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Protein

Parvalbumin alpha

Gene

Pvalb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi52 – 631Add BLAST12
Calcium bindingi91 – 1022Add BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMuscle protein
LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Parvalbumin alpha
Gene namesi
Name:Pvalb
Synonyms:Pva
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:97821 Pvalb

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000735902 – 110Parvalbumin alphaAdd BLAST109

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserine1 Publication1
Modified residuei2PhosphoserineBy similarity1
Modified residuei8PhosphoserineBy similarity1
Modified residuei24PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP32848
PeptideAtlasiP32848
PRIDEiP32848

2D gel databases

SWISS-2DPAGEiP32848
UCD-2DPAGEiP32848

PTM databases

iPTMnetiP32848
PhosphoSitePlusiP32848

Expressioni

Gene expression databases

BgeeiENSMUSG00000005716
CleanExiMM_PVALB
ExpressionAtlasiP32848 baseline and differential
GenevisibleiP32848 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi202517, 1 interactor
IntActiP32848, 1 interactor
MINTiP32848
STRINGi10090.ENSMUSP00000005860

Structurei

3D structure databases

ProteinModelPortaliP32848
SMRiP32848
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 74EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini78 – 110EF-hand 2PROSITE-ProRule annotationAdd BLAST33

Sequence similaritiesi

Belongs to the parvalbumin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0027 Eukaryota
COG5126 LUCA
GeneTreeiENSGT00390000008690
HOGENOMiHOG000037438
HOVERGENiHBG107490
InParanoidiP32848
OMAiAVDSFDH
OrthoDBiEOG091G0ZAO
PhylomeDBiP32848
TreeFamiTF332342

Family and domain databases

InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR008080 Parvalbumin
PANTHERiPTHR11653 PTHR11653, 1 hit
PfamiView protein in Pfam
PF13499 EF-hand_7, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 2 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 2 hits
PS50222 EF_HAND_2, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P32848-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSMTDVLSAE DIKKAIGAFA AADSFDHKKF FQMVGLKKKN PDEVKKVFHI
60 70 80 90 100
LDKDKSGFIE EDELGSILKG FSSDARDLSA KETKTLLAAG DKDGDGKIGV
110
EEFSTLVAES
Length:110
Mass (Da):11,931
Last modified:January 23, 2007 - v3
Checksum:iC54FF4FDD935F51A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti110S → T in CAA38434 (PubMed:2572511).Curated1
Sequence conflicti110S → T in CAA42025 (PubMed:7522680).Curated1

Mass spectrometryi

Molecular mass is 11841.21±0.77 Da from positions 2 - 110. Determined by ESI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54613 mRNA Translation: CAA38434.1
X59382 mRNA Translation: CAA42025.1
BC027424 mRNA Translation: AAH27424.1
S75909 mRNA Translation: AAB33066.1
S75910 mRNA No translation available.
CCDSiCCDS27609.1
PIRiA37414
I65238
RefSeqiNP_001317615.1, NM_001330686.1
NP_038673.2, NM_013645.4
UniGeneiMm.2766

Genome annotation databases

EnsembliENSMUST00000005860; ENSMUSP00000005860; ENSMUSG00000005716
ENSMUST00000120592; ENSMUSP00000112598; ENSMUSG00000005716
GeneIDi19293
KEGGimmu:19293
UCSCiuc007wot.2 mouse

Similar proteinsi

Entry informationi

Entry nameiPRVA_MOUSE
AccessioniPrimary (citable) accession number: P32848
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 154 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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