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Protein

Membrane protein PTM1

Gene

PTM1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

BioCyciYEAST:G3O-31840-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane protein PTM1
Gene namesi
Name:PTM1
Ordered Locus Names:YKL039W
ORF Names:YKL252
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XI

Organism-specific databases

EuPathDBiFungiDB:YKL039W.
SGDiS000001522. PTM1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 197LumenalSequence analysisAdd BLAST171
Transmembranei198 – 218Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini219 – 230CytoplasmicSequence analysisAdd BLAST12
Transmembranei231 – 251Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini252 – 265LumenalSequence analysisAdd BLAST14
Transmembranei266 – 286Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini287 – 304CytoplasmicSequence analysisAdd BLAST18
Transmembranei305 – 325Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini326 – 333LumenalSequence analysis8
Transmembranei334 – 354Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini355 – 381CytoplasmicSequence analysisAdd BLAST27
Transmembranei382 – 402Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini403 – 417LumenalSequence analysisAdd BLAST15
Transmembranei418 – 438Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini439 – 523CytoplasmicSequence analysisAdd BLAST85

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endosome, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000002218027 – 523Membrane protein PTM1Add BLAST497

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi132N-linked (GlcNAc...)Sequence analysis1
Modified residuei480PhosphoserineCombined sources1
Modified residuei483PhosphothreonineCombined sources1
Modified residuei498PhosphothreonineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP32857.
PRIDEiP32857.

PTM databases

iPTMnetiP32857.

Interactioni

Protein-protein interaction databases

BioGridi34093. 35 interactors.
DIPiDIP-1244N.
IntActiP32857. 14 interactors.
MINTiMINT-404939.

Structurei

3D structure databases

ProteinModelPortaliP32857.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LU7TM family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000015417.
HOGENOMiHOG000176489.
InParanoidiP32857.
OMAiVIDITIW.
OrthoDBiEOG092C26YZ.

Family and domain databases

InterProiIPR009637. GPR107-like.
[Graphical view]
PANTHERiPTHR21229. PTHR21229. 2 hits.
PfamiPF06814. Lung_7-TM_R. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P32857-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVYQFCRPF QLFTCFLCYL LVFVKANKEK ISQKNYQVCA GMYSKEDWKG
60 70 80 90 100
KIDPFISFNL KKISGLSDES DPGLVVAIYD FQDFEHLGVQ LPDEEMYYIC
110 120 130 140 150
DDYAIDIGIC EEENRDEFIV QDVVYDPYTS TNRSLANPIM TFSQNEVGLH
160 170 180 190 200
DTRYPIKETG FYCVTAFRSS TSTKFNAVVN FRNAYGQLAG TEINKLPLYG
210 220 230 240 250
LLAVAYVVAM ALYSFAFWKH KHELLPLQKY LLAFFVFLTA ETIFVWAYYD
260 270 280 290 300
LKNEKGDTAG IKVYMVFLSI LTAGKVTFSF FLLLIIALGY GIVYPKLNKT
310 320 330 340 350
LMRRCQMYGA LTYAICIGFL IQSYLTDMEA PSPLILITLI PMALALIIFY
360 370 380 390 400
YMIIRSMTKT VIYLKEQRQI VKLNMYKKLL YIIYASFLSV LAGSIVSSFI
410 420 430 440 450
YVGMNTIDMI EKNWRSRFFV TDFWPTLVYF IVFVTIAFLW RPTDTSYMLA
460 470 480 490 500
ASQQLPTDPE NVADFDLGDL QSFDDQDDAS IITGERGIDE DDLNLNFTDD
510 520
EEGHDNVNNH SQGHGPVSPS PTK
Length:523
Mass (Da):60,018
Last modified:July 1, 2008 - v2
Checksum:i86E7A339FE192DEC
GO

Sequence cautioni

The sequence CAA49300 differs from that shown. Reason: Frameshift at position 513.Curated
The sequence CAA81874 differs from that shown. Reason: Frameshift at position 513.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L11895 Genomic DNA. Translation: AAA34921.1.
X69584 Genomic DNA. Translation: CAA49300.1. Frameshift.
Z28039 Genomic DNA. Translation: CAA81874.1. Frameshift.
BK006944 Genomic DNA. Translation: DAA09117.1.
PIRiS30011.
RefSeqiNP_012885.2. NM_001179605.1.

Genome annotation databases

EnsemblFungiiYKL039W; YKL039W; YKL039W.
GeneIDi853827.
KEGGisce:YKL039W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L11895 Genomic DNA. Translation: AAA34921.1.
X69584 Genomic DNA. Translation: CAA49300.1. Frameshift.
Z28039 Genomic DNA. Translation: CAA81874.1. Frameshift.
BK006944 Genomic DNA. Translation: DAA09117.1.
PIRiS30011.
RefSeqiNP_012885.2. NM_001179605.1.

3D structure databases

ProteinModelPortaliP32857.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34093. 35 interactors.
DIPiDIP-1244N.
IntActiP32857. 14 interactors.
MINTiMINT-404939.

PTM databases

iPTMnetiP32857.

Proteomic databases

MaxQBiP32857.
PRIDEiP32857.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYKL039W; YKL039W; YKL039W.
GeneIDi853827.
KEGGisce:YKL039W.

Organism-specific databases

EuPathDBiFungiDB:YKL039W.
SGDiS000001522. PTM1.

Phylogenomic databases

GeneTreeiENSGT00390000015417.
HOGENOMiHOG000176489.
InParanoidiP32857.
OMAiVIDITIW.
OrthoDBiEOG092C26YZ.

Enzyme and pathway databases

BioCyciYEAST:G3O-31840-MONOMER.

Miscellaneous databases

PROiP32857.

Family and domain databases

InterProiIPR009637. GPR107-like.
[Graphical view]
PANTHERiPTHR21229. PTHR21229. 2 hits.
PfamiPF06814. Lung_7-TM_R. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPTM1_YEAST
AccessioniPrimary (citable) accession number: P32857
Secondary accession number(s): D6VXP7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: July 1, 2008
Last modified: November 2, 2016
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.