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P32847

- B3AT_ONCMY

UniProt

P32847 - B3AT_ONCMY

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Protein

Band 3 anion exchange protein

Gene
slc4a1, ae1
Organism
Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Functions both as a transporter that mediates electroneutral anion exchange across the cell membrane and as a structural protein. Major integral membrane protein of the erythrocyte membrane; required for normal flexibility and stability of the erythrocyte membrane and for normal erythrocyte shape via the interactions of its cytoplasmic domain with cytoskeletal proteins, glycolytic enzymes, and hemoglobin. Functions as a transporter that mediates the 1:1 exchange of inorganic anions across the cell membrane. Mediates chloride-bicarbonate exchange across the cell membrane By similarity.

GO - Molecular functioni

  1. bicarbonate transmembrane transporter activity Source: UniProtKB
  2. inorganic anion exchanger activity Source: UniProtKB

GO - Biological processi

  1. bicarbonate transport Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Anion exchange, Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Band 3 anion exchange protein
Alternative name(s):
Anion exchange protein 1
Short name:
AE 1
Short name:
Anion exchanger 1
Solute carrier family 4 member 1
Gene namesi
Name:slc4a1
Synonyms:ae1
OrganismiOncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Taxonomic identifieri8022 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiProtacanthopterygiiSalmoniformesSalmonidaeSalmoninaeOncorhynchus

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 392392Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei393 – 41321Helical; Reviewed predictionAdd
BLAST
Transmembranei426 – 44520Helical; Reviewed predictionAdd
BLAST
Transmembranei449 – 46820Helical; Reviewed predictionAdd
BLAST
Transmembranei480 – 49920Helical; Reviewed predictionAdd
BLAST
Transmembranei512 – 53019Helical; Reviewed predictionAdd
BLAST
Topological domaini531 – 58151Extracellular Reviewed predictionAdd
BLAST
Transmembranei582 – 60120Helical; Reviewed predictionAdd
BLAST
Topological domaini602 – 61615Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei617 – 63721Helical; Reviewed predictionAdd
BLAST
Topological domaini638 – 67336Extracellular Reviewed predictionAdd
BLAST
Transmembranei674 – 69320Helical; Reviewed predictionAdd
BLAST
Transmembranei712 – 73221Helical; Reviewed predictionAdd
BLAST
Transmembranei772 – 78918Helical; Reviewed predictionAdd
BLAST
Transmembranei794 – 81522Helical; Reviewed predictionAdd
BLAST
Transmembranei853 – 87422Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. basolateral plasma membrane Source: UniProtKB-SubCell
  2. integral component of plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 918918Band 3 anion exchange proteinPRO_0000079213Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi546 – 5461N-linked (GlcNAc...) Reviewed prediction
Glycosylationi568 – 5681N-linked (GlcNAc...) Reviewed prediction
Lipidationi852 – 8521S-palmitoyl cysteine By similarity

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate

Interactioni

Subunit structurei

A dimer in solution, it spans the membrane asymmetrically and appears to be tetrameric By similarity.

Structurei

3D structure databases

ProteinModelPortaliP32847.
SMRiP32847. Positions 378-419, 812-844.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni393 – 918526Membrane (anion exchange)Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG004326.

Family and domain databases

Gene3Di3.40.1100.10. 2 hits.
InterProiIPR001717. Anion_exchange.
IPR002977. Anion_exchange_1.
IPR018241. Anion_exchange_CS.
IPR013769. Band3_cytoplasmic_dom.
IPR011531. HCO3_transpt_C.
IPR003020. HCO3_transpt_euk.
IPR016152. PTrfase/Anion_transptr.
[Graphical view]
PANTHERiPTHR11453. PTHR11453. 1 hit.
PfamiPF07565. Band_3_cyto. 2 hits.
PF00955. HCO3_cotransp. 1 hit.
[Graphical view]
PRINTSiPR00165. ANIONEXCHNGR.
PR01187. ANIONEXHNGR1.
PR01231. HCO3TRNSPORT.
SUPFAMiSSF55804. SSF55804. 1 hit.
TIGRFAMsiTIGR00834. ae. 1 hit.
PROSITEiPS00219. ANION_EXCHANGER_1. 1 hit.
PS00220. ANION_EXCHANGER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P32847-1 [UniParc]FASTAAdd to Basket

