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P32847

- B3AT_ONCMY

UniProt

P32847 - B3AT_ONCMY

Protein

Band 3 anion exchange protein

Gene

slc4a1

Organism
Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 2 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Functions both as a transporter that mediates electroneutral anion exchange across the cell membrane and as a structural protein. Major integral membrane protein of the erythrocyte membrane; required for normal flexibility and stability of the erythrocyte membrane and for normal erythrocyte shape via the interactions of its cytoplasmic domain with cytoskeletal proteins, glycolytic enzymes, and hemoglobin. Functions as a transporter that mediates the 1:1 exchange of inorganic anions across the cell membrane. Mediates chloride-bicarbonate exchange across the cell membrane By similarity.By similarity

    GO - Molecular functioni

    1. bicarbonate transmembrane transporter activity Source: UniProtKB
    2. inorganic anion exchanger activity Source: UniProtKB

    GO - Biological processi

    1. bicarbonate transport Source: UniProtKB

    Keywords - Biological processi

    Anion exchange, Ion transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Band 3 anion exchange protein
    Alternative name(s):
    Anion exchange protein 1
    Short name:
    AE 1
    Short name:
    Anion exchanger 1
    Solute carrier family 4 member 1
    Gene namesi
    Name:slc4a1
    Synonyms:ae1
    OrganismiOncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
    Taxonomic identifieri8022 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiProtacanthopterygiiSalmoniformesSalmonidaeSalmoninaeOncorhynchus

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity. Basolateral cell membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. basolateral plasma membrane Source: UniProtKB-SubCell
    2. integral component of plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 918918Band 3 anion exchange proteinPRO_0000079213Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi546 – 5461N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi568 – 5681N-linked (GlcNAc...)Sequence Analysis
    Lipidationi852 – 8521S-palmitoyl cysteineBy similarity

    Keywords - PTMi

    Glycoprotein, Lipoprotein, Palmitate

    Interactioni

    Subunit structurei

    A dimer in solution, it spans the membrane asymmetrically and appears to be tetrameric.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP32847.
    SMRiP32847. Positions 378-419, 812-844.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 392392CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini531 – 58151ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini602 – 61615CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini638 – 67336ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei393 – 41321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei426 – 44520HelicalSequence AnalysisAdd
    BLAST
    Transmembranei449 – 46820HelicalSequence AnalysisAdd
    BLAST
    Transmembranei480 – 49920HelicalSequence AnalysisAdd
    BLAST
    Transmembranei512 – 53019HelicalSequence AnalysisAdd
    BLAST
    Transmembranei582 – 60120HelicalSequence AnalysisAdd
    BLAST
    Transmembranei617 – 63721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei674 – 69320HelicalSequence AnalysisAdd
    BLAST
    Transmembranei712 – 73221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei772 – 78918HelicalSequence AnalysisAdd
    BLAST
    Transmembranei794 – 81522HelicalSequence AnalysisAdd
    BLAST
    Transmembranei853 – 87422HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni393 – 918526Membrane (anion exchange)Add
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOVERGENiHBG004326.

    Family and domain databases

    Gene3Di3.40.1100.10. 2 hits.
    InterProiIPR001717. Anion_exchange.
    IPR002977. Anion_exchange_1.
    IPR018241. Anion_exchange_CS.
    IPR013769. Band3_cytoplasmic_dom.
    IPR011531. HCO3_transpt_C.
    IPR003020. HCO3_transpt_euk.
    IPR016152. PTrfase/Anion_transptr.
    [Graphical view]
    PANTHERiPTHR11453. PTHR11453. 1 hit.
    PfamiPF07565. Band_3_cyto. 2 hits.
    PF00955. HCO3_cotransp. 1 hit.
    [Graphical view]
    PRINTSiPR00165. ANIONEXCHNGR.
    PR01187. ANIONEXHNGR1.
    PR01231. HCO3TRNSPORT.
    SUPFAMiSSF55804. SSF55804. 1 hit.
    TIGRFAMsiTIGR00834. ae. 1 hit.
    PROSITEiPS00219. ANION_EXCHANGER_1. 1 hit.
    PS00220. ANION_EXCHANGER_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P32847-1 [UniParc]FASTAAdd to Basket

