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Protein

Rab proteins geranylgeranyltransferase component A

Gene

MRS6

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.

Miscellaneous

Present with 23800 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • GDP-dissociation inhibitor activity Source: InterPro
  • GTPase activator activity Source: UniProtKB-KW
  • Rab GTPase binding Source: SGD

GO - Biological processi

  • activation of GTPase activity Source: SGD
  • ER to Golgi vesicle-mediated transport Source: SGD
  • protein geranylgeranylation Source: SGD
  • protein targeting to membrane Source: SGD
  • small GTPase mediated signal transduction Source: InterPro

Keywordsi

Molecular functionGTPase activation

Enzyme and pathway databases

BioCyciYEAST:G3O-33838-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Rab proteins geranylgeranyltransferase component A
Alternative name(s):
Rab escort protein
Short name:
REP
Gene namesi
Name:MRS6
Synonyms:MSI4
Ordered Locus Names:YOR370C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOR370C
SGDiS000005897 MRS6

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000566931 – 603Rab proteins geranylgeranyltransferase component AAdd BLAST603

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei470PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP32864
PaxDbiP32864
PRIDEiP32864

PTM databases

iPTMnetiP32864

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

  • Rab GTPase binding Source: SGD

Protein-protein interaction databases

BioGridi34753, 369 interactors
ComplexPortaliCPX-1636 Protein geranylgeranyltransferase type II complex
DIPiDIP-2246N
IntActiP32864, 18 interactors
MINTiP32864
STRINGi4932.YOR370C

Structurei

3D structure databases

ProteinModelPortaliP32864
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Rab GDI family.Curated

Phylogenomic databases

HOGENOMiHOG000248782
InParanoidiP32864
OMAiLEFQAVG
OrthoDBiEOG092C156X

Family and domain databases

InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR018203 GDP_dissociation_inhibitor
IPR017230 Mrs6
PANTHERiPTHR11787 PTHR11787, 1 hit
PfamiView protein in Pfam
PF00996 GDI, 1 hit
PIRSFiPIRSF037514 Rab_ger_ger_transf_A_fun, 1 hit
PRINTSiPR00891 RABGDIREP
PR00894 YEASTMRS6P
SUPFAMiSSF51905 SSF51905, 1 hit

Sequencei

Sequence statusi: Complete.

P32864-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSPERRPSM AERRPSFFSF TQNPSPLVVP HLAGIEDPLP ATTPDKVDVL
60 70 80 90 100
IAGTGMVESV LAAALAWQGS NVLHIDKNDY YGDTSATLTV DQIKRWVNEV
110 120 130 140 150
NEGSVSCYKN AKLYVSTLIG SGKYSSRDFG IDLSPKILFA KSDLLSILIK
160 170 180 190 200
SRVHQYLEFQ SLSNFHTYEN DCFEKLTNTK QEIFTDQNLP LMTKRNLMKF
210 220 230 240 250
IKFVLNWEAQ TEIWQPYAER TMSDFLGEKF KLEKPQVFEL IFSIGLCYDL
260 270 280 290 300
NVKVPEALQR IRRYLTSFDV YGPFPALCSK YGGPGELSQG FCRSAAVGGA
310 320 330 340 350
TYKLNEKLVS FNPTTKVATF QDGSKVEVSE KVIISPTQAP KDSKHVPQQQ
360 370 380 390 400
YQVHRLTCIV ENPCTEWFNE GESAAMVVFP PGSLKSGNKE VVQAFILGAG
410 420 430 440 450
SEICPEGTIV WYLSTTEQGP RAEMDIDAAL EAMEMALLRE SSSGLENDEE
460 470 480 490 500
IVQLTGNGHT IVNSVKLGQS FKEYVPRERL QFLFKLYYTQ YTSTPPFGVV
510 520 530 540 550
NSSFFDVNQD LEKKYIPGAS DNGVIYTTMP SAEISYDEVV TAAKVLYEKI
560 570 580 590 600
VGSDDDFFDL DFEDEDEIQA SGVANAEQFE NAIDDDDDVN MEGSGEFVGE

MEI
Length:603
Mass (Da):67,374
Last modified:October 1, 1994 - v2
Checksum:i30BB7FFF8D712FFD
GO

Sequence cautioni

The sequence CAA49805 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti132 – 137DLSPKI → MIFPRV in AAA34796 (Ref. 5) Curated6
Sequence conflicti300A → P in CAA49804 (PubMed:7882424).Curated1
Sequence conflicti300A → P in CAA49805 (PubMed:7882424).Curated1
Sequence conflicti300A → P in AAA34796 (Ref. 5) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D26441 Genomic DNA Translation: BAA05460.1
X70339 Genomic DNA Translation: CAA49804.1
X70339 Genomic DNA Translation: CAA49805.1 Different initiation.
Z75278 Genomic DNA Translation: CAA99701.1
M90844 Genomic DNA Translation: AAA34796.1
BK006948 Genomic DNA Translation: DAA11129.1
PIRiS47917
RefSeqiNP_015015.1, NM_001183790.1

Genome annotation databases

EnsemblFungiiYOR370C; YOR370C; YOR370C
GeneIDi854552
KEGGisce:YOR370C

Similar proteinsi

Entry informationi

Entry nameiRAEP_YEAST
AccessioniPrimary (citable) accession number: P32864
Secondary accession number(s): D6W363, Q06761
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1994
Last modified: June 20, 2018
This is version 152 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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