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Protein

Band 3 anion exchange protein

Gene

slc4a1

Organism
Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Functions both as a transporter that mediates electroneutral anion exchange across the cell membrane and as a structural protein. Major integral membrane glycoprotein of the erythrocyte membrane; required for normal flexibility and stability of the erythrocyte membrane and for normal erythrocyte shape via the interactions of its cytoplasmic domain with cytoskeletal proteins, glycolytic enzymes, and hemoglobin. Functions as a transporter that mediates the 1:1 exchange of inorganic anions across the erythrocyte membrane. Mediates chloride-bicarbonate exchange in the kidney, and is required for normal acidification of the urine.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Anion exchange, Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Band 3 anion exchange protein
Alternative name(s):
Anion exchange protein 1
Short name:
AE 1
Short name:
Anion exchanger 1
Solute carrier family 4 member 1
Gene namesi
Name:slc4a1
Synonyms:ae1
OrganismiOncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Taxonomic identifieri8022 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiProtacanthopterygiiSalmoniformesSalmonidaeSalmoninaeOncorhynchus

Subcellular locationi

  • Cell membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 392CytoplasmicBy similarityAdd BLAST392
Transmembranei393 – 416Helical; Name=1By similarityAdd BLAST24
Topological domaini417 – 424ExtracellularBy similarity8
Transmembranei425 – 445Helical; Name=2By similarityAdd BLAST21
Topological domaini446 – 448CytoplasmicBy similarity3
Transmembranei449 – 465Discontinuously helical; Name=3By similarityAdd BLAST17
Topological domaini466 – 474ExtracellularBy similarity9
Transmembranei475 – 495Helical; Name=4By similarityAdd BLAST21
Topological domaini496 – 507CytoplasmicBy similarityAdd BLAST12
Transmembranei508 – 530Helical; Name=5By similarityAdd BLAST23
Topological domaini531 – 583ExtracellularBy similarityAdd BLAST53
Transmembranei584 – 604Helical; Name=6By similarityAdd BLAST21
Topological domaini605 – 615CytoplasmicBy similarityAdd BLAST11
Transmembranei616 – 636Helical; Name=7By similarityAdd BLAST21
Topological domaini637 – 676ExtracellularBy similarityAdd BLAST40
Transmembranei677 – 697Helical; Name=8By similarityAdd BLAST21
Topological domaini698 – 713CytoplasmicBy similarityAdd BLAST16
Transmembranei714 – 732Helical; Name=9By similarityAdd BLAST19
Transmembranei733 – 750Discontinuously helical; Name=10By similarityAdd BLAST18
Topological domaini751 – 769CytoplasmicBy similarityAdd BLAST19
Transmembranei770 – 790Helical; Name=11By similarityAdd BLAST21
Transmembranei791 – 809Helical; Name=12By similarityAdd BLAST19
Topological domaini810 – 847CytoplasmicBy similarityAdd BLAST38
Intramembranei848 – 878Discontinuously helicalBy similarityAdd BLAST31
Topological domaini879 – 918CytoplasmicBy similarityAdd BLAST40

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000792131 – 918Band 3 anion exchange proteinAdd BLAST918

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi546N-linked (GlcNAc...)Sequence analysis1
Glycosylationi568N-linked (GlcNAc...)Sequence analysis1
Lipidationi852S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PRIDEiP32847.

Interactioni

Subunit structurei

A dimer in solution, it spans the membrane asymmetrically and appears to be tetrameric.By similarity

Structurei

3D structure databases

ProteinModelPortaliP32847.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG004326.

