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Protein

Syntaxin-2

Gene

STX2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Essential for epithelial morphogenesis. May mediate Ca2+-regulation of exocytosis acrosomal reaction in sperm.

GO - Molecular functioni

  1. calcium-dependent protein binding Source: HGNC
  2. protein dimerization activity Source: UniProtKB
  3. SNAP receptor activity Source: GO_Central
  4. SNARE binding Source: GO_Central

GO - Biological processi

  1. acrosome reaction Source: HGNC
  2. cell differentiation Source: Ensembl
  3. ectoderm development Source: ProtInc
  4. intracellular protein transport Source: GO_Central
  5. organ morphogenesis Source: ProtInc
  6. protein oligomerization Source: UniProtKB
  7. regulation of blood coagulation Source: UniProtKB
  8. regulation of cytoskeleton organization Source: UniProtKB
  9. response to hydroperoxide Source: UniProtKB
  10. signal transduction Source: ProtInc
  11. synaptic vesicle fusion to presynaptic membrane Source: GO_Central
  12. vesicle docking Source: GO_Central
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin-2
Alternative name(s):
Epimorphin
Gene namesi
Name:STX2
Synonyms:EPIM, STX2A, STX2B, STX2C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:3403. STX2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 264264CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei265 – 28824Helical; Anchor for type IV membrane proteinSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. basolateral plasma membrane Source: HGNC
  2. cell-cell junction Source: Ensembl
  3. cell surface Source: Ensembl
  4. endomembrane system Source: GO_Central
  5. extracellular space Source: UniProtKB
  6. extracellular vesicular exosome Source: UniProtKB
  7. integral component of membrane Source: GO_Central
  8. intracellular membrane-bounded organelle Source: ProtInc
  9. lamellipodium Source: UniProtKB
  10. membrane raft Source: Ensembl
  11. plasma membrane Source: UniProtKB
  12. SNARE complex Source: GO_Central
  13. synaptic vesicle Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27831.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 288288Syntaxin-2PRO_0000210196Add
BLAST

Proteomic databases

MaxQBiP32856.
PaxDbiP32856.
PRIDEiP32856.

PTM databases

PhosphoSiteiP32856.

Expressioni

Gene expression databases

BgeeiP32856.
CleanExiHS_STX2.
GenevestigatoriP32856.

Organism-specific databases

HPAiCAB022658.
HPA038189.

Interactioni

Subunit structurei

Interacts with SYT6 and SYT8; the interaction is Ca2+-dependent.By similarity

Protein-protein interaction databases

BioGridi108368. 17 interactions.
IntActiP32856. 1 interaction.
STRINGi9606.ENSP00000342554.

Structurei

3D structure databases

ProteinModelPortaliP32856.
SMRiP32856. Positions 26-283.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini191 – 25363t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili35 – 10167Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the syntaxin family.Curated
Contains 1 t-SNARE coiled-coil homology domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5074.
GeneTreeiENSGT00760000119200.
HOGENOMiHOG000286023.
HOVERGENiHBG000497.
InParanoidiP32856.
KOiK08486.
OMAiNIERNIM.
OrthoDBiEOG7X9G7R.
PhylomeDBiP32856.
TreeFamiTF313763.

Family and domain databases

InterProiIPR028671. STX2.
IPR006012. Syntaxin/epimorphin_CS.
IPR006011. Syntaxin_N.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view]
PANTHERiPTHR19957:SF36. PTHR19957:SF36. 1 hit.
PfamiPF05739. SNARE. 1 hit.
PF00804. Syntaxin. 1 hit.
[Graphical view]
SMARTiSM00503. SynN. 1 hit.
SM00397. t_SNARE. 1 hit.
[Graphical view]
SUPFAMiSSF47661. SSF47661. 1 hit.
PROSITEiPS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.

Isoform 3 (identifier: P32856-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRDRLPDLTA CRKNDDGDTV VVVEKDHFMD DFFHQVEEIR NSIDKITQYV
60 70 80 90 100
EEVKKNHSII LSAPNPEGKI KEELEDLNKE IKKTANKIRA KLKAIEQSFD
110 120 130 140 150
QDESGNRTSV DLRIRRTQHS VLSRKFVEAM AEYNEAQTLF RERSKGRIQR
160 170 180 190 200
QLEITGRTTT DDELEEMLES GKPSIFTSDI ISDSQITRQA LNEIESRHKD
210 220 230 240 250
IMKLETSIRE LHEMFMDMAM FVETQGEMIN NIERNVMNAT DYVEHAKEET
260 270 280
KKAIKYQSKA RRKKWIIIAV SVVLVAIIAL IIGLSVGK
Length:288
Mass (Da):33,341
Last modified:March 23, 2010 - v3
Checksum:i5668E6BF891360B4
GO
Isoform 1 (identifier: P32856-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     264-288: KWIIIAVSVVLVAIIALIIGLSVGK → LMFIIICVIVLLVILGIILATTLS

Show »
Length:287
Mass (Da):33,337
Checksum:iB3A3B5F6813E0F32
GO
Isoform 2 (identifier: P32856-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     263-288: KKWIIIAVSVVLVAIIALIIGLSVGK → QQHCHSNHIPRAIYP

