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P32856 (STX2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 134. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Syntaxin-2
Alternative name(s):
Epimorphin
Gene names
Name:STX2
Synonyms:EPIM, STX2A, STX2B, STX2C
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length288 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Essential for epithelial morphogenesis. May mediate Ca2+-regulation of exocytosis acrosomal reaction in sperm.

Subunit structure

Interacts with SYT6 and SYT8; the interaction is Ca2+-dependent By similarity.

Subcellular location

Membrane; Single-pass type IV membrane protein.

Sequence similarities

Belongs to the syntaxin family.

Contains 1 t-SNARE coiled-coil homology domain.

Sequence caution

The sequence BAA03436.1 differs from that shown. Reason: Frameshift at several positions.

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainCoiled coil
Transmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processacrosome reaction

Inferred from sequence or structural similarity. Source: HGNC

cell differentiation

Inferred from electronic annotation. Source: Ensembl

ectoderm development

Traceable author statement Ref.1. Source: ProtInc

intracellular protein transport

Inferred from electronic annotation. Source: InterPro

organ morphogenesis

Traceable author statement PubMed 1581962. Source: ProtInc

regulation of blood coagulation

Inferred from mutant phenotype PubMed 21810271. Source: UniProt

regulation of gene expression

Inferred from mutant phenotype PubMed 21810271. Source: UniProt

signal transduction

Traceable author statement PubMed 1581962. Source: ProtInc

   Cellular_componentbasolateral plasma membrane

Inferred from direct assay PubMed 16339081. Source: HGNC

cell surface

Inferred from electronic annotation. Source: Ensembl

cell-cell junction

Inferred from electronic annotation. Source: Ensembl

cytoplasmic vesicle

Inferred from electronic annotation. Source: Ensembl

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

intracellular membrane-bounded organelle

Traceable author statement Ref.1. Source: ProtInc

membrane raft

Inferred from electronic annotation. Source: Ensembl

   Molecular_functioncalcium-dependent protein binding

Inferred from sequence or structural similarity. Source: HGNC

protein binding

Inferred from physical interaction PubMed 12773094. Source: UniProtKB

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms seem to exist.
Isoform 3 (identifier: P32856-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 1 (identifier: P32856-2)

The sequence of this isoform differs from the canonical sequence as follows:
     264-288: KWIIIAVSVVLVAIIALIIGLSVGK → LMFIIICVIVLLVILGIILATTLS
Isoform 2 (identifier: P32856-3)

The sequence of this isoform differs from the canonical sequence as follows:
     263-288: KKWIIIAVSVVLVAIIALIIGLSVGK → QQHCHSNHIPRAIYP

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 288288Syntaxin-2
PRO_0000210196

Regions

Topological domain1 – 264264Cytoplasmic Potential
Transmembrane265 – 28824Helical; Anchor for type IV membrane protein; Potential
Domain191 – 25363t-SNARE coiled-coil homology
Coiled coil35 – 10167 Potential

Natural variations

Alternative sequence263 – 28826KKWII…LSVGK → QQHCHSNHIPRAIYP in isoform 2.
VSP_006335
Alternative sequence264 – 28825KWIII…LSVGK → LMFIIICVIVLLVILGIILA TTLS in isoform 1.
VSP_006334
Natural variant421S → T.
Corresponds to variant rs6486602 [ dbSNP | Ensembl ].
VAR_014850
Natural variant541K → R.
Corresponds to variant rs7301926 [ dbSNP | Ensembl ].
VAR_057259

Experimental info

Sequence conflict891R → A in BAA03436. Ref.1
Sequence conflict2761A → V in BAA03436. Ref.1
Sequence conflict2881K → I in BAA03436. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 3 [UniParc].

Last modified March 23, 2010. Version 3.
Checksum: 5668E6BF891360B4

FASTA28833,341
        10         20         30         40         50         60 
MRDRLPDLTA CRKNDDGDTV VVVEKDHFMD DFFHQVEEIR NSIDKITQYV EEVKKNHSII 

        70         80         90        100        110        120 
LSAPNPEGKI KEELEDLNKE IKKTANKIRA KLKAIEQSFD QDESGNRTSV DLRIRRTQHS 

       130        140        150        160        170        180 
VLSRKFVEAM AEYNEAQTLF RERSKGRIQR QLEITGRTTT DDELEEMLES GKPSIFTSDI 

       190        200        210        220        230        240 
ISDSQITRQA LNEIESRHKD IMKLETSIRE LHEMFMDMAM FVETQGEMIN NIERNVMNAT 

       250        260        270        280 
DYVEHAKEET KKAIKYQSKA RRKKWIIIAV SVVLVAIIAL IIGLSVGK 

« Hide

Isoform 1 [UniParc].

Checksum: B3A3B5F6813E0F32
Show »

FASTA28733,337
Isoform 2 [UniParc].

Checksum: D2188E346FA7E2FA
Show »

FASTA27732,425

References

« Hide 'large scale' references
[1]"Molecular cloning of human epimorphin: identification of isoforms and their unique properties."
Hirai Y.
Biochem. Biophys. Res. Commun. 191:1332-1337(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3).
[2]"The finished DNA sequence of human chromosome 12."
Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. expand/collapse author list , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Testis.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D14582 mRNA. Translation: BAA03436.1. Frameshift.
AC073912 Genomic DNA. No translation available.
BC047496 mRNA. Translation: AAH47496.1.
CCDSCCDS9269.1. [P32856-2]
CCDS9270.1. [P32856-1]
PIRJN0466.
RefSeqNP_001971.2. NM_001980.3. [P32856-2]
NP_919337.1. NM_194356.2. [P32856-1]
XP_005253613.1. XM_005253556.2. [P32856-1]
UniGeneHs.437585.

3D structure databases

ProteinModelPortalP32856.
SMRP32856. Positions 26-283.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid108368. 14 interactions.
IntActP32856. 1 interaction.
STRING9606.ENSP00000342554.

PTM databases

PhosphoSiteP32856.

Polymorphism databases

DMDM292495060.

Proteomic databases

MaxQBP32856.
PaxDbP32856.
PRIDEP32856.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000261653; ENSP00000261653; ENSG00000111450. [P32856-2]
ENST00000392373; ENSP00000376178; ENSG00000111450. [P32856-1]
GeneID2054.
KEGGhsa:2054.
UCSCuc001uio.4. human. [P32856-1]
uc001uip.4. human. [P32856-2]

Organism-specific databases

CTD2054.
GeneCardsGC12M131274.
HGNCHGNC:3403. STX2.
HPACAB022658.
HPA038189.
MIM132350. gene.
neXtProtNX_P32856.
PharmGKBPA27831.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5074.
HOGENOMHOG000286023.
HOVERGENHBG000497.
InParanoidP32856.
KOK08486.
OMARKFVEAM.
OrthoDBEOG7X9G7R.
PhylomeDBP32856.
TreeFamTF313763.

Gene expression databases

BgeeP32856.
CleanExHS_STX2.
GenevestigatorP32856.

Family and domain databases

InterProIPR028671. STX2.
IPR006012. Syntaxin/epimorphin_CS.
IPR006011. Syntaxin_N.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view]
PANTHERPTHR19957:SF36. PTHR19957:SF36. 1 hit.
PfamPF05739. SNARE. 1 hit.
PF00804. Syntaxin. 1 hit.
[Graphical view]
SMARTSM00503. SynN. 1 hit.
SM00397. t_SNARE. 1 hit.
[Graphical view]
SUPFAMSSF47661. SSF47661. 1 hit.
PROSITEPS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSTX2. human.
GeneWikiSTX2.
GenomeRNAi2054.
NextBio8351.
PROP32856.
SOURCESearch...

Entry information

Entry nameSTX2_HUMAN
AccessionPrimary (citable) accession number: P32856
Secondary accession number(s): Q86VW8
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: March 23, 2010
Last modified: July 9, 2014
This is version 134 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM