Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

V-type proton ATPase subunit c'

Gene

VMA11

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei145Essential for proton translocation1

GO - Molecular functioni

  • proton-transporting ATPase activity, rotational mechanism Source: SGD

GO - Biological processi

  • ATP hydrolysis coupled proton transport Source: InterPro
  • vacuolar acidification Source: SGD
Complete GO annotation...

Keywords - Biological processi

Hydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-34121-MONOMER.

Protein family/group databases

TCDBi3.A.2.2.3. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
V-type proton ATPase subunit c'
Short name:
V-ATPase subunit c'
Alternative name(s):
Proteolipid protein VMA11
Trifluoperazine resistance protein 3
V-ATPase 16 kDa proteolipid subunit 2
Vacuolar proton pump c' subunit
Gene namesi
Name:VMA11
Synonyms:CLS9, TFP3
Ordered Locus Names:YPL234C
ORF Names:P1064
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPL234C.
SGDiS000006155. VMA11.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 14VacuolarSequence analysisAdd BLAST14
Transmembranei15 – 37HelicalSequence analysisAdd BLAST23
Topological domaini38 – 59CytoplasmicSequence analysisAdd BLAST22
Transmembranei60 – 80HelicalSequence analysisAdd BLAST21
Topological domaini81 – 98VacuolarSequence analysisAdd BLAST18
Transmembranei99 – 120HelicalSequence analysisAdd BLAST22
Topological domaini121 – 132CytoplasmicSequence analysisAdd BLAST12
Transmembranei133 – 158HelicalSequence analysisAdd BLAST26
Topological domaini159 – 164VacuolarSequence analysis6

GO - Cellular componenti

  • fungal-type vacuole Source: SGD
  • integral component of membrane Source: SGD
  • vacuolar proton-transporting V-type ATPase, V0 domain Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi145E → D: Partial inactivation. 1 Publication1
Mutagenesisi145E → L or Q: Inactivation. 1 Publication1

Chemistry databases

ChEMBLiCHEMBL1795084.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000717881 – 164V-type proton ATPase subunit c'Add BLAST164

Proteomic databases

MaxQBiP32842.
PRIDEiP32842.

Interactioni

Subunit structurei

V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d and e). The proteolipid components c, c' and c'' are present as a hexameric ring that forms the proton-conducting pore.

Protein-protein interaction databases

BioGridi35928. 200 interactors.
DIPiDIP-5394N.
IntActiP32842. 5 interactors.
MINTiMINT-498339.

Chemistry databases

BindingDBiP32842.

Structurei

3D structure databases

ProteinModelPortaliP32842.
SMRiP32842.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000056520.
KOiK02155.
OMAiIMKCLIP.
OrthoDBiEOG092C5DS5.

Family and domain databases

InterProiIPR002379. ATPase_proteolipid_c-like_dom.
IPR000245. ATPase_proteolipid_csu.
IPR011555. ATPase_proteolipid_su_C_euk.
[Graphical view]
PfamiPF00137. ATP-synt_C. 2 hits.
[Graphical view]
PRINTSiPR00122. VACATPASE.
SUPFAMiSSF81333. SSF81333. 1 hit.
TIGRFAMsiTIGR01100. V_ATP_synt_C. 1 hit.

Sequencei

Sequence statusi: Complete.

P32842-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTQLASNIY APLYAPFFGF AGCAAAMVLS CLGAAIGTAK SGIGIAGIGT
60 70 80 90 100
FKPELIMKSL IPVVMSGILA IYGLVVAVLI AGNLSPTEDY TLFNGFMHLS
110 120 130 140 150
CGLCVGFACL SSGYAIGMVG DVGVRKYMHQ PRLFVGIVLI LIFSEVLGLY
160
GMIVALILNT RGSE
Length:164
Mass (Da):17,037
Last modified:October 1, 1993 - v1
Checksum:iC82D165064EEBBF7
GO

Sequence cautioni

The sequence AAA35149 differs from that shown. Reason: Frameshift at position 102.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti27 – 35Missing in AAA35149 (PubMed:2192255).Curated9

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10486 Genomic DNA. Translation: BAA01367.1.
M32736 Genomic DNA. Translation: AAA35149.1. Frameshift.
Z67751 Genomic DNA. Translation: CAA91610.1.
X94561 Genomic DNA. Translation: CAA64253.1.
Z73590 Genomic DNA. Translation: CAA97951.1.
AY558058 Genomic DNA. Translation: AAS56384.1.
BK006949 Genomic DNA. Translation: DAA11202.1.
PIRiA41712.
RefSeqiNP_015090.1. NM_001184048.1.

Genome annotation databases

EnsemblFungiiYPL234C; YPL234C; YPL234C.
GeneIDi855842.
KEGGisce:YPL234C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10486 Genomic DNA. Translation: BAA01367.1.
M32736 Genomic DNA. Translation: AAA35149.1. Frameshift.
Z67751 Genomic DNA. Translation: CAA91610.1.
X94561 Genomic DNA. Translation: CAA64253.1.
Z73590 Genomic DNA. Translation: CAA97951.1.
AY558058 Genomic DNA. Translation: AAS56384.1.
BK006949 Genomic DNA. Translation: DAA11202.1.
PIRiA41712.
RefSeqiNP_015090.1. NM_001184048.1.

3D structure databases

ProteinModelPortaliP32842.
SMRiP32842.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35928. 200 interactors.
DIPiDIP-5394N.
IntActiP32842. 5 interactors.
MINTiMINT-498339.

Chemistry databases

BindingDBiP32842.
ChEMBLiCHEMBL1795084.

Protein family/group databases

TCDBi3.A.2.2.3. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

Proteomic databases

MaxQBiP32842.
PRIDEiP32842.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYPL234C; YPL234C; YPL234C.
GeneIDi855842.
KEGGisce:YPL234C.

Organism-specific databases

EuPathDBiFungiDB:YPL234C.
SGDiS000006155. VMA11.

Phylogenomic databases

HOGENOMiHOG000056520.
KOiK02155.
OMAiIMKCLIP.
OrthoDBiEOG092C5DS5.

Enzyme and pathway databases

BioCyciYEAST:G3O-34121-MONOMER.

Miscellaneous databases

PROiP32842.

Family and domain databases

InterProiIPR002379. ATPase_proteolipid_c-like_dom.
IPR000245. ATPase_proteolipid_csu.
IPR011555. ATPase_proteolipid_su_C_euk.
[Graphical view]
PfamiPF00137. ATP-synt_C. 2 hits.
[Graphical view]
PRINTSiPR00122. VACATPASE.
SUPFAMiSSF81333. SSF81333. 1 hit.
TIGRFAMsiTIGR01100. V_ATP_synt_C. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiVATL2_YEAST
AccessioniPrimary (citable) accession number: P32842
Secondary accession number(s): D6W3D6, P32365
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: November 2, 2016
This is version 158 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 538 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.