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P32856

- STX2_HUMAN

UniProt

P32856 - STX2_HUMAN

Protein

Syntaxin-2

Gene

STX2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 136 (01 Oct 2014)
      Sequence version 3 (23 Mar 2010)
      Previous versions | rss
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    Functioni

    Essential for epithelial morphogenesis. May mediate Ca2+-regulation of exocytosis acrosomal reaction in sperm.

    GO - Molecular functioni

    1. calcium-dependent protein binding Source: HGNC
    2. protein binding Source: UniProtKB

    GO - Biological processi

    1. acrosome reaction Source: HGNC
    2. cell differentiation Source: Ensembl
    3. ectoderm development Source: ProtInc
    4. intracellular protein transport Source: InterPro
    5. organ morphogenesis Source: ProtInc
    6. regulation of blood coagulation Source: UniProt
    7. regulation of gene expression Source: UniProt
    8. signal transduction Source: ProtInc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Syntaxin-2
    Alternative name(s):
    Epimorphin
    Gene namesi
    Name:STX2
    Synonyms:EPIM, STX2A, STX2B, STX2C
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:3403. STX2.

    Subcellular locationi

    GO - Cellular componenti

    1. basolateral plasma membrane Source: HGNC
    2. cell-cell junction Source: Ensembl
    3. cell surface Source: Ensembl
    4. cytoplasmic vesicle Source: Ensembl
    5. extracellular vesicular exosome Source: UniProt
    6. integral component of membrane Source: UniProtKB-KW
    7. intracellular membrane-bounded organelle Source: ProtInc
    8. membrane raft Source: Ensembl

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA27831.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 288288Syntaxin-2PRO_0000210196Add
    BLAST

    Proteomic databases

    MaxQBiP32856.
    PaxDbiP32856.
    PRIDEiP32856.

    PTM databases

    PhosphoSiteiP32856.

    Expressioni

    Gene expression databases

    BgeeiP32856.
    CleanExiHS_STX2.
    GenevestigatoriP32856.

    Organism-specific databases

    HPAiCAB022658.
    HPA038189.

    Interactioni

    Subunit structurei

    Interacts with SYT6 and SYT8; the interaction is Ca2+-dependent.By similarity

    Protein-protein interaction databases

    BioGridi108368. 14 interactions.
    IntActiP32856. 1 interaction.
    STRINGi9606.ENSP00000342554.

    Structurei

    3D structure databases

    ProteinModelPortaliP32856.
    SMRiP32856. Positions 26-283.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 264264CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei265 – 28824Helical; Anchor for type IV membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini191 – 25363t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili35 – 10167Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the syntaxin family.Curated
    Contains 1 t-SNARE coiled-coil homology domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5074.
    HOGENOMiHOG000286023.
    HOVERGENiHBG000497.
    InParanoidiP32856.
    KOiK08486.
    OMAiRKFVEAM.
    OrthoDBiEOG7X9G7R.
    PhylomeDBiP32856.
    TreeFamiTF313763.

    Family and domain databases

    InterProiIPR028671. STX2.
    IPR006012. Syntaxin/epimorphin_CS.
    IPR006011. Syntaxin_N.
    IPR010989. t-SNARE.
    IPR000727. T_SNARE_dom.
    [Graphical view]
    PANTHERiPTHR19957:SF36. PTHR19957:SF36. 1 hit.
    PfamiPF05739. SNARE. 1 hit.
    PF00804. Syntaxin. 1 hit.
    [Graphical view]
    SMARTiSM00503. SynN. 1 hit.
    SM00397. t_SNARE. 1 hit.
    [Graphical view]
    SUPFAMiSSF47661. SSF47661. 1 hit.
    PROSITEiPS00914. SYNTAXIN. 1 hit.
    PS50192. T_SNARE. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Note: Additional isoforms seem to exist.

    Isoform 3 (identifier: P32856-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MRDRLPDLTA CRKNDDGDTV VVVEKDHFMD DFFHQVEEIR NSIDKITQYV    50
    EEVKKNHSII LSAPNPEGKI KEELEDLNKE IKKTANKIRA KLKAIEQSFD 100
    QDESGNRTSV DLRIRRTQHS VLSRKFVEAM AEYNEAQTLF RERSKGRIQR 150
    QLEITGRTTT DDELEEMLES GKPSIFTSDI ISDSQITRQA LNEIESRHKD 200
    IMKLETSIRE LHEMFMDMAM FVETQGEMIN NIERNVMNAT DYVEHAKEET 250
    KKAIKYQSKA RRKKWIIIAV SVVLVAIIAL IIGLSVGK 288
    Length:288
    Mass (Da):33,341
    Last modified:March 23, 2010 - v3
    Checksum:i5668E6BF891360B4
    GO
    Isoform 1 (identifier: P32856-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         264-288: KWIIIAVSVVLVAIIALIIGLSVGK → LMFIIICVIVLLVILGIILATTLS

    Show »
    Length:287
    Mass (Da):33,337
    Checksum:iB3A3B5F6813E0F32
    GO
    Isoform 2 (identifier: P32856-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         263-288: KKWIIIAVSVVLVAIIALIIGLSVGK → QQHCHSNHIPRAIYP

