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P32857

- PTM1_YEAST

UniProt

P32857 - PTM1_YEAST

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Protein

Membrane protein PTM1

Gene

PTM1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

BioCyciYEAST:G3O-31840-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane protein PTM1
Gene namesi
Name:PTM1
Ordered Locus Names:YKL039W
ORF Names:YKL252
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XI

Organism-specific databases

SGDiS000001522. PTM1.

Subcellular locationi

Golgi apparatus membrane 1 Publication; Multi-pass membrane protein 1 Publication. Early endosome membrane 1 Publication; Multi-pass membrane protein 1 Publication
Note: Copurifies with the late Golgi SNARE TLG2.

GO - Cellular componenti

  1. endosome Source: UniProtKB-KW
  2. Golgi apparatus Source: UniProtKB-KW
  3. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endosome, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence AnalysisAdd
BLAST
Chaini27 – 523497Membrane protein PTM1PRO_0000022180Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi132 – 1321N-linked (GlcNAc...)Sequence Analysis
Modified residuei480 – 4801Phosphoserine1 Publication
Modified residuei483 – 4831Phosphothreonine1 Publication
Modified residuei498 – 4981Phosphothreonine1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP32857.
PaxDbiP32857.
PeptideAtlasiP32857.

Expressioni

Gene expression databases

GenevestigatoriP32857.

Interactioni

Protein-protein interaction databases

BioGridi34093. 35 interactions.
DIPiDIP-1244N.
IntActiP32857. 14 interactions.
MINTiMINT-404939.
STRINGi4932.YKL039W.

Structurei

3D structure databases

ProteinModelPortaliP32857.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini27 – 197171LumenalSequence AnalysisAdd
BLAST
Topological domaini219 – 23012CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini252 – 26514LumenalSequence AnalysisAdd
BLAST
Topological domaini287 – 30418CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini326 – 3338LumenalSequence Analysis
Topological domaini355 – 38127CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini403 – 41715LumenalSequence AnalysisAdd
BLAST
Topological domaini439 – 52385CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei198 – 21821Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei231 – 25121Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei266 – 28621Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei305 – 32521Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei334 – 35421Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei382 – 40221Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei418 – 43821Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the LU7TM family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG302490.
GeneTreeiENSGT00390000015417.
HOGENOMiHOG000176489.
InParanoidiP32857.
OMAiFAMSDEI.
OrthoDBiEOG70ZZWZ.

Family and domain databases

InterProiIPR009637. TM_rcpt_euk.
[Graphical view]
PANTHERiPTHR21229. PTHR21229. 1 hit.
PfamiPF06814. Lung_7-TM_R. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P32857 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRVYQFCRPF QLFTCFLCYL LVFVKANKEK ISQKNYQVCA GMYSKEDWKG
60 70 80 90 100
KIDPFISFNL KKISGLSDES DPGLVVAIYD FQDFEHLGVQ LPDEEMYYIC
110 120 130 140 150
DDYAIDIGIC EEENRDEFIV QDVVYDPYTS TNRSLANPIM TFSQNEVGLH
160 170 180 190 200
DTRYPIKETG FYCVTAFRSS TSTKFNAVVN FRNAYGQLAG TEINKLPLYG
210 220 230 240 250
LLAVAYVVAM ALYSFAFWKH KHELLPLQKY LLAFFVFLTA ETIFVWAYYD
260 270 280 290 300
LKNEKGDTAG IKVYMVFLSI LTAGKVTFSF FLLLIIALGY GIVYPKLNKT
310 320 330 340 350
LMRRCQMYGA LTYAICIGFL IQSYLTDMEA PSPLILITLI PMALALIIFY
360 370 380 390 400
YMIIRSMTKT VIYLKEQRQI VKLNMYKKLL YIIYASFLSV LAGSIVSSFI
410 420 430 440 450
YVGMNTIDMI EKNWRSRFFV TDFWPTLVYF IVFVTIAFLW RPTDTSYMLA
460 470 480 490 500
ASQQLPTDPE NVADFDLGDL QSFDDQDDAS IITGERGIDE DDLNLNFTDD
510 520
EEGHDNVNNH SQGHGPVSPS PTK
Length:523
Mass (Da):60,018
Last modified:July 1, 2008 - v2
Checksum:i86E7A339FE192DEC
GO

