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Protein

Parvalbumin alpha

Gene

Pvalb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi52 – 631Add BLAST12
Calcium bindingi91 – 1022Add BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMuscle protein
LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Parvalbumin alpha
Gene namesi
Name:Pvalb
Synonyms:Pva
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:97821. Pvalb.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000735902 – 110Parvalbumin alphaAdd BLAST109

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserine1 Publication1
Modified residuei2PhosphoserineBy similarity1
Modified residuei8PhosphoserineBy similarity1
Modified residuei24PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP32848.
PeptideAtlasiP32848.
PRIDEiP32848.

2D gel databases

SWISS-2DPAGEiP32848.
UCD-2DPAGEiP32848.

PTM databases

iPTMnetiP32848.
PhosphoSitePlusiP32848.

Expressioni

Gene expression databases

BgeeiENSMUSG00000005716.
CleanExiMM_PVALB.
ExpressionAtlasiP32848. baseline and differential.
GenevisibleiP32848. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi202517. 1 interactor.
IntActiP32848. 1 interactor.
MINTiMINT-1869519.
STRINGi10090.ENSMUSP00000005860.

Structurei

3D structure databases

ProteinModelPortaliP32848.
SMRiP32848.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 74EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini78 – 110EF-hand 2PROSITE-ProRule annotationAdd BLAST33

Sequence similaritiesi

Belongs to the parvalbumin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0027. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00390000008690.
HOGENOMiHOG000037438.
HOVERGENiHBG107490.
InParanoidiP32848.
OMAiAVDSFDH.
OrthoDBiEOG091G0ZAO.
PhylomeDBiP32848.
TreeFamiTF332342.

Family and domain databases

InterProiView protein in InterPro
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR008080. Parvalbumin.
PANTHERiPTHR11653. PTHR11653. 1 hit.
PfamiView protein in Pfam
PF13499. EF-hand_7. 1 hit.
SMARTiView protein in SMART
SM00054. EFh. 2 hits.
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiView protein in PROSITE
PS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P32848-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSMTDVLSAE DIKKAIGAFA AADSFDHKKF FQMVGLKKKN PDEVKKVFHI
60 70 80 90 100
LDKDKSGFIE EDELGSILKG FSSDARDLSA KETKTLLAAG DKDGDGKIGV
110
EEFSTLVAES
Length:110
Mass (Da):11,931
Last modified:January 23, 2007 - v3
Checksum:iC54FF4FDD935F51A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti110S → T in CAA38434 (PubMed:2572511).Curated1
Sequence conflicti110S → T in CAA42025 (PubMed:7522680).Curated1

Mass spectrometryi

Molecular mass is 11841.21±0.77 Da from positions 2 - 110. Determined by ESI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54613 mRNA. Translation: CAA38434.1.
X59382 mRNA. Translation: CAA42025.1.
BC027424 mRNA. Translation: AAH27424.1.
S75909 mRNA. Translation: AAB33066.1.
S75910 mRNA. No translation available.
CCDSiCCDS27609.1.
PIRiA37414.
I65238.
RefSeqiNP_001317615.1. NM_001330686.1.
NP_038673.2. NM_013645.4.
UniGeneiMm.2766.

Genome annotation databases

EnsembliENSMUST00000005860; ENSMUSP00000005860; ENSMUSG00000005716.
ENSMUST00000120592; ENSMUSP00000112598; ENSMUSG00000005716.
GeneIDi19293.
KEGGimmu:19293.
UCSCiuc007wot.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiPRVA_MOUSE
AccessioniPrimary (citable) accession number: P32848
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: January 23, 2007
Last modified: August 30, 2017
This is version 151 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families