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P32857

- PTM1_YEAST

UniProt

P32857 - PTM1_YEAST

Protein

Membrane protein PTM1

Gene

PTM1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 2 (01 Jul 2008)
      Previous versions | rss
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    Functioni

    Enzyme and pathway databases

    BioCyciYEAST:G3O-31840-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Membrane protein PTM1
    Gene namesi
    Name:PTM1
    Ordered Locus Names:YKL039W
    ORF Names:YKL252
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XI

    Organism-specific databases

    SGDiS000001522. PTM1.

    Subcellular locationi

    Golgi apparatus membrane 1 Publication; Multi-pass membrane protein 1 Publication. Early endosome membrane 1 Publication; Multi-pass membrane protein 1 Publication
    Note: Copurifies with the late Golgi SNARE TLG2.

    GO - Cellular componenti

    1. early endosome membrane Source: UniProtKB-SubCell
    2. Golgi membrane Source: UniProtKB-SubCell
    3. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endosome, Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2626Sequence AnalysisAdd
    BLAST
    Chaini27 – 523497Membrane protein PTM1PRO_0000022180Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi132 – 1321N-linked (GlcNAc...)Sequence Analysis
    Modified residuei480 – 4801Phosphoserine1 Publication
    Modified residuei483 – 4831Phosphothreonine1 Publication
    Modified residuei498 – 4981Phosphothreonine1 Publication

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiP32857.
    PaxDbiP32857.
    PeptideAtlasiP32857.

    Expressioni

    Gene expression databases

    GenevestigatoriP32857.

    Interactioni

    Protein-protein interaction databases

    BioGridi34093. 35 interactions.
    DIPiDIP-1244N.
    IntActiP32857. 14 interactions.
    MINTiMINT-404939.
    STRINGi4932.YKL039W.

    Structurei

    3D structure databases

    ProteinModelPortaliP32857.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini27 – 197171LumenalSequence AnalysisAdd
    BLAST
    Topological domaini219 – 23012CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini252 – 26514LumenalSequence AnalysisAdd
    BLAST
    Topological domaini287 – 30418CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini326 – 3338LumenalSequence Analysis
    Topological domaini355 – 38127CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini403 – 41715LumenalSequence AnalysisAdd
    BLAST
    Topological domaini439 – 52385CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei198 – 21821Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei231 – 25121Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei266 – 28621Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei305 – 32521Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei334 – 35421Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei382 – 40221Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei418 – 43821Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LU7TM family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG302490.
    GeneTreeiENSGT00390000015417.
    HOGENOMiHOG000176489.
    OMAiFAMSDEI.
    OrthoDBiEOG70ZZWZ.

    Family and domain databases

    InterProiIPR009637. TM_rcpt_euk.
    [Graphical view]
    PANTHERiPTHR21229. PTHR21229. 1 hit.
    PfamiPF06814. Lung_7-TM_R. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P32857-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRVYQFCRPF QLFTCFLCYL LVFVKANKEK ISQKNYQVCA GMYSKEDWKG    50
    KIDPFISFNL KKISGLSDES DPGLVVAIYD FQDFEHLGVQ LPDEEMYYIC 100
    DDYAIDIGIC EEENRDEFIV QDVVYDPYTS TNRSLANPIM TFSQNEVGLH 150
    DTRYPIKETG FYCVTAFRSS TSTKFNAVVN FRNAYGQLAG TEINKLPLYG 200
    LLAVAYVVAM ALYSFAFWKH KHELLPLQKY LLAFFVFLTA ETIFVWAYYD 250
    LKNEKGDTAG IKVYMVFLSI LTAGKVTFSF FLLLIIALGY GIVYPKLNKT 300
    LMRRCQMYGA LTYAICIGFL IQSYLTDMEA PSPLILITLI PMALALIIFY 350
    YMIIRSMTKT VIYLKEQRQI VKLNMYKKLL YIIYASFLSV LAGSIVSSFI 400
    YVGMNTIDMI EKNWRSRFFV TDFWPTLVYF IVFVTIAFLW RPTDTSYMLA 450
    ASQQLPTDPE NVADFDLGDL QSFDDQDDAS IITGERGIDE DDLNLNFTDD 500
    EEGHDNVNNH SQGHGPVSPS PTK 523
    Length:523
    Mass (Da):60,018
    Last modified:July 1, 2008 - v2
    Checksum:i86E7A339FE192DEC
    GO

    Sequence cautioni

    The sequence CAA49300.1 differs from that shown. Reason: Frameshift at position 513.
    The sequence CAA81874.1 differs from that shown. Reason: Frameshift at position 513.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L11895 Genomic DNA. Translation: AAA34921.1.
    X69584 Genomic DNA. Translation: CAA49300.1. Frameshift.
    Z28039 Genomic DNA. Translation: CAA81874.1. Frameshift.
    BK006944 Genomic DNA. Translation: DAA09117.1.
    PIRiS30011.
    RefSeqiNP_012885.2. NM_001179605.1.

    Genome annotation databases

    EnsemblFungiiYKL039W; YKL039W; YKL039W.
    GeneIDi853827.
    KEGGisce:YKL039W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L11895 Genomic DNA. Translation: AAA34921.1 .
    X69584 Genomic DNA. Translation: CAA49300.1 . Frameshift.
    Z28039 Genomic DNA. Translation: CAA81874.1 . Frameshift.
    BK006944 Genomic DNA. Translation: DAA09117.1 .
    PIRi S30011.
    RefSeqi NP_012885.2. NM_001179605.1.

    3D structure databases

    ProteinModelPortali P32857.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 34093. 35 interactions.
    DIPi DIP-1244N.
    IntActi P32857. 14 interactions.
    MINTi MINT-404939.
    STRINGi 4932.YKL039W.

    Proteomic databases

    MaxQBi P32857.
    PaxDbi P32857.
    PeptideAtlasi P32857.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YKL039W ; YKL039W ; YKL039W .
    GeneIDi 853827.
    KEGGi sce:YKL039W.

    Organism-specific databases

    SGDi S000001522. PTM1.

    Phylogenomic databases

    eggNOGi NOG302490.
    GeneTreei ENSGT00390000015417.
    HOGENOMi HOG000176489.
    OMAi FAMSDEI.
    OrthoDBi EOG70ZZWZ.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-31840-MONOMER.

    Miscellaneous databases

    NextBioi 975020.

    Gene expression databases

    Genevestigatori P32857.

    Family and domain databases

    InterProi IPR009637. TM_rcpt_euk.
    [Graphical view ]
    PANTHERi PTHR21229. PTHR21229. 1 hit.
    Pfami PF06814. Lung_7-TM_R. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "PTM1, a putative transmembrane protein, enhances recovery from transformation of a profilin deletion strain."
      Haarer B.K., Petzold A.S., Brown S.S.
      Submitted (MAR-1993) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The sequence of a 12 kb fragment on the left arm of yeast chromosome XI reveals five new open reading frames, including a zinc finger protein and a homolog of the UDP-glucose pyrophosphorylase from potato."
      Purnelle B., Skala J., van Dyck L., Goffeau A.
      Yeast 8:977-986(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Complete DNA sequence of yeast chromosome XI."
      Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C.
      , Domdey H., Duesterhoeft A., Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H., Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L., Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M., Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H., Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J., Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H., Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J., Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S., Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F., Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R., Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W., Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M., Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C., Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H., Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L., van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S., von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M., Becker I., Mewes H.-W.
      Nature 369:371-378(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    4. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    5. "Sequencing and comparison of yeast species to identify genes and regulatory elements."
      Kellis M., Patterson N., Endrizzi M., Birren B.W., Lander E.S.
      Nature 423:241-254(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION OF FRAMESHIFT.
    6. "Immunoisolaton of the yeast Golgi subcompartments and characterization of a novel membrane protein, Svp26, discovered in the Sed5-containing compartments."
      Inadome H., Noda Y., Adachi H., Yoda K.
      Mol. Cell. Biol. 25:7696-7710(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    7. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-480; THR-483 AND THR-498, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiPTM1_YEAST
    AccessioniPrimary (citable) accession number: P32857
    Secondary accession number(s): D6VXP7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1993
    Last sequence update: July 1, 2008
    Last modified: October 1, 2014
    This is version 106 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome XI
      Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

    External Data

    Dasty 3