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P32856

- STX2_HUMAN

UniProt

P32856 - STX2_HUMAN

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Protein
Syntaxin-2
Gene
STX2, EPIM, STX2A, STX2B, STX2C
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Essential for epithelial morphogenesis. May mediate Ca2+-regulation of exocytosis acrosomal reaction in sperm.

GO - Molecular functioni

  1. calcium-dependent protein binding Source: HGNC
  2. protein binding Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. acrosome reaction Source: HGNC
  2. cell differentiation Source: Ensembl
  3. ectoderm development Source: ProtInc
  4. intracellular protein transport Source: InterPro
  5. organ morphogenesis Source: ProtInc
  6. regulation of blood coagulation Source: UniProt
  7. regulation of gene expression Source: UniProt
  8. signal transduction Source: ProtInc
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin-2
Alternative name(s):
Epimorphin
Gene namesi
Name:STX2
Synonyms:EPIM, STX2A, STX2B, STX2C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:3403. STX2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 264264Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei265 – 28824Helical; Anchor for type IV membrane protein; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. basolateral plasma membrane Source: HGNC
  2. cell surface Source: Ensembl
  3. cell-cell junction Source: Ensembl
  4. cytoplasmic vesicle Source: Ensembl
  5. extracellular vesicular exosome Source: UniProt
  6. integral component of membrane Source: UniProtKB-KW
  7. intracellular membrane-bounded organelle Source: ProtInc
  8. membrane raft Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27831.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 288288Syntaxin-2
PRO_0000210196Add
BLAST

Proteomic databases

MaxQBiP32856.
PaxDbiP32856.
PRIDEiP32856.

PTM databases

PhosphoSiteiP32856.

Expressioni

Gene expression databases

BgeeiP32856.
CleanExiHS_STX2.
GenevestigatoriP32856.

Organism-specific databases

HPAiCAB022658.
HPA038189.

Interactioni

Subunit structurei

Interacts with SYT6 and SYT8; the interaction is Ca2+-dependent By similarity.

Protein-protein interaction databases

BioGridi108368. 14 interactions.
IntActiP32856. 1 interaction.
STRINGi9606.ENSP00000342554.

Structurei

3D structure databases

ProteinModelPortaliP32856.
SMRiP32856. Positions 26-283.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini191 – 25363t-SNARE coiled-coil homology
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili35 – 10167 Reviewed prediction
Add
BLAST

Sequence similaritiesi

Belongs to the syntaxin family.

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5074.
HOGENOMiHOG000286023.
HOVERGENiHBG000497.
InParanoidiP32856.
KOiK08486.
OMAiRKFVEAM.
OrthoDBiEOG7X9G7R.
PhylomeDBiP32856.
TreeFamiTF313763.

Family and domain databases

InterProiIPR028671. STX2.
IPR006012. Syntaxin/epimorphin_CS.
IPR006011. Syntaxin_N.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view]
PANTHERiPTHR19957:SF36. PTHR19957:SF36. 1 hit.
PfamiPF05739. SNARE. 1 hit.
PF00804. Syntaxin. 1 hit.
[Graphical view]
SMARTiSM00503. SynN. 1 hit.
SM00397. t_SNARE. 1 hit.
[Graphical view]
SUPFAMiSSF47661. SSF47661. 1 hit.
PROSITEiPS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Note: Additional isoforms seem to exist.

Isoform 3 (identifier: P32856-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MRDRLPDLTA CRKNDDGDTV VVVEKDHFMD DFFHQVEEIR NSIDKITQYV    50
EEVKKNHSII LSAPNPEGKI KEELEDLNKE IKKTANKIRA KLKAIEQSFD 100
QDESGNRTSV DLRIRRTQHS VLSRKFVEAM AEYNEAQTLF RERSKGRIQR 150
QLEITGRTTT DDELEEMLES GKPSIFTSDI ISDSQITRQA LNEIESRHKD 200
IMKLETSIRE LHEMFMDMAM FVETQGEMIN NIERNVMNAT DYVEHAKEET 250
KKAIKYQSKA RRKKWIIIAV SVVLVAIIAL IIGLSVGK 288
Length:288
Mass (Da):33,341
Last modified:March 23, 2010 - v3
Checksum:i5668E6BF891360B4
GO
Isoform 1 (identifier: P32856-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     264-288: KWIIIAVSVVLVAIIALIIGLSVGK → LMFIIICVIVLLVILGIILATTLS

Show »
Length:287
Mass (Da):33,337
Checksum:iB3A3B5F6813E0F32
GO
Isoform 2 (identifier: P32856-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     263-288: KKWIIIAVSVVLVAIIALIIGLSVGK → QQHCHSNHIPRAIYP

