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Protein

Syntaxin PEP12

Gene

PEP12

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in the sorting and targeting of vacuolar proteases.

GO - Molecular functioni

  • SNAP receptor activity Source: SGD
  • SNARE binding Source: GO_Central

GO - Biological processi

  • Golgi to vacuole transport Source: SGD
  • intracellular protein transport Source: InterPro
  • macroautophagy Source: SGD
  • protein localization by the Cvt pathway Source: SGD
  • vacuole inheritance Source: SGD
  • vesicle docking Source: GO_Central
  • vesicle fusion Source: GO_Central

Enzyme and pathway databases

BioCyciYEAST:G3O-33582-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin PEP12
Alternative name(s):
Carboxypeptidase Y-deficient protein 12
Vacuolar protein sorting-associated protein 6
Vacuolar protein-targeting protein 13
Gene namesi
Name:PEP12
Synonyms:VPS6, VPT13
Ordered Locus Names:YOR036W
ORF Names:OR26.29
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOR036W
SGDiS000005562 PEP12

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 268CytoplasmicSequence analysisAdd BLAST268
Transmembranei269 – 288Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST20

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi271L → D: Increases ubiquitination by TUL1. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002102711 – 288Syntaxin PEP12Add BLAST288

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2PhosphoserineCombined sources1
Modified residuei23PhosphoserineCombined sources1

Post-translational modificationi

Ubiquitinated.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP32854
PaxDbiP32854
PRIDEiP32854

PTM databases

iPTMnetiP32854

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

  • SNAP receptor activity Source: SGD
  • SNARE binding Source: GO_Central

Protein-protein interaction databases

BioGridi34438, 118 interactors
DIPiDIP-2021N
IntActiP32854, 17 interactors
MINTiP32854
STRINGi4932.YOR036W

Structurei

3D structure databases

ProteinModelPortaliP32854
SMRiP32854
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini195 – 257t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST63

Sequence similaritiesi

Belongs to the syntaxin family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00450000040239
HOGENOMiHOG000000782
InParanoidiP32854
OMAiEREPINN
OrthoDBiEOG092C4FL0

Family and domain databases

InterProiView protein in InterPro
IPR010989 SNARE
IPR006012 Syntaxin/epimorphin_CS
IPR006011 Syntaxin_N
IPR000727 T_SNARE_dom
PfamiView protein in Pfam
PF05739 SNARE, 1 hit
PF14523 Syntaxin_2, 1 hit
SMARTiView protein in SMART
SM00503 SynN, 1 hit
SM00397 t_SNARE, 1 hit
SUPFAMiSSF47661 SSF47661, 1 hit
PROSITEiView protein in PROSITE
PS00914 SYNTAXIN, 1 hit
PS50192 T_SNARE, 1 hit

Sequencei

Sequence statusi: Complete.

P32854-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEDEFFGGD NEAVWNGSRF SDSPEFQTLK EEVAAELFEI NGQISTLQQF
60 70 80 90 100
TATLKSFIDR GDVSAKVVER INKRSVAKIE EIGGLIKKVN TSVKKMDAIE
110 120 130 140 150
EASLDKTQII AREKLVRDVS YSFQEFQGIQ RQFTQVMKQV NERAKESLEA
160 170 180 190 200
SEMANDAALL DEEQRQNSSK STRIPGSQIV IERDPINNEE FAYQQNLIEQ
210 220 230 240 250
RDQEISNIER GITELNEVFK DLGSVVQQQG VLVDNIEANI YTTSDNTQLA
260 270 280
SDELRKAMRY QKRTSRWRVY LLIVLLVMLL FIFLIMKL
Length:288
Mass (Da):33,006
Last modified:October 1, 1996 - v2
Checksum:iD9F5711339DA1CDA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti13A → G in AAB38370 (PubMed:8730101).Curated1
Sequence conflicti89V → I in AAB38370 (PubMed:8730101).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M90395 Genomic DNA Translation: AAB38370.1
X87331 Genomic DNA Translation: CAA60755.1
Z74944 Genomic DNA Translation: CAA99226.1
BK006948 Genomic DNA Translation: DAA10819.1
PIRiS62175
RefSeqiNP_014679.1, NM_001183455.1

Genome annotation databases

EnsemblFungiiYOR036W; YOR036W; YOR036W
GeneIDi854201
KEGGisce:YOR036W

Similar proteinsi

Entry informationi

Entry nameiPEP12_YEAST
AccessioniPrimary (citable) accession number: P32854
Secondary accession number(s): D6W2A3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 152 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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