    Show »
    Length:277
    Mass (Da):32,425
    Checksum:iD2188E346FA7E2FA
    GO

    Sequence cautioni

    The sequence BAA03436.1 differs from that shown. Reason: Frameshift at several positions.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti89 – 891R → A in BAA03436. (PubMed:8466509)Curated
    Sequence conflicti276 – 2761A → V in BAA03436. (PubMed:8466509)Curated
    Sequence conflicti288 – 2881K → I in BAA03436. (PubMed:8466509)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti42 – 421S → T.
    Corresponds to variant rs6486602 [ dbSNP | Ensembl ].
    VAR_014850
    Natural varianti54 – 541K → R.
    Corresponds to variant rs7301926 [ dbSNP | Ensembl ].
    VAR_057259

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei263 – 28826KKWII…LSVGK → QQHCHSNHIPRAIYP in isoform 2. 1 PublicationVSP_006335Add
    BLAST
    Alternative sequencei264 – 28825KWIII…LSVGK → LMFIIICVIVLLVILGIILA TTLS in isoform 1. 2 PublicationsVSP_006334Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D14582 mRNA. Translation: BAA03436.1. Frameshift.
    AC073912 Genomic DNA. No translation available.
    BC047496 mRNA. Translation: AAH47496.1.
    CCDSiCCDS9269.1. [P32856-2]
    CCDS9270.1. [P32856-1]
    PIRiJN0466.
    RefSeqiNP_001971.2. NM_001980.3. [P32856-2]
    NP_919337.1. NM_194356.2. [P32856-1]
    XP_005253613.1. XM_005253556.2. [P32856-1]
    UniGeneiHs.437585.

    Genome annotation databases

    EnsembliENST00000261653; ENSP00000261653; ENSG00000111450. [P32856-2]
    ENST00000392373; ENSP00000376178; ENSG00000111450. [P32856-1]
    GeneIDi2054.
    KEGGihsa:2054.
    UCSCiuc001uio.4. human. [P32856-1]
    uc001uip.4. human. [P32856-2]

    Polymorphism databases

    DMDMi292495060.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D14582 mRNA. Translation: BAA03436.1 . Frameshift.
    AC073912 Genomic DNA. No translation available.
    BC047496 mRNA. Translation: AAH47496.1 .
    CCDSi CCDS9269.1. [P32856-2 ]
    CCDS9270.1. [P32856-1 ]
    PIRi JN0466.
    RefSeqi NP_001971.2. NM_001980.3. [P32856-2 ]
    NP_919337.1. NM_194356.2. [P32856-1 ]
    XP_005253613.1. XM_005253556.2. [P32856-1 ]
    UniGenei Hs.437585.

    3D structure databases

    ProteinModelPortali P32856.
    SMRi P32856. Positions 26-283.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 108368. 14 interactions.
    IntActi P32856. 1 interaction.
    STRINGi 9606.ENSP00000342554.

    PTM databases

    PhosphoSitei P32856.

    Polymorphism databases

    DMDMi 292495060.

    Proteomic databases

    MaxQBi P32856.
    PaxDbi P32856.
    PRIDEi P32856.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000261653 ; ENSP00000261653 ; ENSG00000111450 . [P32856-2 ]
    ENST00000392373 ; ENSP00000376178 ; ENSG00000111450 . [P32856-1 ]
    GeneIDi 2054.
    KEGGi hsa:2054.
    UCSCi uc001uio.4. human. [P32856-1 ]
    uc001uip.4. human. [P32856-2 ]

    Organism-specific databases

    CTDi 2054.
    GeneCardsi GC12M131274.
    HGNCi HGNC:3403. STX2.
    HPAi CAB022658.
    HPA038189.
    MIMi 132350. gene.
    neXtProti NX_P32856.
    PharmGKBi PA27831.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5074.
    HOGENOMi HOG000286023.
    HOVERGENi HBG000497.
    InParanoidi P32856.
    KOi K08486.
    OMAi RKFVEAM.
    OrthoDBi EOG7X9G7R.
    PhylomeDBi P32856.
    TreeFami TF313763.

    Miscellaneous databases

    ChiTaRSi STX2. human.
    GeneWikii STX2.
    GenomeRNAii 2054.
    NextBioi 8351.
    PROi P32856.
    SOURCEi Search...

    Gene expression databases

    Bgeei P32856.
    CleanExi HS_STX2.
    Genevestigatori P32856.

    Family and domain databases

    InterProi IPR028671. STX2.
    IPR006012. Syntaxin/epimorphin_CS.
    IPR006011. Syntaxin_N.
    IPR010989. t-SNARE.
    IPR000727. T_SNARE_dom.
    [Graphical view ]
    PANTHERi PTHR19957:SF36. PTHR19957:SF36. 1 hit.
    Pfami PF05739. SNARE. 1 hit.
    PF00804. Syntaxin. 1 hit.
    [Graphical view ]
    SMARTi SM00503. SynN. 1 hit.
    SM00397. t_SNARE. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47661. SSF47661. 1 hit.
    PROSITEi PS00914. SYNTAXIN. 1 hit.
    PS50192. T_SNARE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of human epimorphin: identification of isoforms and their unique properties."
      Hirai Y.
      Biochem. Biophys. Res. Commun. 191:1332-1337(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3).
    2. "The finished DNA sequence of human chromosome 12."
      Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
      , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
      Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Testis.

    Entry informationi

    Entry nameiSTX2_HUMAN
    AccessioniPrimary (citable) accession number: P32856
    Secondary accession number(s): Q86VW8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1993
    Last sequence update: March 23, 2010
    Last modified: October 1, 2014
    This is version 136 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3