synonyms:MSI4
Ordered Locus Names:YOR370C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOR370C.
SGDiS000005897. MRS6.

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000566931 – 603Rab proteins geranylgeranyltransferase component AAdd BLAST603

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei470PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP32864.
PRIDEiP32864.

PTM databases

iPTMnetiP32864.

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

  • Rab GTPase binding Source: SGD

Protein-protein interaction databases

BioGridi34753. 367 interactors.
DIPiDIP-2246N.
IntActiP32864. 19 interactors.
MINTiMINT-481776.
STRINGi4932.YOR370C.

Structurei

3D structure databases

ProteinModelPortaliP32864.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Rab GDI family.Curated

Phylogenomic databases

HOGENOMiHOG000248782.
InParanoidiP32864.
OMAiYRYLEFQ.
OrthoDBiEOG092C156X.

Family and domain databases

InterProiView protein in InterPro
IPR023753. FAD/NAD-binding_dom.
IPR018203. GDP_dissociation_inhibitor.
IPR017230. Mrs6.
PANTHERiPTHR11787. PTHR11787. 1 hit.
PfamiView protein in Pfam
PF00996. GDI. 1 hit.
PIRSFiPIRSF037514. Rab_ger_ger_transf_A_fun. 1 hit.
PRINTSiPR00891. RABGDIREP.
PR00894. YEASTMRS6P.
SUPFAMiSSF51905. SSF51905. 1 hit.

Sequencei

Sequence statusi: Complete.

P32864-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSPERRPSM AERRPSFFSF TQNPSPLVVP HLAGIEDPLP ATTPDKVDVL
60 70 80 90 100
IAGTGMVESV LAAALAWQGS NVLHIDKNDY YGDTSATLTV DQIKRWVNEV
110 120 130 140 150
NEGSVSCYKN AKLYVSTLIG SGKYSSRDFG IDLSPKILFA KSDLLSILIK
160 170 180 190 200
SRVHQYLEFQ SLSNFHTYEN DCFEKLTNTK QEIFTDQNLP LMTKRNLMKF
210 220 230 240 250
IKFVLNWEAQ TEIWQPYAER TMSDFLGEKF KLEKPQVFEL IFSIGLCYDL
260 270 280 290 300
NVKVPEALQR IRRYLTSFDV YGPFPALCSK YGGPGELSQG FCRSAAVGGA
310 320 330 340 350
TYKLNEKLVS FNPTTKVATF QDGSKVEVSE KVIISPTQAP KDSKHVPQQQ
360 370 380 390 400
YQVHRLTCIV ENPCTEWFNE GESAAMVVFP PGSLKSGNKE VVQAFILGAG
410 420 430 440 450
SEICPEGTIV WYLSTTEQGP RAEMDIDAAL EAMEMALLRE SSSGLENDEE
460 470 480 490 500
IVQLTGNGHT IVNSVKLGQS FKEYVPRERL QFLFKLYYTQ YTSTPPFGVV
510 520 530 540 550
NSSFFDVNQD LEKKYIPGAS DNGVIYTTMP SAEISYDEVV TAAKVLYEKI
560 570 580 590 600
VGSDDDFFDL DFEDEDEIQA SGVANAEQFE NAIDDDDDVN MEGSGEFVGE

MEI
Length:603
Mass (Da):67,374
Last modified:October 1, 1994 - v2
Checksum:i30BB7FFF8D712FFD
GO

Sequence cautioni

The sequence CAA49805 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti132 – 137DLSPKI → MIFPRV in AAA34796 (Ref. 5) Curated6
Sequence conflicti300A → P in CAA49804 (PubMed:7882424).Curated1
Sequence conflicti300A → P in CAA49805 (PubMed:7882424).Curated1
Sequence conflicti300A → P in AAA34796 (Ref. 5) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D26441 Genomic DNA. Translation: BAA05460.1.
X70339 Genomic DNA. Translation: CAA49804.1.
X70339 Genomic DNA. Translation: CAA49805.1. Different initiation.
Z75278 Genomic DNA. Translation: CAA99701.1.
M90844 Genomic DNA. Translation: AAA34796.1.
BK006948 Genomic DNA. Translation: DAA11129.1.
PIRiS47917.
RefSeqiNP_015015.1. NM_001183790.1.

Genome annotation databases

EnsemblFungiiYOR370C; YOR370C; YOR370C.
GeneIDi854552.
KEGGisce:YOR370C.

Similar proteinsi

Entry informationi

Entry nameiRAEP_YEAST
AccessioniPrimary (citable) accession number: P32864
Secondary accession number(s): D6W363, Q06761
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1994
Last modified: September 27, 2017
This is version 145 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names