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Protein

GABA-specific permease

Gene

UGA4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for high-affinity, high-specificity GABA transport. Also transports putrescine.1 Publication

Miscellaneous

It requires NPR (nitrogen permease reactivator protein) for its full activity.

GO - Molecular functioni

  • antiporter activity Source: GO_Central
  • gamma-aminobutyric acid:proton symporter activity Source: SGD
  • L-amino acid transmembrane transporter activity Source: GO_Central
  • putrescine transmembrane transporter activity Source: SGD

GO - Biological processi

  • gamma-aminobutyric acid transport Source: SGD
  • putrescine transport Source: SGD
  • transmembrane transport Source: SGD

Keywordsi

Biological processTransport

Enzyme and pathway databases

BioCyciYEAST:G3O-29592-MONOMER

Protein family/group databases

TCDBi2.A.3.4.3 the amino acid-polyamine-organocation (apc) family

Names & Taxonomyi

Protein namesi
Recommended name:
GABA-specific permease
Alternative name(s):
GABA-specific transport protein
Gene namesi
Name:UGA4
Ordered Locus Names:YDL210W
ORF Names:D1037
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDL210W
SGDiS000002369 UGA4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 73CytoplasmicSequence analysisAdd BLAST73
Transmembranei74 – 94HelicalSequence analysisAdd BLAST21
Topological domaini95 – 105VacuolarSequence analysisAdd BLAST11
Transmembranei106 – 126HelicalSequence analysisAdd BLAST21
Topological domaini127 – 153CytoplasmicSequence analysisAdd BLAST27
Transmembranei154 – 174HelicalSequence analysisAdd BLAST21
Topological domaini175 – 198VacuolarSequence analysisAdd BLAST24
Transmembranei199 – 219HelicalSequence analysisAdd BLAST21
Topological domaini220 – 228CytoplasmicSequence analysis9
Transmembranei229 – 249HelicalSequence analysisAdd BLAST21
Topological domaini250 – 271VacuolarSequence analysisAdd BLAST22
Transmembranei272 – 292HelicalSequence analysisAdd BLAST21
Topological domaini293 – 312CytoplasmicSequence analysisAdd BLAST20
Transmembranei313 – 333HelicalSequence analysisAdd BLAST21
Topological domaini334 – 364VacuolarSequence analysisAdd BLAST31
Transmembranei365 – 385HelicalSequence analysisAdd BLAST21
Topological domaini386 – 416CytoplasmicSequence analysisAdd BLAST31
Transmembranei417 – 437HelicalSequence analysisAdd BLAST21
Topological domaini438 – 441VacuolarSequence analysis4
Transmembranei442 – 462HelicalSequence analysisAdd BLAST21
Topological domaini463 – 482CytoplasmicSequence analysisAdd BLAST20
Transmembranei483 – 503HelicalSequence analysisAdd BLAST21
Topological domaini504 – 514VacuolarSequence analysisAdd BLAST11
Transmembranei515 – 535HelicalSequence analysisAdd BLAST21
Topological domaini536 – 571CytoplasmicSequence analysisAdd BLAST36

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000541611 – 571GABA-specific permeaseAdd BLAST571

Proteomic databases

PaxDbiP32837

Expressioni

Inductioni

In the presence of GABA.

Interactioni

Protein-protein interaction databases

BioGridi31836, 79 interactors
DIPiDIP-1857N
IntActiP32837, 7 interactors
MINTiP32837
STRINGi4932.YDL210W

Structurei

3D structure databases

ProteinModelPortaliP32837
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00530000067168
HOGENOMiHOG000171300
InParanoidiP32837
OMAiFLAPIWS
OrthoDBiEOG092C1ZUR

Family and domain databases

InterProiView protein in InterPro
IPR002293 AA/rel_permease1
IPR004840 Amoino_acid_permease_CS
PfamiView protein in Pfam
PF13520 AA_permease_2, 1 hit
PIRSFiPIRSF006060 AA_transporter, 1 hit
PROSITEiView protein in PROSITE
PS00218 AMINO_ACID_PERMEASE_1, 1 hit

Sequencei

Sequence statusi: Complete.

P32837-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSMSSKNENK ISVEQRISTD IGQAYQLQGL GSNLRSIRSK TGAGEVNYID
60 70 80 90 100
AAKSVNDNQL LAEIGYKQEL KRQFSTLQVF GIAFSIMGLL PSIASVMGGG
110 120 130 140 150
LGGGPATLVW GWFVAAFFIL LVGITMAEHA SSIPTAGGLY YWTYYYAPEG
160 170 180 190 200
YKEIISFIIG CSNSLALAAG VCSIDYGLAE EIAAAVTLTK DGNFEVTSGK
210 220 230 240 250
LYGIFAGAVV VMCICTCVAS GAIARLQTLS IFANLFIIVL LFIALPIGTK
260 270 280 290 300
HRMGGFNDGD FIFGKYENLS DWNNGWQFCL AGFMPAVWTI GSFDSCVHQS
310 320 330 340 350
EEAKDAKKSV PIGIISSIAV CWILGWLIII CLMACINPDI DSVLDSKYGF
360 370 380 390 400
ALAQIIYDSL GKKWAIAFMS LIAFCQFLMG ASITTAVSRQ VWAFSRDNGL
410 420 430 440 450
PLSKYIKRVD SKYSVPFFAI LAACVGSLIL GLLCLIDDAA TDALFSLAVA
460 470 480 490 500
GNNLAWSTPT VFRLTSGRDL FRPGPFYLGK IWSPIVAWTG VAFQLFIIIL
510 520 530 540 550
VMFPSQQHGI TKSTMNYACV IGPGIWILAG IYYKVYKKKY YHGPATNLSD
560 570
DDYTEAVGAD VIDTIMSKQE P
Length:571
Mass (Da):61,873
Last modified:October 1, 1993 - v1
Checksum:i051B5828654EC784
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X66472 Genomic DNA Translation: CAA47101.1
X99000 Genomic DNA Translation: CAA67481.1
Z74258 Genomic DNA Translation: CAA98788.1
BK006938 Genomic DNA Translation: DAA11654.1
PIRiS30253
RefSeqiNP_010071.1, NM_001180270.1

Genome annotation databases

EnsemblFungiiYDL210W; YDL210W; YDL210W
GeneIDi851317
KEGGisce:YDL210W

Similar proteinsi

Entry informationi

Entry nameiUGA4_YEAST
AccessioniPrimary (citable) accession number: P32837
Secondary accession number(s): D6VRE4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: March 28, 2018
This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health