Family and domain databases

Gene3Di3.40.1100.10. 2 hits.
InterProiIPR001717. Anion_exchange.
IPR002977. Anion_exchange_1.
IPR018241. Anion_exchange_CS.
IPR013769. Band3_cytoplasmic_dom.
IPR011531. HCO3_transpt_C.
IPR003020. HCO3_transpt_euk.
IPR016152. PTrfase/Anion_transptr.
[Graphical view]
PANTHERiPTHR11453. PTHR11453. 1 hit.
PfamiPF07565. Band_3_cyto. 2 hits.
PF00955. HCO3_cotransp. 1 hit.
[Graphical view]
PRINTSiPR00165. ANIONEXCHNGR.
PR01187. ANIONEXHNGR1.
PR01231. HCO3TRNSPORT.
SUPFAMiSSF55804. SSF55804. 1 hit.
TIGRFAMsiTIGR00834. ae. 1 hit.
PROSITEiPS00219. ANION_EXCHANGER_1. 1 hit.
PS00220. ANION_EXCHANGER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P32847-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENDLSFGED VMSYEEESDS AFPSPIRPTP PGHSGNYDLE QSRQEEDSNQ
60 70 80 90 100
AIQSIVVHTD PEAYLNLNTN ANTRGDAQAY VELNELMGNS WQETGRWVGY
110 120 130 140 150
EENFNPGTGK WGPSHVSYLT FKSLIQLRKI MSTGAIILDL QASSLSAVAE
160 170 180 190 200
KVVDELRTKG EIRAADRDGL LRALLQRRSQ SEGAVAQPLG GDIEMQTFSV
210 220 230 240 250
TKQRDTTDSV EASIVLSGVM DSLEKPAVAF VRLGDSVVIE GALEAPVPVR
260 270 280 290 300
FVFVLVGPSQ GGVDYHESGR AMAALMADWV FSLEAYLAPT NKELTNAIAD
310 320 330 340 350
FMDCGIVIPP TEIQDEGMLQ PIIDFQKKML KDRLRPSDTR IIFGGGAKAD
360 370 380 390 400
EADEEPREDP LARTGIPFGG MIKDMKRRYR HYISDFTDAL DPQVLAAVIF
410 420 430 440 450
IYFAALSPAI TFGGLLADKT EHMMGVSELM ISTCVQGIIF AFIAAQPTLV
460 470 480 490 500
IGFSGPLLVF EEAFFAFCKS QEIEYIVGRI WVGLWLVIIV VVIVAVEGSF
510 520 530 540 550
LVKFISRFTQ EIFSILISLI FIYETFSKLG KIFKAHPLVL NYEHLNDSLD
560 570 580 590 600
NPFHPVVKEH IEYHEDGNKT VHEVIHERAY PNTALLSMCL MFGCFFIAYF
610 620 630 640 650
LRQFKNGHFL PGPIRRMIGD FGVPIAIFFM IAVDITIEDA YTQKLVVPKG
660 670 680 690 700
LMVSNPNARG WFINPLGEKK PFPAWMMGAC CVPALLVFIL IFLESQITTL
710 720 730 740 750
IVSKPERKMV KGSGFHLDLL ILVTMGGIAS LFGVPWLSAA TVRSVTHANA
760 770 780 790 800
LTVMSKGPKP EIEKVLEQRI SGMLVAAMVG VSILLEPILK MIPMTALFGI
810 820 830 840 850
FLYMGITSLS GIQMWDRMLL LIVPRKYYPA DAYAQRVTTM KMHLFTLIQM
860 870 880 890 900
VCLGALWMVK MSAFSLALPF VLILTIPLRM AITGTLFTDK EMKCLDASDG
910
KVKFEEEPGE DMYESPLP
Length:918
Mass (Da):101,894
Last modified:February 1, 1996 - v2
Checksum:i37E163141FBDC16A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X61699 mRNA. Translation: CAA43868.1.
PIRiS24318.
RefSeqiNP_001118189.1. NM_001124717.1.
UniGeneiOmy.38980.

Genome annotation databases

GeneIDi100136769.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X61699 mRNA. Translation: CAA43868.1.
PIRiS24318.
RefSeqiNP_001118189.1. NM_001124717.1.
UniGeneiOmy.38980.

3D structure databases

ProteinModelPortaliP32847.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP32847.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100136769.

Phylogenomic databases

HOVERGENiHBG004326.

Family and domain databases

Gene3Di3.40.1100.10. 2 hits.
InterProiIPR001717. Anion_exchange.
IPR002977. Anion_exchange_1.
IPR018241. Anion_exchange_CS.
IPR013769. Band3_cytoplasmic_dom.
IPR011531. HCO3_transpt_C.
IPR003020. HCO3_transpt_euk.
IPR016152. PTrfase/Anion_transptr.
[Graphical view]
PANTHERiPTHR11453. PTHR11453. 1 hit.
PfamiPF07565. Band_3_cyto. 2 hits.
PF00955. HCO3_cotransp. 1 hit.
[Graphical view]
PRINTSiPR00165. ANIONEXCHNGR.
PR01187. ANIONEXHNGR1.
PR01231. HCO3TRNSPORT.
SUPFAMiSSF55804. SSF55804. 1 hit.
TIGRFAMsiTIGR00834. ae. 1 hit.
PROSITEiPS00219. ANION_EXCHANGER_1. 1 hit.
PS00220. ANION_EXCHANGER_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB3AT_ONCMY
AccessioniPrimary (citable) accession number: P32847
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: February 1, 1996
Last modified: October 5, 2016
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.