Show »
Length:277
Mass (Da):32,425
Checksum:iD2188E346FA7E2FA
GO

Sequence cautioni

The sequence BAA03436.1 differs from that shown. Reason: Frameshift at several positions.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti42 – 421S → T.
Corresponds to variant rs6486602 [ dbSNP | Ensembl ].
VAR_014850
Natural varianti54 – 541K → R.
Corresponds to variant rs7301926 [ dbSNP | Ensembl ].
VAR_057259

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei263 – 28826KKWII…LSVGK → QQHCHSNHIPRAIYP in isoform 2.
VSP_006335Add
BLAST
Alternative sequencei264 – 28825KWIII…LSVGK → LMFIIICVIVLLVILGIILA TTLS in isoform 1.
VSP_006334Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti89 – 891R → A in BAA03436. 1 Publication
Sequence conflicti276 – 2761A → V in BAA03436. 1 Publication
Sequence conflicti288 – 2881K → I in BAA03436. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D14582 mRNA. Translation: BAA03436.1. Frameshift.
AC073912 Genomic DNA. No translation available.
BC047496 mRNA. Translation: AAH47496.1.
CCDSiCCDS9269.1. [P32856-2]
CCDS9270.1. [P32856-1]
PIRiJN0466.
RefSeqiNP_001971.2. NM_001980.3. [P32856-2]
NP_919337.1. NM_194356.2. [P32856-1]
XP_005253613.1. XM_005253556.2. [P32856-1]
UniGeneiHs.437585.

Genome annotation databases

EnsembliENST00000261653; ENSP00000261653; ENSG00000111450. [P32856-2]
ENST00000392373; ENSP00000376178; ENSG00000111450. [P32856-1]
GeneIDi2054.
KEGGihsa:2054.
UCSCiuc001uio.4. human. [P32856-1]
uc001uip.4. human. [P32856-2]

Polymorphism databases

DMDMi292495060.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D14582 mRNA. Translation: BAA03436.1 . Frameshift.
AC073912 Genomic DNA. No translation available.
BC047496 mRNA. Translation: AAH47496.1 .
CCDSi CCDS9269.1. [P32856-2 ]
CCDS9270.1. [P32856-1 ]
PIRi JN0466.
RefSeqi NP_001971.2. NM_001980.3. [P32856-2 ]
NP_919337.1. NM_194356.2. [P32856-1 ]
XP_005253613.1. XM_005253556.2. [P32856-1 ]
UniGenei Hs.437585.

3D structure databases

ProteinModelPortali P32856.
SMRi P32856. Positions 26-283.
ModBasei Search...

Protein-protein interaction databases

BioGridi 108368. 14 interactions.
IntActi P32856. 1 interaction.
STRINGi 9606.ENSP00000342554.

PTM databases

PhosphoSitei P32856.

Polymorphism databases

DMDMi 292495060.

Proteomic databases

MaxQBi P32856.
PaxDbi P32856.
PRIDEi P32856.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000261653 ; ENSP00000261653 ; ENSG00000111450 . [P32856-2 ]
ENST00000392373 ; ENSP00000376178 ; ENSG00000111450 . [P32856-1 ]
GeneIDi 2054.
KEGGi hsa:2054.
UCSCi uc001uio.4. human. [P32856-1 ]
uc001uip.4. human. [P32856-2 ]

Organism-specific databases

CTDi 2054.
GeneCardsi GC12M131274.
HGNCi HGNC:3403. STX2.
HPAi CAB022658.
HPA038189.
MIMi 132350. gene.
neXtProti NX_P32856.
PharmGKBi PA27831.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5074.
HOGENOMi HOG000286023.
HOVERGENi HBG000497.
InParanoidi P32856.
KOi K08486.
OMAi RKFVEAM.
OrthoDBi EOG7X9G7R.
PhylomeDBi P32856.
TreeFami TF313763.

Miscellaneous databases

ChiTaRSi STX2. human.
GeneWikii STX2.
GenomeRNAii 2054.
NextBioi 8351.
PROi P32856.
SOURCEi Search...

Gene expression databases

Bgeei P32856.
CleanExi HS_STX2.
Genevestigatori P32856.

Family and domain databases

InterProi IPR028671. STX2.
IPR006012. Syntaxin/epimorphin_CS.
IPR006011. Syntaxin_N.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view ]
PANTHERi PTHR19957:SF36. PTHR19957:SF36. 1 hit.
Pfami PF05739. SNARE. 1 hit.
PF00804. Syntaxin. 1 hit.
[Graphical view ]
SMARTi SM00503. SynN. 1 hit.
SM00397. t_SNARE. 1 hit.
[Graphical view ]
SUPFAMi SSF47661. SSF47661. 1 hit.
PROSITEi PS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of human epimorphin: identification of isoforms and their unique properties."
    Hirai Y.
    Biochem. Biophys. Res. Commun. 191:1332-1337(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3).
  2. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.

Entry informationi

Entry nameiSTX2_HUMAN
AccessioniPrimary (citable) accession number: P32856
Secondary accession number(s): Q86VW8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: March 23, 2010
Last modified: September 3, 2014
This is version 135 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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