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Protein

Mitochondrial chaperone BCS1

Gene

BCS1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Essential for the expression of the Rieske iron-sulfur protein.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi267 – 2748ATPSequence analysis

GO - Molecular functioni

  • ATPase activity Source: SGD
  • ATP binding Source: UniProtKB-KW
  • protein transmembrane transporter activity Source: SGD

GO - Biological processi

  • chaperone-mediated protein complex assembly Source: SGD
  • mitochondrial respiratory chain complex III assembly Source: SGD
  • protein insertion into mitochondrial membrane from inner side Source: SGD
  • protein transmembrane transport Source: GOC
Complete GO annotation...

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-29925-MONOMER.

Protein family/group databases

TCDBi9.A.62.1.1. the aaa-atpase, bcs1 (bcs1) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial chaperone BCS1
Gene namesi
Name:BCS1
Ordered Locus Names:YDR375C
ORF Names:D9481.17
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR375C.
SGDiS000002783. BCS1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4444Mitochondrial intermembrane1 PublicationAdd
BLAST
Transmembranei45 – 6824HelicalCuratedAdd
BLAST
Topological domaini69 – 456388Mitochondrial matrix1 PublicationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 456456Mitochondrial chaperone BCS1PRO_0000084777Add
BLAST

Proteomic databases

MaxQBiP32839.

PTM databases

iPTMnetiP32839.

Interactioni

Protein-protein interaction databases

BioGridi32434. 78 interactions.
IntActiP32839. 1 interaction.
MINTiMINT-4482333.

Structurei

3D structure databases

ProteinModelPortaliP32839.
SMRiP32839. Positions 230-420.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi69 – 8315Mitochondrial-targeting signalAdd
BLAST

Sequence similaritiesi

Belongs to the AAA ATPase family. BCS1 subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000005415.
HOGENOMiHOG000198799.
InParanoidiP32839.
KOiK08900.
OMAiFMTTNHP.
OrthoDBiEOG7PVWZR.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR027243. BCS1/plant_AAA_ATPases.
IPR014851. BCS1_N.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR23070:SF17. PTHR23070:SF17. 1 hit.
PfamiPF00004. AAA. 1 hit.
PF08740. BCS1_N. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM01024. BCS1_N. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00674. AAA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P32839-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDKPIDIQY DKQATPNLSG VITPPTNETG NDSVREKLSK LVGDAMSNNP
60 70 80 90 100
YFAAGGGLMI LGTGLAVARS GIIKASRVLY RQMIVDLEIQ SKDKSYAWFL
110 120 130 140 150
TWMAKHPQRV SRHLSVRTNY IQHDNGSVST KFSLVPGPGN HWIRYKGAFI
160 170 180 190 200
LIKRERSAKM IDIANGSPFE TVTLTTLYRD KHLFDDILNE AKDIALKTTE
210 220 230 240 250
GKTVIYTSFG PEWRKFGQPK AKRMLPSVIL DSGIKEGILD DVYDFMKNGK
260 270 280 290 300
WYSDRGIPYR RGYLLYGPPG SGKTSFIQAL AGELDYNICI LNLSENNLTD
310 320 330 340 350
DRLNHLMNNM PERSILLLED IDAAFNKRSQ TGEQGFHSSV TFSGLLNALD
360 370 380 390 400
GVTSSEETIT FMTTNHPEKL DAAIMRPGRI DYKVFVGNAT PYQVEKMFMK
410 420 430 440 450
FYPGETDICK KFVNSVKELD ITVSTAQLQG LFVMNKDAPH DALKMVSSLR

NANHIF
Length:456
Mass (Da):51,107
Last modified:November 1, 1997 - v2
Checksum:i17750D26B664ED04
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti119 – 1191N → F in AAC09007 (PubMed:1327750).Curated
Sequence conflicti267 – 2671G → S in AAC09007 (PubMed:1327750).Curated
Sequence conflicti349 – 3491L → Q in AAC09007 (PubMed:1327750).Curated
Sequence conflicti351 – 3511G → S in AAC09007 (PubMed:1327750).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S47190 Genomic DNA. Translation: AAC09007.1.
U28373 Genomic DNA. Translation: AAB64811.1.
BK006938 Genomic DNA. Translation: DAA12217.1.
PIRiS61170.
RefSeqiNP_010663.1. NM_001180683.1.

Genome annotation databases

EnsemblFungiiYDR375C; YDR375C; YDR375C.
GeneIDi851981.
KEGGisce:YDR375C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S47190 Genomic DNA. Translation: AAC09007.1.
U28373 Genomic DNA. Translation: AAB64811.1.
BK006938 Genomic DNA. Translation: DAA12217.1.
PIRiS61170.
RefSeqiNP_010663.1. NM_001180683.1.

3D structure databases

ProteinModelPortaliP32839.
SMRiP32839. Positions 230-420.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32434. 78 interactions.
IntActiP32839. 1 interaction.
MINTiMINT-4482333.

Protein family/group databases

TCDBi9.A.62.1.1. the aaa-atpase, bcs1 (bcs1) family.

PTM databases

iPTMnetiP32839.

Proteomic databases

MaxQBiP32839.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDR375C; YDR375C; YDR375C.
GeneIDi851981.
KEGGisce:YDR375C.

Organism-specific databases

EuPathDBiFungiDB:YDR375C.
SGDiS000002783. BCS1.

Phylogenomic databases

GeneTreeiENSGT00390000005415.
HOGENOMiHOG000198799.
InParanoidiP32839.
KOiK08900.
OMAiFMTTNHP.
OrthoDBiEOG7PVWZR.

Enzyme and pathway databases

BioCyciYEAST:G3O-29925-MONOMER.

Miscellaneous databases

NextBioi970127.
PROiP32839.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR027243. BCS1/plant_AAA_ATPases.
IPR014851. BCS1_N.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR23070:SF17. PTHR23070:SF17. 1 hit.
PfamiPF00004. AAA. 1 hit.
PF08740. BCS1_N. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM01024. BCS1_N. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00674. AAA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "BCS1, a novel gene required for the expression of functional Rieske iron-sulfur protein in Saccharomyces cerevisiae."
    Nobrega F.G., Nobrega M.P., Tzagoloff A.
    EMBO J. 11:3821-3829(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV."
    Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T.
    , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P.
    Nature 387:75-78(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "Internal targeting signal of the BCS1 protein: a novel mechanism of import into mitochondria."
    Foelsch H., Guiard B., Neupert W., Stuart R.A.
    EMBO J. 15:479-487(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY.
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiBCS1_YEAST
AccessioniPrimary (citable) accession number: P32839
Secondary accession number(s): D6VT07, Q06404
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: November 1, 1997
Last modified: April 13, 2016
This is version 142 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1990 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.