P32856 (STX2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Syntaxin-2

Alternative name(s):
Epimorphin

Gene names

Name:	STX2
Synonyms:	EPIM, STX2A, STX2B, STX2C

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	288 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Essential for epithelial morphogenesis. May mediate Ca2+-regulation of exocytosis acrosomal reaction in sperm.
Subunit structure	Interacts with SYT6 and SYT8; the interaction is Ca2+-dependent By similarity.
Subcellular location	Membrane; Single-pass type IV membrane protein.
Sequence similarities	Belongs to the syntaxin family. Contains 1 t-SNARE coiled-coil homology domain.
Sequence caution	The sequence BAA03436.1 differs from that shown. Reason: Frameshift at several positions.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	acrosome reaction Inferred from sequence or structural similarity. Source: HGNC cell differentiation Inferred from electronic annotation. Source: Compara ectoderm development Traceable author statement Ref.1. Source: ProtInc intracellular protein transport Inferred from electronic annotation. Source: InterPro organ morphogenesis Traceable author statement PubMed 1581962. Source: ProtInc signal transduction Traceable author statement PubMed 1581962. Source: ProtInc
Cellular_component	basolateral plasma membrane Inferred from direct assay PubMed 16339081. Source: HGNC cell surface Inferred from electronic annotation. Source: Compara cell-cell junction Inferred from electronic annotation. Source: Compara cytoplasmic vesicle Inferred from electronic annotation. Source: Compara integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW intracellular membrane-bounded organelle Traceable author statement Ref.1. Source: ProtInc membrane raft Inferred from electronic annotation. Source: Compara
Molecular_function	calcium-dependent protein binding Inferred from sequence or structural similarity. Source: HGNC
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms seem to exist.

Isoform 3 (identifier: P32856-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 1 (identifier: P32856-2)

The sequence of this isoform differs from the canonical sequence as follows:
     264-288: KWIIIAVSVVLVAIIALIIGLSVGK → LMFIIICVIVLLVILGIILATTLS

Isoform 2 (identifier: P32856-3)

The sequence of this isoform differs from the canonical sequence as follows:
     263-288: KKWIIIAVSVVLVAIIALIIGLSVGK → QQHCHSNHIPRAIYP