Show »
Length:277
Mass (Da):32,425
Checksum:iD2188E346FA7E2FA
GO

Sequence cautioni

The sequence BAA03436.1 differs from that shown. Reason: Frameshift at several positions. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti89 – 891R → A in BAA03436 (PubMed:8466509).Curated
Sequence conflicti276 – 2761A → V in BAA03436 (PubMed:8466509).Curated
Sequence conflicti288 – 2881K → I in BAA03436 (PubMed:8466509).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti42 – 421S → T.
Corresponds to variant rs6486602 [ dbSNP | Ensembl ].
VAR_014850
Natural varianti54 – 541K → R.
Corresponds to variant rs7301926 [ dbSNP | Ensembl ].
VAR_057259

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei263 – 28826KKWII…LSVGK → QQHCHSNHIPRAIYP in isoform 2. 1 PublicationVSP_006335Add
BLAST
Alternative sequencei264 – 28825KWIII…LSVGK → LMFIIICVIVLLVILGIILA TTLS in isoform 1. 2 PublicationsVSP_006334Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14582 mRNA. Translation: BAA03436.1. Frameshift.
AC073912 Genomic DNA. No translation available.
BC047496 mRNA. Translation: AAH47496.1.
CCDSiCCDS9269.1. [P32856-2]
CCDS9270.1. [P32856-1]
PIRiJN0466.
RefSeqiNP_001971.2. NM_001980.3. [P32856-2]
NP_919337.1. NM_194356.2. [P32856-1]
XP_005253613.1. XM_005253556.2. [P32856-1]
UniGeneiHs.437585.

Genome annotation databases

EnsembliENST00000261653; ENSP00000261653; ENSG00000111450. [P32856-2]
ENST00000392373; ENSP00000376178; ENSG00000111450. [P32856-1]
GeneIDi2054.
KEGGihsa:2054.
UCSCiuc001uio.4. human. [P32856-1]
uc001uip.4. human. [P32856-2]

Polymorphism databases

DMDMi292495060.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14582 mRNA. Translation: BAA03436.1. Frameshift.
AC073912 Genomic DNA. No translation available.
BC047496 mRNA. Translation: AAH47496.1.
CCDSiCCDS9269.1. [P32856-2]
CCDS9270.1. [P32856-1]
PIRiJN0466.
RefSeqiNP_001971.2. NM_001980.3. [P32856-2]
NP_919337.1. NM_194356.2. [P32856-1]
XP_005253613.1. XM_005253556.2. [P32856-1]
UniGeneiHs.437585.

3D structure databases

ProteinModelPortaliP32856.
SMRiP32856. Positions 26-283.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108368. 17 interactions.
IntActiP32856. 1 interaction.
STRINGi9606.ENSP00000342554.

PTM databases

PhosphoSiteiP32856.

Polymorphism databases

DMDMi292495060.

Proteomic databases

MaxQBiP32856.
PaxDbiP32856.
PRIDEiP32856.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000261653; ENSP00000261653; ENSG00000111450. [P32856-2]
ENST00000392373; ENSP00000376178; ENSG00000111450. [P32856-1]
GeneIDi2054.
KEGGihsa:2054.
UCSCiuc001uio.4. human. [P32856-1]
uc001uip.4. human. [P32856-2]

Organism-specific databases

CTDi2054.
GeneCardsiGC12M131274.
HGNCiHGNC:3403. STX2.
HPAiCAB022658.
HPA038189.
MIMi132350. gene.
neXtProtiNX_P32856.
PharmGKBiPA27831.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5074.
GeneTreeiENSGT00760000119200.
HOGENOMiHOG000286023.
HOVERGENiHBG000497.
InParanoidiP32856.
KOiK08486.
OMAiNIERNIM.
OrthoDBiEOG7X9G7R.
PhylomeDBiP32856.
TreeFamiTF313763.

Miscellaneous databases

GeneWikiiSTX2.
GenomeRNAii2054.
NextBioi8351.
PROiP32856.
SOURCEiSearch...

Gene expression databases

BgeeiP32856.
CleanExiHS_STX2.
GenevestigatoriP32856.

Family and domain databases

InterProiIPR028671. STX2.
IPR006012. Syntaxin/epimorphin_CS.
IPR006011. Syntaxin_N.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view]
PANTHERiPTHR19957:SF36. PTHR19957:SF36. 1 hit.
PfamiPF05739. SNARE. 1 hit.
PF00804. Syntaxin. 1 hit.
[Graphical view]
SMARTiSM00503. SynN. 1 hit.
SM00397. t_SNARE. 1 hit.
[Graphical view]
SUPFAMiSSF47661. SSF47661. 1 hit.
PROSITEiPS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of human epimorphin: identification of isoforms and their unique properties."
    Hirai Y.
    Biochem. Biophys. Res. Commun. 191:1332-1337(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3).
  2. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.

Entry informationi

Entry nameiSTX2_HUMAN
AccessioniPrimary (citable) accession number: P32856
Secondary accession number(s): Q86VW8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: March 23, 2010
Last modified: March 4, 2015
This is version 141 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.