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Protein

Mitochondrial chaperone BCS1

Gene

BCS1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Essential for the expression of the Rieske iron-sulfur protein.

Miscellaneous

Present with 1990 molecules/cell in log phase SD medium.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi267 – 274ATPSequence analysis8

GO - Molecular functioni

  • ATPase activity, coupled to transmembrane movement of substances Source: SGD
  • ATP binding Source: UniProtKB-KW
  • protein transmembrane transporter activity Source: SGD

GO - Biological processi

  • chaperone-mediated protein complex assembly Source: SGD
  • mitochondrial respiratory chain complex III assembly Source: SGD
  • protein insertion into mitochondrial membrane from inner side Source: SGD

Keywordsi

LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-29925-MONOMER

Protein family/group databases

TCDBi9.A.62.1.1 the aaa-atpase, bcs1 (bcs1) family

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial chaperone BCS1
Gene namesi
Name:BCS1
Ordered Locus Names:YDR375C
ORF Names:D9481.17
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR375C
SGDiS000002783 BCS1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 44Mitochondrial intermembrane1 PublicationAdd BLAST44
Transmembranei45 – 68HelicalCuratedAdd BLAST24
Topological domaini69 – 456Mitochondrial matrix1 PublicationAdd BLAST388

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000847771 – 456Mitochondrial chaperone BCS1Add BLAST456

Proteomic databases

MaxQBiP32839
PaxDbiP32839
PRIDEiP32839

PTM databases

iPTMnetiP32839

Interactioni

Protein-protein interaction databases

BioGridi32434, 217 interactors
IntActiP32839, 1 interactor
STRINGi4932.YDR375C

Structurei

3D structure databases

ProteinModelPortaliP32839
SMRiP32839
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi69 – 83Mitochondrial-targeting signalAdd BLAST15

Sequence similaritiesi

Belongs to the AAA ATPase family. BCS1 subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000005415
HOGENOMiHOG000198799
InParanoidiP32839
KOiK08900
OMAiYQWLLQW
OrthoDBiEOG092C28BK

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR003959 ATPase_AAA_core
IPR003960 ATPase_AAA_CS
IPR027243 BCS1
IPR014851 BCS1_N
IPR027417 P-loop_NTPase
PANTHERiPTHR23070:SF17 PTHR23070:SF17, 1 hit
PfamiView protein in Pfam
PF00004 AAA, 1 hit
PF08740 BCS1_N, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SM01024 BCS1_N, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00674 AAA, 1 hit

Sequencei

Sequence statusi: Complete.

P32839-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDKPIDIQY DKQATPNLSG VITPPTNETG NDSVREKLSK LVGDAMSNNP
60 70 80 90 100
YFAAGGGLMI LGTGLAVARS GIIKASRVLY RQMIVDLEIQ SKDKSYAWFL
110 120 130 140 150
TWMAKHPQRV SRHLSVRTNY IQHDNGSVST KFSLVPGPGN HWIRYKGAFI
160 170 180 190 200
LIKRERSAKM IDIANGSPFE TVTLTTLYRD KHLFDDILNE AKDIALKTTE
210 220 230 240 250
GKTVIYTSFG PEWRKFGQPK AKRMLPSVIL DSGIKEGILD DVYDFMKNGK
260 270 280 290 300
WYSDRGIPYR RGYLLYGPPG SGKTSFIQAL AGELDYNICI LNLSENNLTD
310 320 330 340 350
DRLNHLMNNM PERSILLLED IDAAFNKRSQ TGEQGFHSSV TFSGLLNALD
360 370 380 390 400
GVTSSEETIT FMTTNHPEKL DAAIMRPGRI DYKVFVGNAT PYQVEKMFMK
410 420 430 440 450
FYPGETDICK KFVNSVKELD ITVSTAQLQG LFVMNKDAPH DALKMVSSLR

NANHIF
Length:456
Mass (Da):51,107
Last modified:November 1, 1997 - v2
Checksum:i17750D26B664ED04
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti119N → F in AAC09007 (PubMed:1327750).Curated1
Sequence conflicti267G → S in AAC09007 (PubMed:1327750).Curated1
Sequence conflicti349L → Q in AAC09007 (PubMed:1327750).Curated1
Sequence conflicti351G → S in AAC09007 (PubMed:1327750).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S47190 Genomic DNA Translation: AAC09007.1
U28373 Genomic DNA Translation: AAB64811.1
BK006938 Genomic DNA Translation: DAA12217.1
PIRiS61170
RefSeqiNP_010663.1, NM_001180683.1

Genome annotation databases

EnsemblFungiiYDR375C; YDR375C; YDR375C
GeneIDi851981
KEGGisce:YDR375C

Similar proteinsi

Entry informationi

Entry nameiBCS1_YEAST
AccessioniPrimary (citable) accession number: P32839
Secondary accession number(s): D6VT07, Q06404
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: November 1, 1997
Last modified: April 25, 2018
This is version 161 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health