    « Hide

    MENDLSFGED VMSYEEESDS AFPSPIRPTP PGHSGNYDLE QSRQEEDSNQ    50
    AIQSIVVHTD PEAYLNLNTN ANTRGDAQAY VELNELMGNS WQETGRWVGY 100
    EENFNPGTGK WGPSHVSYLT FKSLIQLRKI MSTGAIILDL QASSLSAVAE 150
    KVVDELRTKG EIRAADRDGL LRALLQRRSQ SEGAVAQPLG GDIEMQTFSV 200
    TKQRDTTDSV EASIVLSGVM DSLEKPAVAF VRLGDSVVIE GALEAPVPVR 250
    FVFVLVGPSQ GGVDYHESGR AMAALMADWV FSLEAYLAPT NKELTNAIAD 300
    FMDCGIVIPP TEIQDEGMLQ PIIDFQKKML KDRLRPSDTR IIFGGGAKAD 350
    EADEEPREDP LARTGIPFGG MIKDMKRRYR HYISDFTDAL DPQVLAAVIF 400
    IYFAALSPAI TFGGLLADKT EHMMGVSELM ISTCVQGIIF AFIAAQPTLV 450
    IGFSGPLLVF EEAFFAFCKS QEIEYIVGRI WVGLWLVIIV VVIVAVEGSF 500
    LVKFISRFTQ EIFSILISLI FIYETFSKLG KIFKAHPLVL NYEHLNDSLD 550
    NPFHPVVKEH IEYHEDGNKT VHEVIHERAY PNTALLSMCL MFGCFFIAYF 600
    LRQFKNGHFL PGPIRRMIGD FGVPIAIFFM IAVDITIEDA YTQKLVVPKG 650
    LMVSNPNARG WFINPLGEKK PFPAWMMGAC CVPALLVFIL IFLESQITTL 700
    IVSKPERKMV KGSGFHLDLL ILVTMGGIAS LFGVPWLSAA TVRSVTHANA 750
    LTVMSKGPKP EIEKVLEQRI SGMLVAAMVG VSILLEPILK MIPMTALFGI 800
    FLYMGITSLS GIQMWDRMLL LIVPRKYYPA DAYAQRVTTM KMHLFTLIQM 850
    VCLGALWMVK MSAFSLALPF VLILTIPLRM AITGTLFTDK EMKCLDASDG 900
    KVKFEEEPGE DMYESPLP 918
    Length:918
    Mass (Da):101,894
    Last modified:February 1, 1996 - v2
    Checksum:i37E163141FBDC16A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X61699 mRNA. Translation: CAA43868.1.
    PIRiS24318.
    RefSeqiNP_001118189.1. NM_001124717.1.
    UniGeneiOmy.38980.

    Genome annotation databases

    GeneIDi100136769.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X61699 mRNA. Translation: CAA43868.1 .
    PIRi S24318.
    RefSeqi NP_001118189.1. NM_001124717.1.
    UniGenei Omy.38980.

    3D structure databases

    ProteinModelPortali P32847.
    SMRi P32847. Positions 378-419, 812-844.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100136769.

    Phylogenomic databases

    HOVERGENi HBG004326.

    Family and domain databases

    Gene3Di 3.40.1100.10. 2 hits.
    InterProi IPR001717. Anion_exchange.
    IPR002977. Anion_exchange_1.
    IPR018241. Anion_exchange_CS.
    IPR013769. Band3_cytoplasmic_dom.
    IPR011531. HCO3_transpt_C.
    IPR003020. HCO3_transpt_euk.
    IPR016152. PTrfase/Anion_transptr.
    [Graphical view ]
    PANTHERi PTHR11453. PTHR11453. 1 hit.
    Pfami PF07565. Band_3_cyto. 2 hits.
    PF00955. HCO3_cotransp. 1 hit.
    [Graphical view ]
    PRINTSi PR00165. ANIONEXCHNGR.
    PR01187. ANIONEXHNGR1.
    PR01231. HCO3TRNSPORT.
    SUPFAMi SSF55804. SSF55804. 1 hit.
    TIGRFAMsi TIGR00834. ae. 1 hit.
    PROSITEi PS00219. ANION_EXCHANGER_1. 1 hit.
    PS00220. ANION_EXCHANGER_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Amino acid sequence of band-3 protein from rainbow trout erythrocytes derived from cDNA."
      Hubner S., Michel F., Rudloff V., Appelhans H.
      Biochem. J. 285:17-23(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiB3AT_ONCMY
    AccessioniPrimary (citable) accession number: P32847
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1993
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 84 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3