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MENDLSFGED VMSYEEESDS AFPSPIRPTP PGHSGNYDLE QSRQEEDSNQ    50
AIQSIVVHTD PEAYLNLNTN ANTRGDAQAY VELNELMGNS WQETGRWVGY 100
EENFNPGTGK WGPSHVSYLT FKSLIQLRKI MSTGAIILDL QASSLSAVAE 150
KVVDELRTKG EIRAADRDGL LRALLQRRSQ SEGAVAQPLG GDIEMQTFSV 200
TKQRDTTDSV EASIVLSGVM DSLEKPAVAF VRLGDSVVIE GALEAPVPVR 250
FVFVLVGPSQ GGVDYHESGR AMAALMADWV FSLEAYLAPT NKELTNAIAD 300
FMDCGIVIPP TEIQDEGMLQ PIIDFQKKML KDRLRPSDTR IIFGGGAKAD 350
EADEEPREDP LARTGIPFGG MIKDMKRRYR HYISDFTDAL DPQVLAAVIF 400
IYFAALSPAI TFGGLLADKT EHMMGVSELM ISTCVQGIIF AFIAAQPTLV 450
IGFSGPLLVF EEAFFAFCKS QEIEYIVGRI WVGLWLVIIV VVIVAVEGSF 500
LVKFISRFTQ EIFSILISLI FIYETFSKLG KIFKAHPLVL NYEHLNDSLD 550
NPFHPVVKEH IEYHEDGNKT VHEVIHERAY PNTALLSMCL MFGCFFIAYF 600
LRQFKNGHFL PGPIRRMIGD FGVPIAIFFM IAVDITIEDA YTQKLVVPKG 650
LMVSNPNARG WFINPLGEKK PFPAWMMGAC CVPALLVFIL IFLESQITTL 700
IVSKPERKMV KGSGFHLDLL ILVTMGGIAS LFGVPWLSAA TVRSVTHANA 750
LTVMSKGPKP EIEKVLEQRI SGMLVAAMVG VSILLEPILK MIPMTALFGI 800
FLYMGITSLS GIQMWDRMLL LIVPRKYYPA DAYAQRVTTM KMHLFTLIQM 850
VCLGALWMVK MSAFSLALPF VLILTIPLRM AITGTLFTDK EMKCLDASDG 900
KVKFEEEPGE DMYESPLP 918
Length:918
Mass (Da):101,894
Last modified:February 1, 1996 - v2
Checksum:i37E163141FBDC16A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X61699 mRNA. Translation: CAA43868.1.
PIRiS24318.
RefSeqiNP_001118189.1. NM_001124717.1.
UniGeneiOmy.38980.

Genome annotation databases

GeneIDi100136769.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X61699 mRNA. Translation: CAA43868.1 .
PIRi S24318.
RefSeqi NP_001118189.1. NM_001124717.1.
UniGenei Omy.38980.

3D structure databases

ProteinModelPortali P32847.
SMRi P32847. Positions 378-419, 812-844.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100136769.

Phylogenomic databases

HOVERGENi HBG004326.

Family and domain databases

Gene3Di 3.40.1100.10. 2 hits.
InterProi IPR001717. Anion_exchange.
IPR002977. Anion_exchange_1.
IPR018241. Anion_exchange_CS.
IPR013769. Band3_cytoplasmic_dom.
IPR011531. HCO3_transpt_C.
IPR003020. HCO3_transpt_euk.
IPR016152. PTrfase/Anion_transptr.
[Graphical view ]
PANTHERi PTHR11453. PTHR11453. 1 hit.
Pfami PF07565. Band_3_cyto. 2 hits.
PF00955. HCO3_cotransp. 1 hit.
[Graphical view ]
PRINTSi PR00165. ANIONEXCHNGR.
PR01187. ANIONEXHNGR1.
PR01231. HCO3TRNSPORT.
SUPFAMi SSF55804. SSF55804. 1 hit.
TIGRFAMsi TIGR00834. ae. 1 hit.
PROSITEi PS00219. ANION_EXCHANGER_1. 1 hit.
PS00220. ANION_EXCHANGER_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Amino acid sequence of band-3 protein from rainbow trout erythrocytes derived from cDNA."
    Hubner S., Michel F., Rudloff V., Appelhans H.
    Biochem. J. 285:17-23(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiB3AT_ONCMY
AccessioniPrimary (citable) accession number: P32847
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: February 1, 1996
Last modified: July 9, 2014
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi