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Protein

GABA-specific permease

Gene

UGA4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Required for high-affinity, high-specificity GABA transport. Also transports putrescine.1 Publication

GO - Molecular functioni

  • antiporter activity Source: GO_Central
  • gamma-aminobutyric acid:proton symporter activity Source: SGD
  • L-amino acid transmembrane transporter activity Source: GO_Central
  • putrescine transmembrane transporter activity Source: SGD

GO - Biological processi

  • gamma-aminobutyric acid transport Source: SGD
  • putrescine transport Source: SGD
  • transmembrane transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-29592-MONOMER.

Protein family/group databases

TCDBi2.A.3.4.3. the amino acid-polyamine-organocation (apc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
GABA-specific permease
Alternative name(s):
GABA-specific transport protein
Gene namesi
Name:UGA4
Ordered Locus Names:YDL210W
ORF Names:D1037
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDL210W.
SGDiS000002369. UGA4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 7373CytoplasmicSequence analysisAdd
BLAST
Transmembranei74 – 9421HelicalSequence analysisAdd
BLAST
Topological domaini95 – 10511VacuolarSequence analysisAdd
BLAST
Transmembranei106 – 12621HelicalSequence analysisAdd
BLAST
Topological domaini127 – 15327CytoplasmicSequence analysisAdd
BLAST
Transmembranei154 – 17421HelicalSequence analysisAdd
BLAST
Topological domaini175 – 19824VacuolarSequence analysisAdd
BLAST
Transmembranei199 – 21921HelicalSequence analysisAdd
BLAST
Topological domaini220 – 2289CytoplasmicSequence analysis
Transmembranei229 – 24921HelicalSequence analysisAdd
BLAST
Topological domaini250 – 27122VacuolarSequence analysisAdd
BLAST
Transmembranei272 – 29221HelicalSequence analysisAdd
BLAST
Topological domaini293 – 31220CytoplasmicSequence analysisAdd
BLAST
Transmembranei313 – 33321HelicalSequence analysisAdd
BLAST
Topological domaini334 – 36431VacuolarSequence analysisAdd
BLAST
Transmembranei365 – 38521HelicalSequence analysisAdd
BLAST
Topological domaini386 – 41631CytoplasmicSequence analysisAdd
BLAST
Transmembranei417 – 43721HelicalSequence analysisAdd
BLAST
Topological domaini438 – 4414VacuolarSequence analysis
Transmembranei442 – 46221HelicalSequence analysisAdd
BLAST
Topological domaini463 – 48220CytoplasmicSequence analysisAdd
BLAST
Transmembranei483 – 50321HelicalSequence analysisAdd
BLAST
Topological domaini504 – 51411VacuolarSequence analysisAdd
BLAST
Transmembranei515 – 53521HelicalSequence analysisAdd
BLAST
Topological domaini536 – 57136CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • fungal-type vacuole membrane Source: SGD
  • integral component of plasma membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 571571GABA-specific permeasePRO_0000054161Add
BLAST

Expressioni

Inductioni

In the presence of GABA.

Interactioni

Protein-protein interaction databases

BioGridi31836. 36 interactions.
DIPiDIP-1857N.
IntActiP32837. 7 interactions.
MINTiMINT-409806.

Structurei

3D structure databases

ProteinModelPortaliP32837.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00530000067168.
HOGENOMiHOG000171300.
InParanoidiP32837.
OMAiTENHINQ.
OrthoDBiEOG092C1ZUR.

Family and domain databases

InterProiIPR002293. AA/rel_permease1.
IPR004840. Amoino_acid_permease_CS.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF13520. AA_permease_2. 1 hit.
[Graphical view]
PIRSFiPIRSF006060. AA_transporter. 1 hit.
PROSITEiPS00218. AMINO_ACID_PERMEASE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P32837-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSMSSKNENK ISVEQRISTD IGQAYQLQGL GSNLRSIRSK TGAGEVNYID
60 70 80 90 100
AAKSVNDNQL LAEIGYKQEL KRQFSTLQVF GIAFSIMGLL PSIASVMGGG
110 120 130 140 150
LGGGPATLVW GWFVAAFFIL LVGITMAEHA SSIPTAGGLY YWTYYYAPEG
160 170 180 190 200
YKEIISFIIG CSNSLALAAG VCSIDYGLAE EIAAAVTLTK DGNFEVTSGK
210 220 230 240 250
LYGIFAGAVV VMCICTCVAS GAIARLQTLS IFANLFIIVL LFIALPIGTK
260 270 280 290 300
HRMGGFNDGD FIFGKYENLS DWNNGWQFCL AGFMPAVWTI GSFDSCVHQS
310 320 330 340 350
EEAKDAKKSV PIGIISSIAV CWILGWLIII CLMACINPDI DSVLDSKYGF
360 370 380 390 400
ALAQIIYDSL GKKWAIAFMS LIAFCQFLMG ASITTAVSRQ VWAFSRDNGL
410 420 430 440 450
PLSKYIKRVD SKYSVPFFAI LAACVGSLIL GLLCLIDDAA TDALFSLAVA
460 470 480 490 500
GNNLAWSTPT VFRLTSGRDL FRPGPFYLGK IWSPIVAWTG VAFQLFIIIL
510 520 530 540 550
VMFPSQQHGI TKSTMNYACV IGPGIWILAG IYYKVYKKKY YHGPATNLSD
560 570
DDYTEAVGAD VIDTIMSKQE P
Length:571
Mass (Da):61,873
Last modified:October 1, 1993 - v1
Checksum:i051B5828654EC784
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X66472 Genomic DNA. Translation: CAA47101.1.
X99000 Genomic DNA. Translation: CAA67481.1.
Z74258 Genomic DNA. Translation: CAA98788.1.
BK006938 Genomic DNA. Translation: DAA11654.1.
PIRiS30253.
RefSeqiNP_010071.1. NM_001180270.1.

Genome annotation databases

EnsemblFungiiYDL210W; YDL210W; YDL210W.
GeneIDi851317.
KEGGisce:YDL210W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X66472 Genomic DNA. Translation: CAA47101.1.
X99000 Genomic DNA. Translation: CAA67481.1.
Z74258 Genomic DNA. Translation: CAA98788.1.
BK006938 Genomic DNA. Translation: DAA11654.1.
PIRiS30253.
RefSeqiNP_010071.1. NM_001180270.1.

3D structure databases

ProteinModelPortaliP32837.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31836. 36 interactions.
DIPiDIP-1857N.
IntActiP32837. 7 interactions.
MINTiMINT-409806.

Protein family/group databases

TCDBi2.A.3.4.3. the amino acid-polyamine-organocation (apc) family.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDL210W; YDL210W; YDL210W.
GeneIDi851317.
KEGGisce:YDL210W.

Organism-specific databases

EuPathDBiFungiDB:YDL210W.
SGDiS000002369. UGA4.

Phylogenomic databases

GeneTreeiENSGT00530000067168.
HOGENOMiHOG000171300.
InParanoidiP32837.
OMAiTENHINQ.
OrthoDBiEOG092C1ZUR.

Enzyme and pathway databases

BioCyciYEAST:G3O-29592-MONOMER.

Miscellaneous databases

PROiP32837.

Family and domain databases

InterProiIPR002293. AA/rel_permease1.
IPR004840. Amoino_acid_permease_CS.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF13520. AA_permease_2. 1 hit.
[Graphical view]
PIRSFiPIRSF006060. AA_transporter. 1 hit.
PROSITEiPS00218. AMINO_ACID_PERMEASE_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUGA4_YEAST
AccessioniPrimary (citable) accession number: P32837
Secondary accession number(s): D6VRE4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: September 7, 2016
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

It requires NPR (nitrogen permease reactivator protein) for its full activity.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.