Sequence cautioni

The sequence CAA49300.1 differs from that shown. Reason: Frameshift at position 513.
The sequence CAA81874.1 differs from that shown. Reason: Frameshift at position 513.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L11895 Genomic DNA. Translation: AAA34921.1.
X69584 Genomic DNA. Translation: CAA49300.1. Frameshift.
Z28039 Genomic DNA. Translation: CAA81874.1. Frameshift.
BK006944 Genomic DNA. Translation: DAA09117.1.
PIRiS30011.
RefSeqiNP_012885.2. NM_001179605.1.

Genome annotation databases

EnsemblFungiiYKL039W; YKL039W; YKL039W.
GeneIDi853827.
KEGGisce:YKL039W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L11895 Genomic DNA. Translation: AAA34921.1 .
X69584 Genomic DNA. Translation: CAA49300.1 . Frameshift.
Z28039 Genomic DNA. Translation: CAA81874.1 . Frameshift.
BK006944 Genomic DNA. Translation: DAA09117.1 .
PIRi S30011.
RefSeqi NP_012885.2. NM_001179605.1.

3D structure databases

ProteinModelPortali P32857.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 34093. 35 interactions.
DIPi DIP-1244N.
IntActi P32857. 14 interactions.
MINTi MINT-404939.
STRINGi 4932.YKL039W.

Proteomic databases

MaxQBi P32857.
PaxDbi P32857.
PeptideAtlasi P32857.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YKL039W ; YKL039W ; YKL039W .
GeneIDi 853827.
KEGGi sce:YKL039W.

Organism-specific databases

SGDi S000001522. PTM1.

Phylogenomic databases

eggNOGi NOG302490.
GeneTreei ENSGT00390000015417.
HOGENOMi HOG000176489.
InParanoidi P32857.
OMAi FAMSDEI.
OrthoDBi EOG70ZZWZ.

Enzyme and pathway databases

BioCyci YEAST:G3O-31840-MONOMER.

Miscellaneous databases

NextBioi 975020.

Gene expression databases

Genevestigatori P32857.

Family and domain databases

InterProi IPR009637. TM_rcpt_euk.
[Graphical view ]
PANTHERi PTHR21229. PTHR21229. 1 hit.
Pfami PF06814. Lung_7-TM_R. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "PTM1, a putative transmembrane protein, enhances recovery from transformation of a profilin deletion strain."
    Haarer B.K., Petzold A.S., Brown S.S.
    Submitted (MAR-1993) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The sequence of a 12 kb fragment on the left arm of yeast chromosome XI reveals five new open reading frames, including a zinc finger protein and a homolog of the UDP-glucose pyrophosphorylase from potato."
    Purnelle B., Skala J., van Dyck L., Goffeau A.
    Yeast 8:977-986(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Complete DNA sequence of yeast chromosome XI."
    Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C.
    , Domdey H., Duesterhoeft A., Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H., Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L., Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M., Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H., Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J., Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H., Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J., Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S., Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F., Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R., Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W., Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M., Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C., Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H., Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L., van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S., von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M., Becker I., Mewes H.-W.
    Nature 369:371-378(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  5. "Sequencing and comparison of yeast species to identify genes and regulatory elements."
    Kellis M., Patterson N., Endrizzi M., Birren B.W., Lander E.S.
    Nature 423:241-254(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION OF FRAMESHIFT.
  6. "Immunoisolaton of the yeast Golgi subcompartments and characterization of a novel membrane protein, Svp26, discovered in the Sed5-containing compartments."
    Inadome H., Noda Y., Adachi H., Yoda K.
    Mol. Cell. Biol. 25:7696-7710(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  7. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-480; THR-483 AND THR-498, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPTM1_YEAST
AccessioniPrimary (citable) accession number: P32857
Secondary accession number(s): D6VXP7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: July 1, 2008
Last modified: October 29, 2014
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

External Data

Dasty 3