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 288	288	Syntaxin-2		PRO_0000210196
Regions
	Topological domain	1 – 264	264	Cytoplasmic Potential
	Transmembrane	265 – 288	24	Helical; Anchor for type IV membrane protein; Potential
	Domain	191 – 253	63	t-SNARE coiled-coil homology
	Coiled coil	35 – 101	67	Potential
Natural variations
	Alternative sequence	263 – 288	26	KKWII…LSVGK → QQHCHSNHIPRAIYP in isoform 2.		VSP_006335
	Alternative sequence	264 – 288	25	KWIII…LSVGK → LMFIIICVIVLLVILGIILA TTLS in isoform 1.		VSP_006334
	Natural variant	42	1	S → T. Corresponds to variant rs6486602 [ dbSNP | Ensembl ].		VAR_014850
	Natural variant	54	1	K → R. Corresponds to variant rs7301926 [ dbSNP | Ensembl ].		VAR_057259
Experimental info
	Sequence conflict	89	1	R → A in BAA03436. Ref.1
	Sequence conflict	276	1	A → V in BAA03436. Ref.1
	Sequence conflict	288	1	K → I in BAA03436. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 3 [UniParc]. Last modified March 23, 2010. Version 3. Checksum: 5668E6BF891360B4	FASTA	288	33,341
	10 20 30 40 50 60 MRDRLPDLTA CRKNDDGDTV VVVEKDHFMD DFFHQVEEIR NSIDKITQYV EEVKKNHSII 70 80 90 100 110 120 LSAPNPEGKI KEELEDLNKE IKKTANKIRA KLKAIEQSFD QDESGNRTSV DLRIRRTQHS 130 140 150 160 170 180 VLSRKFVEAM AEYNEAQTLF RERSKGRIQR QLEITGRTTT DDELEEMLES GKPSIFTSDI 190 200 210 220 230 240 ISDSQITRQA LNEIESRHKD IMKLETSIRE LHEMFMDMAM FVETQGEMIN NIERNVMNAT 250 260 270 280 DYVEHAKEET KKAIKYQSKA RRKKWIIIAV SVVLVAIIAL IIGLSVGK
	Isoform 1 [UniParc]. Checksum: B3A3B5F6813E0F32	FASTA	287	33,337
	10 20 30 40 50 60 MRDRLPDLTA CRKNDDGDTV VVVEKDHFMD DFFHQVEEIR NSIDKITQYV EEVKKNHSII 70 80 90 100 110 120 LSAPNPEGKI KEELEDLNKE IKKTANKIRA KLKAIEQSFD QDESGNRTSV DLRIRRTQHS 130 140 150 160 170 180 VLSRKFVEAM AEYNEAQTLF RERSKGRIQR QLEITGRTTT DDELEEMLES GKPSIFTSDI 190 200 210 220 230 240 ISDSQITRQA LNEIESRHKD IMKLETSIRE LHEMFMDMAM FVETQGEMIN NIERNVMNAT 250 260 270 280 DYVEHAKEET KKAIKYQSKA RRKLMFIIIC VIVLLVILGI ILATTLS
	Isoform 2 [UniParc]. Checksum: D2188E346FA7E2FA	FASTA	277	32,425
	10 20 30 40 50 60 MRDRLPDLTA CRKNDDGDTV VVVEKDHFMD DFFHQVEEIR NSIDKITQYV EEVKKNHSII 70 80 90 100 110 120 LSAPNPEGKI KEELEDLNKE IKKTANKIRA KLKAIEQSFD QDESGNRTSV DLRIRRTQHS 130 140 150 160 170 180 VLSRKFVEAM AEYNEAQTLF RERSKGRIQR QLEITGRTTT DDELEEMLES GKPSIFTSDI 190 200 210 220 230 240 ISDSQITRQA LNEIESRHKD IMKLETSIRE LHEMFMDMAM FVETQGEMIN NIERNVMNAT 250 260 270 DYVEHAKEET KKAIKYQSKA RRQQHCHSNH IPRAIYP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning of human epimorphin: identification of isoforms and their unique properties." Hirai Y. Biochem. Biophys. Res. Commun. 191:1332-1337(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3).
[2]	"The finished DNA sequence of human chromosome 12." Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A. Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Testis.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D14582 mRNA. Translation: BAA03436.1. Frameshift. AC073912 Genomic DNA. No translation available. BC047496 mRNA. Translation: AAH47496.1.
IPI	IPI00221209. IPI00221210. IPI00336034.
PIR	JN0466.
RefSeq	NP_001971.2. NM_001980.3. NP_919337.1. NM_194356.2.
UniGene	Hs.437585.
3D structure databases
ProteinModelPortal	P32856.
SMR	P32856. Positions 26-149, 188-283.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000342554.
PTM databases
PhosphoSite	P32856.
Polymorphism databases
DMDM	292495060.
Proteomic databases
PaxDb	P32856.
PRIDE	P32856.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000261653; ENSP00000261653; ENSG00000111450. ENST00000392373; ENSP00000376178; ENSG00000111450.
GeneID	2054.
KEGG	hsa:2054.
UCSC	uc001uio.3. human. uc001uip.3. human.
Organism-specific databases
CTD	2054.
GeneCards	GC12M131274.
HGNC	HGNC:3403. STX2.
HPA	CAB022658.
MIM	132350. gene.
neXtProt	NX_P32856.
PharmGKB	PA27831.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5074.
HOGENOM	HOG000286023.
HOVERGEN	HBG000497.
InParanoid	P32856.
KO	K08486.
OMA	FVEVMTQ.
PhylomeDB	P32856.
Enzyme and pathway databases
Reactome	REACT_116125. Disease. REACT_13685. Neuronal System.
Gene expression databases
Bgee	P32856.
CleanEx	HS_STX2.
Genevestigator	P32856.
GermOnline	ENSG00000111450. Homo sapiens.
Family and domain databases
InterPro	IPR006012. Syntaxin/epimorphin_CS. IPR006011. Syntaxin_N. IPR010989. t-SNARE. IPR000727. T_SNARE_dom. [Graphical view]
Pfam	PF05739. SNARE. 1 hit. PF00804. Syntaxin. 1 hit. [Graphical view]
SMART	SM00503. SynN. 1 hit. SM00397. t_SNARE. 1 hit. [Graphical view]
SUPFAM	SSF47661. t-snare. 1 hit.
PROSITE	PS00914. SYNTAXIN. 1 hit. PS50192. T_SNARE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	STX2. human.
GenomeRNAi	2054.
NextBio	8351.
SOURCE	Search...

Entry information

Entry name

STX2_HUMAN

Accession

Primary (citable) accession number: P32856
Secondary accession number(s): Q86VW8

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1993
Last sequence update:	March 23, 2010
Last modified:	April 3, 2013
This is version 123 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.